Compound Information
Test on : GPCR
Compound Name : CHEMBL176857
Inchikey : RIJBDOXTEPVDPJ-APSNUPSMSA-N
ChemSpider : 8003115
Pubchem CID : 9827373
ChEMBL : CHEMBL176857
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (0.51%) |
TYK2 | inactive (-1.22%) |
JAK2 | inactive (3.2%) |
JAK3 | inactive (5.39%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (9.31%) |
FES | inactive (4.41%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (27.92%) |
ABL2 | inactive (15.11%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (3.65%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (6.48%) |
BTK | inactive (2.07%) |
TXK | inactive (6.65%) |
TEC | inactive (10.27%) |
ITK | inactive (3.95%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (3.92%) |
SRM | inactive (14.66%) |
FRK | inactive (2.12%) |
BLK | inactive (10.7%) |
LCK | inactive (8.22%) |
HCK | inactive (12.52%) |
FGR | inactive (11.62%) |
FYN | inactive (26.27%) |
SRC | inactive (17.09%) |
YES | inactive (12.93%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (3.18%) |
EphA4 | inactive (6.4%) |
EphA3 | inactive (5.49%) |
EphB4 | inactive (4.26%) |
EphB3 | inactive (5.59%) |
EphB2 | inactive (7.78%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (39.1%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-0.96%) |
ZAP70 | inactive (6.67%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (5.69%) |
ALK | inactive (6.47%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (26.15%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (6.87%) |
IGF1R | inactive (2.09%) |
IRR | inactive (1.02%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (10.57%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (5.9%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | active (61.66%) |
TRKB | active (89.24%) |
TRKC | active (93.93%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (7.63%) |
MET | inactive (4.03%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-1.51%) |
MER | inactive (7.77%) |
TYRO3 | inactive (3.41%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (11.1%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (13.98%) |
FGFR2 | inactive (17.98%) |
FGFR3 | inactive (14.01%) |
FGFR4 | inactive (1.97%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (4.73%) |
KDR | inactive (8.56%) |
FLT4 | inactive (4.28%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (7.16%) |
KIT | inactive (27.9%) |
FLT3 | inactive (6.62%) |
PDGFRa | inactive (16.94%) |
PDGFRb | inactive (11.57%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (6.14%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (0.66%) |
TNK1 | active (80.4%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (2.08%) |
ErbB2 | inactive (-4.15%) |
ErbB4 | inactive (17.72%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (1.85%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (10.53%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (5.34%) |
MST1 | inactive (8.19%) |
MST2 | inactive (8.09%) |
MST4 | inactive (13.49%) |
HGK | inactive (13.97%) |
MINK | inactive (13.31%) |
LOK | inactive (5.99%) |
PAK1 | inactive (6.23%) |
PAK3 | inactive (5.35%) |
PAK2 | inactive (2.48%) |
PAK5 | inactive (0.44%) |
PAK6 | inactive (-6.64%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (5.7%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (5.66%) |
CK1g2 | inactive (6.34%) |
CK1g1 | inactive (5.44%) |
CK1g3 | inactive (3.37%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (9.04%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | active (57.24%) |
AurC | active (87.54%) |
AurA | active (93.04%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (0.39%) |
NEK2 | inactive (6.16%) |
NEK9 | inactive (3.53%) |
NEK7 | inactive (3.62%) |
NEK6 | inactive (0.04%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (6.07%) |
IKKe | inactive (12.5%) |
IKKb | inactive (-0.48%) |
IKKa | inactive (0.71%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (9.88%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | active (57.19%) |
GPRK6 | inactive (30.3%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (2.52%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (1.75%) |
MSK2 | inactive (6.3%) |
RSK1 | inactive (0.08%) |
RSK2 | inactive (1.15%) |
RSK4 | inactive (2.05%) |
RSK3 | inactive (3.85%) |
p70S6K | inactive (2.75%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (2.36%) |
AKT1 | inactive (0.15%) |
AKT3 | inactive (0.61%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (5.53%) |
SGK3 | inactive (0.16%) |
SGK2 | inactive (2.58%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (1.62%) |
PKCg | inactive (2.98%) |
PKCa | inactive (1.73%) |
PKCt | inactive (1.73%) |
PKCi | inactive (2.57%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (5.97%) |
PKG1 | inactive (5.3%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (0.16%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (2.31%) |
ROCK2 | inactive (2.15%) |
MRCKb | inactive (-0.72%) |
MRCKa | inactive (-2.56%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (6.73%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (1.21%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (1.67%) |
CaMK1d | inactive (1.73%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (7.04%) |
PHKg2 | inactive (3.85%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (7.42%) |
CaMK2a | inactive (5.91%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (0.67%) |
MAPKAPK2 | inactive (1.69%) |
MAPKAPK3 | inactive (6.33%) |
MNK2 | inactive (40.12%) |
MNK1 | inactive (11.73%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (6.21%) |
PKD1 | inactive (6.42%) |
PKD2 | inactive (6.48%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (5.18%) |
MARK3 | inactive (1.27%) |
MARK1 | inactive (7.22%) |
QIK | inactive (10.45%) |
SIK | inactive (9.01%) |
NuaK1 | inactive (6.09%) |
BRSK1 | inactive (5.82%) |
BRSK2 | inactive (4.72%) |
MELK | inactive (8.21%) |
CHK1 | inactive (3.84%) |
PASK | inactive (-3.29%) |
AMPKa1 | inactive (9.85%) |
AMPKa2 | inactive (7.88%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (1.91%) |
TSSK1 | inactive (6.09%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (4.6%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (-0.06%) |
PIM3 | inactive (-1.54%) |
PIM1 | inactive (3.18%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (8.54%) |
p38a | inactive (11.27%) |
p38b | inactive (5.73%) |
p38d | inactive (9.18%) |
Erk2 | inactive (4.68%) |
Erk1 | inactive (2.3%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (10.03%) |
GSK3B | inactive (8.88%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-5.25%) |
MSSK1 | inactive (-0.04%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (9.88%) |
CLK2 | inactive (5.09%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (7.53%) |
HIPK4 | inactive (10.93%) |
DYRK1B | inactive (4.16%) |
DYRK1A | inactive (11.22%) |
DYRK2 | inactive (4.79%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (3.83%) |