Compound Information
Test on : GPCR
Compound Name : GW827099X
Inchikey : VCIUEFSUNSUNPA-UHFFFAOYSA-N
ChemSpider : 5021875
Pubchem CID : 6539409
ChEMBL : CHEMBL365297
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (2.04%) |
TYK2 | inactive (-3.36%) |
JAK2 | inactive (1.88%) |
JAK3 | inactive (-1.41%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (13.81%) |
FES | inactive (6.43%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | active (62.56%) |
ABL2 | active (56.14%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (12.45%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (49.4%) |
BTK | inactive (5.26%) |
TXK | inactive (38.05%) |
TEC | inactive (45.28%) |
ITK | inactive (0.31%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | active (67.82%) |
SRM | inactive (9.83%) |
FRK | inactive (25.43%) |
BLK | active (71.23%) |
LCK | active (85.12%) |
HCK | active (71.48%) |
FGR | active (83.95%) |
FYN | active (88.05%) |
SRC | active (83.86%) |
YES | active (96.6%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (14.42%) |
EphA4 | active (55.46%) |
EphA3 | inactive (18.19%) |
EphB4 | active (64.82%) |
EphB3 | inactive (16.23%) |
EphB2 | active (73.57%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (44%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-3.1%) |
ZAP70 | inactive (3.06%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (5.5%) |
ALK | inactive (7.86%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (10.88%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (18.26%) |
IGF1R | inactive (3.49%) |
IRR | inactive (1.61%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | active (82.52%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (3.55%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (16.7%) |
TRKB | inactive (12.79%) |
TRKC | inactive (8.83%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (4.64%) |
MET | inactive (10.66%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-5.61%) |
MER | inactive (31.51%) |
TYRO3 | inactive (24.79%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | active (64.87%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (15.87%) |
FGFR2 | inactive (23.53%) |
FGFR3 | inactive (13.5%) |
FGFR4 | inactive (3.32%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (30.79%) |
KDR | active (75.54%) |
FLT4 | inactive (47.74%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | active (59.14%) |
KIT | active (91.92%) |
FLT3 | inactive (6.52%) |
PDGFRa | active (54.81%) |
PDGFRb | active (69.7%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (23.4%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (13.04%) |
TNK1 | inactive (30.36%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | active (82.07%) |
ErbB2 | inactive (41.38%) |
ErbB4 | active (94.58%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (2.18%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (25.89%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (12.13%) |
MST1 | inactive (5.1%) |
MST2 | inactive (3.21%) |
MST4 | inactive (7.97%) |
HGK | active (73.25%) |
MINK | active (65.25%) |
LOK | inactive (41.83%) |
PAK1 | inactive (9.76%) |
PAK3 | inactive (4.47%) |
PAK2 | inactive (2.5%) |
PAK5 | inactive (-2.83%) |
PAK6 | inactive (-1.03%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (11.66%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | active (72.51%) |
CK1g2 | active (61.65%) |
CK1g1 | active (58.51%) |
CK1g3 | active (76.09%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (28.81%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (12.22%) |
AurC | inactive (22.86%) |
AurA | inactive (33.68%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (1.02%) |
NEK2 | inactive (4.48%) |
NEK9 | inactive (11.96%) |
NEK7 | inactive (4.83%) |
NEK6 | inactive (3.68%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (4.55%) |
IKKe | inactive (7.06%) |
IKKb | inactive (4.62%) |
IKKa | inactive (7.87%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (19.18%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (5.57%) |
GPRK6 | inactive (1.87%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (1.48%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (2.22%) |
MSK2 | inactive (3.9%) |
RSK1 | inactive (4.94%) |
RSK2 | inactive (1.36%) |
RSK4 | inactive (5.49%) |
RSK3 | inactive (4.22%) |
p70S6K | inactive (2.69%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (1.14%) |
AKT1 | inactive (0.97%) |
AKT3 | inactive (1.56%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (3.42%) |
SGK3 | inactive (0.8%) |
SGK2 | inactive (0.65%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (6.09%) |
PKCg | inactive (7.86%) |
PKCa | inactive (15.27%) |
PKCt | inactive (3.8%) |
PKCi | inactive (3.27%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (3.43%) |
PKG1 | inactive (4.25%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (0.09%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (1.7%) |
ROCK2 | inactive (2.36%) |
MRCKb | inactive (1.27%) |
MRCKa | inactive (20.36%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (5.77%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (-0.42%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (1.52%) |
CaMK1d | inactive (8.91%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (6.66%) |
PHKg2 | inactive (0.54%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (5.51%) |
CaMK2a | inactive (4.05%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (0.49%) |
MAPKAPK2 | inactive (1.39%) |
MAPKAPK3 | inactive (37.76%) |
MNK2 | inactive (-0.01%) |
MNK1 | inactive (4.06%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (48.4%) |
PKD1 | inactive (36.49%) |
PKD2 | active (52.1%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (2.65%) |
MARK3 | inactive (-0.42%) |
MARK1 | inactive (3.47%) |
QIK | inactive (44.63%) |
SIK | inactive (38.37%) |
NuaK1 | inactive (-0.79%) |
BRSK1 | inactive (-0.53%) |
BRSK2 | inactive (-0.44%) |
MELK | inactive (9.58%) |
CHK1 | inactive (-1.02%) |
PASK | inactive (-3.15%) |
AMPKa1 | inactive (1.48%) |
AMPKa2 | inactive (4.39%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (1.02%) |
TSSK1 | inactive (2.68%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (2.12%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (-0.97%) |
PIM3 | inactive (-3.73%) |
PIM1 | inactive (1.21%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | active (84.94%) |
p38a | active (92.81%) |
p38b | active (78.7%) |
p38d | inactive (6.19%) |
Erk2 | inactive (11.09%) |
Erk1 | inactive (11.29%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | active (59.74%) |
GSK3B | active (76.14%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-6.44%) |
MSSK1 | inactive (-1.91%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (0.91%) |
CLK2 | inactive (1.21%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (-1.1%) |
HIPK4 | inactive (4.58%) |
DYRK1B | inactive (-1.69%) |
DYRK1A | inactive (3.37%) |
DYRK2 | inactive (4.44%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (0.07%) |