Compound Information
Test on : RBC, Millipore
Compound Name
RBC : 608512-97-6
Millipore : PKR Inhibitor
Inchikey
Same : VFBGXTUGODTSPK-N
RBC : VFBGXTUGODTSPK-UHFFFAOYSA-N
Millipore : VFBGXTUGODTSPK-BAQGIRSFSA-N
ChemSpider
RBC : 28467728
Millipore : 4990932
Pubchem CID
RBC : 57351456
Millipore : 6490494
ChEMBL
RBC : -
Millipore : CHEMBL235641
RBC | Millipore |
| |
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
AGC
AGC - PDK1
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
PDK1 | inactive (76.73%) | active (31%) |
AGC - Akt
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
AKT1 | inactive (79.23%) | inactive (99%) |
AKT2 | inactive (89.71%) | inactive (128%) |
AKT3 | inactive (90.23%) | inactive (78%) |
AGC - DMPK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
DMPK1 | inactive (95.79%) | inactive (120%) |
MRCKa | inactive (94.16%) | inactive (104%) |
MRCKb | inactive (87.81%) | inactive (75%) |
ROCK1 | active (26.01%) | inactive (59%) |
ROCK2 | active (11.68%) | active (5%) |
AGC - GRK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
BARK1 | inactive (107.27%) | - |
BARK2 | inactive (97.31%) | - |
GPRK4 | inactive (86.89%) | - |
GPRK5 | inactive (81.33%) | inactive (71%) |
GPRK6 | inactive (67.72%) | inactive (78%) |
GPRK7 | inactive (81.27%) | inactive (63%) |
AGC - RSK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
MSK1 | active (34.66%) | active (43%) |
MSK2 | active (28%) | active (20%) |
p70S6K | inactive (57.11%) | active (46%) |
p70S6Kb | inactive (95.14%) | - |
RSK2 | active (28.02%) | active (18%) |
RSK4 | active (8.68%) | active (14%) |
RSK1 | active (20.44%) | active (5%) |
RSK3 | active (7.84%) | active (28%) |
AGC - PKA
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
PKACg | inactive (87.58%) | - |
PRKX | active (28.21%) | active (24%) |
PKACa | active (40.08%) | active (25%) |
AGC - PKC
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
PKCa | inactive (91.36%) | inactive (67%) |
PKCd | active (29.15%) | active (15%) |
PKCe | active (19.45%) | active (27%) |
PKCh | active (41.16%) | active (23%) |
PKCg | inactive (98.68%) | inactive (69%) |
PKCi | inactive (80.28%) | inactive (85%) |
PKCt | inactive (112.33%) | active (49%) |
PKCz | inactive (83.18%) | inactive (86%) |
PKCb | inactive (87.58%) | - |
AGC - PKG
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
PKG2 | active (3%) | - |
PKG1 | active (17.46%) | - |
AGC - PKN
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
PKN1 | active (22.02%) | - |
PKN2 | active (44.05%) | active (4%) |
AGC - SGK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
SGK1 | active (24.67%) | active (31%) |
SGK2 | active (24.96%) | active (12%) |
SGK3 | inactive (81.25%) | inactive (73%) |
AGC - NDR
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
NDR1 | inactive (51.03%) | - |
TK
TK - Abl
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
ABL1 | inactive (71.63%) | inactive (66%) |
ABL2 | inactive (69.82%) | inactive (82%) |
TK - Ack
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
ACK | inactive (71.24%) | inactive (64%) |
TK - ALK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
ALK | inactive (72.44%) | inactive (72%) |
LTK | inactive (82.99%) | - |
TK - Axl
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
AXL | inactive (100.7%) | active (26%) |
MER | inactive (75.09%) | active (6%) |
TYRO3 | inactive (84.13%) | inactive (56%) |
TK - Src
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
BLK | inactive (81.27%) | active (44%) |
BRK | inactive (64.47%) | inactive (66%) |
SRC | inactive (78.1%) | inactive (70%) |
FGR | inactive (62.81%) | active (47%) |
FRK | inactive (84.96%) | inactive (83%) |
FYN | inactive (75.13%) | active (46%) |
HCK | inactive (73.89%) | inactive (58%) |
LCK | inactive (84.84%) | inactive (55%) |
SRM | inactive (96.93%) | - |
YES | inactive (54.31%) | inactive (52%) |
LYN | inactive (73.22%) | active (46%) |
TK - Tec
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
BMX | inactive (81.9%) | inactive (52%) |
BTK | inactive (85.18%) | inactive (88%) |
ITK | inactive (80.89%) | inactive (67%) |
TEC | inactive (115.53%) | - |
TXK | inactive (70.14%) | inactive (82%) |
TK - PDGFR
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
KIT | active (46.79%) | active (25%) |
FLT3 | active (2.82%) | active (1%) |
FMS | inactive (58.51%) | active (22%) |
PDGFRb | active (40.97%) | inactive (79%) |
PDGFRa | inactive (57.73%) | inactive (68%) |
TK - Csk
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
CSK | inactive (87.2%) | inactive (104%) |
CTK | inactive (101.94%) | - |
TK - DDR
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
DDR2 | inactive (100.69%) | inactive (113%) |
TK - EGFR
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
EGFR | inactive (74.42%) | inactive (116%) |
ErbB2 | inactive (99.76%) | - |
ErbB4 | inactive (94.77%) | inactive (88%) |
TK - Eph
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
EphA1 | inactive (83.94%) | inactive (58%) |
EphA2 | inactive (78.83%) | inactive (77%) |
EphA3 | inactive (77.13%) | inactive (82%) |
EphA4 | inactive (85.57%) | inactive (102%) |
EphA5 | inactive (92.35%) | inactive (89%) |
EphA6 | active (48.65%) | - |
EphA7 | inactive (71.27%) | inactive (77%) |
EphA8 | inactive (93.43%) | inactive (95%) |
EphB1 | inactive (62.23%) | inactive (60%) |
EphB2 | inactive (94.25%) | inactive (87%) |
EphB3 | inactive (86.05%) | inactive (120%) |
EphB4 | inactive (90.56%) | inactive (79%) |
TK - FAK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
FAK | inactive (71.39%) | inactive (73%) |
PYK2 | inactive (88.01%) | inactive (79%) |
TK - Fer
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
FER | inactive (77.87%) | inactive (97%) |
FES | inactive (73.5%) | inactive (62%) |
TK - FGFR
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
FGFR1 | active (41.31%) | active (9%) |
FGFR2 | active (37.6%) | active (18%) |
FGFR3 | active (34.75%) | active (19%) |
FGFR4 | inactive (90.67%) | inactive (112%) |
TK - VEGFR
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
FLT1 | active (40.09%) | active (1%) |
FLT4 | active (12.11%) | active (0%) |
KDR | active (34.51%) | active (2%) |
TK - InsR
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
IGF1R | inactive (97.5%) | inactive (132%) |
IRR | inactive (100.36%) | inactive (119%) |
INSR | inactive (93.27%) | inactive (85%) |
TK - JakA
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
JAK1 | inactive (53.95%) | - |
JAK2 | inactive (69.9%) | inactive (59%) |
JAK3 | active (20.63%) | active (16%) |
TYK2 | active (12.35%) | - |
TK - Musk
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
MUSK | active (21.61%) | inactive (53%) |
TK - Ret
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
RET | active (10.56%) | active (9%) |
TK - Met
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
RON | inactive (70.18%) | inactive (60%) |
MET | inactive (74.42%) | active (18%) |
TK - Sev
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
ROS | inactive (73.65%) | inactive (88%) |
TK - Syk
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
SYK | inactive (74.41%) | inactive (101%) |
ZAP70 | inactive (99.03%) | inactive (102%) |
TK - Tie
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
TIE2 | inactive (90.57%) | inactive (67%) |
TK - Trk
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
TRKA | inactive (53.74%) | active (3%) |
TRKB | active (17.37%) | active (19%) |
TRKC | active (6.55%) | - |
TKL
TKL - STKR
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
ALK1 | inactive (112.76%) | - |
ALK2 | inactive (143.53%) | - |
ALK4 | inactive (130.99%) | inactive (85%) |
TGFbR1 | inactive (103.11%) | inactive (68%) |
TGFbR2 | inactive (75.11%) | - |
TKL - RAF
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
ARAF | inactive (115.03%) | - |
BRAF | inactive (100.23%) | - |
RAF1 | inactive (104.3%) | active (48%) |
TKL - IRAK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
IRAK1 | inactive (52.51%) | active (28%) |
IRAK4 | inactive (59.48%) | active (41%) |
TKL - LISK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
LIMK1 | inactive (61.27%) | inactive (55%) |
TKL - LRRK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
LRRK2 | active (8.5%) | - |
TKL - MLK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
MLK1 | active (46.08%) | active (9%) |
MLK2 | inactive (65.36%) | - |
MLK3 | active (28.86%) | - |
TAK1 | active (11.97%) | active (16%) |
ZAK | inactive (52.84%) | - |
TKL - RIPK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
RIPK2 | inactive (84.96%) | inactive (59%) |
CAMK
CAMK - CAMKL
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
NuaK1 | active (0.75%) | active (6%) |
BRSK1 | active (10.03%) | active (2%) |
BRSK2 | active (10.25%) | active (11%) |
CHK1 | active (27.09%) | active (35%) |
LKB1 | active (13.52%) | active (21%) |
MARK1 | active (19.96%) | active (9%) |
MARK3 | active (21.26%) | - |
MARK4 | active (12.85%) | - |
MELK | active (4.74%) | active (6%) |
PASK | active (40.85%) | active (46%) |
QIK | inactive (74.01%) | - |
NuaK2 | active (41.21%) | - |
MARK2 | active (16.72%) | active (10%) |
AMPKa1 | - | active (10%) |
AMPKa2 | - | active (3%) |
SIK | - | active (49%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
CaMK1a | inactive (81.91%) | inactive (72%) |
CaMK1b | inactive (99.56%) | - |
CaMK1d | inactive (117.32%) | inactive (72%) |
CaMK1g | inactive (102.26%) | - |
CaMK4 | inactive (101.15%) | inactive (80%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
CaMK2a | active (42.26%) | - |
CaMK2b | active (40.76%) | active (13%) |
CaMK2d | inactive (53.06%) | active (18%) |
CaMK2g | inactive (101.04%) | active (21%) |
CAMK - RAD53
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
CHK2 | active (49.84%) | active (50%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
DAPK1 | inactive (94.35%) | inactive (85%) |
DAPK2 | inactive (125.24%) | inactive (71%) |
DRAK1 | active (6.82%) | active (1%) |
DAPK3 | inactive (89.1%) | inactive (68%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
DCLK2 | inactive (69.76%) | inactive (55%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
MAPKAPK2 | inactive (97.59%) | inactive (82%) |
MAPKAPK3 | inactive (91.02%) | inactive (103%) |
MAPKAPK5 | inactive (74.45%) | active (49%) |
MNK1 | active (9.89%) | - |
MNK2 | active (17.64%) | active (9%) |
CAMK - MLCK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
smMLCK | active (40.07%) | active (25%) |
skMLCK | active (12.04%) | - |
CAMK - PHK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
PHKg1 | active (37.18%) | - |
PHKg2 | inactive (68.08%) | active (47%) |
CAMK - PIM
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
PIM1 | active (28.24%) | active (26%) |
PIM2 | inactive (83.05%) | active (13%) |
PIM3 | active (34.87%) | inactive (53%) |
CAMK - PKD
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
PKD1 | active (4.14%) | active (5%) |
PKD3 | active (3.58%) | - |
PKD2 | active (4.17%) | active (30%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
TSSK1 | inactive (60.09%) | inactive (68%) |
TSSK2 | inactive (94.88%) | inactive (89%) |
CAMK - STK33
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
STK33 | active (35.7%) | inactive (62%) |
STE
STE - STE11
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
MAP3K5 | inactive (61.55%) | active (26%) |
MAP3K2 | inactive (77.32%) | - |
MAP3K3 | inactive (82.51%) | - |
STE - STE-Unique
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
COT | inactive (103.18%) | - |
NIK | inactive (141.92%) | - |
STE - STE20
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
GCK | active (10%) | active (7%) |
HGK | active (5.36%) | - |
KHS1 | active (6.41%) | - |
LOK | active (37.96%) | active (29%) |
MINK | active (24.43%) | active (27%) |
MST1 | active (5.51%) | active (1%) |
MST2 | active (3.37%) | active (2%) |
MST3 | active (11.61%) | active (3%) |
MST4 | active (10.77%) | - |
OSR1 | inactive (79.76%) | - |
PAK1 | inactive (81.12%) | - |
PAK2 | inactive (82.83%) | inactive (96%) |
PAK3 | inactive (85.45%) | inactive (71%) |
PAK4 | inactive (76.46%) | inactive (67%) |
PAK5 | inactive (87.83%) | inactive (70%) |
PAK6 | inactive (92.76%) | inactive (83%) |
SLK | inactive (62.9%) | - |
YSK1 | active (30.66%) | - |
STLK3 | inactive (93.67%) | - |
TAO1 | active (37.52%) | active (11%) |
TAO2 | inactive (56.91%) | active (33%) |
TAO3 | active (18.56%) | active (17%) |
MYO3B | active (30.95%) | - |
STE - STE7
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
MAP2K1 | inactive (87.17%) | active (15%) |
MAP2K2 | inactive (95.03%) | - |
MAP2K6 | inactive (56.81%) | active (-1%) |
MAP2K7 | - | active (43%) |
Other
Other - Aur
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
AurA | active (20.01%) | active (0%) |
AurB | active (11.08%) | active (2%) |
AurC | active (31.39%) | active (18%) |
Other - CAMKK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
CaMKK1 | inactive (58.14%) | - |
CaMKK2 | inactive (54.44%) | - |
Other - Haspin
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
Haspin | active (5.68%) | active (3%) |
Other - IKK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
IKKa | inactive (53.2%) | active (8%) |
IKKb | inactive (70.24%) | inactive (68%) |
IKKe | active (27.64%) | - |
TBK1 | active (18.79%) | active (7%) |
Other - NEK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
NEK1 | active (34.31%) | - |
NEK11 | inactive (111.62%) | active (50%) |
NEK2 | inactive (77.22%) | inactive (64%) |
NEK4 | active (39.49%) | - |
NEK6 | inactive (93.16%) | inactive (80%) |
NEK7 | inactive (79.56%) | inactive (84%) |
NEK9 | active (31.96%) | - |
NEK3 | inactive (80.2%) | inactive (102%) |
Other - TOPK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
PBK | inactive (67.36%) | - |
Other - PLK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
PLK1 | inactive (88.99%) | inactive (84%) |
PLK2 | inactive (78.73%) | active (49%) |
PLK3 | inactive (86.68%) | inactive (70%) |
Other - SgK496
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
SgK496 | inactive (97.03%) | - |
Other - NAK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
MPSK1 | active (27.95%) | - |
Other - TTK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
TTK | active (31.15%) | - |
Other - ULK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
ULK1 | active (20.96%) | - |
ULK2 | inactive (51.52%) | active (37%) |
ULK3 | inactive (57.87%) | active (42%) |
Other - WEE
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
Wee1 | inactive (75.43%) | - |
Other - WNK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
Wnk2 | inactive (120.26%) | inactive (89%) |
Wnk3 | inactive (84.94%) | inactive (84%) |
Other - TLK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
TLK2 | active (16.37%) | active (19%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC | Millipore |
---|
CK1 | 7 | 6 | 4 |
VRK | 3 | 1 | 1 |
CK1 - CK1
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
CK1d | active (42.84%) | active (23%) |
CK1g1 | inactive (86.93%) | inactive (70%) |
CK1g2 | inactive (79.15%) | inactive (63%) |
CK1g3 | inactive (65.78%) | inactive (61%) |
CK1a | inactive (67.65%) | - |
CK1e | active (35.67%) | - |
CK1 - VRK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
VRK1 | inactive (69.07%) | - |
VRK2 | - | inactive (75%) |
CMGC
CMGC
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC | Millipore |
---|
CK2 | 3 | 2 | 2 |
CLK | 4 | 4 | 2 |
DYRK | 10 | 9 | 4 |
MAPK | 14 | 10 | 10 |
GSK | 2 | 2 | 2 |
SRPK | 3 | 3 | 3 |
CMGC - CK2
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
CK2a1 | active (48.2%) | active (30%) |
CK2a2 | active (21.97%) | active (12%) |
CMGC - CLK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
CLK1 | active (19.92%) | - |
CLK2 | active (9.96%) | active (8%) |
CLK3 | inactive (65.54%) | active (38%) |
CLK4 | active (9.93%) | - |
CMGC - DYRK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
DYRK1A | active (15.36%) | - |
DYRK1B | active (11.34%) | - |
DYRK2 | active (12.09%) | active (1%) |
DYRK3 | active (39.21%) | - |
DYRK4 | inactive (93.56%) | - |
HIPK1 | inactive (102.93%) | inactive (64%) |
HIPK2 | inactive (81.24%) | active (32%) |
HIPK3 | inactive (78.68%) | active (31%) |
HIPK4 | inactive (87.8%) | - |
CMGC - MAPK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
Erk1 | active (11.56%) | active (5%) |
Erk2 | active (28.79%) | active (4%) |
JNK3 | inactive (116.96%) | active (20%) |
NLK | active (35.53%) | active (29%) |
p38a | inactive (93.9%) | inactive (80%) |
p38b | inactive (96.12%) | inactive (71%) |
p38d | inactive (90.43%) | inactive (62%) |
p38g | inactive (92.23%) | active (50%) |
JNK1 | inactive (86.59%) | inactive (63%) |
JNK2 | active (45.84%) | inactive (71%) |
CMGC - GSK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
GSK3A | active (2.04%) | active (4%) |
GSK3B | active (6.34%) | active (4%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
MSSK1 | inactive (90.2%) | inactive (98%) |
SRPK1 | inactive (108.28%) | inactive (102%) |
SRPK2 | inactive (97.77%) | inactive (104%) |
Atypical
Atypical
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC | Millipore |
---|
PDHK | 5 | 1 | - |
Alpha | 6 | - | 1 |
PIKK | 6 | - | 1 |
Atypical - PDHK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
PDHK1 | inactive (76.73%) | - |
Atypical - Alpha
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
eEF2K | - | inactive (79%) |
Atypical - PIKK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
FRAP | - | inactive (73%) |