Compound Information
Test on : GPCR
Compound Name : CHEMBL361237
Inchikey : WDANXJFHYRXNLL-UHFFFAOYSA-N
ChemSpider : 9465207
Pubchem CID : 11290221
ChEMBL : CHEMBL361237
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (6.76%) |
TYK2 | inactive (-1.99%) |
JAK2 | inactive (4.07%) |
JAK3 | inactive (1.8%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (11.06%) |
FES | inactive (4.26%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (27.78%) |
ABL2 | inactive (20.15%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (5.38%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (6.23%) |
BTK | inactive (0.99%) |
TXK | inactive (6%) |
TEC | inactive (6.46%) |
ITK | inactive (2.71%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (20.57%) |
SRM | inactive (3.74%) |
FRK | inactive (2.66%) |
BLK | inactive (12.09%) |
LCK | inactive (16.7%) |
HCK | inactive (17.46%) |
FGR | inactive (14.11%) |
FYN | inactive (12.38%) |
SRC | inactive (14.2%) |
YES | inactive (37.77%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (0.59%) |
EphA4 | inactive (14.56%) |
EphA3 | inactive (6.22%) |
EphB4 | inactive (5.58%) |
EphB3 | inactive (5.14%) |
EphB2 | inactive (15.19%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (14.29%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (0.4%) |
ZAP70 | inactive (1.99%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (7.86%) |
ALK | inactive (5.68%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (15.82%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (43.32%) |
IGF1R | inactive (24.38%) |
IRR | inactive (1.87%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (-5.99%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (7.29%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (4.77%) |
TRKB | inactive (3.45%) |
TRKC | inactive (5.31%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (7.82%) |
MET | inactive (10.08%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-3.07%) |
MER | inactive (5.56%) |
TYRO3 | inactive (2.87%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (14.75%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (4.14%) |
FGFR2 | inactive (11.78%) |
FGFR3 | inactive (11.37%) |
FGFR4 | inactive (3.47%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (6.56%) |
KDR | active (71.08%) |
FLT4 | inactive (11.57%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (7.59%) |
KIT | inactive (9.66%) |
FLT3 | inactive (3.75%) |
PDGFRa | active (51.7%) |
PDGFRb | inactive (42.91%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (4.32%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (3.57%) |
TNK1 | inactive (6.8%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (21.7%) |
ErbB2 | inactive (6.61%) |
ErbB4 | inactive (48.55%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (2.12%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (7.72%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (3.82%) |
MST1 | inactive (6.98%) |
MST2 | inactive (5.82%) |
MST4 | inactive (9.07%) |
HGK | active (61.8%) |
MINK | inactive (47.91%) |
LOK | inactive (10.07%) |
PAK1 | inactive (6.35%) |
PAK3 | inactive (5.56%) |
PAK2 | inactive (2.07%) |
PAK5 | inactive (4.21%) |
PAK6 | inactive (-1.32%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (4.31%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (15.15%) |
CK1g2 | inactive (8.8%) |
CK1g1 | inactive (10.52%) |
CK1g3 | inactive (16.85%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (6.9%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (7.91%) |
AurC | inactive (-0.03%) |
AurA | inactive (10.6%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (36.03%) |
NEK2 | inactive (6.71%) |
NEK9 | inactive (11.07%) |
NEK7 | inactive (3.14%) |
NEK6 | inactive (5.03%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (6.6%) |
IKKe | inactive (7.4%) |
IKKb | inactive (4.99%) |
IKKa | inactive (5.46%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (7.77%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (7.94%) |
GPRK6 | inactive (5.57%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (4.53%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (3.83%) |
MSK2 | inactive (4.49%) |
RSK1 | inactive (7.04%) |
RSK2 | inactive (3.18%) |
RSK4 | inactive (3.36%) |
RSK3 | inactive (3.03%) |
p70S6K | inactive (2.7%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (2.19%) |
AKT1 | inactive (1.34%) |
AKT3 | inactive (1.9%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (4.24%) |
SGK3 | inactive (3.66%) |
SGK2 | inactive (4.34%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (6.71%) |
PKCg | inactive (4.5%) |
PKCa | inactive (2.9%) |
PKCt | inactive (3.74%) |
PKCi | inactive (1.59%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (4.3%) |
PKG1 | inactive (4.97%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (3.14%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (2.11%) |
ROCK2 | inactive (5.66%) |
MRCKb | inactive (0.94%) |
MRCKa | inactive (3.87%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (4.06%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (1.19%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (-0.24%) |
CaMK1d | inactive (0.5%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (7.81%) |
PHKg2 | inactive (5.79%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (4.81%) |
CaMK2a | inactive (4.65%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (2.44%) |
MAPKAPK2 | inactive (1.53%) |
MAPKAPK3 | inactive (24.56%) |
MNK2 | inactive (5.26%) |
MNK1 | inactive (8.56%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (41.76%) |
PKD1 | inactive (45.03%) |
PKD2 | active (51.85%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (2.43%) |
MARK3 | inactive (3.12%) |
MARK1 | inactive (7.14%) |
QIK | inactive (11.62%) |
SIK | inactive (7.23%) |
NuaK1 | inactive (7.09%) |
BRSK1 | inactive (3.32%) |
BRSK2 | inactive (5.28%) |
MELK | inactive (22.32%) |
CHK1 | inactive (5.94%) |
PASK | inactive (-0.64%) |
AMPKa1 | inactive (5.29%) |
AMPKa2 | inactive (3.37%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (2.23%) |
TSSK1 | inactive (6.63%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (4.25%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (0.96%) |
PIM3 | inactive (2.02%) |
PIM1 | inactive (2.38%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (25.32%) |
p38a | active (76.36%) |
p38b | inactive (33.1%) |
p38d | inactive (5.76%) |
Erk2 | inactive (5.05%) |
Erk1 | inactive (3.86%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (20.83%) |
GSK3B | inactive (19.64%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (1.42%) |
MSSK1 | inactive (2.22%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (6.28%) |
CLK2 | inactive (8.8%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (13.87%) |
HIPK4 | inactive (10.99%) |
DYRK1B | inactive (19.75%) |
DYRK1A | inactive (37.38%) |
DYRK2 | inactive (5.03%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (12.98%) |