Compound Information
Test on : GPCR
Compound Name : CHEMBL241517
Inchikey : PILHXMMEJPSZLL-UHFFFAOYSA-N
ChemSpider : 9456927
Pubchem CID : 11281930
ChEMBL : CHEMBL241517
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (6.91%) |
TYK2 | inactive (-2.5%) |
JAK2 | inactive (1.31%) |
JAK3 | inactive (-0.64%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (29.99%) |
FES | inactive (7.1%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | active (87.57%) |
ABL2 | active (78.44%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | active (73.32%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | active (56.52%) |
BTK | inactive (25.1%) |
TXK | active (91.59%) |
TEC | active (75.22%) |
ITK | inactive (3.69%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (47.46%) |
SRM | inactive (6.75%) |
FRK | inactive (14.18%) |
BLK | inactive (28.16%) |
LCK | active (52.4%) |
HCK | active (76.11%) |
FGR | inactive (45.82%) |
FYN | inactive (32.61%) |
SRC | active (57.07%) |
YES | active (56.37%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | active (89.7%) |
EphA4 | active (92.05%) |
EphA3 | active (68.62%) |
EphB4 | active (87.09%) |
EphB3 | inactive (21.96%) |
EphB2 | active (88.69%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (20.75%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-4.44%) |
ZAP70 | inactive (2.18%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | active (54.58%) |
ALK | inactive (13.85%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (6.78%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (1.76%) |
IGF1R | inactive (1.23%) |
IRR | inactive (4.45%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (11.19%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (1.44%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (2.2%) |
TRKB | inactive (3.28%) |
TRKC | inactive (1.1%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (15.81%) |
MET | inactive (3.25%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-2.44%) |
MER | inactive (10.63%) |
TYRO3 | inactive (25.08%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (48.99%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (16.09%) |
FGFR2 | inactive (32.83%) |
FGFR3 | inactive (23.31%) |
FGFR4 | inactive (5.88%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (14.95%) |
KDR | inactive (34.18%) |
FLT4 | inactive (12.58%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (43.73%) |
KIT | active (98.07%) |
FLT3 | inactive (5.98%) |
PDGFRa | active (72.13%) |
PDGFRb | active (53.44%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (11.08%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (36.6%) |
TNK1 | inactive (35.96%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (14.22%) |
ErbB2 | inactive (6.32%) |
ErbB4 | inactive (29.55%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (2.08%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (15.28%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (31.35%) |
MST1 | inactive (6.44%) |
MST2 | inactive (6.15%) |
MST4 | inactive (2.44%) |
HGK | active (92.6%) |
MINK | active (91.6%) |
LOK | inactive (24.66%) |
PAK1 | inactive (5.65%) |
PAK3 | inactive (3.51%) |
PAK2 | inactive (1.78%) |
PAK5 | inactive (3.74%) |
PAK6 | inactive (-1.87%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (6.87%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (36.55%) |
CK1g2 | inactive (3.79%) |
CK1g1 | inactive (4.15%) |
CK1g3 | inactive (4.97%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (2.5%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (14.69%) |
AurC | inactive (24.59%) |
AurA | inactive (5.8%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (3.98%) |
NEK2 | inactive (4.74%) |
NEK9 | inactive (-0.67%) |
NEK7 | inactive (-0.15%) |
NEK6 | inactive (3.81%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (3.47%) |
IKKe | inactive (6.28%) |
IKKb | inactive (5.65%) |
IKKa | inactive (-3.58%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (14.26%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (6.1%) |
GPRK6 | inactive (-0.33%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (-0.19%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (0.77%) |
MSK2 | inactive (2.86%) |
RSK1 | inactive (6.15%) |
RSK2 | inactive (2.98%) |
RSK4 | inactive (3.24%) |
RSK3 | inactive (2.68%) |
p70S6K | inactive (0.72%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (2.33%) |
AKT1 | inactive (1.09%) |
AKT3 | inactive (5.34%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (2.35%) |
SGK3 | inactive (0.56%) |
SGK2 | inactive (4.55%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (6.59%) |
PKCg | inactive (2.77%) |
PKCa | inactive (2.74%) |
PKCt | inactive (2.11%) |
PKCi | inactive (2.27%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (1.46%) |
PKG1 | inactive (-0.14%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (1.14%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (1.47%) |
ROCK2 | inactive (2.92%) |
MRCKb | inactive (0.71%) |
MRCKa | inactive (7.9%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (7.7%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (0.61%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (1.03%) |
CaMK1d | inactive (0.88%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (5.24%) |
PHKg2 | inactive (6.66%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (2.95%) |
CaMK2a | inactive (0.53%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (1.77%) |
MAPKAPK2 | inactive (1.12%) |
MAPKAPK3 | inactive (15.66%) |
MNK2 | inactive (6.22%) |
MNK1 | inactive (4.48%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (33.1%) |
PKD1 | inactive (35.02%) |
PKD2 | inactive (43.82%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (5.58%) |
MARK3 | inactive (5.19%) |
MARK1 | inactive (5.62%) |
QIK | inactive (28.77%) |
SIK | active (61.01%) |
NuaK1 | inactive (2.44%) |
BRSK1 | inactive (5.62%) |
BRSK2 | inactive (6.56%) |
MELK | inactive (2.9%) |
CHK1 | inactive (2.44%) |
PASK | inactive (1.05%) |
AMPKa1 | inactive (4.69%) |
AMPKa2 | inactive (4.34%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (2.51%) |
TSSK1 | inactive (4.96%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (3.2%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (0.78%) |
PIM3 | inactive (0.91%) |
PIM1 | inactive (0.67%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (20.53%) |
p38a | active (55.87%) |
p38b | active (62.26%) |
p38d | inactive (1.94%) |
Erk2 | inactive (7.98%) |
Erk1 | inactive (5.48%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (4.87%) |
GSK3B | inactive (3.65%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-3.1%) |
MSSK1 | inactive (0.1%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (0.34%) |
CLK2 | inactive (-0.72%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (3.02%) |
HIPK4 | inactive (4.49%) |
DYRK1B | inactive (0.74%) |
DYRK1A | inactive (3.66%) |
DYRK2 | inactive (2.46%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (3.4%) |