Compound Information
Test on : GPCR
Compound Name : GW631581B
Inchikey : RKNRDRPDYXCRPG-UHFFFAOYSA-N
ChemSpider : 4487004
Pubchem CID : 5329853
ChEMBL : CHEMBL176553
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (5.5%) |
TYK2 | inactive (-1.72%) |
JAK2 | inactive (1.78%) |
JAK3 | inactive (-1.92%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (3.14%) |
FES | inactive (3.89%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (35.37%) |
ABL2 | inactive (29.43%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (4.79%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (6.51%) |
BTK | inactive (0.87%) |
TXK | inactive (8.54%) |
TEC | inactive (7.94%) |
ITK | inactive (3.63%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (7.86%) |
SRM | inactive (3.5%) |
FRK | inactive (4.62%) |
BLK | inactive (20.14%) |
LCK | inactive (14.47%) |
HCK | inactive (19.92%) |
FGR | inactive (30.18%) |
FYN | inactive (26.54%) |
SRC | inactive (49.71%) |
YES | inactive (39.52%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (2.39%) |
EphA4 | inactive (13.69%) |
EphA3 | inactive (8.57%) |
EphB4 | inactive (4.64%) |
EphB3 | inactive (3.15%) |
EphB2 | inactive (11.46%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (9.54%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-7.57%) |
ZAP70 | inactive (1.02%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (5.66%) |
ALK | inactive (4.06%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (11.86%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (5.64%) |
IGF1R | inactive (4.18%) |
IRR | inactive (2.43%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (7.93%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (4.72%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (19.71%) |
TRKB | inactive (35.22%) |
TRKC | inactive (30.53%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (-0.05%) |
MET | inactive (5.98%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-6.19%) |
MER | inactive (4.87%) |
TYRO3 | inactive (8.91%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (8.97%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (7.89%) |
FGFR2 | inactive (11.69%) |
FGFR3 | inactive (10.2%) |
FGFR4 | inactive (-0.29%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (18.76%) |
KDR | inactive (19.32%) |
FLT4 | inactive (9.4%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | active (56.29%) |
KIT | active (97.2%) |
FLT3 | active (90.51%) |
PDGFRa | active (54.28%) |
PDGFRb | active (62.88%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (7.85%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (3.07%) |
TNK1 | inactive (31.06%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (5.26%) |
ErbB2 | inactive (3.72%) |
ErbB4 | inactive (14.6%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (2.83%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (6.68%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (7.2%) |
MST1 | inactive (6.2%) |
MST2 | inactive (6.9%) |
MST4 | inactive (-4.28%) |
HGK | inactive (18.79%) |
MINK | inactive (19.46%) |
LOK | inactive (12.89%) |
PAK1 | inactive (6.69%) |
PAK3 | inactive (3.26%) |
PAK2 | inactive (1.6%) |
PAK5 | inactive (4.51%) |
PAK6 | inactive (-4.99%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (3.91%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (3.47%) |
CK1g2 | inactive (5.36%) |
CK1g1 | inactive (4.78%) |
CK1g3 | inactive (3.43%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (2.5%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (19.66%) |
AurC | inactive (29.63%) |
AurA | inactive (30.32%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (4.11%) |
NEK2 | inactive (5.95%) |
NEK9 | inactive (7.35%) |
NEK7 | inactive (5.01%) |
NEK6 | inactive (1.56%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (4.2%) |
IKKe | inactive (10.88%) |
IKKb | inactive (7.8%) |
IKKa | inactive (4.19%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (11.91%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (18.74%) |
GPRK6 | inactive (-0.63%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (0.31%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (-0.44%) |
MSK2 | inactive (2.84%) |
RSK1 | inactive (1.99%) |
RSK2 | inactive (2.61%) |
RSK4 | inactive (2.83%) |
RSK3 | inactive (3.57%) |
p70S6K | inactive (3.04%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (2.08%) |
AKT1 | inactive (1.33%) |
AKT3 | inactive (3.26%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (4.7%) |
SGK3 | inactive (3%) |
SGK2 | inactive (4.37%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (6.3%) |
PKCg | inactive (2.55%) |
PKCa | inactive (1.72%) |
PKCt | inactive (3.38%) |
PKCi | inactive (3.11%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (2.19%) |
PKG1 | inactive (1.96%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (4.53%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (2.6%) |
ROCK2 | inactive (-3.98%) |
MRCKb | inactive (0.65%) |
MRCKa | inactive (-1.27%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (5.38%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (1.7%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (-1.65%) |
CaMK1d | inactive (-0.66%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (14.12%) |
PHKg2 | inactive (5.45%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (7.34%) |
CaMK2a | inactive (1.52%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (2.34%) |
MAPKAPK2 | inactive (1.2%) |
MAPKAPK3 | inactive (3.61%) |
MNK2 | inactive (12.41%) |
MNK1 | inactive (10.85%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (4.51%) |
PKD1 | inactive (5.16%) |
PKD2 | inactive (1.86%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (3.56%) |
MARK3 | inactive (2.48%) |
MARK1 | inactive (4.72%) |
QIK | inactive (33.81%) |
SIK | inactive (20.59%) |
NuaK1 | inactive (32.72%) |
BRSK1 | inactive (8.79%) |
BRSK2 | inactive (7.23%) |
MELK | inactive (5.97%) |
CHK1 | inactive (0.7%) |
PASK | inactive (-0.79%) |
AMPKa1 | inactive (5.67%) |
AMPKa2 | inactive (8.23%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (2.49%) |
TSSK1 | inactive (4.53%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (-0.73%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (0.6%) |
PIM3 | inactive (-0.34%) |
PIM1 | inactive (1.63%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (3.23%) |
p38a | inactive (5.68%) |
p38b | inactive (5.59%) |
p38d | inactive (4.13%) |
Erk2 | inactive (6.06%) |
Erk1 | inactive (5.68%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (14.55%) |
GSK3B | inactive (11.51%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-2%) |
MSSK1 | inactive (1.14%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (1.09%) |
CLK2 | inactive (2.12%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (17.1%) |
HIPK4 | inactive (12.5%) |
DYRK1B | inactive (0.86%) |
DYRK1A | inactive (6.1%) |
DYRK2 | inactive (1.69%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (3.91%) |