Compound Information
Test on : GPCR
Compound Name : GSK614526A
Inchikey : QQQGLCMEJYJOMK-YDALLXLXSA-N
ChemSpider : 28484519
Pubchem CID : 56603966
ChEMBL : CHEMBL1909375
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (2.18%) |
TYK2 | inactive (-1.89%) |
JAK2 | inactive (-2.12%) |
JAK3 | inactive (0.33%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (0.7%) |
FES | inactive (4.12%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (-0.45%) |
ABL2 | inactive (2.28%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (-0.82%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (-0.7%) |
BTK | inactive (1.17%) |
TXK | inactive (1.67%) |
TEC | inactive (1.67%) |
ITK | inactive (0.41%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (2.47%) |
SRM | inactive (0.87%) |
FRK | inactive (0.68%) |
BLK | inactive (1.76%) |
LCK | inactive (3.66%) |
HCK | inactive (1%) |
FGR | inactive (2.16%) |
FYN | inactive (1.07%) |
SRC | inactive (-2.58%) |
YES | inactive (2.07%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (0.02%) |
EphA4 | inactive (2.58%) |
EphA3 | inactive (-1.12%) |
EphB4 | inactive (1.1%) |
EphB3 | inactive (0.62%) |
EphB2 | inactive (-3.01%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (22.98%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-4.11%) |
ZAP70 | inactive (-0.24%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (2.22%) |
ALK | inactive (1.45%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (0.45%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (-1.35%) |
IGF1R | inactive (0.19%) |
IRR | inactive (-0.44%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (2.67%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (-3.74%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (-3.52%) |
TRKB | inactive (0.79%) |
TRKC | inactive (-0.37%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (-2.78%) |
MET | inactive (5.81%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (0.17%) |
MER | inactive (-0.43%) |
TYRO3 | inactive (1.75%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (25.17%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (0.08%) |
FGFR2 | inactive (0.8%) |
FGFR3 | inactive (0.67%) |
FGFR4 | inactive (2.23%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (17.37%) |
KDR | active (81.33%) |
FLT4 | inactive (33.92%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (1.4%) |
KIT | inactive (-2.57%) |
FLT3 | inactive (-0.61%) |
PDGFRa | inactive (24.37%) |
PDGFRb | inactive (47.2%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (4.39%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (-0.46%) |
TNK1 | inactive (1.67%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (1.8%) |
ErbB2 | inactive (3.51%) |
ErbB4 | inactive (7.9%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (0.53%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (0.01%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (3.31%) |
MST1 | inactive (2.14%) |
MST2 | inactive (2.41%) |
MST4 | inactive (-0.64%) |
HGK | inactive (2.54%) |
MINK | inactive (0.93%) |
LOK | inactive (5.64%) |
PAK1 | inactive (7.58%) |
PAK3 | inactive (4.06%) |
PAK2 | inactive (16.59%) |
PAK5 | inactive (49.77%) |
PAK6 | active (58.43%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (0.19%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (-2.58%) |
CK1g2 | inactive (2.18%) |
CK1g1 | inactive (2.69%) |
CK1g3 | inactive (3.35%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (-3.86%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (0.87%) |
AurC | inactive (1.45%) |
AurA | inactive (1.08%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (0.55%) |
NEK2 | inactive (0.91%) |
NEK9 | inactive (0.02%) |
NEK7 | inactive (-0.58%) |
NEK6 | inactive (0.79%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (41.18%) |
IKKe | active (98.7%) |
IKKb | inactive (4.4%) |
IKKa | inactive (-0.05%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (4.1%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (14.01%) |
GPRK6 | inactive (0.91%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (4.72%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (7.89%) |
MSK2 | inactive (17.49%) |
RSK1 | inactive (23.27%) |
RSK2 | inactive (24.88%) |
RSK4 | inactive (8.09%) |
RSK3 | inactive (13.28%) |
p70S6K | inactive (25.38%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | - |
AKT1 | active (91.12%) |
AKT3 | active (90.43%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (2.09%) |
SGK3 | inactive (47.44%) |
SGK2 | inactive (2.29%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | active (96.35%) |
PKCg | inactive (44.59%) |
PKCa | inactive (18.35%) |
PKCt | active (72.29%) |
PKCi | inactive (11.39%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | active (76.49%) |
PKG1 | active (76.38%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | active (85.38%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (12.39%) |
ROCK2 | inactive (10.04%) |
MRCKb | inactive (19.53%) |
MRCKa | inactive (23.52%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (1.08%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (2.93%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (-0.65%) |
CaMK1d | inactive (0.84%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (2.21%) |
PHKg2 | inactive (1.65%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (0.35%) |
CaMK2a | inactive (-2.05%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (0.32%) |
MAPKAPK2 | inactive (-0.71%) |
MAPKAPK3 | inactive (-0.82%) |
MNK2 | inactive (-0.07%) |
MNK1 | inactive (1.82%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (15.88%) |
PKD1 | inactive (19.2%) |
PKD2 | inactive (12.62%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | active (55.16%) |
MARK3 | active (67.86%) |
MARK1 | active (61.09%) |
QIK | inactive (6.59%) |
SIK | inactive (4.19%) |
NuaK1 | inactive (34.39%) |
BRSK1 | inactive (1.83%) |
BRSK2 | inactive (1.11%) |
MELK | inactive (18.39%) |
CHK1 | inactive (2.95%) |
PASK | inactive (7.61%) |
AMPKa1 | inactive (39.34%) |
AMPKa2 | inactive (4.25%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (2.67%) |
TSSK1 | active (70.38%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (0.89%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (7.09%) |
PIM3 | inactive (10.11%) |
PIM1 | inactive (7.63%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (0.92%) |
p38a | inactive (0.75%) |
p38b | inactive (1.41%) |
p38d | inactive (-1.56%) |
Erk2 | inactive (1.3%) |
Erk1 | inactive (2.32%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (44.41%) |
GSK3B | inactive (46.85%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-2.53%) |
MSSK1 | inactive (-4.41%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (-0.53%) |
CLK2 | inactive (9.59%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (6.03%) |
HIPK4 | inactive (0.31%) |
DYRK1B | inactive (-1.07%) |
DYRK1A | inactive (-0.73%) |
DYRK2 | inactive (-2.07%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (-1.67%) |