Compound Information
Test on : GPCR
Compound Name : SB-358518
Inchikey : QOJSERWVVHZZPL-UHFFFAOYSA-N
ChemSpider : 5021953
Pubchem CID : 6539487
ChEMBL : CHEMBL352222
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (4.63%) |
TYK2 | inactive (2.74%) |
JAK2 | inactive (-0.7%) |
JAK3 | inactive (24.46%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (0.45%) |
FES | inactive (0.99%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (0.82%) |
ABL2 | inactive (3.78%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (0.7%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (0.42%) |
BTK | inactive (1.62%) |
TXK | inactive (0.63%) |
TEC | inactive (5.27%) |
ITK | inactive (0.8%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (2.07%) |
SRM | inactive (0.6%) |
FRK | inactive (0.95%) |
BLK | inactive (1.36%) |
LCK | inactive (3.48%) |
HCK | inactive (0.75%) |
FGR | inactive (3.7%) |
FYN | inactive (0.6%) |
SRC | inactive (-0.12%) |
YES | inactive (3.65%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (-0.45%) |
EphA4 | inactive (1.76%) |
EphA3 | inactive (1.24%) |
EphB4 | inactive (1.7%) |
EphB3 | inactive (3.06%) |
EphB2 | inactive (0.02%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (5.27%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-2.48%) |
ZAP70 | inactive (0.91%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (1.2%) |
ALK | inactive (3.11%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (4.51%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (1.56%) |
IGF1R | inactive (-0.5%) |
IRR | inactive (0.1%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (1.09%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (-3.35%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (-0.43%) |
TRKB | inactive (0.97%) |
TRKC | inactive (1.33%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (0.58%) |
MET | inactive (6.2%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (1.02%) |
MER | inactive (0.18%) |
TYRO3 | inactive (1.3%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (3.36%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (7.05%) |
FGFR2 | inactive (21.66%) |
FGFR3 | inactive (14.53%) |
FGFR4 | inactive (0.22%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (1.09%) |
KDR | inactive (8.59%) |
FLT4 | inactive (2.54%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (27.01%) |
KIT | inactive (-0.5%) |
FLT3 | inactive (3.35%) |
PDGFRa | inactive (4.4%) |
PDGFRb | inactive (4.95%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (4.76%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (-0.08%) |
TNK1 | inactive (16.71%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (1.18%) |
ErbB2 | inactive (2.08%) |
ErbB4 | inactive (9.81%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (0.63%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (3.75%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (5.47%) |
MST1 | active (56.46%) |
MST2 | active (50.67%) |
MST4 | inactive (10.47%) |
HGK | inactive (4.07%) |
MINK | inactive (2.65%) |
LOK | inactive (13.62%) |
PAK1 | inactive (-0.91%) |
PAK3 | inactive (0.99%) |
PAK2 | inactive (-1%) |
PAK5 | inactive (-2.87%) |
PAK6 | inactive (3.31%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (2.69%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (-0.13%) |
CK1g2 | inactive (1.13%) |
CK1g1 | inactive (1.75%) |
CK1g3 | inactive (2.61%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (-1.62%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (3.34%) |
AurC | inactive (6.2%) |
AurA | inactive (7.69%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (1.19%) |
NEK2 | inactive (0.86%) |
NEK9 | inactive (4.74%) |
NEK7 | inactive (0.43%) |
NEK6 | inactive (1.08%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (47.44%) |
IKKe | inactive (15.25%) |
IKKb | inactive (4.99%) |
IKKa | inactive (-1.55%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (3.3%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (4.27%) |
GPRK6 | inactive (0.24%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (0.78%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (-1.6%) |
MSK2 | inactive (1.45%) |
RSK1 | inactive (3.34%) |
RSK2 | inactive (9.07%) |
RSK4 | inactive (11.19%) |
RSK3 | inactive (10.8%) |
p70S6K | inactive (0.65%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (1.26%) |
AKT1 | inactive (0.14%) |
AKT3 | inactive (0.95%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (0.49%) |
SGK3 | inactive (1.23%) |
SGK2 | inactive (-0.94%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (1.81%) |
PKCg | inactive (1.14%) |
PKCa | inactive (1.77%) |
PKCt | inactive (0.93%) |
PKCi | inactive (-1.31%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (3.19%) |
PKG1 | inactive (1.99%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (2.86%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (-0.21%) |
ROCK2 | inactive (0.12%) |
MRCKb | inactive (0.29%) |
MRCKa | inactive (-0.25%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (0.98%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (1.71%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (0.54%) |
CaMK1d | inactive (0.37%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (4.24%) |
PHKg2 | inactive (2.81%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (1.23%) |
CaMK2a | inactive (-0.51%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (0.55%) |
MAPKAPK2 | inactive (0.31%) |
MAPKAPK3 | inactive (1.9%) |
MNK2 | inactive (2.79%) |
MNK1 | inactive (3.09%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (3.53%) |
PKD1 | inactive (1.22%) |
PKD2 | inactive (2.21%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (6.06%) |
MARK3 | inactive (6.69%) |
MARK1 | inactive (6.27%) |
QIK | inactive (5.17%) |
SIK | inactive (3.71%) |
NuaK1 | inactive (13.69%) |
BRSK1 | inactive (4.78%) |
BRSK2 | inactive (3.68%) |
MELK | inactive (-3.64%) |
CHK1 | inactive (1.06%) |
PASK | inactive (1.32%) |
AMPKa1 | inactive (5.09%) |
AMPKa2 | inactive (4.91%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (0.2%) |
TSSK1 | inactive (0.86%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (1.81%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (1.61%) |
PIM3 | inactive (0.87%) |
PIM1 | inactive (1.59%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (1.1%) |
p38a | inactive (6.98%) |
p38b | inactive (1.62%) |
p38d | inactive (-0.48%) |
Erk2 | inactive (4.35%) |
Erk1 | inactive (2.24%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | active (85.02%) |
GSK3B | active (80.72%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-1.65%) |
MSSK1 | inactive (-0.59%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (2.15%) |
CLK2 | inactive (12.52%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (-1.52%) |
HIPK4 | inactive (1.09%) |
DYRK1B | inactive (10.52%) |
DYRK1A | inactive (20.12%) |
DYRK2 | inactive (-1.6%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (-1.15%) |