Compound Information
Test on : DRx
Compound Name : SCHEMBL16139562
Inchikey : UIARLYUEJFELEN-FMLDBKJISA-N
ChemSpider : 68026569
Pubchem CID : 14096317
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
| bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
| active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
Other
Other - NAK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| AAK1 | active (3.1nM) |
| BIKE | active (16nM) |
| GAK | active (7.3nM) |
| MPSK1 | active (19nM) |
Other - Aur
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| AurA | active (16nM) |
| AurB | active (16nM) |
| AurC | active (4.1nM) |
Other - CAMKK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| CaMKK1 | active (23nM) |
| CaMKK2 | active (15nM) |
Other - PEK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| HRI | inactive (10001nM) |
| PKR | active (120nM) |
Other - IRE
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| IRE1 | active (5.7nM) |
Other - IKK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| IKKa | active (9nM) |
| IKKb | active (12nM) |
| IKKe | active (11nM) |
| TBK1 | active (18nM) |
Other - NEK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| NEK1 | active (2500nM) |
| NEK11 | inactive (10001nM) |
| NEK2 | inactive (4900nM) |
| NEK3 | inactive (10001nM) |
| NEK4 | inactive (10001nM) |
| NEK5 | inactive (5600nM) |
| NEK6 | inactive (4400nM) |
| NEK7 | inactive (4000nM) |
| NEK9 | inactive (5400nM) |
Other - WEE
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| MYT1 | inactive (10001nM) |
| Wee1 | active (1200nM) |
| Wee1B | inactive (7900nM) |
Other - PLK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| PLK1 | active (220nM) |
| PLK2 | active (330nM) |
| PLK3 | active (2300nM) |
| PLK4 | active (1.5nM) |
Other - SgK496
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| SgK496 | active (5.3nM) |
Other - NKF1
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| SBK | active (200nM) |
| SgK110 | active (120nM) |
Other - NKF4
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| CLIK1 | active (810nM) |
Other - ULK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| Fused | inactive (3800nM) |
| ULK1 | active (1000nM) |
| ULK2 | active (60nM) |
| ULK3 | active (4.9nM) |
Other - TLK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| TLK1 | active (110nM) |
| TLK2 | active (64nM) |
Other - TTK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| TTK | active (6.5nM) |
TK
TK - Abl
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| ABL1 | inactive (3200nM) |
| ABL2 | inactive (6500nM) |
TK - ALK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| ALK | active (71nM) |
| LTK | active (490nM) |
TK - Axl
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| AXL | active (35nM) |
| MER | active (32nM) |
| TYRO3 | active (650nM) |
TK - Src
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| BLK | active (160nM) |
| BRK | active (1700nM) |
| FGR | active (52nM) |
| FRK | active (740nM) |
| FYN | active (84nM) |
| HCK | active (270nM) |
| LCK | active (430nM) |
| LYN | active (190nM) |
| SRC | active (640nM) |
| SRM | active (820nM) |
| YES | active (160nM) |
TK - Tec
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| BMX | active (200nM) |
| BTK | active (66nM) |
| ITK | active (290nM) |
| TEC | active (1200nM) |
| TXK | active (660nM) |
TK - PDGFR
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| FMS | active (110nM) |
| FLT3 | active (8.5nM) |
| KIT | active (150nM) |
| PDGFRa | active (350nM) |
| PDGFRb | active (29nM) |
TK - Csk
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| CSK | active (260nM) |
| CTK | active (970nM) |
TK - DDR
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| DDR1 | active (510nM) |
| DDR2 | active (400nM) |
TK - EGFR
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| EGFR | active (1100nM) |
| ErbB2 | inactive (10001nM) |
| ErbB3 | inactive (5500nM) |
| ErbB4 | active (1400nM) |
TK - Eph
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| EphA1 | active (380nM) |
| EphA2 | active (790nM) |
| EphA3 | active (160nM) |
| EphA4 | active (1700nM) |
| EphA5 | inactive (5900nM) |
| EphA6 | active (1200nM) |
| EphA7 | active (260nM) |
| EphA8 | inactive (10001nM) |
| EphB1 | inactive (5200nM) |
| EphB2 | inactive (6900nM) |
| EphB3 | inactive (10001nM) |
| EphB4 | inactive (6900nM) |
| EphB6 | active (98nM) |
TK - FAK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| FAK | active (1100nM) |
| PYK2 | active (41nM) |
TK - Fer
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| FER | active (28nM) |
| FES | active (370nM) |
TK - FGFR
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| FGFR1 | active (310nM) |
| FGFR2 | active (660nM) |
| FGFR3 | active (580nM) |
| FGFR4 | active (1800nM) |
TK - VEGFR
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| FLT1 | active (120nM) |
| FLT4 | active (17nM) |
| KDR | active (220nM) |
TK - InsR
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| IGF1R | inactive (4200nM) |
| INSR | active (1100nM) |
| IRR | active (1800nM) |
TK - JakA
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| JAK1 | active (8.8nM) |
| JAK2 | active (3.7nM) |
| JAK3 | active (2.3nM) |
| TYK2 | active (15nM) |
TK - Met
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| MET | active (290nM) |
| RON | inactive (8200nM) |
TK - Musk
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| MUSK | inactive (4100nM) |
TK - Ret
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| RET | active (20nM) |
TK - Sev
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| ROS | active (26nM) |
TK - Syk
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| SYK | active (9.5nM) |
| ZAP70 | active (16nM) |
TK - Tie
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| TIE1 | active (680nM) |
| TIE2 | active (630nM) |
TK - Ack
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| TNK1 | active (9.3nM) |
| ACK | active (6.6nM) |
TK - Trk
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| TRKA | active (8.3nM) |
| TRKB | active (14nM) |
| TRKC | active (14nM) |
TKL
TKL - STKR
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| ALK2 | active (75nM) |
| ALK4 | active (86nM) |
| ACTR2 | active (2500nM) |
| ACTR2B | inactive (3800nM) |
| ALK1 | active (2200nM) |
| BMPR1A | active (950nM) |
| BMPR1B | active (57nM) |
| BMPR2 | active (1500nM) |
| TGFbR1 | active (120nM) |
| TGFbR2 | active (540nM) |
TKL - RIPK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| SgK288 | active (32nM) |
| RIPK1 | inactive (10001nM) |
| RIPK2 | active (640nM) |
| ANKRD3 | active (13nM) |
TKL - RAF
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| BRAF | inactive (10001nM) |
| RAF1 | inactive (10001nM) |
TKL - MLK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| DLK | active (840nM) |
| LZK | active (340nM) |
| MLK1 | active (3.5nM) |
| MLK2 | active (15nM) |
| MLK3 | active (18nM) |
| TAK1 | active (2.9nM) |
| HH498 | active (2100nM) |
| ZAK | inactive (6700nM) |
TKL - IRAK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| IRAK1 | active (6.1nM) |
| IRAK3 | active (16nM) |
| IRAK4 | active (1.7nM) |
TKL - LISK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| LIMK1 | active (1600nM) |
| LIMK2 | inactive (10001nM) |
| TESK1 | active (290nM) |
TKL - LRRK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| LRRK2 | active (3.6nM) |
Atypical
Atypical
| Test Member No. in Family |
|---|
| Family | no. Member on 518kinase | DRx |
|---|
| ABC1 | 5 | 2 |
| PIKK | 6 | 1 |
| RIO | 3 | 3 |
| Alpha | 6 | 1 |
Atypical - ABC1
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| ADCK3 | inactive (10001nM) |
| ADCK4 | inactive (10001nM) |
Atypical - PIKK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| FRAP | inactive (10001nM) |
Atypical - RIO
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| RIOK1 | active (9nM) |
| RIOK2 | inactive (6700nM) |
| RIOK3 | active (7.7nM) |
Atypical - Alpha
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| ChaK2 | inactive (10001nM) |
AGC
AGC - Akt
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| AKT1 | inactive (4400nM) |
| AKT2 | active (2100nM) |
| AKT3 | inactive (6200nM) |
AGC - DMPK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| CRIK | active (85nM) |
| DMPK1 | active (240nM) |
| DMPK2 | active (2500nM) |
| MRCKa | inactive (9200nM) |
| MRCKb | active (1000nM) |
| ROCK1 | active (56nM) |
| ROCK2 | active (71nM) |
AGC - GRK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| RHOK | active (24nM) |
| GPRK4 | active (12nM) |
| GPRK7 | active (7.2nM) |
AGC - NDR
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| LATS1 | active (30nM) |
| LATS2 | active (1nM) |
| NDR1 | active (220nM) |
| NDR2 | active (370nM) |
AGC - MAST
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| MAST1 | active (19nM) |
AGC - PDK1
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| PDK1 | active (3.4nM) |
AGC - PKA
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| PKACa | active (220nM) |
| PKACb | active (160nM) |
| PRKX | active (42nM) |
AGC - PKN
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| PKN1 | active (5.3nM) |
| PKN2 | active (1.8nM) |
AGC - PKC
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| PKCd | active (240nM) |
| PKCe | active (160nM) |
| PKCh | active (140nM) |
| PKCi | active (1800nM) |
| PKCt | active (100nM) |
AGC - PKG
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| PKG1 | active (370nM) |
| PKG2 | active (25nM) |
AGC - RSK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| p70S6K | active (69nM) |
AGC - SGK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| SGK3 | active (5.8nM) |
AGC - YANK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| YANK1 | active (2100nM) |
| YANK2 | inactive (5900nM) |
| YANK3 | inactive (8000nM) |
CAMK
CAMK - CAMKL
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| AMPKa1 | active (25nM) |
| AMPKa2 | active (56nM) |
| NuaK1 | active (3.7nM) |
| BRSK1 | active (25nM) |
| BRSK2 | active (16nM) |
| CHK1 | active (2.8nM) |
| HUNK | active (570nM) |
| LKB1 | active (57nM) |
| MARK1 | active (83nM) |
| MARK2 | active (14nM) |
| MARK3 | active (49nM) |
| MARK4 | active (120nM) |
| MELK | active (26nM) |
| NIM1 | active (1800nM) |
| QSK | active (120nM) |
| SIK | active (82nM) |
| QIK | active (15nM) |
| NuaK2 | active (1nM) |
| SNRK | inactive (10001nM) |
CAMK - CAMK1
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| CaMK1a | active (130nM) |
| CaMK1d | active (47nM) |
| CaMK1g | active (470nM) |
| CaMK4 | active (3000nM) |
CAMK - CAMK2
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| CaMK2a | active (10nM) |
| CaMK2b | active (59nM) |
| CaMK2d | active (8.8nM) |
| CaMK2g | active (26nM) |
CAMK - CASK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| CASK | active (330nM) |
CAMK - RAD53
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| CHK2 | active (210nM) |
CAMK - DAPK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| DAPK1 | active (80nM) |
| DAPK2 | active (63nM) |
| DAPK3 | active (82nM) |
| DRAK1 | active (3.4nM) |
| DRAK2 | active (5nM) |
CAMK - DCAMKL
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| DCLK1 | inactive (10001nM) |
| DCLK2 | inactive (4500nM) |
| DCLK3 | active (1100nM) |
CAMK - MAPKAPK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| MAPKAPK2 | active (230nM) |
| MAPKAPK5 | active (930nM) |
| MNK1 | active (56nM) |
| MNK2 | active (1.4nM) |
CAMK - MLCK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| caMLCK | active (12nM) |
| smMLCK | active (13nM) |
| skMLCK | active (56nM) |
| SgK085 | active (29nM) |
CAMK - PHK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| PHKg1 | active (0.39nM) |
| PHKg2 | active (1.7nM) |
CAMK - PIM
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| PIM1 | active (200nM) |
| PIM2 | active (250nM) |
| PIM3 | active (18nM) |
CAMK - PKD
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| PKD1 | active (14nM) |
| PKD2 | active (8.1nM) |
| PKD3 | active (8.9nM) |
CAMK - STK33
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| STK33 | active (26nM) |
CAMK - TSSK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| TSSK1 | active (98nM) |
STE
STE
| Test Member No. in Family |
|---|
| Family | no. Member on 518kinase | DRx |
|---|
| STE11 | 8 | 8 |
| STE20 | 31 | 27 |
| STE7 | 7 | 7 |
STE - STE11
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| MAP3K5 | active (70nM) |
| MAP3K6 | active (170nM) |
| MAP3K1 | inactive (4400nM) |
| MAP3K7 | active (3.4nM) |
| MAP3K2 | active (4.8nM) |
| MAP3K3 | active (6nM) |
| MAP3K4 | active (2600nM) |
| MAP3K8 | active (0.52nM) |
STE - STE20
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| HPK1 | active (38nM) |
| LOK | active (5.7nM) |
| GCK | active (4.7nM) |
| KHS2 | active (110nM) |
| HGK | active (23nM) |
| KHS1 | active (43nM) |
| MINK | active (3.6nM) |
| MST1 | active (3nM) |
| MST2 | active (2.4nM) |
| MST3 | active (760nM) |
| MST4 | active (230nM) |
| MYO3A | active (260nM) |
| MYO3B | active (770nM) |
| OSR1 | inactive (8000nM) |
| PAK1 | active (30nM) |
| PAK2 | active (43nM) |
| PAK3 | active (35nM) |
| PAK4 | active (24nM) |
| PAK6 | active (9.9nM) |
| PAK5 | active (24nM) |
| SLK | active (35nM) |
| STLK3 | active (1100nM) |
| TAO1 | active (70nM) |
| TAO2 | active (500nM) |
| TAO3 | active (86nM) |
| TNIK | active (5.4nM) |
| YSK1 | active (97nM) |
STE - STE7
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| MAP2K1 | active (3.5nM) |
| MAP2K2 | active (3.9nM) |
| MAP2K3 | active (5nM) |
| MAP2K4 | active (3.8nM) |
| MAP2K5 | active (7nM) |
| MAP2K6 | active (44nM) |
| MAP2K7 | active (80nM) |
CMGC
CMGC - CDK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| PITSLRE | inactive (10001nM) |
| CHED | active (1000nM) |
| CDK11 | inactive (10001nM) |
| PCTAIRE1 | active (27nM) |
| PCTAIRE2 | active (720nM) |
| PCTAIRE3 | inactive (10001nM) |
| PFTAIRE2 | active (1300nM) |
| PFTAIRE1 | active (720nM) |
CMGC - CDKL
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| CDKL1 | active (490nM) |
| CDKL2 | active (43nM) |
| CDKL3 | active (430nM) |
| CDKL5 | active (10nM) |
CMGC - CLK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| CLK1 | active (9.6nM) |
| CLK2 | active (44nM) |
| CLK3 | inactive (10001nM) |
| CLK4 | active (3nM) |
CMGC - CK2
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| CK2a1 | active (2600nM) |
| CK2a2 | active (970nM) |
CMGC - DYRK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| DYRK1A | active (20nM) |
| DYRK1B | active (29nM) |
| DYRK2 | active (22nM) |
| HIPK1 | active (590nM) |
| HIPK2 | active (370nM) |
| HIPK3 | active (250nM) |
| HIPK4 | active (150nM) |
| PRP4 | active (550nM) |
CMGC - MAPK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| Erk1 | inactive (9800nM) |
| Erk2 | inactive (10001nM) |
| Erk3 | inactive (10001nM) |
| Erk4 | inactive (10001nM) |
| Erk5 | active (1100nM) |
| Erk7 | active (4.9nM) |
| JNK1 | active (11nM) |
| JNK2 | active (320nM) |
| JNK3 | active (12nM) |
| NLK | active (770nM) |
| p38a | inactive (10001nM) |
| p38b | inactive (10001nM) |
| p38d | inactive (3500nM) |
| p38g | active (370nM) |
CMGC - GSK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| GSK3A | active (2300nM) |
| GSK3B | active (1300nM) |
CMGC - RCK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| ICK | active (39nM) |
| MAK | active (1700nM) |
CMGC - SRPK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| SRPK1 | active (10nM) |
| SRPK2 | active (51nM) |
| MSSK1 | active (13nM) |
CK1
CK1
| Test Member No. in Family |
|---|
| Family | no. Member on 518kinase | DRx |
|---|
| CK1 | 7 | 7 |
| VRK | 3 | 1 |
CK1 - CK1
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| CK1a | inactive (10001nM) |
| CK1a2 | inactive (7100nM) |
| CK1d | inactive (10001nM) |
| CK1e | inactive (10001nM) |
| CK1g1 | inactive (10001nM) |
| CK1g2 | inactive (10001nM) |
| CK1g3 | inactive (10001nM) |
CK1 - VRK
| Bioactivity |
|---|
| Kinase | DRx |
|---|
| VRK2 | inactive (10001nM) |
