Compound Information
Test on : GPCR
Compound Name : GW708336X
Inchikey : RLKIXFRFDGFKOP-UHFFFAOYSA-N
ChemSpider : 8368964
Pubchem CID : 10193464
ChEMBL : CHEMBL495771
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (-6.96%) |
TYK2 | inactive (-4.59%) |
JAK2 | inactive (1.85%) |
JAK3 | inactive (-0.05%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (1.58%) |
FES | inactive (4.53%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (13.69%) |
ABL2 | inactive (9.11%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (5.31%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (2.31%) |
BTK | inactive (2.33%) |
TXK | inactive (6.11%) |
TEC | inactive (8.36%) |
ITK | inactive (3.22%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (7.89%) |
SRM | inactive (-0.4%) |
FRK | inactive (1.99%) |
BLK | inactive (7.51%) |
LCK | inactive (3.4%) |
HCK | inactive (11.68%) |
FGR | inactive (8.79%) |
FYN | inactive (4.87%) |
SRC | inactive (8.4%) |
YES | inactive (0.73%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (0.18%) |
EphA4 | inactive (10.94%) |
EphA3 | inactive (5.8%) |
EphB4 | inactive (1.96%) |
EphB3 | inactive (3.96%) |
EphB2 | inactive (9.21%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (15.45%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-2.21%) |
ZAP70 | inactive (-0.37%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (6.33%) |
ALK | inactive (9.86%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (23.73%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (8.56%) |
IGF1R | inactive (5%) |
IRR | inactive (1.15%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (3.9%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (9.05%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (0.98%) |
TRKB | inactive (1.21%) |
TRKC | inactive (2.55%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (1.76%) |
MET | inactive (2.41%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-5.65%) |
MER | inactive (6.24%) |
TYRO3 | inactive (2.97%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (15.62%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (9.37%) |
FGFR2 | inactive (11.41%) |
FGFR3 | inactive (10.95%) |
FGFR4 | inactive (1.73%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (8.82%) |
KDR | inactive (47.98%) |
FLT4 | inactive (29.88%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (33.73%) |
KIT | inactive (20.94%) |
FLT3 | inactive (17.18%) |
PDGFRa | active (76.77%) |
PDGFRb | active (51.72%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (5.76%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (0.94%) |
TNK1 | inactive (17.76%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (6.33%) |
ErbB2 | inactive (1.94%) |
ErbB4 | inactive (15.29%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (4.62%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (11.52%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (5.78%) |
MST1 | inactive (10.31%) |
MST2 | inactive (8.11%) |
MST4 | inactive (-4.91%) |
HGK | inactive (20.91%) |
MINK | inactive (13.88%) |
LOK | inactive (12.13%) |
PAK1 | inactive (5.07%) |
PAK3 | inactive (4.93%) |
PAK2 | inactive (3.04%) |
PAK5 | inactive (1.19%) |
PAK6 | inactive (6.8%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (9.33%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (15.78%) |
CK1g2 | inactive (10.38%) |
CK1g1 | inactive (8.05%) |
CK1g3 | inactive (8.91%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (2.08%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (46.82%) |
AurC | active (75.45%) |
AurA | inactive (21.97%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (6.78%) |
NEK2 | inactive (4.05%) |
NEK9 | inactive (-2.57%) |
NEK7 | inactive (4.77%) |
NEK6 | inactive (0.56%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (6.36%) |
IKKe | inactive (5.49%) |
IKKb | inactive (5.82%) |
IKKa | inactive (15.73%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | active (60.1%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (6.6%) |
GPRK6 | inactive (1.72%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (5%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (3.75%) |
MSK2 | inactive (6.24%) |
RSK1 | inactive (8.38%) |
RSK2 | inactive (6.33%) |
RSK4 | inactive (10.47%) |
RSK3 | inactive (5.06%) |
p70S6K | inactive (3.7%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (2.75%) |
AKT1 | inactive (1.04%) |
AKT3 | inactive (1.78%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (3.4%) |
SGK3 | inactive (2.23%) |
SGK2 | inactive (9.02%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (2.99%) |
PKCg | inactive (1.85%) |
PKCa | inactive (6.27%) |
PKCt | inactive (1.61%) |
PKCi | inactive (3.89%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (11.9%) |
PKG1 | inactive (6.68%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (-0.73%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (5.25%) |
ROCK2 | inactive (10.66%) |
MRCKb | inactive (0.61%) |
MRCKa | inactive (-0.69%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (7.4%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (-2.52%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (2.07%) |
CaMK1d | inactive (2.68%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (29.52%) |
PHKg2 | inactive (12.24%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (9.6%) |
CaMK2a | inactive (6.53%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (0.41%) |
MAPKAPK2 | inactive (1.97%) |
MAPKAPK3 | inactive (6.31%) |
MNK2 | inactive (42.5%) |
MNK1 | inactive (19.78%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (49.9%) |
PKD1 | inactive (39.6%) |
PKD2 | active (52.4%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (5.05%) |
MARK3 | inactive (12.94%) |
MARK1 | inactive (10.29%) |
QIK | inactive (7.7%) |
SIK | inactive (5.66%) |
NuaK1 | inactive (25.56%) |
BRSK1 | inactive (6.62%) |
BRSK2 | inactive (7.84%) |
MELK | inactive (43.85%) |
CHK1 | inactive (1.64%) |
PASK | inactive (-0.94%) |
AMPKa1 | inactive (6.88%) |
AMPKa2 | inactive (7.62%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (-3.76%) |
TSSK1 | inactive (5.12%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (3.38%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (0.92%) |
PIM3 | inactive (4.8%) |
PIM1 | inactive (3.37%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (26.07%) |
p38a | inactive (16.55%) |
p38b | inactive (13.07%) |
p38d | inactive (19.74%) |
Erk2 | inactive (7.25%) |
Erk1 | inactive (3.9%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (26.35%) |
GSK3B | inactive (18.21%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (1.29%) |
MSSK1 | inactive (9.24%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (8.62%) |
CLK2 | active (52.03%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (28.97%) |
HIPK4 | inactive (20.56%) |
DYRK1B | inactive (35.82%) |
DYRK1A | inactive (40.39%) |
DYRK2 | inactive (32.77%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (7.14%) |