Compound Information
Test on : GPCR
Compound Name : GSK269962 hydrochloride
Inchikey : UYKVMFKKKLLDGL-UHFFFAOYSA-N
ChemSpider : 28483786
Pubchem CID : 57398146
ChEMBL : CHEMBL1909363
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (12.13%) |
TYK2 | inactive (-1.28%) |
JAK2 | inactive (1.29%) |
JAK3 | inactive (-0.45%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (2.2%) |
FES | inactive (2.83%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (11.11%) |
ABL2 | inactive (7.99%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (2.94%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (2.53%) |
BTK | inactive (-2.04%) |
TXK | inactive (5.82%) |
TEC | inactive (5.81%) |
ITK | inactive (0.94%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (4.32%) |
SRM | inactive (-0.69%) |
FRK | inactive (0.86%) |
BLK | inactive (2.41%) |
LCK | inactive (4.63%) |
HCK | inactive (4.67%) |
FGR | inactive (5.54%) |
FYN | inactive (5.35%) |
SRC | inactive (7.72%) |
YES | inactive (4.67%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (-2.47%) |
EphA4 | inactive (7.73%) |
EphA3 | inactive (4.85%) |
EphB4 | inactive (3.05%) |
EphB3 | inactive (5.06%) |
EphB2 | inactive (6.97%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (13%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (1.88%) |
ZAP70 | inactive (-1.56%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (1.51%) |
ALK | inactive (3.72%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (11.01%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (7.3%) |
IGF1R | inactive (1.49%) |
IRR | inactive (0.16%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (-0.68%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (-1.35%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (-0.09%) |
TRKB | inactive (0.84%) |
TRKC | inactive (2.49%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (5%) |
MET | inactive (7.84%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-2.93%) |
MER | inactive (2.56%) |
TYRO3 | inactive (2.81%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (10.43%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (5.99%) |
FGFR2 | inactive (3.45%) |
FGFR3 | inactive (1.9%) |
FGFR4 | inactive (2.48%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (2.14%) |
KDR | inactive (7.83%) |
FLT4 | inactive (0.92%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (2.86%) |
KIT | inactive (3.53%) |
FLT3 | inactive (3.19%) |
PDGFRa | inactive (9.57%) |
PDGFRb | inactive (9.39%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (6.59%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (-0.19%) |
TNK1 | inactive (5.9%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (3%) |
ErbB2 | inactive (2%) |
ErbB4 | inactive (10.41%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (1.66%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (6.86%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (-1.08%) |
MST1 | inactive (3.43%) |
MST2 | inactive (3.84%) |
MST4 | inactive (2.57%) |
HGK | inactive (13.16%) |
MINK | inactive (12.47%) |
LOK | inactive (9.94%) |
PAK1 | inactive (5.84%) |
PAK3 | inactive (2.69%) |
PAK2 | inactive (0.34%) |
PAK5 | inactive (-0.29%) |
PAK6 | inactive (-8.77%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (3.8%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (1.31%) |
CK1g2 | inactive (3.09%) |
CK1g1 | inactive (2.93%) |
CK1g3 | inactive (1.58%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (2.83%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (8.22%) |
AurC | inactive (4.33%) |
AurA | inactive (43.01%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (3.94%) |
NEK2 | inactive (2.29%) |
NEK9 | inactive (16.98%) |
NEK7 | inactive (3.89%) |
NEK6 | inactive (4.96%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (7.42%) |
IKKe | inactive (27.54%) |
IKKb | inactive (2.67%) |
IKKa | inactive (10.11%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (10.25%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (9.5%) |
GPRK6 | inactive (9.42%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (4%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | active (78.06%) |
MSK2 | active (76.72%) |
RSK1 | active (70.57%) |
RSK2 | active (54.56%) |
RSK4 | inactive (13.85%) |
RSK3 | active (60.95%) |
p70S6K | active (93%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (7.74%) |
AKT1 | inactive (7.87%) |
AKT3 | inactive (7.9%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (34.71%) |
SGK3 | active (74.28%) |
SGK2 | active (58.51%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | active (94.9%) |
PKCg | active (55.05%) |
PKCa | inactive (34.09%) |
PKCt | active (67.43%) |
PKCi | active (64.89%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | active (66.31%) |
PKG1 | active (76.57%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | active (63.15%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | active (93.73%) |
ROCK2 | active (90.45%) |
MRCKb | active (58.98%) |
MRCKa | inactive (42.33%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (13.27%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (2.71%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (2.49%) |
CaMK1d | inactive (2.35%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (6.37%) |
PHKg2 | inactive (1.77%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (4%) |
CaMK2a | inactive (2.17%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (1.44%) |
MAPKAPK2 | inactive (0.54%) |
MAPKAPK3 | inactive (3.54%) |
MNK2 | inactive (21.01%) |
MNK1 | inactive (13.34%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (2.69%) |
PKD1 | inactive (3.36%) |
PKD2 | inactive (4.52%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (4.43%) |
MARK3 | inactive (8.24%) |
MARK1 | inactive (13.29%) |
QIK | inactive (13.8%) |
SIK | inactive (10.1%) |
NuaK1 | inactive (26.89%) |
BRSK1 | inactive (0.26%) |
BRSK2 | inactive (2.71%) |
MELK | active (50.46%) |
CHK1 | inactive (4.37%) |
PASK | inactive (-0.7%) |
AMPKa1 | inactive (2.06%) |
AMPKa2 | inactive (3.43%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (3.44%) |
TSSK1 | active (72.79%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (-1.31%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (0.68%) |
PIM3 | inactive (2.09%) |
PIM1 | inactive (10.43%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (5.85%) |
p38a | inactive (5.87%) |
p38b | inactive (1.06%) |
p38d | inactive (4.61%) |
Erk2 | inactive (4.07%) |
Erk1 | inactive (-0.18%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | active (56.53%) |
GSK3B | active (53.85%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-3.13%) |
MSSK1 | inactive (-1.29%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (1.22%) |
CLK2 | inactive (-0.12%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (11.5%) |
HIPK4 | inactive (10.39%) |
DYRK1B | inactive (0.86%) |
DYRK1A | inactive (4.24%) |
DYRK2 | inactive (5.39%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (5.71%) |