Compound Information
Test on : GPCR
Compound Name : GSK237700A
Inchikey : UHCHLTQBLNUYRT-LBPRGKRZSA-N
ChemSpider : 24719677
Pubchem CID : 25263117
ChEMBL : CHEMBL521806
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (3.27%) |
TYK2 | inactive (-4.63%) |
JAK2 | inactive (1.08%) |
JAK3 | inactive (1.97%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (8.42%) |
FES | inactive (2.83%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (28.37%) |
ABL2 | inactive (11.43%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (5.68%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (6.64%) |
BTK | inactive (1.4%) |
TXK | inactive (5.82%) |
TEC | inactive (7.65%) |
ITK | inactive (3.19%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (7.91%) |
SRM | inactive (-1.13%) |
FRK | inactive (4.28%) |
BLK | active (51.23%) |
LCK | inactive (19.63%) |
HCK | inactive (43.29%) |
FGR | inactive (32.17%) |
FYN | inactive (27.46%) |
SRC | inactive (30.09%) |
YES | inactive (33.18%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (1.17%) |
EphA4 | inactive (14.25%) |
EphA3 | inactive (6.21%) |
EphB4 | inactive (4.23%) |
EphB3 | inactive (3.66%) |
EphB2 | inactive (14.07%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (13.96%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-4.6%) |
ZAP70 | inactive (2.45%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (4.56%) |
ALK | inactive (6.34%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (29.06%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (3.04%) |
IGF1R | inactive (2.3%) |
IRR | inactive (3.99%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (1.58%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (14.08%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (6.09%) |
TRKB | inactive (18.59%) |
TRKC | inactive (32.53%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (2.55%) |
MET | inactive (3.23%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-5.82%) |
MER | inactive (10.29%) |
TYRO3 | inactive (6%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | active (72.1%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (17.19%) |
FGFR2 | inactive (21.92%) |
FGFR3 | inactive (24.27%) |
FGFR4 | inactive (2.7%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (13.32%) |
KDR | active (67.73%) |
FLT4 | active (67.58%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (9.87%) |
KIT | inactive (11.92%) |
FLT3 | inactive (3.2%) |
PDGFRa | active (73.77%) |
PDGFRb | active (68.24%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (24.2%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (6.07%) |
TNK1 | active (79.53%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (7.32%) |
ErbB2 | inactive (6.51%) |
ErbB4 | inactive (14.2%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (2.08%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (5.17%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (20.2%) |
MST1 | inactive (40.27%) |
MST2 | inactive (34.83%) |
MST4 | inactive (-7.1%) |
HGK | inactive (31.97%) |
MINK | inactive (28.54%) |
LOK | active (79.53%) |
PAK1 | inactive (9.51%) |
PAK3 | inactive (5.27%) |
PAK2 | inactive (2.93%) |
PAK5 | inactive (4.73%) |
PAK6 | inactive (-1.4%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (3.99%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (4.44%) |
CK1g2 | inactive (5.19%) |
CK1g1 | inactive (5.05%) |
CK1g3 | inactive (3.53%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | active (97.66%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (38.77%) |
AurC | inactive (49.31%) |
AurA | inactive (18.13%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (19.33%) |
NEK2 | inactive (10.36%) |
NEK9 | inactive (38.35%) |
NEK7 | inactive (4.57%) |
NEK6 | inactive (0.67%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (26.97%) |
IKKe | inactive (7.74%) |
IKKb | inactive (4.88%) |
IKKa | inactive (8.5%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (9.98%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (4.64%) |
GPRK6 | inactive (2.39%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (7.69%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (11.62%) |
MSK2 | inactive (5.46%) |
RSK1 | inactive (4.51%) |
RSK2 | inactive (5.13%) |
RSK4 | inactive (6.8%) |
RSK3 | inactive (6.66%) |
p70S6K | inactive (2.16%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (1.94%) |
AKT1 | inactive (1.3%) |
AKT3 | inactive (1.32%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (4.72%) |
SGK3 | inactive (7.31%) |
SGK2 | inactive (3.95%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (3.1%) |
PKCg | inactive (1.93%) |
PKCa | inactive (3.87%) |
PKCt | inactive (3.24%) |
PKCi | inactive (4.88%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (5.22%) |
PKG1 | inactive (4.72%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (3.91%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (3.27%) |
ROCK2 | inactive (5.4%) |
MRCKb | inactive (3.35%) |
MRCKa | inactive (0.91%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (11.6%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (3.6%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (-3.56%) |
CaMK1d | inactive (1.53%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (8.24%) |
PHKg2 | inactive (6.6%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (5.01%) |
CaMK2a | inactive (-1%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (1.22%) |
MAPKAPK2 | inactive (5%) |
MAPKAPK3 | inactive (10.86%) |
MNK2 | inactive (7.84%) |
MNK1 | inactive (2.74%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (4.78%) |
PKD1 | inactive (6.69%) |
PKD2 | inactive (2.84%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (7.69%) |
MARK3 | inactive (8.06%) |
MARK1 | inactive (9.07%) |
QIK | inactive (12.04%) |
SIK | inactive (18.15%) |
NuaK1 | inactive (22.41%) |
BRSK1 | inactive (44.04%) |
BRSK2 | active (58.87%) |
MELK | inactive (9.71%) |
CHK1 | inactive (11.3%) |
PASK | inactive (1.28%) |
AMPKa1 | inactive (10.62%) |
AMPKa2 | inactive (5.06%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (1.24%) |
TSSK1 | inactive (5.73%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (8.9%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (0.91%) |
PIM3 | inactive (4.24%) |
PIM1 | inactive (1.8%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (8.24%) |
p38a | inactive (7.39%) |
p38b | inactive (2.35%) |
p38d | inactive (3.82%) |
Erk2 | inactive (6.55%) |
Erk1 | inactive (3.07%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (6.38%) |
GSK3B | inactive (5.97%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-2.08%) |
MSSK1 | inactive (-0.07%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (2.08%) |
CLK2 | inactive (0.86%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (4.95%) |
HIPK4 | inactive (22.14%) |
DYRK1B | inactive (5.29%) |
DYRK1A | inactive (8.19%) |
DYRK2 | inactive (3.36%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (3.34%) |