Compound Information
Test on : RBC
Compound Name : (2S)-2-({6-[(3-AMINO-5-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL
Inchikey : RAMROQQYRRQPDL-OAHLLOKOSA-N
ChemSpider : 5290490
Pubchem CID : 6914609
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
AGC
AGC - PDK1
Bioactivity |
---|
Kinase | RBC |
---|
PDK1 | inactive (105.55%) |
AGC - Akt
Bioactivity |
---|
Kinase | RBC |
---|
AKT1 | inactive (116.75%) |
AKT2 | inactive (100.45%) |
AKT3 | inactive (101.15%) |
AGC - DMPK
Bioactivity |
---|
Kinase | RBC |
---|
DMPK1 | inactive (99.74%) |
MRCKa | inactive (99.4%) |
MRCKb | inactive (98.45%) |
ROCK1 | inactive (90.01%) |
ROCK2 | inactive (100.76%) |
AGC - GRK
Bioactivity |
---|
Kinase | RBC |
---|
BARK1 | inactive (82.99%) |
BARK2 | inactive (97.09%) |
GPRK4 | inactive (103.27%) |
GPRK5 | inactive (100.57%) |
GPRK6 | inactive (72.14%) |
GPRK7 | inactive (79.32%) |
AGC - RSK
Bioactivity |
---|
Kinase | RBC |
---|
MSK1 | inactive (103.01%) |
MSK2 | inactive (89.3%) |
p70S6K | inactive (95.54%) |
p70S6Kb | inactive (98.17%) |
RSK2 | inactive (54.06%) |
RSK4 | active (46.12%) |
RSK1 | active (37.21%) |
RSK3 | active (48.67%) |
AGC - PKA
Bioactivity |
---|
Kinase | RBC |
---|
PKACg | - |
PRKX | inactive (101.28%) |
PKACa | inactive (101.33%) |
AGC - PKC
Bioactivity |
---|
Kinase | RBC |
---|
PKCa | inactive (66.15%) |
PKCd | inactive (87.61%) |
PKCe | inactive (105.16%) |
PKCh | inactive (99.45%) |
PKCg | inactive (106.83%) |
PKCi | inactive (89.55%) |
PKCt | inactive (119.19%) |
PKCz | inactive (101.26%) |
PKCb | inactive (97.34%) |
AGC - PKG
Bioactivity |
---|
Kinase | RBC |
---|
PKG2 | inactive (88.77%) |
PKG1 | inactive (103.94%) |
AGC - PKN
Bioactivity |
---|
Kinase | RBC |
---|
PKN1 | inactive (93.33%) |
PKN2 | inactive (97.96%) |
AGC - SGK
Bioactivity |
---|
Kinase | RBC |
---|
SGK1 | inactive (93.09%) |
SGK2 | inactive (121.31%) |
SGK3 | inactive (99.91%) |
AGC - NDR
Bioactivity |
---|
Kinase | RBC |
---|
NDR1 | active (0%) |
TK
TK - Abl
Bioactivity |
---|
Kinase | RBC |
---|
ABL1 | active (45.51%) |
ABL2 | active (21.32%) |
TK - Ack
Bioactivity |
---|
Kinase | RBC |
---|
ACK | active (47.82%) |
TK - ALK
Bioactivity |
---|
Kinase | RBC |
---|
ALK | inactive (79.65%) |
LTK | inactive (103.07%) |
TK - Axl
Bioactivity |
---|
Kinase | RBC |
---|
AXL | inactive (93.08%) |
MER | inactive (79.7%) |
TYRO3 | inactive (103.12%) |
TK - Src
Bioactivity |
---|
Kinase | RBC |
---|
BLK | inactive (79.65%) |
BRK | inactive (85.6%) |
SRC | active (3.75%) |
FGR | active (15.02%) |
FRK | inactive (70.29%) |
FYN | active (18.92%) |
HCK | active (27.31%) |
LCK | inactive (70.17%) |
SRM | inactive (96.83%) |
YES | active (7.03%) |
LYN | active (23.07%) |
TK - Tec
Bioactivity |
---|
Kinase | RBC |
---|
BMX | inactive (81.89%) |
BTK | active (33.03%) |
ITK | inactive (80.24%) |
TEC | inactive (129.61%) |
TXK | active (42.54%) |
TK - PDGFR
Bioactivity |
---|
Kinase | RBC |
---|
KIT | inactive (86.15%) |
FLT3 | active (8.35%) |
FMS | inactive (71.09%) |
PDGFRb | inactive (98.07%) |
PDGFRa | inactive (89.42%) |
TK - Csk
Bioactivity |
---|
Kinase | RBC |
---|
CSK | inactive (79.28%) |
CTK | inactive (111.14%) |
TK - DDR
Bioactivity |
---|
Kinase | RBC |
---|
DDR2 | inactive (127.93%) |
TK - EGFR
Bioactivity |
---|
Kinase | RBC |
---|
EGFR | inactive (93.9%) |
ErbB2 | inactive (92.91%) |
ErbB4 | inactive (131.04%) |
TK - Eph
Bioactivity |
---|
Kinase | RBC |
---|
EphA1 | inactive (76.89%) |
EphA2 | inactive (67.54%) |
EphA3 | inactive (86.64%) |
EphA4 | inactive (61.35%) |
EphA5 | inactive (63.98%) |
EphA6 | - |
EphA7 | inactive (80.2%) |
EphA8 | inactive (92.5%) |
EphB1 | inactive (59.19%) |
EphB2 | inactive (73.62%) |
EphB3 | inactive (95.33%) |
EphB4 | inactive (58.39%) |
TK - FAK
Bioactivity |
---|
Kinase | RBC |
---|
FAK | inactive (59.53%) |
PYK2 | inactive (63.57%) |
TK - Fer
Bioactivity |
---|
Kinase | RBC |
---|
FER | inactive (54.9%) |
FES | inactive (69.19%) |
TK - FGFR
Bioactivity |
---|
Kinase | RBC |
---|
FGFR1 | inactive (76.66%) |
FGFR2 | inactive (97.27%) |
FGFR3 | inactive (79.4%) |
FGFR4 | inactive (93.39%) |
TK - VEGFR
Bioactivity |
---|
Kinase | RBC |
---|
FLT1 | inactive (97.54%) |
FLT4 | inactive (80.7%) |
KDR | inactive (101.5%) |
TK - InsR
Bioactivity |
---|
Kinase | RBC |
---|
IGF1R | inactive (72.99%) |
IRR | inactive (70.76%) |
INSR | inactive (85.03%) |
TK - JakA
Bioactivity |
---|
Kinase | RBC |
---|
JAK1 | inactive (100.94%) |
JAK2 | inactive (99.95%) |
JAK3 | inactive (107.5%) |
TYK2 | inactive (57.92%) |
TK - Musk
Bioactivity |
---|
Kinase | RBC |
---|
MUSK | active (46.04%) |
TK - Ret
Bioactivity |
---|
Kinase | RBC |
---|
RET | inactive (61.6%) |
TK - Met
Bioactivity |
---|
Kinase | RBC |
---|
RON | inactive (121.56%) |
MET | inactive (109.4%) |
TK - Sev
Bioactivity |
---|
Kinase | RBC |
---|
ROS | inactive (96.55%) |
TK - Syk
Bioactivity |
---|
Kinase | RBC |
---|
SYK | inactive (81.1%) |
ZAP70 | inactive (101.55%) |
TK - Tie
Bioactivity |
---|
Kinase | RBC |
---|
TIE2 | inactive (92.45%) |
TK - Trk
Bioactivity |
---|
Kinase | RBC |
---|
TRKA | active (45.35%) |
TRKB | active (3.04%) |
TRKC | active (4.42%) |
TKL
TKL - STKR
Bioactivity |
---|
Kinase | RBC |
---|
ALK1 | inactive (108.78%) |
ALK2 | inactive (99.42%) |
ALK4 | inactive (106.52%) |
TGFbR1 | inactive (102.84%) |
TGFbR2 | inactive (93.49%) |
TKL - RAF
Bioactivity |
---|
Kinase | RBC |
---|
ARAF | inactive (82.39%) |
BRAF | inactive (97.45%) |
RAF1 | inactive (113.1%) |
TKL - IRAK
Bioactivity |
---|
Kinase | RBC |
---|
IRAK1 | inactive (97.08%) |
IRAK4 | inactive (86.76%) |
TKL - LISK
Bioactivity |
---|
Kinase | RBC |
---|
LIMK1 | inactive (106.54%) |
TKL - LRRK
Bioactivity |
---|
Kinase | RBC |
---|
LRRK2 | inactive (100.84%) |
TKL - MLK
Bioactivity |
---|
Kinase | RBC |
---|
MLK1 | active (7.81%) |
MLK2 | inactive (95.08%) |
MLK3 | active (17.71%) |
TAK1 | inactive (51.27%) |
ZAK | inactive (92.26%) |
TKL - RIPK
Bioactivity |
---|
Kinase | RBC |
---|
RIPK2 | inactive (87.72%) |
CAMK
CAMK - CAMKL
Bioactivity |
---|
Kinase | RBC |
---|
NuaK1 | inactive (61.55%) |
BRSK1 | inactive (93.13%) |
BRSK2 | inactive (88.25%) |
CHK1 | inactive (96.19%) |
LKB1 | inactive (60.25%) |
MARK1 | inactive (87.47%) |
MARK3 | inactive (85.2%) |
MARK4 | inactive (71.16%) |
MELK | inactive (51.5%) |
PASK | inactive (106.11%) |
QIK | inactive (104%) |
NuaK2 | inactive (81.43%) |
MARK2 | inactive (74.12%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | RBC |
---|
CaMK1a | inactive (95.31%) |
CaMK1b | inactive (131.66%) |
CaMK1d | inactive (103.16%) |
CaMK1g | inactive (104.67%) |
CaMK4 | inactive (97.43%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | RBC |
---|
CaMK2a | inactive (83.93%) |
CaMK2b | inactive (98.18%) |
CaMK2d | inactive (87.31%) |
CaMK2g | inactive (104.49%) |
CAMK - RAD53
Bioactivity |
---|
Kinase | RBC |
---|
CHK2 | inactive (96.28%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | RBC |
---|
DAPK1 | inactive (95.33%) |
DAPK2 | inactive (100.74%) |
DRAK1 | inactive (96.3%) |
DAPK3 | inactive (96.72%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | RBC |
---|
DCLK2 | inactive (104.59%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | RBC |
---|
MAPKAPK2 | inactive (92.77%) |
MAPKAPK3 | inactive (98.41%) |
MAPKAPK5 | inactive (95.81%) |
MNK1 | inactive (99.14%) |
MNK2 | inactive (113.18%) |
CAMK - MLCK
Bioactivity |
---|
Kinase | RBC |
---|
smMLCK | inactive (81.3%) |
skMLCK | inactive (99.49%) |
CAMK - PHK
Bioactivity |
---|
Kinase | RBC |
---|
PHKg1 | inactive (81.1%) |
PHKg2 | inactive (104.51%) |
CAMK - PIM
Bioactivity |
---|
Kinase | RBC |
---|
PIM1 | inactive (98%) |
PIM2 | inactive (113.15%) |
PIM3 | inactive (93.01%) |
CAMK - PKD
Bioactivity |
---|
Kinase | RBC |
---|
PKD1 | inactive (94.21%) |
PKD3 | inactive (89.2%) |
PKD2 | inactive (103.12%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | RBC |
---|
TSSK1 | inactive (91.25%) |
TSSK2 | inactive (101.9%) |
CAMK - STK33
Bioactivity |
---|
Kinase | RBC |
---|
STK33 | inactive (56.22%) |
STE
STE - STE11
Bioactivity |
---|
Kinase | RBC |
---|
MAP3K5 | inactive (95.58%) |
MAP3K2 | inactive (83.07%) |
MAP3K3 | inactive (100.01%) |
STE - STE-Unique
Bioactivity |
---|
Kinase | RBC |
---|
COT | inactive (109.19%) |
NIK | inactive (100.3%) |
STE - STE20
Bioactivity |
---|
Kinase | RBC |
---|
GCK | inactive (90.71%) |
HGK | inactive (86.05%) |
KHS1 | inactive (82.48%) |
LOK | inactive (55.6%) |
MINK | inactive (94.49%) |
MST1 | inactive (63.64%) |
MST2 | inactive (70.01%) |
MST3 | inactive (75.92%) |
MST4 | inactive (67.82%) |
OSR1 | inactive (100.4%) |
PAK1 | inactive (81.76%) |
PAK2 | inactive (95.47%) |
PAK3 | inactive (101.4%) |
PAK4 | inactive (101.52%) |
PAK5 | active (44.34%) |
PAK6 | inactive (57.26%) |
SLK | active (39.77%) |
YSK1 | inactive (81.81%) |
STLK3 | inactive (83.66%) |
TAO1 | inactive (79.91%) |
TAO2 | inactive (82.15%) |
TAO3 | inactive (86.85%) |
MYO3B | active (0%) |
STE - STE7
Bioactivity |
---|
Kinase | RBC |
---|
MAP2K1 | inactive (91.33%) |
MAP2K2 | inactive (87.5%) |
MAP2K6 | inactive (92.54%) |
Other
Other - Aur
Bioactivity |
---|
Kinase | RBC |
---|
AurA | inactive (80.45%) |
AurB | inactive (87.79%) |
AurC | inactive (91.9%) |
Other - CAMKK
Bioactivity |
---|
Kinase | RBC |
---|
CaMKK1 | inactive (86.84%) |
CaMKK2 | active (33.25%) |
Other - Haspin
Bioactivity |
---|
Kinase | RBC |
---|
Haspin | inactive (99.88%) |
Other - IKK
Bioactivity |
---|
Kinase | RBC |
---|
IKKa | inactive (97.26%) |
IKKb | inactive (104.23%) |
IKKe | inactive (88.44%) |
TBK1 | inactive (86.62%) |
Other - NEK
Bioactivity |
---|
Kinase | RBC |
---|
NEK1 | inactive (81.49%) |
NEK11 | inactive (84.23%) |
NEK2 | inactive (94.41%) |
NEK4 | inactive (80.18%) |
NEK6 | inactive (110.67%) |
NEK7 | inactive (89.01%) |
NEK9 | inactive (69.42%) |
NEK3 | inactive (100.4%) |
Other - TOPK
Bioactivity |
---|
Kinase | RBC |
---|
PBK | inactive (75.63%) |
Other - PLK
Bioactivity |
---|
Kinase | RBC |
---|
PLK1 | inactive (54.95%) |
PLK2 | inactive (92.01%) |
PLK3 | inactive (62.84%) |
Other - SgK496
Bioactivity |
---|
Kinase | RBC |
---|
SgK496 | inactive (93.12%) |
Other - NAK
Bioactivity |
---|
Kinase | RBC |
---|
MPSK1 | inactive (73.98%) |
Other - TTK
Bioactivity |
---|
Kinase | RBC |
---|
TTK | inactive (84.52%) |
Other - ULK
Bioactivity |
---|
Kinase | RBC |
---|
ULK1 | active (41.52%) |
ULK2 | inactive (74.89%) |
ULK3 | active (0%) |
Other - WEE
Bioactivity |
---|
Kinase | RBC |
---|
Wee1 | inactive (70.75%) |
Other - WNK
Bioactivity |
---|
Kinase | RBC |
---|
Wnk2 | inactive (112.16%) |
Wnk3 | inactive (76.9%) |
Other - TLK
Bioactivity |
---|
Kinase | RBC |
---|
TLK2 | active (0%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC |
---|
CK1 | 7 | 6 |
VRK | 3 | 1 |
CK1 - CK1
Bioactivity |
---|
Kinase | RBC |
---|
CK1d | inactive (65.73%) |
CK1g1 | active (26.43%) |
CK1g2 | active (35.19%) |
CK1g3 | active (13.4%) |
CK1a | inactive (75.51%) |
CK1e | inactive (82.72%) |
CK1 - VRK
Bioactivity |
---|
Kinase | RBC |
---|
VRK1 | inactive (85.84%) |
CMGC
CMGC - CK2
Bioactivity |
---|
Kinase | RBC |
---|
CK2a1 | inactive (99.27%) |
CK2a2 | inactive (105.74%) |
CMGC - CLK
Bioactivity |
---|
Kinase | RBC |
---|
CLK1 | inactive (51.91%) |
CLK2 | active (17.65%) |
CLK3 | inactive (85.46%) |
CLK4 | active (16.49%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | RBC |
---|
DYRK1A | inactive (57.1%) |
DYRK1B | active (38.27%) |
DYRK2 | inactive (93.22%) |
DYRK3 | inactive (103.33%) |
DYRK4 | inactive (91.62%) |
HIPK1 | inactive (99.16%) |
HIPK2 | inactive (94.27%) |
HIPK3 | inactive (99.42%) |
HIPK4 | inactive (96.41%) |
CMGC - MAPK
Bioactivity |
---|
Kinase | RBC |
---|
Erk1 | inactive (105.9%) |
Erk2 | inactive (95.41%) |
JNK3 | inactive (94.57%) |
NLK | inactive (93.91%) |
p38a | inactive (98.92%) |
p38b | inactive (96.29%) |
p38d | inactive (101.48%) |
p38g | inactive (101.81%) |
JNK1 | inactive (93.42%) |
JNK2 | inactive (99.83%) |
CMGC - GSK
Bioactivity |
---|
Kinase | RBC |
---|
GSK3A | inactive (100.64%) |
GSK3B | inactive (102.65%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | RBC |
---|
MSSK1 | active (37.69%) |
SRPK1 | inactive (62.14%) |
SRPK2 | active (30.98%) |
Atypical
Atypical
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC |
---|
PDHK | 5 | 1 |
Atypical - PDHK
Bioactivity |
---|
Kinase | RBC |
---|
PDHK1 | inactive (105.55%) |