Compound Information
Test on : GPCR
Compound Name : GW805758X
Inchikey : UODXTGBFBIFREQ-UHFFFAOYSA-N
ChemSpider : 5021830
Pubchem CID : 6539364
ChEMBL : CHEMBL359963
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (8.98%) |
TYK2 | inactive (-0.13%) |
JAK2 | inactive (8.72%) |
JAK3 | inactive (6.19%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (15.97%) |
FES | inactive (25.53%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (13.27%) |
ABL2 | inactive (10.62%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (6.02%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (5.9%) |
BTK | inactive (-0.53%) |
TXK | inactive (3.04%) |
TEC | inactive (7.14%) |
ITK | inactive (1.41%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (6.47%) |
SRM | inactive (3.15%) |
FRK | inactive (1.12%) |
BLK | inactive (4.76%) |
LCK | inactive (3.47%) |
HCK | inactive (8.83%) |
FGR | inactive (7.87%) |
FYN | inactive (6.49%) |
SRC | inactive (13.39%) |
YES | inactive (6.98%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (0.28%) |
EphA4 | inactive (10.35%) |
EphA3 | inactive (4.55%) |
EphB4 | inactive (2.76%) |
EphB3 | inactive (2.55%) |
EphB2 | inactive (14.45%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (45.83%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (9.02%) |
ZAP70 | inactive (6.84%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (10.64%) |
ALK | inactive (23.73%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | active (62.36%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (48.23%) |
IGF1R | active (53.13%) |
IRR | inactive (8.71%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (0.75%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (8.57%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (7.94%) |
TRKB | inactive (6.18%) |
TRKC | inactive (9.1%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (16.84%) |
MET | inactive (13.47%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (0.39%) |
MER | inactive (7.98%) |
TYRO3 | inactive (4.27%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (14.44%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (4.17%) |
FGFR2 | inactive (7.86%) |
FGFR3 | inactive (6.25%) |
FGFR4 | inactive (3.28%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (10.95%) |
KDR | inactive (14.61%) |
FLT4 | inactive (9.77%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | active (72.12%) |
KIT | active (95.49%) |
FLT3 | active (61.1%) |
PDGFRa | inactive (43.5%) |
PDGFRb | inactive (40.77%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (4.32%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (2.14%) |
TNK1 | inactive (49.26%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (6.88%) |
ErbB2 | inactive (3.22%) |
ErbB4 | inactive (11.56%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (1.84%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (13.66%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (23.38%) |
MST1 | inactive (20.05%) |
MST2 | inactive (18.61%) |
MST4 | inactive (2.8%) |
HGK | inactive (18.66%) |
MINK | inactive (14.58%) |
LOK | inactive (8.29%) |
PAK1 | inactive (3.55%) |
PAK3 | inactive (2.33%) |
PAK2 | inactive (0.9%) |
PAK5 | inactive (2.48%) |
PAK6 | inactive (2.84%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (9.57%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (12.92%) |
CK1g2 | inactive (24.88%) |
CK1g1 | inactive (8.9%) |
CK1g3 | inactive (13.56%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (4.81%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (43.13%) |
AurC | active (74.59%) |
AurA | active (65.79%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (13.53%) |
NEK2 | inactive (8.45%) |
NEK9 | inactive (11.04%) |
NEK7 | inactive (4.87%) |
NEK6 | inactive (3.3%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (13.88%) |
IKKe | inactive (7.95%) |
IKKb | inactive (23.02%) |
IKKa | active (64.08%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (22.22%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (3.19%) |
GPRK6 | inactive (3.14%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (3.9%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (1.36%) |
MSK2 | inactive (2.98%) |
RSK1 | inactive (3.69%) |
RSK2 | inactive (2.08%) |
RSK4 | inactive (1.84%) |
RSK3 | inactive (2.76%) |
p70S6K | inactive (1.58%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (1.13%) |
AKT1 | inactive (0.64%) |
AKT3 | inactive (1.51%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (3.19%) |
SGK3 | inactive (0.79%) |
SGK2 | inactive (3.21%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (3.89%) |
PKCg | inactive (5.49%) |
PKCa | inactive (6.9%) |
PKCt | inactive (2.84%) |
PKCi | inactive (-0.49%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (3.05%) |
PKG1 | inactive (4.3%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (1.43%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (10.92%) |
ROCK2 | inactive (24.67%) |
MRCKb | inactive (-0.74%) |
MRCKa | inactive (-0.92%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (3.38%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (-1.7%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (2.83%) |
CaMK1d | inactive (2.35%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (7.97%) |
PHKg2 | inactive (3.83%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (8.29%) |
CaMK2a | inactive (4.19%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (1.09%) |
MAPKAPK2 | inactive (0.39%) |
MAPKAPK3 | inactive (6.14%) |
MNK2 | inactive (15.16%) |
MNK1 | inactive (11.75%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (15.64%) |
PKD1 | inactive (15.9%) |
PKD2 | inactive (15.58%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (2.61%) |
MARK3 | inactive (3.95%) |
MARK1 | inactive (4.24%) |
QIK | inactive (11.34%) |
SIK | inactive (8.55%) |
NuaK1 | inactive (48.87%) |
BRSK1 | inactive (3.13%) |
BRSK2 | inactive (4.11%) |
MELK | inactive (26.3%) |
CHK1 | inactive (-2.41%) |
PASK | inactive (-0.93%) |
AMPKa1 | inactive (3.55%) |
AMPKa2 | inactive (4.11%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (0.57%) |
TSSK1 | inactive (5.95%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (-2.33%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (1.73%) |
PIM3 | inactive (6.16%) |
PIM1 | inactive (2.45%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (27.03%) |
p38a | inactive (28.16%) |
p38b | inactive (5.44%) |
p38d | inactive (5.42%) |
Erk2 | inactive (9.29%) |
Erk1 | inactive (3%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | active (76%) |
GSK3B | active (75.41%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-0.8%) |
MSSK1 | inactive (0.7%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (13.96%) |
CLK2 | active (65.35%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | active (87.84%) |
HIPK4 | active (50.57%) |
DYRK1B | active (82.12%) |
DYRK1A | active (81.17%) |
DYRK2 | inactive (14.02%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (43.41%) |