Compound Information
Test on : GPCR
Compound Name : GW575808A
Inchikey : QZFLQLMWGKMMGY-UHFFFAOYSA-N
ChemSpider : 28485076
Pubchem CID : 57392873
ChEMBL : CHEMBL1909381
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (32.66%) |
TYK2 | inactive (16.87%) |
JAK2 | inactive (45.75%) |
JAK3 | inactive (14%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (23.4%) |
FES | inactive (10.74%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | active (79.5%) |
ABL2 | active (77.12%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (35.43%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | active (56.72%) |
BTK | inactive (29.06%) |
TXK | inactive (43.71%) |
TEC | active (57.07%) |
ITK | inactive (0.3%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | active (91.54%) |
SRM | inactive (41.03%) |
FRK | active (87.61%) |
BLK | active (71.23%) |
LCK | active (72.18%) |
HCK | active (83.45%) |
FGR | active (72.76%) |
FYN | active (89.36%) |
SRC | active (90.66%) |
YES | active (78.5%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (23.28%) |
EphA4 | active (62.86%) |
EphA3 | inactive (33.88%) |
EphB4 | inactive (29.06%) |
EphB3 | inactive (-0.39%) |
EphB2 | inactive (38.58%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (47.76%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (14.24%) |
ZAP70 | inactive (6.83%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (15.94%) |
ALK | inactive (10.86%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | active (61.35%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (13.7%) |
IGF1R | inactive (17.17%) |
IRR | inactive (3.49%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (30.01%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (26.74%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (6.07%) |
TRKB | inactive (21.65%) |
TRKC | inactive (11.51%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (13.34%) |
MET | inactive (6.87%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (0.42%) |
MER | inactive (11.74%) |
TYRO3 | active (55.02%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | active (85.7%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (34.8%) |
FGFR2 | inactive (26.62%) |
FGFR3 | inactive (18.43%) |
FGFR4 | inactive (3.08%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | active (97.76%) |
KDR | active (90.7%) |
FLT4 | active (95.01%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (49.89%) |
KIT | inactive (42.67%) |
FLT3 | active (64.51%) |
PDGFRa | active (82.34%) |
PDGFRb | active (79.7%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (39.73%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (28.82%) |
TNK1 | active (52.13%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (11.69%) |
ErbB2 | inactive (5.7%) |
ErbB4 | inactive (20.16%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (6.55%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (10.38%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (8.97%) |
MST1 | inactive (12.2%) |
MST2 | inactive (10.09%) |
MST4 | inactive (2.75%) |
HGK | inactive (28.93%) |
MINK | inactive (22.01%) |
LOK | inactive (38.93%) |
PAK1 | inactive (8.57%) |
PAK3 | inactive (3.98%) |
PAK2 | inactive (1.45%) |
PAK5 | inactive (11.16%) |
PAK6 | inactive (4.03%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (4.94%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (4.05%) |
CK1g2 | inactive (0.87%) |
CK1g1 | inactive (1.43%) |
CK1g3 | inactive (0.07%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (6.17%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (42.65%) |
AurC | active (85.42%) |
AurA | active (73.41%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (3.58%) |
NEK2 | inactive (2.98%) |
NEK9 | inactive (10.17%) |
NEK7 | inactive (4.4%) |
NEK6 | inactive (2.69%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (19.65%) |
IKKe | inactive (19.41%) |
IKKb | inactive (26.75%) |
IKKa | inactive (9.75%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (16.34%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (0.17%) |
GPRK6 | inactive (6.26%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (6.25%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (1.01%) |
MSK2 | inactive (4.49%) |
RSK1 | inactive (3.62%) |
RSK2 | inactive (2.23%) |
RSK4 | inactive (7.33%) |
RSK3 | inactive (3.37%) |
p70S6K | inactive (6.47%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (-2.15%) |
AKT1 | inactive (-2.06%) |
AKT3 | inactive (-1.07%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (4.05%) |
SGK3 | inactive (3.83%) |
SGK2 | inactive (3.06%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (4.32%) |
PKCg | inactive (16.44%) |
PKCa | inactive (8.24%) |
PKCt | inactive (2.94%) |
PKCi | inactive (-0.31%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (7.68%) |
PKG1 | inactive (3.77%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (2.66%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (5.78%) |
ROCK2 | inactive (13.62%) |
MRCKb | inactive (-0.07%) |
MRCKa | inactive (1.81%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (12.79%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (0.3%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (-0.14%) |
CaMK1d | inactive (4.12%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (10.39%) |
PHKg2 | inactive (6.26%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (5.54%) |
CaMK2a | inactive (3.19%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (1.29%) |
MAPKAPK2 | inactive (0.74%) |
MAPKAPK3 | inactive (7.65%) |
MNK2 | inactive (16.74%) |
MNK1 | inactive (13.4%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (9.43%) |
PKD1 | inactive (12.13%) |
PKD2 | inactive (10.08%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (6.22%) |
MARK3 | inactive (12.5%) |
MARK1 | inactive (6.45%) |
QIK | active (53.5%) |
SIK | active (80.22%) |
NuaK1 | inactive (41.13%) |
BRSK1 | inactive (6.23%) |
BRSK2 | inactive (9.72%) |
MELK | inactive (7.7%) |
CHK1 | inactive (2.08%) |
PASK | inactive (0.18%) |
AMPKa1 | inactive (6.79%) |
AMPKa2 | inactive (5.29%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (1.65%) |
TSSK1 | inactive (5.19%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (0.43%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (-3.06%) |
PIM3 | inactive (1.91%) |
PIM1 | inactive (1.49%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (14.55%) |
p38a | inactive (27.97%) |
p38b | inactive (17.68%) |
p38d | inactive (4.69%) |
Erk2 | inactive (4.19%) |
Erk1 | inactive (5.1%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (14.87%) |
GSK3B | inactive (17.44%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (1.41%) |
MSSK1 | inactive (7.12%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (3.09%) |
CLK2 | inactive (6.94%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (0.47%) |
HIPK4 | inactive (10.81%) |
DYRK1B | inactive (11.8%) |
DYRK1A | inactive (26.54%) |
DYRK2 | inactive (7.18%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (10.46%) |