Compound Information
Test on : GPCR
Compound Name : GW784752X
Inchikey : PVIMTNAWPMEBAK-LSHDLFTRSA-N
ChemSpider : 7879030
Pubchem CID : 9604911
ChEMBL : CHEMBL306865
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (15.31%) |
TYK2 | inactive (0.71%) |
JAK2 | inactive (13.5%) |
JAK3 | inactive (10.56%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (11.74%) |
FES | inactive (5.85%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | active (89.02%) |
ABL2 | active (82.83%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (16.81%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (46.65%) |
BTK | inactive (2.16%) |
TXK | inactive (18.56%) |
TEC | inactive (17.23%) |
ITK | inactive (5.47%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (23.14%) |
SRM | inactive (14.3%) |
FRK | inactive (5.75%) |
BLK | active (63.6%) |
LCK | active (84.02%) |
HCK | active (59.23%) |
FGR | active (69.98%) |
FYN | active (73.76%) |
SRC | active (87.26%) |
YES | active (72.97%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (15.76%) |
EphA4 | inactive (35.45%) |
EphA3 | inactive (6.97%) |
EphB4 | inactive (13.66%) |
EphB3 | inactive (3.82%) |
EphB2 | inactive (30.38%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (16.46%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (9.95%) |
ZAP70 | inactive (3.98%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (6.38%) |
ALK | inactive (7.96%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | active (75.95%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (7.36%) |
IGF1R | inactive (4.88%) |
IRR | inactive (5.33%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (9.37%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (45.56%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (12.79%) |
TRKB | inactive (37.59%) |
TRKC | inactive (36.94%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | active (60.85%) |
MET | inactive (49.47%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (6.36%) |
MER | inactive (39.16%) |
TYRO3 | inactive (41.58%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | active (50.26%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (8.02%) |
FGFR2 | inactive (14.54%) |
FGFR3 | inactive (11.94%) |
FGFR4 | inactive (7.56%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (27.61%) |
KDR | active (69.23%) |
FLT4 | inactive (38.42%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (30.18%) |
KIT | active (57.21%) |
FLT3 | inactive (28.27%) |
PDGFRa | active (79.52%) |
PDGFRb | active (81.18%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (37.53%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (9.3%) |
TNK1 | active (52.29%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (28.81%) |
ErbB2 | inactive (5.53%) |
ErbB4 | inactive (20.85%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (4.07%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (21.51%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (7.06%) |
MST1 | inactive (12.78%) |
MST2 | inactive (10.69%) |
MST4 | inactive (7.18%) |
HGK | active (67.7%) |
MINK | active (55.4%) |
LOK | inactive (33.51%) |
PAK1 | inactive (7.75%) |
PAK3 | inactive (5.78%) |
PAK2 | inactive (2.37%) |
PAK5 | inactive (6.09%) |
PAK6 | inactive (-8.53%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (7.23%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (11.18%) |
CK1g2 | inactive (9.79%) |
CK1g1 | inactive (7.48%) |
CK1g3 | inactive (6.59%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (3.32%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (43.09%) |
AurC | active (61.4%) |
AurA | active (73.77%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (12.5%) |
NEK2 | inactive (5.47%) |
NEK9 | inactive (6.71%) |
NEK7 | inactive (3.46%) |
NEK6 | inactive (3.93%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (13.1%) |
IKKe | inactive (9.13%) |
IKKb | inactive (4.07%) |
IKKa | inactive (1.71%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (18.53%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (5.17%) |
GPRK6 | inactive (1.85%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (8.82%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (4.1%) |
MSK2 | inactive (4.26%) |
RSK1 | inactive (7.17%) |
RSK2 | inactive (4.26%) |
RSK4 | inactive (4.33%) |
RSK3 | inactive (4.92%) |
p70S6K | inactive (7.24%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (-0.44%) |
AKT1 | inactive (-0.78%) |
AKT3 | inactive (0.47%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (16.05%) |
SGK3 | inactive (6.6%) |
SGK2 | inactive (11.95%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (2.1%) |
PKCg | inactive (7.85%) |
PKCa | inactive (8.07%) |
PKCt | inactive (5.71%) |
PKCi | inactive (13.06%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (6.05%) |
PKG1 | - |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (2.86%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (9.67%) |
ROCK2 | inactive (19.39%) |
MRCKb | inactive (0.77%) |
MRCKa | inactive (3.78%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (4.89%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (1.8%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (-1.96%) |
CaMK1d | inactive (2.43%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (17.64%) |
PHKg2 | inactive (7.43%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (12.82%) |
CaMK2a | inactive (6.87%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (3.04%) |
MAPKAPK2 | inactive (1.87%) |
MAPKAPK3 | inactive (4.56%) |
MNK2 | active (59.25%) |
MNK1 | active (70.42%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (9.03%) |
PKD1 | inactive (10.09%) |
PKD2 | inactive (9.06%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (5.01%) |
MARK3 | inactive (7.7%) |
MARK1 | inactive (9.17%) |
QIK | active (54.05%) |
SIK | inactive (27.85%) |
NuaK1 | active (54.58%) |
BRSK1 | active (52.5%) |
BRSK2 | active (60.07%) |
MELK | inactive (6.51%) |
CHK1 | inactive (5.7%) |
PASK | inactive (0.25%) |
AMPKa1 | inactive (9.15%) |
AMPKa2 | inactive (7.87%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (2.48%) |
TSSK1 | inactive (5.05%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (4.53%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (1.69%) |
PIM3 | inactive (4.38%) |
PIM1 | inactive (3.36%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (11.24%) |
p38a | inactive (16.39%) |
p38b | inactive (10.85%) |
p38d | inactive (43.32%) |
Erk2 | inactive (7.16%) |
Erk1 | inactive (7.65%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | active (90.03%) |
GSK3B | active (89.21%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (4.65%) |
MSSK1 | inactive (1.8%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (19.29%) |
CLK2 | inactive (34.97%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | active (69.85%) |
HIPK4 | active (61.3%) |
DYRK1B | active (53.88%) |
DYRK1A | active (72.26%) |
DYRK2 | active (58.94%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | active (59.73%) |