Compound Information
Test on : RBC
Compound Name : TWS119
Inchikey : VPVLEBIVXZSOMQ-UHFFFAOYSA-N
ChemSpider : 7828205
Pubchem CID : 9549289
ChEMBL : CHEMBL405759
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
AGC
AGC - PDK1
Bioactivity |
---|
Kinase | RBC |
---|
PDK1 | inactive (86.85%) |
AGC - Akt
Bioactivity |
---|
Kinase | RBC |
---|
AKT1 | inactive (92.51%) |
AKT2 | inactive (109.41%) |
AKT3 | inactive (96.21%) |
AGC - DMPK
Bioactivity |
---|
Kinase | RBC |
---|
DMPK1 | inactive (95.15%) |
MRCKa | inactive (87.68%) |
MRCKb | inactive (93.46%) |
ROCK1 | inactive (94.06%) |
ROCK2 | inactive (94.55%) |
AGC - GRK
Bioactivity |
---|
Kinase | RBC |
---|
BARK1 | inactive (107.67%) |
BARK2 | inactive (100.5%) |
GPRK4 | inactive (94.7%) |
GPRK5 | inactive (128.23%) |
GPRK6 | inactive (98.01%) |
GPRK7 | inactive (102.11%) |
AGC - RSK
Bioactivity |
---|
Kinase | RBC |
---|
MSK1 | inactive (83.59%) |
MSK2 | inactive (102.82%) |
p70S6K | inactive (95.26%) |
p70S6Kb | inactive (94.72%) |
RSK2 | inactive (96.93%) |
RSK4 | inactive (95.37%) |
RSK1 | inactive (104.8%) |
RSK3 | inactive (91.55%) |
AGC - PKA
Bioactivity |
---|
Kinase | RBC |
---|
PKACg | - |
PRKX | inactive (113.94%) |
PKACa | inactive (92.33%) |
AGC - PKC
Bioactivity |
---|
Kinase | RBC |
---|
PKCa | inactive (95.61%) |
PKCd | inactive (95.7%) |
PKCe | inactive (97.41%) |
PKCh | inactive (90.02%) |
PKCg | inactive (88.14%) |
PKCi | inactive (84.65%) |
PKCt | inactive (64.55%) |
PKCz | inactive (93.96%) |
PKCb | inactive (97.46%) |
AGC - PKG
Bioactivity |
---|
Kinase | RBC |
---|
PKG2 | inactive (108.18%) |
PKG1 | inactive (103.33%) |
AGC - PKN
Bioactivity |
---|
Kinase | RBC |
---|
PKN1 | inactive (105.1%) |
PKN2 | inactive (72.02%) |
AGC - SGK
Bioactivity |
---|
Kinase | RBC |
---|
SGK1 | inactive (101%) |
SGK2 | inactive (96.23%) |
SGK3 | inactive (116.54%) |
AGC - NDR
Bioactivity |
---|
Kinase | RBC |
---|
NDR1 | active (0%) |
TK
TK - Abl
Bioactivity |
---|
Kinase | RBC |
---|
ABL1 | active (5.5%) |
ABL2 | active (1.4%) |
TK - Ack
Bioactivity |
---|
Kinase | RBC |
---|
ACK | active (19.61%) |
TK - ALK
Bioactivity |
---|
Kinase | RBC |
---|
ALK | inactive (80.89%) |
LTK | active (16.76%) |
TK - Axl
Bioactivity |
---|
Kinase | RBC |
---|
AXL | inactive (75.92%) |
MER | inactive (63.77%) |
TYRO3 | inactive (52.06%) |
TK - Src
Bioactivity |
---|
Kinase | RBC |
---|
BLK | active (38.12%) |
BRK | active (11.11%) |
SRC | active (2.07%) |
FGR | active (5.28%) |
FRK | active (6.95%) |
FYN | active (7.92%) |
HCK | active (6.65%) |
LCK | active (24.25%) |
SRM | inactive (94.41%) |
YES | active (6.05%) |
LYN | active (11.06%) |
TK - Tec
Bioactivity |
---|
Kinase | RBC |
---|
BMX | active (24.28%) |
BTK | active (33.62%) |
ITK | inactive (102.2%) |
TEC | inactive (107.57%) |
TXK | active (24.48%) |
TK - PDGFR
Bioactivity |
---|
Kinase | RBC |
---|
KIT | active (35.09%) |
FLT3 | active (30.74%) |
FMS | active (13.58%) |
PDGFRb | active (39.85%) |
PDGFRa | inactive (73.62%) |
TK - Csk
Bioactivity |
---|
Kinase | RBC |
---|
CSK | active (43.63%) |
CTK | inactive (97.81%) |
TK - DDR
Bioactivity |
---|
Kinase | RBC |
---|
DDR2 | active (29.26%) |
TK - EGFR
Bioactivity |
---|
Kinase | RBC |
---|
EGFR | active (7.89%) |
ErbB2 | inactive (76.57%) |
ErbB4 | inactive (75.79%) |
TK - Eph
Bioactivity |
---|
Kinase | RBC |
---|
EphA1 | active (31.19%) |
EphA2 | active (48.16%) |
EphA3 | active (39.72%) |
EphA4 | active (48.3%) |
EphA5 | active (41.67%) |
EphA6 | - |
EphA7 | inactive (77.22%) |
EphA8 | inactive (57.52%) |
EphB1 | active (40%) |
EphB2 | active (40.74%) |
EphB3 | inactive (78.78%) |
EphB4 | - |
TK - FAK
Bioactivity |
---|
Kinase | RBC |
---|
FAK | inactive (88.43%) |
PYK2 | inactive (65.56%) |
TK - Fer
Bioactivity |
---|
Kinase | RBC |
---|
FER | active (44.03%) |
FES | inactive (73.83%) |
TK - FGFR
Bioactivity |
---|
Kinase | RBC |
---|
FGFR1 | active (39.26%) |
FGFR2 | active (46.12%) |
FGFR3 | inactive (67.9%) |
FGFR4 | active (45.09%) |
TK - VEGFR
Bioactivity |
---|
Kinase | RBC |
---|
FLT1 | active (8.56%) |
FLT4 | active (15.83%) |
KDR | active (6.7%) |
TK - InsR
Bioactivity |
---|
Kinase | RBC |
---|
IGF1R | inactive (99.51%) |
IRR | inactive (96.34%) |
INSR | inactive (93.71%) |
TK - JakA
Bioactivity |
---|
Kinase | RBC |
---|
JAK1 | inactive (106.31%) |
JAK2 | inactive (85.43%) |
JAK3 | inactive (122.54%) |
TYK2 | active (36.89%) |
TK - Musk
Bioactivity |
---|
Kinase | RBC |
---|
MUSK | inactive (62.8%) |
TK - Ret
Bioactivity |
---|
Kinase | RBC |
---|
RET | active (-0.23%) |
TK - Met
Bioactivity |
---|
Kinase | RBC |
---|
RON | inactive (103.1%) |
MET | inactive (109.88%) |
TK - Sev
Bioactivity |
---|
Kinase | RBC |
---|
ROS | active (39.7%) |
TK - Syk
Bioactivity |
---|
Kinase | RBC |
---|
SYK | active (36.14%) |
ZAP70 | inactive (97.5%) |
TK - Tie
Bioactivity |
---|
Kinase | RBC |
---|
TIE2 | inactive (60.7%) |
TK - Trk
Bioactivity |
---|
Kinase | RBC |
---|
TRKA | inactive (90.54%) |
TRKB | inactive (95.47%) |
TRKC | inactive (63.32%) |
TKL
TKL - STKR
Bioactivity |
---|
Kinase | RBC |
---|
ALK1 | inactive (70.29%) |
ALK2 | inactive (182.6%) |
ALK4 | inactive (122.17%) |
TGFbR1 | inactive (100.63%) |
TGFbR2 | active (42.56%) |
TKL - RAF
Bioactivity |
---|
Kinase | RBC |
---|
ARAF | inactive (57.31%) |
BRAF | inactive (53.25%) |
RAF1 | inactive (85.9%) |
TKL - IRAK
Bioactivity |
---|
Kinase | RBC |
---|
IRAK1 | inactive (91.42%) |
IRAK4 | inactive (88.21%) |
TKL - LISK
Bioactivity |
---|
Kinase | RBC |
---|
LIMK1 | active (22.13%) |
TKL - LRRK
Bioactivity |
---|
Kinase | RBC |
---|
LRRK2 | inactive (93.37%) |
TKL - MLK
Bioactivity |
---|
Kinase | RBC |
---|
MLK1 | active (16.23%) |
MLK2 | inactive (79.23%) |
MLK3 | inactive (52.42%) |
TAK1 | inactive (63.01%) |
ZAK | active (13.89%) |
TKL - RIPK
Bioactivity |
---|
Kinase | RBC |
---|
RIPK2 | active (30.51%) |
CAMK
CAMK - CAMKL
Bioactivity |
---|
Kinase | RBC |
---|
NuaK1 | active (37%) |
BRSK1 | inactive (83.08%) |
BRSK2 | inactive (86.93%) |
CHK1 | inactive (66.21%) |
LKB1 | active (12.37%) |
MARK1 | inactive (83.01%) |
MARK3 | inactive (77.5%) |
MARK4 | inactive (68.85%) |
MELK | inactive (93.4%) |
PASK | inactive (96.22%) |
QIK | inactive (69.44%) |
NuaK2 | inactive (90.3%) |
MARK2 | inactive (79.03%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | RBC |
---|
CaMK1a | inactive (112.2%) |
CaMK1b | inactive (98.24%) |
CaMK1d | inactive (97.71%) |
CaMK1g | inactive (99%) |
CaMK4 | inactive (94.9%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | RBC |
---|
CaMK2a | inactive (114.93%) |
CaMK2b | inactive (100.7%) |
CaMK2d | inactive (99.83%) |
CaMK2g | inactive (105.41%) |
CAMK - RAD53
Bioactivity |
---|
Kinase | RBC |
---|
CHK2 | inactive (75.85%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | RBC |
---|
DAPK1 | inactive (89.07%) |
DAPK2 | inactive (106.04%) |
DRAK1 | inactive (93.66%) |
DAPK3 | inactive (93.96%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | RBC |
---|
DCLK2 | inactive (89.04%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | RBC |
---|
MAPKAPK2 | inactive (108.07%) |
MAPKAPK3 | inactive (97.59%) |
MAPKAPK5 | inactive (124.69%) |
MNK1 | inactive (87.63%) |
MNK2 | inactive (67.46%) |
CAMK - MLCK
Bioactivity |
---|
Kinase | RBC |
---|
smMLCK | inactive (81.73%) |
skMLCK | active (29.94%) |
CAMK - PHK
Bioactivity |
---|
Kinase | RBC |
---|
PHKg1 | inactive (81.52%) |
PHKg2 | inactive (108.97%) |
CAMK - PIM
Bioactivity |
---|
Kinase | RBC |
---|
PIM1 | inactive (85.89%) |
PIM2 | inactive (107.83%) |
PIM3 | inactive (128.81%) |
CAMK - PKD
Bioactivity |
---|
Kinase | RBC |
---|
PKD1 | inactive (94.44%) |
PKD3 | inactive (91.02%) |
PKD2 | inactive (81.68%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | RBC |
---|
TSSK1 | inactive (91.12%) |
TSSK2 | inactive (95.62%) |
CAMK - STK33
Bioactivity |
---|
Kinase | RBC |
---|
STK33 | inactive (80.28%) |
STE
STE - STE11
Bioactivity |
---|
Kinase | RBC |
---|
MAP3K5 | inactive (94.87%) |
MAP3K2 | inactive (86.94%) |
MAP3K3 | inactive (96.43%) |
STE - STE-Unique
Bioactivity |
---|
Kinase | RBC |
---|
COT | inactive (99.65%) |
NIK | inactive (69.64%) |
STE - STE20
Bioactivity |
---|
Kinase | RBC |
---|
GCK | inactive (55.5%) |
HGK | active (12.46%) |
KHS1 | active (18.42%) |
LOK | active (45.84%) |
MINK | active (34.69%) |
MST1 | inactive (94.43%) |
MST2 | inactive (108.69%) |
MST3 | inactive (64.19%) |
MST4 | inactive (83.75%) |
OSR1 | inactive (118.57%) |
PAK1 | inactive (87.96%) |
PAK2 | inactive (88.93%) |
PAK3 | inactive (79.83%) |
PAK4 | inactive (99.82%) |
PAK5 | inactive (86.87%) |
PAK6 | inactive (109.06%) |
SLK | inactive (64.09%) |
YSK1 | inactive (91.58%) |
STLK3 | inactive (119.13%) |
TAO1 | inactive (142.19%) |
TAO2 | inactive (81.43%) |
TAO3 | inactive (93.51%) |
MYO3B | active (0%) |
STE - STE7
Bioactivity |
---|
Kinase | RBC |
---|
MAP2K1 | inactive (76.27%) |
MAP2K2 | inactive (103.72%) |
MAP2K6 | inactive (90.13%) |
Other
Other - Aur
Bioactivity |
---|
Kinase | RBC |
---|
AurA | inactive (78.25%) |
AurB | inactive (71.86%) |
AurC | inactive (77.67%) |
Other - CAMKK
Bioactivity |
---|
Kinase | RBC |
---|
CaMKK1 | inactive (113.23%) |
CaMKK2 | inactive (95.86%) |
Other - Haspin
Bioactivity |
---|
Kinase | RBC |
---|
Haspin | inactive (93.29%) |
Other - IKK
Bioactivity |
---|
Kinase | RBC |
---|
IKKa | inactive (101.9%) |
IKKb | inactive (90.79%) |
IKKe | inactive (88.12%) |
TBK1 | inactive (92.89%) |
Other - NEK
Bioactivity |
---|
Kinase | RBC |
---|
NEK1 | inactive (92.34%) |
NEK11 | inactive (89.58%) |
NEK2 | inactive (98.05%) |
NEK4 | inactive (91.39%) |
NEK6 | inactive (90.18%) |
NEK7 | inactive (99.44%) |
NEK9 | inactive (103.43%) |
NEK3 | inactive (57.48%) |
Other - TOPK
Bioactivity |
---|
Kinase | RBC |
---|
PBK | inactive (93.86%) |
Other - PLK
Bioactivity |
---|
Kinase | RBC |
---|
PLK1 | inactive (103.96%) |
PLK2 | inactive (106.23%) |
PLK3 | inactive (95.67%) |
Other - SgK496
Bioactivity |
---|
Kinase | RBC |
---|
SgK496 | inactive (83.41%) |
Other - NAK
Bioactivity |
---|
Kinase | RBC |
---|
MPSK1 | inactive (70.36%) |
Other - TTK
Bioactivity |
---|
Kinase | RBC |
---|
TTK | inactive (104.01%) |
Other - ULK
Bioactivity |
---|
Kinase | RBC |
---|
ULK1 | inactive (142.62%) |
ULK2 | inactive (97.46%) |
ULK3 | active (0%) |
Other - WEE
Bioactivity |
---|
Kinase | RBC |
---|
Wee1 | inactive (85.45%) |
Other - WNK
Bioactivity |
---|
Kinase | RBC |
---|
Wnk2 | inactive (103.43%) |
Wnk3 | inactive (88.5%) |
Other - TLK
Bioactivity |
---|
Kinase | RBC |
---|
TLK2 | active (0%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC |
---|
CK1 | 7 | 6 |
VRK | 3 | 1 |
CK1 - CK1
Bioactivity |
---|
Kinase | RBC |
---|
CK1d | inactive (96.82%) |
CK1g1 | inactive (101.8%) |
CK1g2 | inactive (84.89%) |
CK1g3 | inactive (92.57%) |
CK1a | inactive (61.78%) |
CK1e | inactive (92.89%) |
CK1 - VRK
Bioactivity |
---|
Kinase | RBC |
---|
VRK1 | inactive (81.62%) |
CMGC
CMGC - CK2
Bioactivity |
---|
Kinase | RBC |
---|
CK2a1 | inactive (96.77%) |
CK2a2 | inactive (96.51%) |
CMGC - CLK
Bioactivity |
---|
Kinase | RBC |
---|
CLK1 | inactive (93.01%) |
CLK2 | inactive (98.76%) |
CLK3 | inactive (73.96%) |
CLK4 | inactive (104.38%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | RBC |
---|
DYRK1A | inactive (103.25%) |
DYRK1B | inactive (100.3%) |
DYRK2 | inactive (76.93%) |
DYRK3 | inactive (89.81%) |
DYRK4 | inactive (100.86%) |
HIPK1 | inactive (82.71%) |
HIPK2 | inactive (99.99%) |
HIPK3 | inactive (93.98%) |
HIPK4 | inactive (102.98%) |
CMGC - MAPK
Bioactivity |
---|
Kinase | RBC |
---|
Erk1 | inactive (86.86%) |
Erk2 | inactive (113.63%) |
JNK3 | inactive (89.41%) |
NLK | inactive (87.69%) |
p38a | inactive (98.08%) |
p38b | inactive (108.43%) |
p38d | inactive (104.18%) |
p38g | inactive (88.56%) |
JNK1 | inactive (94.4%) |
JNK2 | inactive (110.73%) |
CMGC - GSK
Bioactivity |
---|
Kinase | RBC |
---|
GSK3A | active (41.59%) |
GSK3B | active (48.13%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | RBC |
---|
MSSK1 | inactive (100.95%) |
SRPK1 | inactive (107.37%) |
SRPK2 | inactive (99.11%) |
Atypical
Atypical
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC |
---|
PDHK | 5 | 1 |
Atypical - PDHK
Bioactivity |
---|
Kinase | RBC |
---|
PDHK1 | inactive (86.85%) |