Compound Information
Test on : GPCR
Compound Name : GW612286X
Inchikey : SQQAPOSROFWHIB-UHFFFAOYSA-N
ChemSpider : 7998359
Pubchem CID : 9822610
ChEMBL : CHEMBL479079
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | active (66.54%) |
TYK2 | inactive (33.27%) |
JAK2 | active (72.46%) |
JAK3 | inactive (27.75%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (36.09%) |
FES | inactive (10.57%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | active (69.74%) |
ABL2 | active (69.87%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | active (67.92%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | active (64.78%) |
BTK | inactive (34.93%) |
TXK | active (61.88%) |
TEC | active (63.12%) |
ITK | inactive (7.07%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | active (55.42%) |
SRM | inactive (12.59%) |
FRK | inactive (11.51%) |
BLK | active (69.3%) |
LCK | active (82.39%) |
HCK | active (67.74%) |
FGR | active (57.46%) |
FYN | active (85.44%) |
SRC | active (92.08%) |
YES | active (70.69%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | active (71.05%) |
EphA4 | active (75.18%) |
EphA3 | inactive (15.26%) |
EphB4 | active (54.84%) |
EphB3 | inactive (0.24%) |
EphB2 | active (65.53%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | active (84.35%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (42.8%) |
ZAP70 | inactive (32.67%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (33.3%) |
ALK | inactive (39.29%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | active (70%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | active (64.7%) |
IGF1R | active (76.8%) |
IRR | inactive (3.74%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (43.06%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | active (72.48%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | active (64.07%) |
TRKB | inactive (40.96%) |
TRKC | inactive (17.28%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (34.43%) |
MET | inactive (12.3%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (1.16%) |
MER | inactive (14.42%) |
TYRO3 | inactive (27.93%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | active (84.05%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (24.79%) |
FGFR2 | inactive (39.78%) |
FGFR3 | inactive (30.51%) |
FGFR4 | inactive (2.48%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | active (87.99%) |
KDR | active (72.47%) |
FLT4 | active (105.58%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | active (94.06%) |
KIT | active (95.8%) |
FLT3 | active (90.35%) |
PDGFRa | active (91.57%) |
PDGFRb | active (87.53%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (49.76%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | active (52.89%) |
TNK1 | active (77.34%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (22.18%) |
ErbB2 | inactive (0.32%) |
ErbB4 | inactive (27.61%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (6.36%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (9.2%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (7.42%) |
MST1 | inactive (7.86%) |
MST2 | inactive (6.19%) |
MST4 | inactive (3%) |
HGK | inactive (12.39%) |
MINK | inactive (11.04%) |
LOK | active (77.6%) |
PAK1 | inactive (7.51%) |
PAK3 | inactive (5.23%) |
PAK2 | inactive (3.21%) |
PAK5 | inactive (15.33%) |
PAK6 | inactive (-1.27%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (4.1%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (0.47%) |
CK1g2 | inactive (9.2%) |
CK1g1 | inactive (1.23%) |
CK1g3 | inactive (-0.68%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (4.34%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (24.21%) |
AurC | active (79.7%) |
AurA | active (66.52%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (7.77%) |
NEK2 | inactive (0.41%) |
NEK9 | inactive (5.56%) |
NEK7 | inactive (2.17%) |
NEK6 | inactive (-0.68%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (26.33%) |
IKKe | inactive (12.92%) |
IKKb | inactive (16.97%) |
IKKa | inactive (-0.92%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (8.41%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (-1.95%) |
GPRK6 | inactive (-4.13%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (4.89%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (2.96%) |
MSK2 | inactive (2.58%) |
RSK1 | inactive (-0.01%) |
RSK2 | inactive (0.03%) |
RSK4 | inactive (2.74%) |
RSK3 | inactive (0.74%) |
p70S6K | inactive (1.09%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (1.19%) |
AKT1 | inactive (1.09%) |
AKT3 | inactive (1.18%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (5.3%) |
SGK3 | inactive (1.07%) |
SGK2 | inactive (-0.14%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (-1.03%) |
PKCg | inactive (5.39%) |
PKCa | inactive (10.24%) |
PKCt | inactive (-0.29%) |
PKCi | inactive (3.92%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (2.71%) |
PKG1 | inactive (3.61%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (-0.26%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (7.47%) |
ROCK2 | inactive (12.08%) |
MRCKb | inactive (1.78%) |
MRCKa | inactive (-0.15%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (9.02%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (2.5%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (4.68%) |
CaMK1d | inactive (6.21%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (5.26%) |
PHKg2 | inactive (0.52%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (3.54%) |
CaMK2a | inactive (4.38%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (-1.77%) |
MAPKAPK2 | inactive (0.86%) |
MAPKAPK3 | inactive (1.36%) |
MNK2 | inactive (19.23%) |
MNK1 | inactive (13.47%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (2.54%) |
PKD1 | inactive (2.11%) |
PKD2 | inactive (2.94%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (8%) |
MARK3 | inactive (9.39%) |
MARK1 | inactive (8.82%) |
QIK | inactive (28.01%) |
SIK | active (51.17%) |
NuaK1 | inactive (35.5%) |
BRSK1 | inactive (3.29%) |
BRSK2 | inactive (1.97%) |
MELK | inactive (8.73%) |
CHK1 | inactive (3.35%) |
PASK | inactive (0.33%) |
AMPKa1 | inactive (1.71%) |
AMPKa2 | inactive (5.95%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (-0.95%) |
TSSK1 | inactive (12.61%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (2.65%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (1.57%) |
PIM3 | inactive (-0.7%) |
PIM1 | inactive (1.26%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (13.63%) |
p38a | inactive (10.03%) |
p38b | inactive (6.13%) |
p38d | inactive (4.71%) |
Erk2 | inactive (3.16%) |
Erk1 | inactive (2.18%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (17.3%) |
GSK3B | inactive (16.09%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-3.51%) |
MSSK1 | inactive (0.79%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (6.44%) |
CLK2 | inactive (2.36%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (1.88%) |
HIPK4 | inactive (3.91%) |
DYRK1B | inactive (5.43%) |
DYRK1A | inactive (7.54%) |
DYRK2 | inactive (4.25%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (0.29%) |