Compound Information


Test on : DRx, Metz

Compound Name
DRx, Metz : 445430-58-0

Inchikey
Same : PSPFQEBFYXJZEV-N
DRx, Metz : PSPFQEBFYXJZEV-UHFFFAOYSA-N

ChemSpider
DRx, Metz : 7989508

Pubchem CID
DRx, Metz : 9813758

ChEMBL
DRx, Metz : CHEMBL249697




DRx RBC Metz Millipore GPCR
bioactivity Kd (nM) Remain Activity (%) Ki (nM) Remain Activity (%) Inhibition (%)
active criteria <3000nM <50% <1000nM <50% >50%

Other


Test Member No. in Family
Familyno. Member on 518kinaseDRxMetz
44-
332
221
42-
21-
444
1192
331
443
11-
32-
21-
54-
22-
11-
1-1
1-1
Other - NAK

Bioactivity
KinaseDRxMetz
AAK1inactive (10001nM)-
BIKEinactive (10001nM)-
GAKinactive (10001nM)-
MPSK1inactive (10001nM)-
Other - Aur

Bioactivity
KinaseDRxMetz
AurAinactive (10001nM)-
AurBinactive (10001nM)inactive (1995.26nM)
AurCinactive (10001nM)-
Other - CAMKK

Bioactivity
KinaseDRxMetz
CaMKK1inactive (10001nM)-
CaMKK2inactive (10001nM)-
Other - PEK

Bioactivity
KinaseDRxMetz
HRIinactive (10001nM)-
PKRinactive (10001nM)-
Other - IRE

Bioactivity
KinaseDRxMetz
IRE1active (1000nM)-
Other - IKK

Bioactivity
KinaseDRxMetz
IKKaactive (1700nM)-
IKKbactive (130nM)-
IKKeinactive (10001nM)-
TBK1inactive (10001nM)-
Other - NEK

Bioactivity
KinaseDRxMetz
NEK1inactive (10001nM)-
NEK11inactive (10001nM)-
NEK2inactive (10001nM)-
NEK3inactive (10001nM)-
NEK4inactive (10001nM)-
NEK5inactive (10001nM)-
NEK6inactive (10001nM)-
NEK7inactive (10001nM)-
NEK9inactive (10001nM)-
Other - WEE

Bioactivity
KinaseDRxMetz
MYT1inactive (10001nM)-
Wee1inactive (10001nM)-
Wee1Binactive (10001nM)-
Other - PLK

Bioactivity
KinaseDRxMetz
PLK1inactive (10001nM)-
PLK2inactive (10001nM)-
PLK3inactive (10001nM)-
PLK4inactive (10001nM)-
Other - SgK496

Bioactivity
KinaseDRxMetz
SgK496inactive (10001nM)-
Other - NKF1

Bioactivity
KinaseDRxMetz
SBKinactive (10001nM)-
SgK110inactive (10001nM)-
Other - NKF4

Bioactivity
KinaseDRxMetz
CLIK1inactive (10001nM)-
Other - ULK

Bioactivity
KinaseDRxMetz
Fusedinactive (6500nM)-
ULK1inactive (10001nM)-
ULK2inactive (10001nM)-
ULK3inactive (10001nM)-
Other - TLK

Bioactivity
KinaseDRxMetz
TLK1inactive (10001nM)-
TLK2inactive (10001nM)-
Other - TTK

Bioactivity
KinaseDRxMetz
TTKinactive (10001nM)-
Other - CDC7

Bioactivity
KinaseDRxMetz
CDC7--
Other - TOPK

Bioactivity
KinaseDRxMetz
PBK--

TK


Test Member No. in Family
Familyno. Member on 518kinaseDRxMetz
221
222
332
11119
553
555
221
22-
443
14131
222
222
442
333
332
443
222
11-
111
111
221
22-
221
333
TK - Abl

Bioactivity
KinaseDRxMetz
ABL1inactive (10001nM)-
ABL2inactive (10001nM)-
TK - ALK

Bioactivity
KinaseDRxMetz
ALKinactive (10001nM)-
LTKinactive (10001nM)-
TK - Axl

Bioactivity
KinaseDRxMetz
AXLinactive (10001nM)-
MERinactive (10001nM)-
TYRO3inactive (10001nM)-
TK - Src

Bioactivity
KinaseDRxMetz
BLKinactive (10001nM)-
BRKinactive (10001nM)-
FGRinactive (10001nM)-
FRKinactive (10001nM)-
FYNinactive (10001nM)-
HCKinactive (10001nM)-
LCKinactive (10001nM)-
LYNinactive (10001nM)-
SRCinactive (10001nM)-
SRMinactive (10001nM)-
YESinactive (10001nM)-
TK - Tec

Bioactivity
KinaseDRxMetz
BMXinactive (10001nM)-
BTKinactive (10001nM)-
ITKinactive (10001nM)-
TECinactive (10001nM)-
TXKinactive (10001nM)-
TK - PDGFR

Bioactivity
KinaseDRxMetz
FMSinactive (10001nM)-
FLT3inactive (10001nM)-
KITinactive (10001nM)-
PDGFRainactive (10001nM)-
PDGFRbinactive (10001nM)-
TK - Csk

Bioactivity
KinaseDRxMetz
CSKinactive (10001nM)-
CTKinactive (10001nM)-
TK - DDR

Bioactivity
KinaseDRxMetz
DDR1inactive (10001nM)-
DDR2inactive (10001nM)-
TK - EGFR

Bioactivity
KinaseDRxMetz
EGFRinactive (10001nM)-
ErbB2inactive (10001nM)-
ErbB3inactive (10001nM)-
ErbB4inactive (10001nM)-
TK - Eph

Bioactivity
KinaseDRxMetz
EphA1inactive (10001nM)-
EphA2inactive (10001nM)-
EphA3inactive (10001nM)-
EphA4inactive (10001nM)-
EphA5inactive (10001nM)-
EphA6inactive (10001nM)-
EphA7inactive (10001nM)-
EphA8inactive (10001nM)-
EphB1inactive (10001nM)-
EphB2inactive (10001nM)-
EphB3inactive (10001nM)-
EphB4inactive (10001nM)-
EphB6inactive (10001nM)-
TK - FAK

Bioactivity
KinaseDRxMetz
FAKinactive (10001nM)-
PYK2inactive (10001nM)-
TK - Fer

Bioactivity
KinaseDRxMetz
FERinactive (10001nM)-
FESinactive (10001nM)-
TK - FGFR

Bioactivity
KinaseDRxMetz
FGFR1inactive (10001nM)-
FGFR2inactive (10001nM)-
FGFR3inactive (10001nM)-
FGFR4inactive (10001nM)-
TK - VEGFR

Bioactivity
KinaseDRxMetz
FLT1inactive (10001nM)-
FLT4inactive (10001nM)-
KDRinactive (10001nM)-
TK - InsR

Bioactivity
KinaseDRxMetz
IGF1Rinactive (10001nM)-
INSRinactive (10001nM)-
IRRinactive (10001nM)-
TK - JakA

Bioactivity
KinaseDRxMetz
JAK1inactive (10001nM)-
JAK2inactive (10001nM)-
JAK3inactive (10001nM)-
TYK2inactive (10001nM)-
TK - Met

Bioactivity
KinaseDRxMetz
METinactive (10001nM)-
RONinactive (10001nM)-
TK - Musk

Bioactivity
KinaseDRxMetz
MUSKinactive (10001nM)-
TK - Ret

Bioactivity
KinaseDRxMetz
RETinactive (10001nM)-
TK - Sev

Bioactivity
KinaseDRxMetz
ROSinactive (10001nM)-
TK - Syk

Bioactivity
KinaseDRxMetz
SYKinactive (10001nM)-
ZAP70inactive (10001nM)-
TK - Tie

Bioactivity
KinaseDRxMetz
TIE1inactive (10001nM)-
TIE2inactive (10001nM)-
TK - Ack

Bioactivity
KinaseDRxMetz
TNK1inactive (10001nM)-
ACKinactive (10001nM)-
TK - Trk

Bioactivity
KinaseDRxMetz
TRKAinactive (10001nM)-
TRKBinactive (10001nM)-
TRKCinactive (10001nM)-

TKL


Test Member No. in Family
Familyno. Member on 518kinaseDRxMetz
12101
54-
521
1082
432
431
211
TKL - STKR

Bioactivity
KinaseDRxMetz
ALK2inactive (10001nM)-
ALK4inactive (10001nM)-
ACTR2inactive (10001nM)-
ACTR2Binactive (10001nM)-
ALK1inactive (10001nM)-
BMPR1Ainactive (10001nM)-
BMPR1Binactive (10001nM)-
BMPR2inactive (10001nM)-
TGFbR1inactive (10001nM)-
TGFbR2inactive (10001nM)-
TKL - RIPK

Bioactivity
KinaseDRxMetz
SgK288inactive (10001nM)-
RIPK1inactive (10001nM)-
RIPK2inactive (10001nM)-
ANKRD3inactive (10001nM)-
TKL - RAF

Bioactivity
KinaseDRxMetz
BRAFinactive (10001nM)-
RAF1inactive (10001nM)-
TKL - MLK

Bioactivity
KinaseDRxMetz
DLKinactive (10001nM)-
LZKinactive (10001nM)-
MLK1inactive (10001nM)-
MLK2inactive (10001nM)-
MLK3inactive (10001nM)-
TAK1inactive (10001nM)-
HH498inactive (10001nM)-
ZAKinactive (10001nM)-
TKL - IRAK

Bioactivity
KinaseDRxMetz
IRAK1inactive (10001nM)-
IRAK3inactive (10001nM)-
IRAK4inactive (10001nM)-
TKL - LISK

Bioactivity
KinaseDRxMetz
LIMK1inactive (10001nM)inactive (7943.28nM)
LIMK2inactive (10001nM)-
TESK1inactive (10001nM)-
TKL - LRRK

Bioactivity
KinaseDRxMetz
LRRK2inactive (10001nM)-

Atypical


Test Member No. in Family
Familyno. Member on 518kinaseDRxMetz
52-
61-
33-
611
Atypical - ABC1

Bioactivity
KinaseDRxMetz
ADCK3inactive (10001nM)-
ADCK4inactive (10001nM)-
Atypical - PIKK

Bioactivity
KinaseDRxMetz
FRAPinactive (10001nM)-
Atypical - RIO

Bioactivity
KinaseDRxMetz
RIOK1inactive (10001nM)-
RIOK2inactive (10001nM)-
RIOK3inactive (10001nM)-
Atypical - Alpha

Bioactivity
KinaseDRxMetz
ChaK2inactive (10001nM)-
eEF2K--

AGC


Test Member No. in Family
Familyno. Member on 518kinaseDRxMetz
333
773
731
44-
51-
111
532
321
955
222
814
311
33-
AGC - Akt

Bioactivity
KinaseDRxMetz
AKT1inactive (10001nM)-
AKT2inactive (10001nM)-
AKT3inactive (10001nM)-
AGC - DMPK

Bioactivity
KinaseDRxMetz
CRIKinactive (10001nM)-
DMPK1inactive (10001nM)-
DMPK2inactive (10001nM)-
MRCKainactive (10001nM)-
MRCKbinactive (10001nM)-
ROCK1inactive (10001nM)-
ROCK2inactive (10001nM)-
AGC - GRK

Bioactivity
KinaseDRxMetz
RHOKinactive (10001nM)-
GPRK4inactive (10001nM)-
GPRK7inactive (10001nM)-
GPRK5--
AGC - NDR

Bioactivity
KinaseDRxMetz
LATS1inactive (10001nM)-
LATS2inactive (10001nM)-
NDR1inactive (10001nM)-
NDR2inactive (10001nM)-
AGC - MAST

Bioactivity
KinaseDRxMetz
MAST1inactive (10001nM)-
AGC - PDK1

Bioactivity
KinaseDRxMetz
PDK1inactive (10001nM)-
AGC - PKA

Bioactivity
KinaseDRxMetz
PKACainactive (10001nM)-
PKACbinactive (10001nM)-
PRKXinactive (10001nM)-
AGC - PKN

Bioactivity
KinaseDRxMetz
PKN1inactive (10001nM)-
PKN2inactive (10001nM)-
AGC - PKC

Bioactivity
KinaseDRxMetz
PKCdinactive (10001nM)-
PKCeinactive (10001nM)-
PKChinactive (10001nM)-
PKCiinactive (10001nM)-
PKCtinactive (10001nM)-
PKCg--
PKCz--
AGC - PKG

Bioactivity
KinaseDRxMetz
PKG1inactive (10001nM)-
PKG2inactive (10001nM)-
AGC - RSK

Bioactivity
KinaseDRxMetz
p70S6Kinactive (10001nM)-
RSK2--
MSK1--
MSK2--
AGC - SGK

Bioactivity
KinaseDRxMetz
SGK3inactive (10001nM)-
SGK1--
AGC - YANK

Bioactivity
KinaseDRxMetz
YANK1inactive (10001nM)-
YANK2inactive (10001nM)-
YANK3inactive (10001nM)-

CAMK


Test Member No. in Family
Familyno. Member on 518kinaseDRxMetz
20199
542
444
11-
111
552
331
544
54-
221
333
332
111
512
CAMK - CAMKL

Bioactivity
KinaseDRxMetz
AMPKa1inactive (10001nM)-
AMPKa2inactive (10001nM)-
NuaK1inactive (10001nM)-
BRSK1inactive (10001nM)-
BRSK2inactive (10001nM)-
CHK1inactive (10001nM)-
HUNKinactive (10001nM)-
LKB1inactive (10001nM)-
MARK1inactive (10001nM)-
MARK2inactive (10001nM)-
MARK3inactive (10001nM)-
MARK4inactive (10001nM)-
MELKinactive (10001nM)-
NIM1inactive (10001nM)-
QSKinactive (10001nM)-
SIKinactive (10001nM)-
QIKinactive (10001nM)-
NuaK2inactive (10001nM)-
SNRKinactive (10001nM)-
PASK--
CAMK - CAMK1

Bioactivity
KinaseDRxMetz
CaMK1ainactive (10001nM)-
CaMK1dinactive (10001nM)-
CaMK1ginactive (10001nM)-
CaMK4inactive (10001nM)-
CAMK - CAMK2

Bioactivity
KinaseDRxMetz
CaMK2ainactive (10001nM)-
CaMK2binactive (10001nM)-
CaMK2dinactive (10001nM)-
CaMK2ginactive (10001nM)-
CAMK - CASK

Bioactivity
KinaseDRxMetz
CASKinactive (10001nM)-
CAMK - RAD53

Bioactivity
KinaseDRxMetz
CHK2inactive (10001nM)-
CAMK - DAPK

Bioactivity
KinaseDRxMetz
DAPK1inactive (10001nM)-
DAPK2inactive (10001nM)-
DAPK3inactive (10001nM)-
DRAK1inactive (10001nM)-
DRAK2inactive (10001nM)-
CAMK - DCAMKL

Bioactivity
KinaseDRxMetz
DCLK1inactive (10001nM)-
DCLK2inactive (10001nM)-
DCLK3active (1700nM)-
CAMK - MAPKAPK

Bioactivity
KinaseDRxMetz
MAPKAPK2inactive (10001nM)-
MAPKAPK5inactive (10001nM)-
MNK1inactive (10001nM)-
MNK2inactive (10001nM)-
MAPKAPK3--
CAMK - MLCK

Bioactivity
KinaseDRxMetz
caMLCKinactive (10001nM)-
smMLCKinactive (10001nM)-
skMLCKinactive (10001nM)-
SgK085active (700nM)-
CAMK - PHK

Bioactivity
KinaseDRxMetz
PHKg1inactive (10001nM)-
PHKg2inactive (10001nM)-
CAMK - PIM

Bioactivity
KinaseDRxMetz
PIM1inactive (10001nM)-
PIM2inactive (10001nM)-
PIM3inactive (10001nM)-
CAMK - PKD

Bioactivity
KinaseDRxMetz
PKD1inactive (4600nM)-
PKD2inactive (10001nM)inactive (3981.07nM)
PKD3inactive (10001nM)inactive (3981.07nM)
CAMK - STK33

Bioactivity
KinaseDRxMetz
STK33inactive (10001nM)-
CAMK - TSSK

Bioactivity
KinaseDRxMetz
TSSK1inactive (10001nM)-
TSSK2--

STE


Test Member No. in Family
Familyno. Member on 518kinaseDRxMetz
88-
31279
772
STE - STE11

Bioactivity
KinaseDRxMetz
MAP3K5inactive (10001nM)-
MAP3K6inactive (10001nM)-
MAP3K1inactive (10001nM)-
MAP3K7inactive (10001nM)-
MAP3K2inactive (10001nM)-
MAP3K3inactive (10001nM)-
MAP3K4inactive (10001nM)-
MAP3K8active (260nM)-
STE - STE20

Bioactivity
KinaseDRxMetz
HPK1inactive (10001nM)-
LOKinactive (10001nM)-
GCKinactive (10001nM)-
KHS2inactive (10001nM)-
HGKinactive (10001nM)-
KHS1inactive (10001nM)-
MINKinactive (10001nM)-
MST1inactive (10001nM)-
MST2inactive (10001nM)-
MST3inactive (10001nM)-
MST4inactive (10001nM)-
MYO3Ainactive (10001nM)-
MYO3Binactive (10001nM)-
OSR1inactive (10001nM)-
PAK1inactive (10001nM)-
PAK2inactive (10001nM)-
PAK3inactive (10001nM)-
PAK4inactive (10001nM)-
PAK6inactive (10001nM)-
PAK5inactive (10001nM)-
SLKinactive (10001nM)-
STLK3inactive (10001nM)-
TAO1inactive (10001nM)inactive (7943.28nM)
TAO2inactive (10001nM)-
TAO3inactive (10001nM)-
TNIKinactive (10001nM)-
YSK1inactive (10001nM)-
STE - STE7

Bioactivity
KinaseDRxMetz
MAP2K1inactive (10001nM)-
MAP2K2inactive (10001nM)-
MAP2K3inactive (10001nM)-
MAP2K4inactive (10001nM)-
MAP2K5inactive (10001nM)-
MAP2K6inactive (10001nM)-
MAP2K7inactive (10001nM)-

CMGC


Test Member No. in Family
Familyno. Member on 518kinaseDRxMetz
2087
54-
442
321
1086
14148
222
32-
331
CMGC - CDK

Bioactivity
KinaseDRxMetz
PITSLREactive (420nM)-
CHEDactive (800nM)-
CDK11inactive (10001nM)-
PCTAIRE1active (890nM)-
PCTAIRE2inactive (10001nM)-
PCTAIRE3inactive (10001nM)-
PFTAIRE2inactive (10001nM)-
PFTAIRE1inactive (10001nM)-
CDC2-inactive (3981.07nM)
CDK2-inactive (1995.26nM)
CDK5--
CDK8--
CDK7--
CDK9--
CMGC - CDKL

Bioactivity
KinaseDRxMetz
CDKL1inactive (10001nM)-
CDKL2inactive (10001nM)-
CDKL3inactive (10001nM)-
CDKL5inactive (10001nM)-
CMGC - CLK

Bioactivity
KinaseDRxMetz
CLK1inactive (10001nM)-
CLK2inactive (10001nM)-
CLK3inactive (10001nM)-
CLK4inactive (10001nM)-
CMGC - CK2

Bioactivity
KinaseDRxMetz
CK2a1inactive (10001nM)-
CK2a2inactive (10001nM)-
CMGC - DYRK

Bioactivity
KinaseDRxMetz
DYRK1Ainactive (10001nM)-
DYRK1Binactive (10001nM)-
DYRK2active (2100nM)-
HIPK1inactive (10001nM)-
HIPK2inactive (10001nM)-
HIPK3inactive (10001nM)-
HIPK4inactive (8100nM)-
PRP4inactive (10001nM)-
DYRK3--
DYRK4--
CMGC - MAPK

Bioactivity
KinaseDRxMetz
Erk1inactive (10001nM)-
Erk2inactive (10001nM)-
Erk3inactive (4300nM)-
Erk4inactive (10001nM)-
Erk5active (620nM)-
Erk7inactive (4500nM)-
JNK1inactive (10001nM)-
JNK2inactive (10001nM)-
JNK3inactive (10001nM)-
NLKinactive (10001nM)-
p38ainactive (10001nM)-
p38binactive (10001nM)-
p38dinactive (10001nM)-
p38ginactive (10001nM)-
CMGC - GSK

Bioactivity
KinaseDRxMetz
GSK3Ainactive (10001nM)-
GSK3Binactive (10001nM)-
CMGC - RCK

Bioactivity
KinaseDRxMetz
ICKinactive (10001nM)-
MAKinactive (10001nM)-
CMGC - SRPK

Bioactivity
KinaseDRxMetz
SRPK1inactive (10001nM)-
SRPK2inactive (10001nM)-
MSSK1inactive (10001nM)-

CK1


Test Member No. in Family
Familyno. Member on 518kinaseDRxMetz
775
31-
CK1 - CK1

Bioactivity
KinaseDRxMetz
CK1ainactive (10001nM)-
CK1a2inactive (10001nM)-
CK1dinactive (10001nM)inactive (6309.57nM)
CK1einactive (10001nM)-
CK1g1inactive (10001nM)-
CK1g2inactive (10001nM)-
CK1g3inactive (10001nM)-
CK1 - VRK

Bioactivity
KinaseDRxMetz
VRK2inactive (10001nM)-