Compound Information
Test on : GPCR
Compound Name : GW439255X
Inchikey : TZPMELZXMICXNO-VOTSOKGWSA-N
ChemSpider : 23278135
Pubchem CID : 44418545
ChEMBL : CHEMBL374060
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (7.09%) |
TYK2 | inactive (-2.24%) |
JAK2 | inactive (3.69%) |
JAK3 | inactive (6.16%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (3.02%) |
FES | inactive (2.34%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (31.91%) |
ABL2 | inactive (36.2%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (32.91%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (47.28%) |
BTK | inactive (12.76%) |
TXK | inactive (36.92%) |
TEC | inactive (30.16%) |
ITK | inactive (2.71%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | active (67.5%) |
SRM | inactive (43.35%) |
FRK | inactive (20.1%) |
BLK | inactive (21.7%) |
LCK | inactive (26.77%) |
HCK | active (51.49%) |
FGR | inactive (34.03%) |
FYN | inactive (39.08%) |
SRC | active (58.57%) |
YES | inactive (31.06%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | active (60.75%) |
EphA4 | active (80.59%) |
EphA3 | inactive (22.42%) |
EphB4 | active (70.42%) |
EphB3 | inactive (49.22%) |
EphB2 | active (67.95%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (7.22%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (0.64%) |
ZAP70 | inactive (1.02%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (2.98%) |
ALK | inactive (5.54%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (10.38%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (4.74%) |
IGF1R | inactive (2.33%) |
IRR | inactive (1.64%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (2.49%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (3.99%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (2.95%) |
TRKB | inactive (5.2%) |
TRKC | inactive (5.85%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (8.66%) |
MET | inactive (5.5%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-3.72%) |
MER | inactive (2.87%) |
TYRO3 | inactive (4.32%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (7.34%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (3.93%) |
FGFR2 | inactive (5.08%) |
FGFR3 | inactive (7.63%) |
FGFR4 | inactive (2.64%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (2.37%) |
KDR | inactive (6%) |
FLT4 | inactive (1.34%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (38.58%) |
KIT | active (85.74%) |
FLT3 | inactive (1.9%) |
PDGFRa | inactive (42.59%) |
PDGFRb | inactive (43.31%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (3.67%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (4.9%) |
TNK1 | inactive (15.65%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (5.14%) |
ErbB2 | inactive (2.48%) |
ErbB4 | inactive (16.05%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (1.36%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (7.71%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (7.97%) |
MST1 | inactive (8.26%) |
MST2 | inactive (6.28%) |
MST4 | inactive (2.31%) |
HGK | inactive (15.17%) |
MINK | inactive (9.55%) |
LOK | inactive (17.51%) |
PAK1 | inactive (2.7%) |
PAK3 | inactive (2.76%) |
PAK2 | inactive (0.96%) |
PAK5 | inactive (4.26%) |
PAK6 | inactive (-0.98%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (3.99%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (3.48%) |
CK1g2 | inactive (3.13%) |
CK1g1 | inactive (2.97%) |
CK1g3 | inactive (3.16%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (2.82%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (6.42%) |
AurC | inactive (-1.91%) |
AurA | inactive (14.88%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (4.15%) |
NEK2 | inactive (2.53%) |
NEK9 | inactive (2.6%) |
NEK7 | inactive (3.53%) |
NEK6 | inactive (2.59%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (2.33%) |
IKKe | active (91.68%) |
IKKb | inactive (2.32%) |
IKKa | inactive (1.81%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (4.42%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (6.87%) |
GPRK6 | inactive (2.46%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (2.04%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (3.7%) |
MSK2 | inactive (3.1%) |
RSK1 | inactive (1.77%) |
RSK2 | inactive (1.88%) |
RSK4 | inactive (1.11%) |
RSK3 | inactive (1.41%) |
p70S6K | inactive (0.31%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (0.98%) |
AKT1 | inactive (0.97%) |
AKT3 | inactive (1.34%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (2.22%) |
SGK3 | inactive (0.63%) |
SGK2 | inactive (4.38%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (3.71%) |
PKCg | inactive (2.62%) |
PKCa | inactive (0.77%) |
PKCt | inactive (1.91%) |
PKCi | inactive (0.22%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (2.65%) |
PKG1 | inactive (3.58%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (6.36%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (2.78%) |
ROCK2 | inactive (3.55%) |
MRCKb | inactive (2.65%) |
MRCKa | inactive (1.93%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (2.31%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (6.15%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (1.35%) |
CaMK1d | inactive (1.19%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (-7.1%) |
PHKg2 | inactive (1.25%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (5.41%) |
CaMK2a | inactive (3.26%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (1.6%) |
MAPKAPK2 | inactive (1%) |
MAPKAPK3 | inactive (2.47%) |
MNK2 | inactive (9.67%) |
MNK1 | inactive (16.73%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (2.64%) |
PKD1 | inactive (2.96%) |
PKD2 | inactive (1.78%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (0.19%) |
MARK3 | inactive (1.89%) |
MARK1 | inactive (2.93%) |
QIK | inactive (12.35%) |
SIK | active (71.88%) |
NuaK1 | inactive (4.1%) |
BRSK1 | inactive (5.15%) |
BRSK2 | inactive (3.54%) |
MELK | inactive (5.89%) |
CHK1 | inactive (3.47%) |
PASK | inactive (0.02%) |
AMPKa1 | inactive (3.91%) |
AMPKa2 | inactive (4.01%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (1.69%) |
TSSK1 | inactive (1.67%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (1.3%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (1.55%) |
PIM3 | inactive (2.22%) |
PIM1 | inactive (0.23%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (1.71%) |
p38a | inactive (6.26%) |
p38b | inactive (5.95%) |
p38d | inactive (1.43%) |
Erk2 | inactive (4.61%) |
Erk1 | inactive (5.66%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (8.44%) |
GSK3B | inactive (7.76%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (0.59%) |
MSSK1 | inactive (-3.77%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (6.2%) |
CLK2 | inactive (0.81%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (7.33%) |
HIPK4 | inactive (2.43%) |
DYRK1B | inactive (7.3%) |
DYRK1A | inactive (8.73%) |
DYRK2 | inactive (3.56%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (7.86%) |