Compound Information
Test on : GPCR
Compound Name : GW813360X
Inchikey : VARGUUBRJVQGHK-AUEPDCJTSA-N
ChemSpider : 7879034
Pubchem CID : 9604915
ChEMBL : CHEMBL204934
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (16.28%) |
TYK2 | inactive (3.46%) |
JAK2 | inactive (0.37%) |
JAK3 | inactive (-2.19%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (4.82%) |
FES | inactive (-1.27%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | active (72.16%) |
ABL2 | active (59.45%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (7.17%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (16.12%) |
BTK | inactive (-2.79%) |
TXK | inactive (4.69%) |
TEC | inactive (5.03%) |
ITK | inactive (-1.27%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (15.2%) |
SRM | inactive (6.19%) |
FRK | inactive (0.9%) |
BLK | inactive (15.75%) |
LCK | inactive (29.31%) |
HCK | inactive (16.31%) |
FGR | inactive (18.99%) |
FYN | inactive (25.58%) |
SRC | active (50.4%) |
YES | inactive (36.37%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (0.55%) |
EphA4 | inactive (25.6%) |
EphA3 | inactive (-0.79%) |
EphB4 | inactive (0.65%) |
EphB3 | inactive (-4.51%) |
EphB2 | inactive (16.21%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (10.54%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-1.09%) |
ZAP70 | inactive (-3.33%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (0.9%) |
ALK | inactive (-4.64%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (4.38%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (-4.12%) |
IGF1R | inactive (-8.19%) |
IRR | inactive (0.57%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (1.99%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (17.06%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (7.04%) |
TRKB | inactive (6.69%) |
TRKC | inactive (9.77%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (0.14%) |
MET | inactive (6.87%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-2.08%) |
MER | inactive (4.47%) |
TYRO3 | inactive (4.59%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (13.94%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (-2.61%) |
FGFR2 | inactive (10.7%) |
FGFR3 | inactive (3.63%) |
FGFR4 | inactive (-3.96%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (1.4%) |
KDR | inactive (11.2%) |
FLT4 | inactive (-4.88%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (24.9%) |
KIT | active (83.36%) |
FLT3 | inactive (6.95%) |
PDGFRa | active (53.62%) |
PDGFRb | inactive (49.91%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (9.67%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (3.07%) |
TNK1 | inactive (19.33%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (8.31%) |
ErbB2 | inactive (7.49%) |
ErbB4 | inactive (2.45%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (0.01%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (-1.09%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (1.25%) |
MST1 | inactive (7.14%) |
MST2 | inactive (7.42%) |
MST4 | inactive (-2.88%) |
HGK | inactive (16.89%) |
MINK | inactive (16.85%) |
LOK | inactive (16.32%) |
PAK1 | inactive (1.58%) |
PAK3 | inactive (0.31%) |
PAK2 | inactive (-0.99%) |
PAK5 | inactive (10.85%) |
PAK6 | inactive (3.44%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (-0.71%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (0.8%) |
CK1g2 | inactive (-5.36%) |
CK1g1 | inactive (-4.26%) |
CK1g3 | inactive (-3.3%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (-0.54%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (7.54%) |
AurC | inactive (-1.49%) |
AurA | inactive (13%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (9.07%) |
NEK2 | inactive (-1.3%) |
NEK9 | inactive (5.21%) |
NEK7 | inactive (-2.76%) |
NEK6 | inactive (2.69%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (2.56%) |
IKKe | inactive (4.51%) |
IKKb | inactive (3.32%) |
IKKa | inactive (-1.74%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (5.77%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (5.64%) |
GPRK6 | inactive (8.28%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (1.39%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (1.02%) |
MSK2 | inactive (3.95%) |
RSK1 | inactive (4.66%) |
RSK2 | inactive (4.76%) |
RSK4 | inactive (1.9%) |
RSK3 | inactive (0.82%) |
p70S6K | inactive (1.15%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (-4.73%) |
AKT1 | inactive (-3.41%) |
AKT3 | inactive (-3.32%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (4.05%) |
SGK3 | inactive (3.83%) |
SGK2 | inactive (2.41%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (0.69%) |
PKCg | inactive (3.14%) |
PKCa | inactive (-3.28%) |
PKCt | inactive (4.42%) |
PKCi | inactive (-0.97%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (4.98%) |
PKG1 | inactive (3.77%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (5.16%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (1.07%) |
ROCK2 | inactive (6.91%) |
MRCKb | inactive (0.7%) |
MRCKa | inactive (3.69%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (-0.32%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (-0.03%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (-5.3%) |
CaMK1d | inactive (-0.39%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (2.55%) |
PHKg2 | inactive (6.48%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (-1.61%) |
CaMK2a | inactive (1.18%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (2.56%) |
MAPKAPK2 | inactive (-0.48%) |
MAPKAPK3 | inactive (-2.07%) |
MNK2 | inactive (13.69%) |
MNK1 | inactive (16.5%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (-4.97%) |
PKD1 | inactive (-5.45%) |
PKD2 | inactive (-5.5%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (4.83%) |
MARK3 | inactive (3.88%) |
MARK1 | inactive (6.09%) |
QIK | inactive (34.08%) |
SIK | inactive (12.03%) |
NuaK1 | inactive (22.32%) |
BRSK1 | inactive (4.34%) |
BRSK2 | inactive (6.3%) |
MELK | inactive (-4.7%) |
CHK1 | inactive (0.31%) |
PASK | inactive (4.15%) |
AMPKa1 | inactive (3.79%) |
AMPKa2 | inactive (1.47%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (4.98%) |
TSSK1 | inactive (5.32%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (-2.81%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (-3.43%) |
PIM3 | inactive (6.5%) |
PIM1 | inactive (-0.03%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (-0.57%) |
p38a | inactive (-0.98%) |
p38b | inactive (0.89%) |
p38d | inactive (-2.04%) |
Erk2 | inactive (-0.07%) |
Erk1 | inactive (2.27%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (34.68%) |
GSK3B | inactive (32.38%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (4.2%) |
MSSK1 | inactive (0.28%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (-2.92%) |
CLK2 | inactive (5.72%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (-0.32%) |
HIPK4 | inactive (3.74%) |
DYRK1B | inactive (-0.65%) |
DYRK1A | inactive (2.17%) |
DYRK2 | inactive (2.96%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (10.75%) |