Compound Information
Test on : GPCR
Compound Name : GW407323A
Inchikey : UBABNUZHWFXYNS-UHFFFAOYSA-N
ChemSpider : 26639371
Pubchem CID : 56681565
ChEMBL : CHEMBL1794053
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (-0.48%) |
TYK2 | inactive (2.43%) |
JAK2 | inactive (-1.87%) |
JAK3 | inactive (2.02%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (3.05%) |
FES | inactive (-3.65%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (12.72%) |
ABL2 | inactive (9.86%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (-6.6%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (-0.09%) |
BTK | inactive (-0.23%) |
TXK | inactive (0.27%) |
TEC | inactive (-1%) |
ITK | inactive (1.31%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (0.1%) |
SRM | active (52.98%) |
FRK | inactive (3.29%) |
BLK | inactive (5.56%) |
LCK | inactive (4.41%) |
HCK | inactive (7.14%) |
FGR | inactive (5.44%) |
FYN | inactive (8.82%) |
SRC | inactive (-0.25%) |
YES | inactive (6.08%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (-4.26%) |
EphA4 | inactive (-2.56%) |
EphA3 | inactive (-2.41%) |
EphB4 | inactive (-2.45%) |
EphB3 | inactive (-4.71%) |
EphB2 | inactive (-1.17%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (6.43%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (0.99%) |
ZAP70 | inactive (-1.62%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (17.39%) |
ALK | inactive (1.3%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (7.73%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (1.87%) |
IGF1R | inactive (0.82%) |
IRR | inactive (-2.21%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (2.46%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (2.75%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (2.45%) |
TRKB | inactive (9.18%) |
TRKC | inactive (16.65%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (2.87%) |
MET | inactive (4.73%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (2.96%) |
MER | inactive (3.29%) |
TYRO3 | inactive (2.67%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (12.26%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (-1.36%) |
FGFR2 | inactive (1.88%) |
FGFR3 | inactive (1.45%) |
FGFR4 | inactive (3.96%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (0.2%) |
KDR | inactive (11.28%) |
FLT4 | inactive (6.47%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (2.56%) |
KIT | inactive (3.41%) |
FLT3 | inactive (0.66%) |
PDGFRa | inactive (5.96%) |
PDGFRb | inactive (7.52%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (3.72%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (-0.19%) |
TNK1 | inactive (37.06%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (5.53%) |
ErbB2 | inactive (2.84%) |
ErbB4 | inactive (-0.4%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (-0.15%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (13.66%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (5.61%) |
MST1 | inactive (9.55%) |
MST2 | inactive (12.19%) |
MST4 | inactive (15.51%) |
HGK | active (75.3%) |
MINK | active (56.86%) |
LOK | inactive (6.29%) |
PAK1 | inactive (-1.51%) |
PAK3 | inactive (-1.99%) |
PAK2 | inactive (-1.94%) |
PAK5 | inactive (-3.15%) |
PAK6 | inactive (-10.71%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (-1.25%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (-1.31%) |
CK1g2 | inactive (-0.74%) |
CK1g1 | inactive (-1.14%) |
CK1g3 | inactive (0.95%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (3.62%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (6.47%) |
AurC | inactive (9.45%) |
AurA | inactive (29.19%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (2.14%) |
NEK2 | inactive (2.78%) |
NEK9 | inactive (8.59%) |
NEK7 | inactive (-1.46%) |
NEK6 | inactive (3.09%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (0.36%) |
IKKe | inactive (-0.65%) |
IKKb | inactive (0.06%) |
IKKa | inactive (2.3%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (-0.27%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (22.77%) |
GPRK6 | inactive (10.66%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (-0.58%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (0.13%) |
MSK2 | inactive (-0.48%) |
RSK1 | inactive (4.1%) |
RSK2 | inactive (1.6%) |
RSK4 | inactive (2.87%) |
RSK3 | inactive (1.44%) |
p70S6K | inactive (1.12%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (-0.83%) |
AKT1 | inactive (-1.22%) |
AKT3 | inactive (-0.36%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (0.56%) |
SGK3 | inactive (-0.04%) |
SGK2 | inactive (2.1%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (-1.96%) |
PKCg | inactive (2.01%) |
PKCa | inactive (1.51%) |
PKCt | inactive (0.33%) |
PKCi | inactive (0.34%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (1.49%) |
PKG1 | inactive (1.43%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (0.42%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (-0.02%) |
ROCK2 | inactive (2.2%) |
MRCKb | inactive (0.83%) |
MRCKa | inactive (-1.5%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (0.55%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (-0.78%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (-2.75%) |
CaMK1d | inactive (9%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (5.21%) |
PHKg2 | inactive (-2.57%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (-1.31%) |
CaMK2a | inactive (-3.05%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (-0.3%) |
MAPKAPK2 | inactive (-1.55%) |
MAPKAPK3 | inactive (-1.51%) |
MNK2 | inactive (10.6%) |
MNK1 | inactive (7.91%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (-1.34%) |
PKD1 | inactive (-1.78%) |
PKD2 | inactive (-1.39%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (1.73%) |
MARK3 | inactive (-2.49%) |
MARK1 | inactive (1.58%) |
QIK | inactive (-0.64%) |
SIK | inactive (-3.45%) |
NuaK1 | inactive (5.77%) |
BRSK1 | inactive (6.62%) |
BRSK2 | inactive (8.7%) |
MELK | inactive (5.36%) |
CHK1 | inactive (1.34%) |
PASK | inactive (-1.85%) |
AMPKa1 | inactive (6.79%) |
AMPKa2 | inactive (1.63%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (0.36%) |
TSSK1 | inactive (-0.1%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (-4.53%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | active (50.09%) |
PIM3 | inactive (42.67%) |
PIM1 | inactive (25.55%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (-4.58%) |
p38a | inactive (-0.33%) |
p38b | inactive (2.83%) |
p38d | inactive (-1.28%) |
Erk2 | inactive (-2.89%) |
Erk1 | inactive (1.82%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (4.94%) |
GSK3B | inactive (4.42%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (1.39%) |
MSSK1 | inactive (-1.79%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (2.88%) |
CLK2 | inactive (2.39%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (4.76%) |
HIPK4 | inactive (11.27%) |
DYRK1B | inactive (3.44%) |
DYRK1A | inactive (4.89%) |
DYRK2 | inactive (-0.96%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (24.14%) |