Compound Information
Test on : GPCR
Compound Name : GW784307A
Inchikey : PMDIOXBUJXUENT-KVQMOARXSA-N
ChemSpider : 28485078
Pubchem CID : 57396353
ChEMBL : CHEMBL1909383
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (18.1%) |
TYK2 | inactive (5.84%) |
JAK2 | inactive (14.07%) |
JAK3 | inactive (15.45%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (1.12%) |
FES | inactive (3.63%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | active (83.09%) |
ABL2 | active (82.05%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (22.03%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (46.32%) |
BTK | inactive (1.98%) |
TXK | inactive (29.35%) |
TEC | inactive (19.6%) |
ITK | inactive (8.64%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | active (53.38%) |
SRM | inactive (19.94%) |
FRK | inactive (12.18%) |
BLK | active (73.04%) |
LCK | active (94.39%) |
HCK | active (68.85%) |
FGR | active (82.08%) |
FYN | active (84.48%) |
SRC | active (89.72%) |
YES | active (86.01%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (5.44%) |
EphA4 | inactive (15.95%) |
EphA3 | inactive (6.35%) |
EphB4 | inactive (30.46%) |
EphB3 | inactive (7.32%) |
EphB2 | inactive (46.38%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (12.08%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (5.44%) |
ZAP70 | inactive (4.14%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (4.37%) |
ALK | inactive (8.56%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (41.67%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (1.97%) |
IGF1R | inactive (4.69%) |
IRR | inactive (1.31%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (40.96%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | active (80.33%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (12.05%) |
TRKB | inactive (26.49%) |
TRKC | inactive (20.66%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | active (66.26%) |
MET | active (55.74%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (40.91%) |
MER | active (59.28%) |
TYRO3 | active (60.58%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | active (66.9%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (9.7%) |
FGFR2 | inactive (10.69%) |
FGFR3 | inactive (9.95%) |
FGFR4 | inactive (4.18%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (37.32%) |
KDR | active (68.65%) |
FLT4 | active (53.46%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (37.75%) |
KIT | active (65.78%) |
FLT3 | active (54.92%) |
PDGFRa | active (74.1%) |
PDGFRb | active (77.56%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (46.37%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (13.15%) |
TNK1 | active (68.35%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | active (56.35%) |
ErbB2 | inactive (10.5%) |
ErbB4 | inactive (49.87%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (1.87%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (27.76%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (21.76%) |
MST1 | inactive (10.11%) |
MST2 | inactive (6.3%) |
MST4 | inactive (0.63%) |
HGK | active (78.06%) |
MINK | active (64.84%) |
LOK | active (61.25%) |
PAK1 | inactive (5.32%) |
PAK3 | inactive (3.69%) |
PAK2 | inactive (1.56%) |
PAK5 | inactive (7.55%) |
PAK6 | inactive (12.92%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (4.04%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (7.14%) |
CK1g2 | inactive (8.69%) |
CK1g1 | inactive (11.65%) |
CK1g3 | inactive (11.91%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (2.1%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (38.63%) |
AurC | active (57%) |
AurA | active (62.74%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (7.24%) |
NEK2 | inactive (1.98%) |
NEK9 | inactive (1.36%) |
NEK7 | inactive (-1.23%) |
NEK6 | inactive (0.35%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (11.18%) |
IKKe | inactive (-5.84%) |
IKKb | inactive (0.86%) |
IKKa | inactive (4.43%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (11.58%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (-8.73%) |
GPRK6 | inactive (-7.47%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (8.14%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (8.01%) |
MSK2 | inactive (4.69%) |
RSK1 | inactive (6.32%) |
RSK2 | inactive (5.65%) |
RSK4 | inactive (6.67%) |
RSK3 | inactive (8.18%) |
p70S6K | inactive (20.88%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (-2.95%) |
AKT1 | inactive (-4.74%) |
AKT3 | inactive (-1.17%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (47.91%) |
SGK3 | inactive (3.92%) |
SGK2 | inactive (40.06%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (0.62%) |
PKCg | inactive (4.05%) |
PKCa | inactive (9.37%) |
PKCt | inactive (1.46%) |
PKCi | inactive (10.31%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (20.49%) |
PKG1 | inactive (1.97%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (5.04%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (7.32%) |
ROCK2 | inactive (9.45%) |
MRCKb | inactive (8.24%) |
MRCKa | inactive (7.78%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (3.14%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (0.78%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (1.87%) |
CaMK1d | inactive (5.99%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (30.48%) |
PHKg2 | inactive (7.38%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (36.06%) |
CaMK2a | inactive (10.45%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (0.52%) |
MAPKAPK2 | inactive (1.08%) |
MAPKAPK3 | inactive (4.06%) |
MNK2 | active (67.54%) |
MNK1 | active (72.87%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (4.71%) |
PKD1 | inactive (7.26%) |
PKD2 | inactive (6.33%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (16.76%) |
MARK3 | inactive (18.36%) |
MARK1 | inactive (16.68%) |
QIK | active (75.95%) |
SIK | active (61.22%) |
NuaK1 | active (77.24%) |
BRSK1 | active (67.18%) |
BRSK2 | active (71.98%) |
MELK | inactive (11.5%) |
CHK1 | inactive (5.69%) |
PASK | inactive (-0.48%) |
AMPKa1 | inactive (12.29%) |
AMPKa2 | inactive (14.51%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (-0.81%) |
TSSK1 | inactive (0.43%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (4.78%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (0.88%) |
PIM3 | inactive (3.82%) |
PIM1 | inactive (8.23%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (3.96%) |
p38a | inactive (11.79%) |
p38b | inactive (3.19%) |
p38d | inactive (23.46%) |
Erk2 | inactive (4.38%) |
Erk1 | inactive (2.75%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | active (82.71%) |
GSK3B | active (79.38%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-2.59%) |
MSSK1 | inactive (0.91%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (31.71%) |
CLK2 | active (73.73%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | active (78.79%) |
HIPK4 | active (75.83%) |
DYRK1B | active (57.06%) |
DYRK1A | active (71.59%) |
DYRK2 | active (66.32%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | active (62.21%) |