Compound Information
Test on : RBC
Compound Name : CGP 57380
Inchikey : UQPMANVRZYYQMD-UHFFFAOYSA-N
ChemSpider : 9819164
Pubchem CID : 11644425
ChEMBL : CHEMBL1240885
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
AGC
AGC - PDK1
Bioactivity |
---|
Kinase | RBC |
---|
PDK1 | inactive (102.4%) |
AGC - Akt
Bioactivity |
---|
Kinase | RBC |
---|
AKT1 | inactive (93.3%) |
AKT2 | inactive (107.9%) |
AKT3 | inactive (104.45%) |
AGC - DMPK
Bioactivity |
---|
Kinase | RBC |
---|
DMPK1 | inactive (114.39%) |
MRCKa | inactive (102.85%) |
MRCKb | inactive (105.84%) |
ROCK1 | inactive (100.38%) |
ROCK2 | inactive (92.12%) |
AGC - GRK
Bioactivity |
---|
Kinase | RBC |
---|
BARK1 | inactive (98.62%) |
BARK2 | inactive (101.84%) |
GPRK4 | inactive (98.8%) |
GPRK5 | inactive (97.08%) |
GPRK6 | inactive (102.86%) |
GPRK7 | inactive (104.81%) |
AGC - RSK
Bioactivity |
---|
Kinase | RBC |
---|
MSK1 | inactive (96.67%) |
MSK2 | inactive (113.57%) |
p70S6K | inactive (94.26%) |
p70S6Kb | inactive (96.77%) |
RSK2 | inactive (89.82%) |
RSK4 | inactive (71.7%) |
RSK1 | inactive (82.17%) |
RSK3 | inactive (70.57%) |
AGC - PKA
Bioactivity |
---|
Kinase | RBC |
---|
PKACg | inactive (96.24%) |
PRKX | inactive (90.37%) |
PKACa | inactive (96.76%) |
AGC - PKC
Bioactivity |
---|
Kinase | RBC |
---|
PKCa | inactive (98.02%) |
PKCd | inactive (111.69%) |
PKCe | inactive (99.49%) |
PKCh | inactive (84.67%) |
PKCg | inactive (95.97%) |
PKCi | inactive (91.28%) |
PKCt | inactive (102.58%) |
PKCz | inactive (108.6%) |
PKCb | inactive (104.98%) |
AGC - PKG
Bioactivity |
---|
Kinase | RBC |
---|
PKG2 | inactive (97.03%) |
PKG1 | inactive (95.72%) |
AGC - PKN
Bioactivity |
---|
Kinase | RBC |
---|
PKN1 | inactive (102.13%) |
PKN2 | inactive (81.98%) |
AGC - SGK
Bioactivity |
---|
Kinase | RBC |
---|
SGK1 | inactive (91.51%) |
SGK2 | inactive (96.47%) |
SGK3 | inactive (102.11%) |
AGC - NDR
Bioactivity |
---|
Kinase | RBC |
---|
NDR1 | inactive (101.29%) |
TK
TK - Abl
Bioactivity |
---|
Kinase | RBC |
---|
ABL1 | inactive (88.09%) |
ABL2 | inactive (82.27%) |
TK - Ack
Bioactivity |
---|
Kinase | RBC |
---|
ACK | inactive (61.53%) |
TK - ALK
Bioactivity |
---|
Kinase | RBC |
---|
ALK | inactive (88.92%) |
LTK | inactive (92.46%) |
TK - Axl
Bioactivity |
---|
Kinase | RBC |
---|
AXL | active (45.4%) |
MER | inactive (90.72%) |
TYRO3 | inactive (100.03%) |
TK - Src
Bioactivity |
---|
Kinase | RBC |
---|
BLK | inactive (100.71%) |
BRK | inactive (68.25%) |
SRC | inactive (89.59%) |
FGR | inactive (89.46%) |
FRK | inactive (90.03%) |
FYN | inactive (93.01%) |
HCK | inactive (90.71%) |
LCK | inactive (98.3%) |
SRM | inactive (103.56%) |
YES | inactive (92.87%) |
LYN | inactive (89.73%) |
TK - Tec
Bioactivity |
---|
Kinase | RBC |
---|
BMX | inactive (89.55%) |
BTK | inactive (82.28%) |
ITK | inactive (93.91%) |
TEC | inactive (86.04%) |
TXK | inactive (67.56%) |
TK - PDGFR
Bioactivity |
---|
Kinase | RBC |
---|
KIT | inactive (93.54%) |
FLT3 | inactive (78.35%) |
FMS | inactive (101.35%) |
PDGFRb | inactive (97.98%) |
PDGFRa | inactive (101.38%) |
TK - Csk
Bioactivity |
---|
Kinase | RBC |
---|
CSK | inactive (80.21%) |
CTK | inactive (95.63%) |
TK - DDR
Bioactivity |
---|
Kinase | RBC |
---|
DDR2 | inactive (94.2%) |
TK - EGFR
Bioactivity |
---|
Kinase | RBC |
---|
EGFR | inactive (100.39%) |
ErbB2 | inactive (100.84%) |
ErbB4 | inactive (120.87%) |
TK - Eph
Bioactivity |
---|
Kinase | RBC |
---|
EphA1 | inactive (101.02%) |
EphA2 | inactive (89.86%) |
EphA3 | inactive (107.06%) |
EphA4 | inactive (90.1%) |
EphA5 | inactive (87.05%) |
EphA6 | active (49.32%) |
EphA7 | inactive (101.14%) |
EphA8 | inactive (94.03%) |
EphB1 | inactive (87.05%) |
EphB2 | inactive (91.56%) |
EphB3 | inactive (87.72%) |
EphB4 | inactive (87.78%) |
TK - FAK
Bioactivity |
---|
Kinase | RBC |
---|
FAK | inactive (103.08%) |
PYK2 | inactive (101.44%) |
TK - Fer
Bioactivity |
---|
Kinase | RBC |
---|
FER | inactive (100.11%) |
FES | inactive (100.04%) |
TK - FGFR
Bioactivity |
---|
Kinase | RBC |
---|
FGFR1 | inactive (91.24%) |
FGFR2 | inactive (97.16%) |
FGFR3 | inactive (101.44%) |
FGFR4 | inactive (107.47%) |
TK - VEGFR
Bioactivity |
---|
Kinase | RBC |
---|
FLT1 | inactive (87.3%) |
FLT4 | inactive (92.91%) |
KDR | inactive (104.41%) |
TK - InsR
Bioactivity |
---|
Kinase | RBC |
---|
IGF1R | inactive (103.53%) |
IRR | inactive (96.93%) |
INSR | inactive (98.5%) |
TK - JakA
Bioactivity |
---|
Kinase | RBC |
---|
JAK1 | inactive (98.98%) |
JAK2 | inactive (105.03%) |
JAK3 | inactive (102.19%) |
TYK2 | inactive (92.28%) |
TK - Musk
Bioactivity |
---|
Kinase | RBC |
---|
MUSK | inactive (93.86%) |
TK - Ret
Bioactivity |
---|
Kinase | RBC |
---|
RET | inactive (78.13%) |
TK - Met
Bioactivity |
---|
Kinase | RBC |
---|
RON | inactive (93.74%) |
MET | inactive (124.12%) |
TK - Sev
Bioactivity |
---|
Kinase | RBC |
---|
ROS | inactive (99.85%) |
TK - Syk
Bioactivity |
---|
Kinase | RBC |
---|
SYK | inactive (97.4%) |
ZAP70 | inactive (95.2%) |
TK - Tie
Bioactivity |
---|
Kinase | RBC |
---|
TIE2 | inactive (94.92%) |
TK - Trk
Bioactivity |
---|
Kinase | RBC |
---|
TRKA | inactive (108.72%) |
TRKB | inactive (100.94%) |
TRKC | inactive (81.54%) |
TKL
TKL - STKR
Bioactivity |
---|
Kinase | RBC |
---|
ALK1 | inactive (107.87%) |
ALK2 | inactive (127.22%) |
ALK4 | inactive (104.25%) |
TGFbR1 | - |
TGFbR2 | inactive (100.63%) |
TKL - RAF
Bioactivity |
---|
Kinase | RBC |
---|
ARAF | inactive (80.68%) |
BRAF | inactive (91.69%) |
RAF1 | inactive (96.71%) |
TKL - IRAK
Bioactivity |
---|
Kinase | RBC |
---|
IRAK1 | inactive (91.83%) |
IRAK4 | inactive (88.25%) |
TKL - LISK
Bioactivity |
---|
Kinase | RBC |
---|
LIMK1 | inactive (95.25%) |
TKL - LRRK
Bioactivity |
---|
Kinase | RBC |
---|
LRRK2 | inactive (89.63%) |
TKL - MLK
Bioactivity |
---|
Kinase | RBC |
---|
MLK1 | inactive (99.99%) |
MLK2 | inactive (85.94%) |
MLK3 | inactive (93.86%) |
TAK1 | inactive (99.95%) |
ZAK | inactive (88%) |
TKL - RIPK
Bioactivity |
---|
Kinase | RBC |
---|
RIPK2 | inactive (68.67%) |
CAMK
CAMK - CAMKL
Bioactivity |
---|
Kinase | RBC |
---|
NuaK1 | inactive (95.47%) |
BRSK1 | inactive (63.05%) |
BRSK2 | inactive (60.58%) |
CHK1 | inactive (87.98%) |
LKB1 | inactive (97.07%) |
MARK1 | inactive (93.76%) |
MARK3 | inactive (92.52%) |
MARK4 | inactive (99.45%) |
MELK | inactive (97.69%) |
PASK | inactive (91.78%) |
QIK | inactive (78.71%) |
NuaK2 | inactive (90.36%) |
MARK2 | inactive (87%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | RBC |
---|
CaMK1a | inactive (103.34%) |
CaMK1b | inactive (98.39%) |
CaMK1d | inactive (130.27%) |
CaMK1g | inactive (97.18%) |
CaMK4 | inactive (103.48%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | RBC |
---|
CaMK2a | inactive (104.54%) |
CaMK2b | inactive (97.68%) |
CaMK2d | inactive (92.45%) |
CaMK2g | inactive (119.1%) |
CAMK - RAD53
Bioactivity |
---|
Kinase | RBC |
---|
CHK2 | inactive (98.61%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | RBC |
---|
DAPK1 | inactive (115.51%) |
DAPK2 | inactive (85.51%) |
DRAK1 | inactive (88.06%) |
DAPK3 | inactive (124.25%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | RBC |
---|
DCLK2 | inactive (99.54%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | RBC |
---|
MAPKAPK2 | inactive (104.78%) |
MAPKAPK3 | inactive (94%) |
MAPKAPK5 | inactive (80.94%) |
MNK1 | inactive (75.23%) |
MNK2 | inactive (72.35%) |
CAMK - MLCK
Bioactivity |
---|
Kinase | RBC |
---|
smMLCK | inactive (94.71%) |
skMLCK | inactive (87.35%) |
CAMK - PHK
Bioactivity |
---|
Kinase | RBC |
---|
PHKg1 | inactive (87.47%) |
PHKg2 | inactive (101.44%) |
CAMK - PIM
Bioactivity |
---|
Kinase | RBC |
---|
PIM1 | inactive (95.51%) |
PIM2 | inactive (89.27%) |
PIM3 | inactive (95.01%) |
CAMK - PKD
Bioactivity |
---|
Kinase | RBC |
---|
PKD1 | inactive (98.89%) |
PKD3 | inactive (86.66%) |
PKD2 | inactive (81.3%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | RBC |
---|
TSSK1 | inactive (96.35%) |
TSSK2 | inactive (90.75%) |
CAMK - STK33
Bioactivity |
---|
Kinase | RBC |
---|
STK33 | inactive (94.27%) |
STE
STE - STE11
Bioactivity |
---|
Kinase | RBC |
---|
MAP3K5 | inactive (110.63%) |
MAP3K2 | inactive (95.55%) |
MAP3K3 | inactive (87.56%) |
STE - STE-Unique
Bioactivity |
---|
Kinase | RBC |
---|
COT | inactive (99.73%) |
NIK | inactive (111.14%) |
STE - STE20
Bioactivity |
---|
Kinase | RBC |
---|
GCK | inactive (88.94%) |
HGK | inactive (59.41%) |
KHS1 | inactive (51.98%) |
LOK | inactive (70.51%) |
MINK | inactive (88.93%) |
MST1 | inactive (90.35%) |
MST2 | inactive (90.8%) |
MST3 | inactive (81.6%) |
MST4 | inactive (91.02%) |
OSR1 | inactive (109.64%) |
PAK1 | inactive (95.17%) |
PAK2 | inactive (102.9%) |
PAK3 | inactive (103.88%) |
PAK4 | inactive (104.32%) |
PAK5 | inactive (116.43%) |
PAK6 | inactive (108.69%) |
SLK | inactive (99.45%) |
YSK1 | inactive (112.28%) |
STLK3 | inactive (88.5%) |
TAO1 | inactive (91.95%) |
TAO2 | inactive (97.29%) |
TAO3 | inactive (92.41%) |
MYO3B | inactive (87.91%) |
STE - STE7
Bioactivity |
---|
Kinase | RBC |
---|
MAP2K1 | inactive (101.22%) |
MAP2K2 | inactive (89.96%) |
MAP2K6 | inactive (87.61%) |
Other
Other - Aur
Bioactivity |
---|
Kinase | RBC |
---|
AurA | inactive (92.26%) |
AurB | inactive (96.87%) |
AurC | inactive (96.01%) |
Other - CAMKK
Bioactivity |
---|
Kinase | RBC |
---|
CaMKK1 | inactive (101.16%) |
CaMKK2 | inactive (83.62%) |
Other - Haspin
Bioactivity |
---|
Kinase | RBC |
---|
Haspin | inactive (87.74%) |
Other - IKK
Bioactivity |
---|
Kinase | RBC |
---|
IKKa | inactive (99.49%) |
IKKb | inactive (104.61%) |
IKKe | inactive (100.02%) |
TBK1 | inactive (99.64%) |
Other - NEK
Bioactivity |
---|
Kinase | RBC |
---|
NEK1 | inactive (93.97%) |
NEK11 | inactive (101.76%) |
NEK2 | inactive (89.29%) |
NEK4 | inactive (92.81%) |
NEK6 | inactive (101.55%) |
NEK7 | inactive (97.02%) |
NEK9 | inactive (97.92%) |
NEK3 | inactive (102.24%) |
Other - TOPK
Bioactivity |
---|
Kinase | RBC |
---|
PBK | inactive (87.57%) |
Other - PLK
Bioactivity |
---|
Kinase | RBC |
---|
PLK1 | inactive (99.94%) |
PLK2 | inactive (101.18%) |
PLK3 | inactive (98.02%) |
Other - SgK496
Bioactivity |
---|
Kinase | RBC |
---|
SgK496 | inactive (109.01%) |
Other - NAK
Bioactivity |
---|
Kinase | RBC |
---|
MPSK1 | inactive (107.68%) |
Other - TTK
Bioactivity |
---|
Kinase | RBC |
---|
TTK | inactive (96.12%) |
Other - ULK
Bioactivity |
---|
Kinase | RBC |
---|
ULK1 | inactive (95.6%) |
ULK2 | inactive (110.27%) |
ULK3 | inactive (92.83%) |
Other - WEE
Bioactivity |
---|
Kinase | RBC |
---|
Wee1 | inactive (93.93%) |
Other - WNK
Bioactivity |
---|
Kinase | RBC |
---|
Wnk2 | inactive (109.85%) |
Wnk3 | inactive (103.38%) |
Other - TLK
Bioactivity |
---|
Kinase | RBC |
---|
TLK2 | inactive (79.03%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC |
---|
CK1 | 7 | 6 |
VRK | 3 | 1 |
CK1 - CK1
Bioactivity |
---|
Kinase | RBC |
---|
CK1d | inactive (67.67%) |
CK1g1 | inactive (83.27%) |
CK1g2 | inactive (95.74%) |
CK1g3 | inactive (97.85%) |
CK1a | inactive (90.25%) |
CK1e | inactive (80.45%) |
CK1 - VRK
Bioactivity |
---|
Kinase | RBC |
---|
VRK1 | inactive (82.92%) |
CMGC
CMGC - CK2
Bioactivity |
---|
Kinase | RBC |
---|
CK2a1 | inactive (89.91%) |
CK2a2 | - |
CMGC - CLK
Bioactivity |
---|
Kinase | RBC |
---|
CLK1 | inactive (102.19%) |
CLK2 | inactive (92.42%) |
CLK3 | inactive (111.81%) |
CLK4 | inactive (88.72%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | RBC |
---|
DYRK1A | inactive (86.43%) |
DYRK1B | inactive (99.24%) |
DYRK2 | inactive (90.55%) |
DYRK3 | inactive (89.02%) |
DYRK4 | inactive (104.15%) |
HIPK1 | inactive (106.41%) |
HIPK2 | inactive (105.91%) |
HIPK3 | inactive (100.5%) |
HIPK4 | inactive (98.55%) |
CMGC - MAPK
Bioactivity |
---|
Kinase | RBC |
---|
Erk1 | inactive (105.01%) |
Erk2 | inactive (80.83%) |
JNK3 | inactive (100.5%) |
NLK | inactive (95.4%) |
p38a | inactive (79.51%) |
p38b | inactive (108.19%) |
p38d | inactive (104.44%) |
p38g | inactive (94.18%) |
JNK1 | inactive (111.23%) |
JNK2 | inactive (102.92%) |
CMGC - GSK
Bioactivity |
---|
Kinase | RBC |
---|
GSK3A | inactive (88.65%) |
GSK3B | inactive (101%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | RBC |
---|
MSSK1 | inactive (91.46%) |
SRPK1 | inactive (104.43%) |
SRPK2 | inactive (97.1%) |
Atypical
Atypical
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC |
---|
PDHK | 5 | 1 |
Atypical - PDHK
Bioactivity |
---|
Kinase | RBC |
---|
PDHK1 | inactive (102.4%) |