Compound Information
Test on : GPCR
Compound Name : SB-476429-A
Inchikey : QTHDVKCBIJCECK-UHFFFAOYSA-N
ChemSpider : 28485372
Pubchem CID : 57399803
ChEMBL : CHEMBL1909412
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (2.34%) |
TYK2 | inactive (-1.84%) |
JAK2 | inactive (0.75%) |
JAK3 | inactive (1.41%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (2.5%) |
FES | inactive (1.79%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | active (53.08%) |
ABL2 | active (55.78%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (7.83%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (28.92%) |
BTK | inactive (6.57%) |
TXK | active (61.11%) |
TEC | inactive (33.04%) |
ITK | inactive (1.29%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | active (58.72%) |
SRM | inactive (21.66%) |
FRK | inactive (35.26%) |
BLK | inactive (10.43%) |
LCK | inactive (33.02%) |
HCK | active (55.15%) |
FGR | inactive (32.79%) |
FYN | inactive (31.8%) |
SRC | active (63.28%) |
YES | inactive (37.73%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (8.19%) |
EphA4 | inactive (21.95%) |
EphA3 | inactive (2.67%) |
EphB4 | inactive (9.77%) |
EphB3 | inactive (12.85%) |
EphB2 | inactive (8.63%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (-0.14%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (1.13%) |
ZAP70 | inactive (1.92%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (1.88%) |
ALK | inactive (2.22%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (8.44%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (2.07%) |
IGF1R | inactive (-0.25%) |
IRR | inactive (-1.54%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (9.1%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (2.08%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (-1.42%) |
TRKB | inactive (0.73%) |
TRKC | inactive (1.61%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (2.55%) |
MET | inactive (14.52%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (3.04%) |
MER | inactive (6.1%) |
TYRO3 | inactive (5.26%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | active (76.56%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (1.38%) |
FGFR2 | inactive (6.76%) |
FGFR3 | inactive (5.11%) |
FGFR4 | inactive (2.75%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | active (70.61%) |
KDR | active (74.84%) |
FLT4 | active (68.97%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (5.68%) |
KIT | inactive (2.11%) |
FLT3 | inactive (3.28%) |
PDGFRa | inactive (25.61%) |
PDGFRb | inactive (30.98%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (21.03%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (-0.9%) |
TNK1 | inactive (1.42%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (21.83%) |
ErbB2 | inactive (-0.9%) |
ErbB4 | inactive (28.93%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (0.37%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | active (55.18%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (4.41%) |
MST1 | inactive (0.25%) |
MST2 | inactive (-1.23%) |
MST4 | inactive (0.12%) |
HGK | inactive (17.22%) |
MINK | inactive (14.08%) |
LOK | inactive (23.69%) |
PAK1 | inactive (2.83%) |
PAK3 | inactive (-0.37%) |
PAK2 | inactive (-1.01%) |
PAK5 | inactive (-6.81%) |
PAK6 | inactive (0.88%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (2.23%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (15.74%) |
CK1g2 | inactive (2.74%) |
CK1g1 | inactive (2.73%) |
CK1g3 | inactive (3.09%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (2.1%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (6.56%) |
AurC | inactive (5.03%) |
AurA | inactive (9.73%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (1.09%) |
NEK2 | inactive (0.73%) |
NEK9 | inactive (-0.05%) |
NEK7 | inactive (1.7%) |
NEK6 | inactive (-1.57%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (1.76%) |
IKKe | inactive (-0.03%) |
IKKb | inactive (0.02%) |
IKKa | inactive (-3.91%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (7.44%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (2.84%) |
GPRK6 | inactive (-0.98%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (2.41%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (2.56%) |
MSK2 | inactive (2.82%) |
RSK1 | inactive (1.3%) |
RSK2 | inactive (-1.09%) |
RSK4 | inactive (0.03%) |
RSK3 | inactive (1.53%) |
p70S6K | inactive (0.71%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (-0.26%) |
AKT1 | inactive (0.47%) |
AKT3 | inactive (0.68%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (0.21%) |
SGK3 | inactive (-0.81%) |
SGK2 | inactive (-10.06%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (3.81%) |
PKCg | inactive (0.42%) |
PKCa | inactive (2.46%) |
PKCt | inactive (-0.18%) |
PKCi | inactive (-0.02%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (3.58%) |
PKG1 | inactive (2.4%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (-2.14%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (2.17%) |
ROCK2 | inactive (0.95%) |
MRCKb | inactive (1.3%) |
MRCKa | inactive (-0.06%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (0.67%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (5.14%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (0.53%) |
CaMK1d | inactive (0.23%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (3.18%) |
PHKg2 | inactive (-1.08%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (2.12%) |
CaMK2a | inactive (2.11%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (-1.34%) |
MAPKAPK2 | inactive (-0.56%) |
MAPKAPK3 | inactive (30.88%) |
MNK2 | inactive (4.8%) |
MNK1 | inactive (6.58%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (1.93%) |
PKD1 | inactive (2.64%) |
PKD2 | inactive (4.23%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (2.57%) |
MARK3 | inactive (5.09%) |
MARK1 | inactive (2.6%) |
QIK | inactive (8.19%) |
SIK | inactive (3.96%) |
NuaK1 | inactive (3.79%) |
BRSK1 | inactive (0.59%) |
BRSK2 | inactive (1.33%) |
MELK | inactive (-1.02%) |
CHK1 | inactive (2.53%) |
PASK | inactive (-0.1%) |
AMPKa1 | inactive (-1.38%) |
AMPKa2 | inactive (3.06%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (-1.3%) |
TSSK1 | inactive (0.46%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (1.16%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (1.13%) |
PIM3 | inactive (-0.73%) |
PIM1 | inactive (0.18%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (15.85%) |
p38a | active (77.11%) |
p38b | active (53.97%) |
p38d | inactive (1.79%) |
Erk2 | inactive (0.67%) |
Erk1 | inactive (0.95%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (32.55%) |
GSK3B | active (65.43%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-4.18%) |
MSSK1 | inactive (-2.01%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (3.14%) |
CLK2 | inactive (0.72%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (5.53%) |
HIPK4 | inactive (8.45%) |
DYRK1B | inactive (3.42%) |
DYRK1A | inactive (3.85%) |
DYRK2 | inactive (0.81%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (1.53%) |