Compound Information
Test on : GPCR
Compound Name : GW679410X
Inchikey : UNNVAVXBYOPNHR-UHFFFAOYSA-N
ChemSpider : 8077618
Pubchem CID : 9901964
ChEMBL : CHEMBL202891
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (7.4%) |
TYK2 | inactive (-4.16%) |
JAK2 | inactive (4.19%) |
JAK3 | inactive (-0.62%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (7.83%) |
FES | inactive (3.93%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | active (59.75%) |
ABL2 | inactive (35.59%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (10.28%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (5.27%) |
BTK | inactive (1.28%) |
TXK | inactive (3.18%) |
TEC | inactive (5.59%) |
ITK | inactive (2.05%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (7.25%) |
SRM | inactive (0.71%) |
FRK | inactive (2.92%) |
BLK | inactive (3.9%) |
LCK | inactive (5.16%) |
HCK | inactive (10.31%) |
FGR | inactive (4.21%) |
FYN | inactive (3.5%) |
SRC | inactive (11.1%) |
YES | inactive (7.41%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (1.07%) |
EphA4 | inactive (14.05%) |
EphA3 | inactive (7.51%) |
EphB4 | inactive (2.68%) |
EphB3 | inactive (2.2%) |
EphB2 | inactive (10.19%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (13.93%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-0.69%) |
ZAP70 | inactive (2.09%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (5.89%) |
ALK | inactive (5.23%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (8.62%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (3.43%) |
IGF1R | inactive (3.01%) |
IRR | inactive (3.15%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (3.66%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (4.1%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (3.12%) |
TRKB | inactive (3.9%) |
TRKC | inactive (5.62%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (21.33%) |
MET | inactive (3.52%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-5.64%) |
MER | inactive (2.69%) |
TYRO3 | inactive (4.46%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (5.9%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (-0.51%) |
FGFR2 | inactive (4.55%) |
FGFR3 | inactive (5.23%) |
FGFR4 | inactive (6.88%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (8.02%) |
KDR | inactive (47.96%) |
FLT4 | inactive (4.26%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (5.24%) |
KIT | inactive (9.66%) |
FLT3 | - |
PDGFRa | inactive (42.08%) |
PDGFRb | inactive (31.86%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (2.66%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (3.35%) |
TNK1 | inactive (11.86%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (6.06%) |
ErbB2 | inactive (6.13%) |
ErbB4 | inactive (10.63%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (2.03%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (6.98%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (2.15%) |
MST1 | inactive (10.58%) |
MST2 | inactive (10.14%) |
MST4 | inactive (-0.46%) |
HGK | active (80.33%) |
MINK | active (72.74%) |
LOK | inactive (8.57%) |
PAK1 | inactive (3.96%) |
PAK3 | inactive (5.49%) |
PAK2 | inactive (1.63%) |
PAK5 | inactive (1.94%) |
PAK6 | inactive (-3.15%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (4.25%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (11.51%) |
CK1g2 | inactive (5.19%) |
CK1g1 | inactive (5.78%) |
CK1g3 | inactive (6.59%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (4.38%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (5.71%) |
AurC | inactive (-1.66%) |
AurA | inactive (5.58%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (3.74%) |
NEK2 | inactive (4.88%) |
NEK9 | inactive (9.65%) |
NEK7 | inactive (3.19%) |
NEK6 | inactive (4.34%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (6.38%) |
IKKe | inactive (9.71%) |
IKKb | inactive (8.08%) |
IKKa | inactive (10.53%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (10.48%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (6.26%) |
GPRK6 | inactive (8.91%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (3.02%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (4.22%) |
MSK2 | inactive (4.77%) |
RSK1 | inactive (6.34%) |
RSK2 | inactive (4.06%) |
RSK4 | inactive (1.8%) |
RSK3 | inactive (4.07%) |
p70S6K | inactive (3.73%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (1.95%) |
AKT1 | inactive (1.5%) |
AKT3 | inactive (1.52%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (7.39%) |
SGK3 | inactive (6.74%) |
SGK2 | inactive (5.93%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (5.03%) |
PKCg | inactive (1.71%) |
PKCa | inactive (2.09%) |
PKCt | inactive (5.05%) |
PKCi | inactive (0.87%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (4.61%) |
PKG1 | inactive (5.45%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (6.17%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (4.3%) |
ROCK2 | inactive (7.92%) |
MRCKb | inactive (0.6%) |
MRCKa | inactive (3.02%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (4.49%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (0.82%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (-3.38%) |
CaMK1d | inactive (-1.05%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (6.04%) |
PHKg2 | inactive (8.39%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (3.97%) |
CaMK2a | inactive (6.7%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (4.32%) |
MAPKAPK2 | inactive (2.73%) |
MAPKAPK3 | inactive (13.98%) |
MNK2 | inactive (6.65%) |
MNK1 | inactive (7.19%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (27.24%) |
PKD1 | inactive (37.76%) |
PKD2 | inactive (44.84%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (2.28%) |
MARK3 | inactive (5.51%) |
MARK1 | inactive (7.25%) |
QIK | inactive (11.27%) |
SIK | inactive (7.23%) |
NuaK1 | inactive (2.48%) |
BRSK1 | inactive (2.6%) |
BRSK2 | inactive (3.41%) |
MELK | inactive (8.05%) |
CHK1 | inactive (6.57%) |
PASK | inactive (0.75%) |
AMPKa1 | inactive (6.63%) |
AMPKa2 | inactive (3.44%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (3.88%) |
TSSK1 | inactive (5.54%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (6.22%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (1.29%) |
PIM3 | inactive (1.9%) |
PIM1 | inactive (0.03%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (9.74%) |
p38a | inactive (37.18%) |
p38b | inactive (14.09%) |
p38d | inactive (4.1%) |
Erk2 | inactive (5.26%) |
Erk1 | inactive (8.82%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (5.27%) |
GSK3B | inactive (6.22%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (2.7%) |
MSSK1 | inactive (0.75%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (1.7%) |
CLK2 | inactive (0.26%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (4.88%) |
HIPK4 | inactive (-2.34%) |
DYRK1B | inactive (2.54%) |
DYRK1A | inactive (6.71%) |
DYRK2 | inactive (3.1%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (8.65%) |