Compound Information
Test on : GPCR
Compound Name : GW458787A
Inchikey : URAIHJKKRZAQEB-UHFFFAOYSA-N
ChemSpider : 28485673
Pubchem CID : 57398151
ChEMBL : CHEMBL1909385
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (5.72%) |
TYK2 | inactive (-2.79%) |
JAK2 | inactive (0.35%) |
JAK3 | inactive (-1.45%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (0.38%) |
FES | inactive (3.54%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (5.59%) |
ABL2 | inactive (4.87%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (9.28%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (8.85%) |
BTK | inactive (6.4%) |
TXK | inactive (3.39%) |
TEC | inactive (7.43%) |
ITK | inactive (2.16%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (13.73%) |
SRM | inactive (2.59%) |
FRK | inactive (0.96%) |
BLK | inactive (14.07%) |
LCK | inactive (22.01%) |
HCK | inactive (14.34%) |
FGR | inactive (20.15%) |
FYN | inactive (14.95%) |
SRC | inactive (12.49%) |
YES | inactive (42.12%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (1.18%) |
EphA4 | inactive (11.46%) |
EphA3 | inactive (5.62%) |
EphB4 | inactive (3%) |
EphB3 | inactive (5.08%) |
EphB2 | inactive (7.66%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (6.51%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-0.71%) |
ZAP70 | inactive (2.51%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (4.57%) |
ALK | inactive (2.76%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (8.89%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (2.86%) |
IGF1R | inactive (2.03%) |
IRR | inactive (2.07%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (2.07%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (1.04%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (2.55%) |
TRKB | inactive (4.99%) |
TRKC | inactive (5.1%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (3.8%) |
MET | inactive (4.43%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-1.88%) |
MER | inactive (43.66%) |
TYRO3 | inactive (4.25%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (9.8%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (3.85%) |
FGFR2 | inactive (4.3%) |
FGFR3 | inactive (3.89%) |
FGFR4 | inactive (0.38%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (2.68%) |
KDR | inactive (6.56%) |
FLT4 | inactive (4.64%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (6.19%) |
KIT | inactive (8.96%) |
FLT3 | inactive (6.62%) |
PDGFRa | inactive (10.36%) |
PDGFRb | inactive (4.72%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (4.15%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (2.69%) |
TNK1 | inactive (16.62%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | active (94.13%) |
ErbB2 | active (73.03%) |
ErbB4 | active (96.64%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (1.78%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (6.13%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (1.58%) |
MST1 | inactive (3.52%) |
MST2 | inactive (3.74%) |
MST4 | inactive (1.34%) |
HGK | inactive (6.76%) |
MINK | inactive (5.67%) |
LOK | inactive (7.82%) |
PAK1 | inactive (5.65%) |
PAK3 | inactive (3.33%) |
PAK2 | inactive (-0.94%) |
PAK5 | inactive (2.57%) |
PAK6 | inactive (-0.08%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (2.72%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (1.55%) |
CK1g2 | inactive (2.81%) |
CK1g1 | inactive (3.35%) |
CK1g3 | inactive (1.23%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (3.52%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (10.01%) |
AurC | inactive (7.65%) |
AurA | inactive (7.7%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (2.22%) |
NEK2 | inactive (3.32%) |
NEK9 | inactive (15.52%) |
NEK7 | inactive (3.65%) |
NEK6 | inactive (3.11%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (3.03%) |
IKKe | inactive (4.6%) |
IKKb | inactive (5.3%) |
IKKa | inactive (3.98%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (7.19%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (4.87%) |
GPRK6 | inactive (3.33%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (2.92%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (0.66%) |
MSK2 | inactive (2.56%) |
RSK1 | inactive (3.81%) |
RSK2 | inactive (2.78%) |
RSK4 | inactive (1.11%) |
RSK3 | inactive (4.28%) |
p70S6K | inactive (2.62%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (1.64%) |
AKT1 | inactive (0.62%) |
AKT3 | inactive (2%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (2.28%) |
SGK3 | inactive (1.87%) |
SGK2 | inactive (1.93%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (3.6%) |
PKCg | inactive (3.26%) |
PKCa | inactive (1.49%) |
PKCt | inactive (2.01%) |
PKCi | inactive (1.87%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (2.6%) |
PKG1 | inactive (1.88%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (1.49%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (1.69%) |
ROCK2 | inactive (2.23%) |
MRCKb | inactive (1.22%) |
MRCKa | inactive (-2.61%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (12.89%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (1.03%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (-0.36%) |
CaMK1d | inactive (1.27%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (4.75%) |
PHKg2 | inactive (4.2%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (1.68%) |
CaMK2a | inactive (-1%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (1.42%) |
MAPKAPK2 | inactive (0.72%) |
MAPKAPK3 | inactive (2.48%) |
MNK2 | inactive (15.69%) |
MNK1 | inactive (6.82%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (3.51%) |
PKD1 | inactive (4.08%) |
PKD2 | inactive (2.54%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (1.3%) |
MARK3 | inactive (-0.22%) |
MARK1 | inactive (2.05%) |
QIK | inactive (6.41%) |
SIK | inactive (9.04%) |
NuaK1 | inactive (1.06%) |
BRSK1 | inactive (1.23%) |
BRSK2 | inactive (4.33%) |
MELK | inactive (3.76%) |
CHK1 | inactive (0.28%) |
PASK | inactive (0.95%) |
AMPKa1 | inactive (3.44%) |
AMPKa2 | inactive (4.61%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (2.17%) |
TSSK1 | inactive (4.28%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (1.36%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (0.74%) |
PIM3 | inactive (1.6%) |
PIM1 | inactive (1.03%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (2.48%) |
p38a | inactive (7.34%) |
p38b | inactive (4.87%) |
p38d | inactive (1.45%) |
Erk2 | inactive (3.85%) |
Erk1 | inactive (1.62%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (3.44%) |
GSK3B | inactive (3.37%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-2.56%) |
MSSK1 | inactive (0.73%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (0.48%) |
CLK2 | inactive (0.73%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (3.06%) |
HIPK4 | inactive (4.91%) |
DYRK1B | inactive (1.88%) |
DYRK1A | inactive (4.22%) |
DYRK2 | inactive (2.62%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (3.86%) |