Compound Information
Test on : GPCR
Compound Name : GW794607X
Inchikey : UUZWUKJJOLIQMT-BRJLIKDPSA-N
ChemSpider : 7879045
Pubchem CID : 9604926
ChEMBL : CHEMBL67241
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (11.66%) |
TYK2 | inactive (4.3%) |
JAK2 | inactive (14.68%) |
JAK3 | inactive (8.21%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (9.15%) |
FES | inactive (5.6%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | active (75.33%) |
ABL2 | active (61.86%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (12.07%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (13.36%) |
BTK | inactive (4.2%) |
TXK | inactive (8.54%) |
TEC | inactive (7.76%) |
ITK | inactive (10.77%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | active (51.03%) |
SRM | inactive (7.86%) |
FRK | inactive (3.14%) |
BLK | active (62.91%) |
LCK | active (68.34%) |
HCK | inactive (35.84%) |
FGR | active (51.98%) |
FYN | active (52.81%) |
SRC | active (81.78%) |
YES | active (82.84%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (5.31%) |
EphA4 | inactive (17.41%) |
EphA3 | inactive (3.12%) |
EphB4 | inactive (5.77%) |
EphB3 | inactive (1.75%) |
EphB2 | inactive (9.31%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (12.24%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-2.86%) |
ZAP70 | inactive (3.95%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (4.23%) |
ALK | inactive (3.35%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (33.41%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (0.96%) |
IGF1R | inactive (-0.01%) |
IRR | inactive (1.63%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (7.68%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (49.94%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (7.34%) |
TRKB | inactive (33.89%) |
TRKC | inactive (36.78%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | active (57.91%) |
MET | inactive (48.99%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (13.16%) |
MER | inactive (25.61%) |
TYRO3 | inactive (42.78%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | active (54.73%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (3.31%) |
FGFR2 | inactive (19.35%) |
FGFR3 | inactive (8.88%) |
FGFR4 | inactive (3.38%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (19.7%) |
KDR | active (64.93%) |
FLT4 | inactive (40.68%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (17.55%) |
KIT | inactive (23.7%) |
FLT3 | inactive (17.6%) |
PDGFRa | active (78.39%) |
PDGFRb | active (78.83%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (36.19%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (3.51%) |
TNK1 | inactive (47.95%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (33.47%) |
ErbB2 | inactive (4.49%) |
ErbB4 | inactive (42.97%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (0.71%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (1.5%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (3.57%) |
MST1 | inactive (12.31%) |
MST2 | inactive (9.89%) |
MST4 | inactive (-1.3%) |
HGK | inactive (44.14%) |
MINK | inactive (35.91%) |
LOK | inactive (28.42%) |
PAK1 | inactive (-0.69%) |
PAK3 | inactive (1.61%) |
PAK2 | inactive (-0.31%) |
PAK5 | inactive (5.05%) |
PAK6 | inactive (2.09%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (2.07%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (1.89%) |
CK1g2 | inactive (1.01%) |
CK1g1 | inactive (1.57%) |
CK1g3 | inactive (0.9%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (0.93%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (43.75%) |
AurC | active (58.52%) |
AurA | active (70.67%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (7.87%) |
NEK2 | inactive (0.85%) |
NEK9 | inactive (0.45%) |
NEK7 | inactive (-0.91%) |
NEK6 | inactive (2.63%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (20.19%) |
IKKe | inactive (13.41%) |
IKKb | inactive (3.19%) |
IKKa | inactive (0.68%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (15.69%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (4.45%) |
GPRK6 | inactive (3.97%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (10.31%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (-2.6%) |
MSK2 | inactive (2.6%) |
RSK1 | inactive (4.72%) |
RSK2 | inactive (4.75%) |
RSK4 | inactive (3.54%) |
RSK3 | inactive (2.43%) |
p70S6K | inactive (8.74%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (-0.08%) |
AKT1 | inactive (-0.51%) |
AKT3 | inactive (-1.08%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (13.57%) |
SGK3 | inactive (5.07%) |
SGK2 | inactive (10.93%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (2.92%) |
PKCg | inactive (5.49%) |
PKCa | inactive (1.45%) |
PKCt | inactive (2.98%) |
PKCi | inactive (12.49%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (4.72%) |
PKG1 | inactive (2.57%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (4.42%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (13.68%) |
ROCK2 | inactive (28.15%) |
MRCKb | inactive (0.92%) |
MRCKa | inactive (5.18%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (0.34%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (2.98%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (-3.1%) |
CaMK1d | inactive (1.66%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (19.53%) |
PHKg2 | inactive (7.69%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (1.17%) |
CaMK2a | inactive (3.36%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (1.6%) |
MAPKAPK2 | inactive (-2.37%) |
MAPKAPK3 | inactive (-4.82%) |
MNK2 | active (72.19%) |
MNK1 | active (69.11%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (0.02%) |
PKD1 | inactive (1.22%) |
PKD2 | inactive (1.21%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (9.44%) |
MARK3 | inactive (9.23%) |
MARK1 | inactive (10.3%) |
QIK | inactive (21.13%) |
SIK | inactive (9.54%) |
NuaK1 | inactive (36.34%) |
BRSK1 | inactive (24.68%) |
BRSK2 | inactive (29.03%) |
MELK | inactive (3.93%) |
CHK1 | inactive (-5.65%) |
PASK | inactive (3.05%) |
AMPKa1 | inactive (3.53%) |
AMPKa2 | inactive (2.07%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (3.17%) |
TSSK1 | inactive (6.17%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (-8.41%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (0.32%) |
PIM3 | inactive (4.06%) |
PIM1 | inactive (1.01%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (6.14%) |
p38a | inactive (7.62%) |
p38b | inactive (25.53%) |
p38d | inactive (3.1%) |
Erk2 | inactive (1.54%) |
Erk1 | inactive (3.62%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | active (71.83%) |
GSK3B | active (68.7%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (3.51%) |
MSSK1 | inactive (0.97%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (9.87%) |
CLK2 | inactive (10.94%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (13.5%) |
HIPK4 | inactive (27.67%) |
DYRK1B | inactive (9.45%) |
DYRK1A | inactive (20.55%) |
DYRK2 | inactive (14.23%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (14.12%) |