Compound Information
Test on : GPCR
Compound Name : CHEMBL218859
Inchikey : VCTNTQPZRCNWJA-BQYQJAHWSA-N
ChemSpider : 23278129
Pubchem CID : 44418539
ChEMBL : CHEMBL218859
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (-1.32%) |
TYK2 | inactive (0.52%) |
JAK2 | inactive (2.41%) |
JAK3 | inactive (-0.59%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (3.37%) |
FES | inactive (-0.68%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | active (57.27%) |
ABL2 | active (51.33%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (24.64%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (42.36%) |
BTK | inactive (7.27%) |
TXK | inactive (35.56%) |
TEC | inactive (38.19%) |
ITK | inactive (-3.29%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | active (61.86%) |
SRM | inactive (9.33%) |
FRK | inactive (17.32%) |
BLK | inactive (16.2%) |
LCK | inactive (29.99%) |
HCK | active (58.86%) |
FGR | inactive (29.57%) |
FYN | inactive (29.56%) |
SRC | active (59.01%) |
YES | inactive (32.95%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (44.44%) |
EphA4 | active (80.91%) |
EphA3 | inactive (16.06%) |
EphB4 | inactive (45.71%) |
EphB3 | inactive (2.29%) |
EphB2 | active (65.93%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (-2.35%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-0.51%) |
ZAP70 | inactive (-4.22%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (-0.39%) |
ALK | inactive (-1.77%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (1.85%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (4.95%) |
IGF1R | inactive (-5.13%) |
IRR | inactive (1.08%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (36.76%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (5.15%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (0.47%) |
TRKB | inactive (0.22%) |
TRKC | inactive (1.16%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (0.77%) |
MET | inactive (1.41%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (3.27%) |
MER | inactive (3.56%) |
TYRO3 | inactive (2.18%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (7.32%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (-3.96%) |
FGFR2 | inactive (-2.09%) |
FGFR3 | inactive (-3.86%) |
FGFR4 | inactive (-4.47%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (1.51%) |
KDR | inactive (3.51%) |
FLT4 | inactive (-8.92%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (44.44%) |
KIT | active (51.68%) |
FLT3 | inactive (1.3%) |
PDGFRa | inactive (34.38%) |
PDGFRb | inactive (26.25%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (7.69%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (9.44%) |
TNK1 | inactive (16.54%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (5.96%) |
ErbB2 | inactive (1.84%) |
ErbB4 | inactive (2.45%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (0.42%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (5.69%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (4.59%) |
MST1 | inactive (3.51%) |
MST2 | inactive (2.73%) |
MST4 | inactive (2.22%) |
HGK | inactive (7.57%) |
MINK | inactive (3.59%) |
LOK | inactive (10.35%) |
PAK1 | inactive (3.72%) |
PAK3 | inactive (0.85%) |
PAK2 | inactive (-0.05%) |
PAK5 | inactive (2.41%) |
PAK6 | inactive (2.54%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (0.41%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (2.33%) |
CK1g2 | inactive (-0.99%) |
CK1g1 | inactive (-2.08%) |
CK1g3 | inactive (-0.55%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (0.2%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (-3.06%) |
AurC | inactive (-9.54%) |
AurA | inactive (-0.78%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (2.88%) |
NEK2 | inactive (-0.77%) |
NEK9 | inactive (2.51%) |
NEK7 | inactive (0.6%) |
NEK6 | inactive (0.01%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (0.94%) |
IKKe | inactive (0.54%) |
IKKb | inactive (-0.96%) |
IKKa | inactive (-0.54%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (5.33%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (-7.66%) |
GPRK6 | inactive (-0.29%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (2.39%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (-0.95%) |
MSK2 | inactive (1.5%) |
RSK1 | inactive (0.45%) |
RSK2 | inactive (-0.28%) |
RSK4 | inactive (0.69%) |
RSK3 | inactive (0.63%) |
p70S6K | inactive (0.86%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (-4.29%) |
AKT1 | inactive (-2.92%) |
AKT3 | inactive (-2.42%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (2.02%) |
SGK3 | inactive (0.16%) |
SGK2 | inactive (-3.14%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (1.62%) |
PKCg | inactive (0.78%) |
PKCa | inactive (-1.89%) |
PKCt | inactive (0.76%) |
PKCi | inactive (-1.56%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (1.58%) |
PKG1 | inactive (4.28%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (0.53%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (0.33%) |
ROCK2 | inactive (1.34%) |
MRCKb | inactive (-0.99%) |
MRCKa | inactive (4.17%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (-0.03%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (-2.53%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (0.99%) |
CaMK1d | inactive (0.73%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (-0.59%) |
PHKg2 | inactive (0.8%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (1.43%) |
CaMK2a | inactive (3.13%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (-0.41%) |
MAPKAPK2 | inactive (-0.68%) |
MAPKAPK3 | inactive (0.25%) |
MNK2 | inactive (5.36%) |
MNK1 | inactive (8.06%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (-3.04%) |
PKD1 | inactive (-2.47%) |
PKD2 | inactive (-2.22%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (1.46%) |
MARK3 | inactive (2%) |
MARK1 | inactive (0.89%) |
QIK | inactive (27.56%) |
SIK | active (75.99%) |
NuaK1 | inactive (2.93%) |
BRSK1 | inactive (5.17%) |
BRSK2 | inactive (5.16%) |
MELK | inactive (0.37%) |
CHK1 | inactive (0.19%) |
PASK | inactive (0.92%) |
AMPKa1 | inactive (0.48%) |
AMPKa2 | inactive (0.33%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (-1.42%) |
TSSK1 | inactive (-1.47%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (0.45%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (-3.47%) |
PIM3 | inactive (2.65%) |
PIM1 | inactive (1.36%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (1.94%) |
p38a | inactive (7.55%) |
p38b | inactive (2.24%) |
p38d | inactive (-0.13%) |
Erk2 | inactive (0.43%) |
Erk1 | inactive (3.65%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (-0.82%) |
GSK3B | inactive (-0.33%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (0.21%) |
MSSK1 | inactive (2.87%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (-2.04%) |
CLK2 | inactive (-1.19%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (2.67%) |
HIPK4 | inactive (6.66%) |
DYRK1B | inactive (1.89%) |
DYRK1A | inactive (2.27%) |
DYRK2 | inactive (-0.61%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (5.37%) |