Compound Information
Test on : GPCR
Compound Name : GW693917A
Inchikey : QMTGTQNHZXEXLD-UHFFFAOYSA-N
ChemSpider : 28484236
Pubchem CID : 57401572
ChEMBL : CHEMBL1909369
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (9.06%) |
TYK2 | inactive (1.02%) |
JAK2 | inactive (7.31%) |
JAK3 | inactive (0.75%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (6.3%) |
FES | inactive (0.99%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | active (79.75%) |
ABL2 | active (73.6%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (33.41%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (2.68%) |
BTK | inactive (-0.85%) |
TXK | inactive (2.35%) |
TEC | inactive (-0.83%) |
ITK | inactive (2.72%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (0.36%) |
SRM | inactive (-0.86%) |
FRK | inactive (4.14%) |
BLK | inactive (3.2%) |
LCK | inactive (47.13%) |
HCK | inactive (28.34%) |
FGR | inactive (9.94%) |
FYN | inactive (21.05%) |
SRC | inactive (26.9%) |
YES | inactive (11.51%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | active (93.51%) |
EphA4 | active (86.1%) |
EphA3 | active (68.43%) |
EphB4 | active (72.98%) |
EphB3 | inactive (36.64%) |
EphB2 | active (83.72%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (6.74%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (0.26%) |
ZAP70 | inactive (-0.75%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (2.2%) |
ALK | inactive (6.26%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (7.35%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (3.09%) |
IGF1R | inactive (1.6%) |
IRR | inactive (-1.09%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | active (83.59%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | active (85.63%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | active (81.52%) |
TRKB | active (60.98%) |
TRKC | active (88.47%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (1.28%) |
MET | inactive (34.63%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (46.61%) |
MER | inactive (4.8%) |
TYRO3 | inactive (39.96%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | active (88.42%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (16.87%) |
FGFR2 | inactive (29.7%) |
FGFR3 | inactive (11.54%) |
FGFR4 | inactive (3.25%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | active (78.1%) |
KDR | active (85.11%) |
FLT4 | active (52.77%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (39.14%) |
KIT | active (73.92%) |
FLT3 | inactive (47.12%) |
PDGFRa | active (83.52%) |
PDGFRb | active (55.89%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | active (77.97%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (1.35%) |
TNK1 | inactive (27.19%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (3.16%) |
ErbB2 | inactive (-0.72%) |
ErbB4 | inactive (3.36%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (0.25%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (22.05%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (28.61%) |
MST1 | inactive (-1.63%) |
MST2 | inactive (-0.3%) |
MST4 | inactive (1.71%) |
HGK | inactive (8.34%) |
MINK | inactive (6.19%) |
LOK | active (55.42%) |
PAK1 | inactive (1.52%) |
PAK3 | inactive (0.28%) |
PAK2 | inactive (-0.42%) |
PAK5 | inactive (-1.37%) |
PAK6 | inactive (-8.13%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (1.52%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (3.01%) |
CK1g2 | inactive (-0.08%) |
CK1g1 | inactive (-0.02%) |
CK1g3 | inactive (0.18%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (0.38%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (30.8%) |
AurC | active (50.41%) |
AurA | inactive (7.02%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (1.38%) |
NEK2 | inactive (0.69%) |
NEK9 | inactive (-3.04%) |
NEK7 | inactive (0.53%) |
NEK6 | inactive (-4.58%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (-0.01%) |
IKKe | inactive (-1.19%) |
IKKb | inactive (-1.14%) |
IKKa | inactive (-0.96%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (9.84%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (6.1%) |
GPRK6 | inactive (-1.53%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (0.43%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (0.93%) |
MSK2 | inactive (2.86%) |
RSK1 | inactive (2.46%) |
RSK2 | inactive (2.83%) |
RSK4 | inactive (1.65%) |
RSK3 | inactive (13.06%) |
p70S6K | inactive (23.22%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (-0.64%) |
AKT1 | inactive (-0.66%) |
AKT3 | inactive (-0.4%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (0.95%) |
SGK3 | inactive (1.57%) |
SGK2 | inactive (0.53%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (1.44%) |
PKCg | inactive (0.59%) |
PKCa | inactive (9.89%) |
PKCt | inactive (-1.1%) |
PKCi | inactive (0.66%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (1.92%) |
PKG1 | inactive (2.05%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (-0.17%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (1.94%) |
ROCK2 | inactive (1.17%) |
MRCKb | inactive (1.68%) |
MRCKa | inactive (-1.54%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (-0.04%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (-7.94%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (2.48%) |
CaMK1d | inactive (2.93%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (1.81%) |
PHKg2 | inactive (-1.17%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (1.63%) |
CaMK2a | inactive (0.75%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (-0.36%) |
MAPKAPK2 | inactive (-0.42%) |
MAPKAPK3 | inactive (20.29%) |
MNK2 | inactive (7.88%) |
MNK1 | inactive (15.71%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (0.53%) |
PKD1 | inactive (0.84%) |
PKD2 | inactive (1.09%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (0.37%) |
MARK3 | inactive (-0.18%) |
MARK1 | inactive (0.29%) |
QIK | inactive (-6.65%) |
SIK | inactive (0.54%) |
NuaK1 | inactive (-3.55%) |
BRSK1 | inactive (0.34%) |
BRSK2 | inactive (0.24%) |
MELK | inactive (3.51%) |
CHK1 | inactive (0.48%) |
PASK | inactive (-0.57%) |
AMPKa1 | inactive (0.03%) |
AMPKa2 | inactive (1.67%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (0.19%) |
TSSK1 | inactive (1.02%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (-1.22%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (0.12%) |
PIM3 | inactive (0.5%) |
PIM1 | inactive (1.19%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (3.25%) |
p38a | active (63.66%) |
p38b | active (51.45%) |
p38d | inactive (0.18%) |
Erk2 | inactive (0.7%) |
Erk1 | inactive (-0.75%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (4.01%) |
GSK3B | inactive (5.68%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-2.01%) |
MSSK1 | inactive (9.68%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (0.05%) |
CLK2 | inactive (3.04%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (0.81%) |
HIPK4 | inactive (33.49%) |
DYRK1B | inactive (2.02%) |
DYRK1A | inactive (2.5%) |
DYRK2 | inactive (0.21%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (1.75%) |