Compound Information
Test on : GPCR
Compound Name : GW806290X
Inchikey : WIIIHAKKVLVGJX-UHFFFAOYSA-N
ChemSpider : 5021835
Pubchem CID : 6539369
ChEMBL : CHEMBL361894
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (19.71%) |
TYK2 | inactive (12.75%) |
JAK2 | inactive (20.59%) |
JAK3 | inactive (45.97%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (43.74%) |
FES | inactive (47.95%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (38.68%) |
ABL2 | inactive (43.89%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (14.9%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (14.46%) |
BTK | inactive (3.99%) |
TXK | inactive (17.64%) |
TEC | inactive (19.79%) |
ITK | inactive (5.82%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (13.7%) |
SRM | inactive (1.78%) |
FRK | inactive (3.19%) |
BLK | inactive (9.58%) |
LCK | inactive (9.06%) |
HCK | inactive (16.79%) |
FGR | inactive (14.52%) |
FYN | inactive (8.63%) |
SRC | inactive (32.33%) |
YES | inactive (18.29%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (5.71%) |
EphA4 | inactive (28.18%) |
EphA3 | inactive (5.48%) |
EphB4 | inactive (12.46%) |
EphB3 | inactive (6.8%) |
EphB2 | inactive (29.43%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | active (84.58%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (13.23%) |
ZAP70 | inactive (9.39%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (21.87%) |
ALK | inactive (31.72%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | active (82.69%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | active (58.52%) |
IGF1R | active (56.58%) |
IRR | inactive (15.24%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (2.07%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (26.87%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (9.5%) |
TRKB | inactive (18.06%) |
TRKC | inactive (21.33%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (16.83%) |
MET | inactive (16.77%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (10.05%) |
MER | inactive (19.59%) |
TYRO3 | inactive (25.03%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (21.9%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (5.22%) |
FGFR2 | inactive (15.88%) |
FGFR3 | inactive (15.73%) |
FGFR4 | inactive (4.77%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (20.47%) |
KDR | inactive (37.4%) |
FLT4 | inactive (21.76%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | active (85.65%) |
KIT | active (106.47%) |
FLT3 | active (75.68%) |
PDGFRa | active (51.45%) |
PDGFRb | active (67.26%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (20.52%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (21.67%) |
TNK1 | active (64.46%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (4.28%) |
ErbB2 | inactive (2.67%) |
ErbB4 | inactive (12.4%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (7.85%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (33.34%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | active (56.47%) |
MST1 | inactive (19.05%) |
MST2 | inactive (16.05%) |
MST4 | inactive (-0.78%) |
HGK | active (51.54%) |
MINK | inactive (40.43%) |
LOK | inactive (23.8%) |
PAK1 | inactive (4.56%) |
PAK3 | inactive (4.73%) |
PAK2 | inactive (3.37%) |
PAK5 | inactive (14.72%) |
PAK6 | inactive (9.62%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (27.75%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (44.88%) |
CK1g2 | inactive (46.85%) |
CK1g1 | inactive (22.09%) |
CK1g3 | inactive (38.03%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (29.4%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | active (65.24%) |
AurC | active (96.8%) |
AurA | active (85.47%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (20.38%) |
NEK2 | inactive (15.4%) |
NEK9 | inactive (49.9%) |
NEK7 | inactive (6.49%) |
NEK6 | inactive (4.5%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (23.85%) |
IKKe | inactive (20.51%) |
IKKb | inactive (30.04%) |
IKKa | active (60.55%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (35%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (2.89%) |
GPRK6 | inactive (4.01%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (6.44%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (6.82%) |
MSK2 | inactive (6.51%) |
RSK1 | inactive (7.26%) |
RSK2 | inactive (4.28%) |
RSK4 | inactive (9.17%) |
RSK3 | inactive (4.85%) |
p70S6K | inactive (5.63%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (1.47%) |
AKT1 | inactive (0.95%) |
AKT3 | inactive (2.1%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (7.34%) |
SGK3 | inactive (-0.29%) |
SGK2 | inactive (1.72%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (8.26%) |
PKCg | inactive (9.81%) |
PKCa | inactive (20.36%) |
PKCt | inactive (5.92%) |
PKCi | inactive (1.82%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (8.51%) |
PKG1 | inactive (18.9%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (2.29%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (9.73%) |
ROCK2 | inactive (19.14%) |
MRCKb | inactive (1.8%) |
MRCKa | inactive (0.87%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (9.21%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (1.89%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (1.89%) |
CaMK1d | inactive (5.85%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (27.64%) |
PHKg2 | inactive (17.1%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (35.69%) |
CaMK2a | inactive (15.3%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (2.58%) |
MAPKAPK2 | inactive (2.24%) |
MAPKAPK3 | inactive (3.81%) |
MNK2 | inactive (25.88%) |
MNK1 | inactive (14.49%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | active (50.5%) |
PKD1 | inactive (45.06%) |
PKD2 | inactive (38.2%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (16.42%) |
MARK3 | inactive (24.83%) |
MARK1 | inactive (24.28%) |
QIK | inactive (17.66%) |
SIK | inactive (20.41%) |
NuaK1 | active (83.16%) |
BRSK1 | inactive (6.78%) |
BRSK2 | inactive (9.28%) |
MELK | active (51.56%) |
CHK1 | inactive (6.81%) |
PASK | inactive (0.82%) |
AMPKa1 | inactive (11.56%) |
AMPKa2 | inactive (12.62%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (4.19%) |
TSSK1 | inactive (18.06%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (3.76%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (4.39%) |
PIM3 | inactive (16.17%) |
PIM1 | inactive (7.95%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | active (54.37%) |
p38a | inactive (13.31%) |
p38b | inactive (9.95%) |
p38d | inactive (16.27%) |
Erk2 | inactive (23.98%) |
Erk1 | inactive (12%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | active (92.49%) |
GSK3B | active (91.02%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (2.88%) |
MSSK1 | inactive (1.61%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | active (51.98%) |
CLK2 | active (97.62%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | active (92.97%) |
HIPK4 | active (79.84%) |
DYRK1B | active (88.93%) |
DYRK1A | active (87.57%) |
DYRK2 | active (50.79%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (47.54%) |