Compound Information
Test on : GPCR
Compound Name : GW827106X
Inchikey : PHMQSKGFSDGFMK-UHFFFAOYSA-N
ChemSpider : 5021880
Pubchem CID : 6539414
ChEMBL : CHEMBL188257
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (1.48%) |
TYK2 | inactive (-1.85%) |
JAK2 | inactive (-0.78%) |
JAK3 | inactive (-0.04%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (11.81%) |
FES | inactive (7.51%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (25.8%) |
ABL2 | inactive (33.17%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (2.25%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (8.65%) |
BTK | inactive (3.53%) |
TXK | inactive (3.19%) |
TEC | inactive (11.93%) |
ITK | inactive (0.71%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | active (67.52%) |
SRM | inactive (0.99%) |
FRK | inactive (3.44%) |
BLK | inactive (39.54%) |
LCK | active (66.84%) |
HCK | inactive (45.98%) |
FGR | active (79.76%) |
FYN | inactive (36.61%) |
SRC | active (51.66%) |
YES | active (95.75%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (0.86%) |
EphA4 | inactive (13.77%) |
EphA3 | inactive (0.38%) |
EphB4 | inactive (15.59%) |
EphB3 | inactive (6.41%) |
EphB2 | inactive (35%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (10.22%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-0.41%) |
ZAP70 | inactive (-0.83%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (23.51%) |
ALK | inactive (35.24%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (21.88%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (24.09%) |
IGF1R | inactive (7.28%) |
IRR | inactive (3.24%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | active (79.76%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (-1.95%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (20.2%) |
TRKB | inactive (18.74%) |
TRKC | inactive (6.72%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (8.88%) |
MET | inactive (8.57%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (8.45%) |
MER | inactive (12.89%) |
TYRO3 | inactive (9.92%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (47.32%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (11.24%) |
FGFR2 | inactive (22.09%) |
FGFR3 | inactive (12.58%) |
FGFR4 | inactive (1.91%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (26.84%) |
KDR | active (64.04%) |
FLT4 | active (56.35%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | active (66.75%) |
KIT | active (85.24%) |
FLT3 | inactive (-0.57%) |
PDGFRa | inactive (29.55%) |
PDGFRb | inactive (20.62%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (45.88%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (3.47%) |
TNK1 | active (51.11%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (34.09%) |
ErbB2 | inactive (17.18%) |
ErbB4 | active (107.71%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (-0.94%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (5.07%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (4.16%) |
MST1 | inactive (1.99%) |
MST2 | inactive (-0.28%) |
MST4 | inactive (0.26%) |
HGK | inactive (9.82%) |
MINK | inactive (7.26%) |
LOK | active (55.08%) |
PAK1 | inactive (-2.26%) |
PAK3 | inactive (1.51%) |
PAK2 | inactive (0.11%) |
PAK5 | inactive (-5%) |
PAK6 | inactive (-1.85%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (1.59%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (3.14%) |
CK1g2 | inactive (3.08%) |
CK1g1 | inactive (3.57%) |
CK1g3 | inactive (1.38%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (2.45%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (17.37%) |
AurC | inactive (46.76%) |
AurA | active (63.19%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (2.9%) |
NEK2 | inactive (3.9%) |
NEK9 | inactive (8.39%) |
NEK7 | inactive (1.38%) |
NEK6 | inactive (0.26%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (1.43%) |
IKKe | inactive (-0.27%) |
IKKb | inactive (1.7%) |
IKKa | inactive (1.71%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (11.57%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (2.81%) |
GPRK6 | inactive (-1.49%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (0.74%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (-0.38%) |
MSK2 | inactive (-0.23%) |
RSK1 | inactive (-1.03%) |
RSK2 | inactive (0.87%) |
RSK4 | inactive (2.56%) |
RSK3 | inactive (0.17%) |
p70S6K | inactive (-0.95%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (-0.18%) |
AKT1 | inactive (-0.09%) |
AKT3 | inactive (2.32%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (1.98%) |
SGK3 | inactive (0.46%) |
SGK2 | inactive (0.9%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (2.32%) |
PKCg | inactive (3.96%) |
PKCa | inactive (0.51%) |
PKCt | inactive (2.58%) |
PKCi | inactive (0.67%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (-1.06%) |
PKG1 | inactive (-2.7%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (-0.08%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (0.84%) |
ROCK2 | inactive (1.51%) |
MRCKb | - |
MRCKa | inactive (-2.49%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (0.02%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (-0.74%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (-0.47%) |
CaMK1d | inactive (0.03%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (6.21%) |
PHKg2 | inactive (0.83%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (0.2%) |
CaMK2a | inactive (-2.04%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (-0.76%) |
MAPKAPK2 | inactive (0.03%) |
MAPKAPK3 | inactive (36.99%) |
MNK2 | inactive (1.25%) |
MNK1 | inactive (0.14%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (8.59%) |
PKD1 | inactive (6.6%) |
PKD2 | inactive (9.73%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (0.93%) |
MARK3 | inactive (1.83%) |
MARK1 | inactive (2.66%) |
QIK | inactive (6.1%) |
SIK | inactive (12.54%) |
NuaK1 | inactive (2.67%) |
BRSK1 | inactive (2.44%) |
BRSK2 | inactive (1.64%) |
MELK | inactive (2.58%) |
CHK1 | inactive (-1.19%) |
PASK | inactive (0.37%) |
AMPKa1 | inactive (1.64%) |
AMPKa2 | inactive (0.38%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (-0.78%) |
TSSK1 | inactive (-0.16%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (2.06%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (1.11%) |
PIM3 | inactive (2.15%) |
PIM1 | inactive (-0.36%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | active (64.64%) |
p38a | active (86.99%) |
p38b | active (75.37%) |
p38d | inactive (-1.08%) |
Erk2 | inactive (0.95%) |
Erk1 | inactive (1.27%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (2.53%) |
GSK3B | inactive (5.33%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-2.72%) |
MSSK1 | inactive (-0.23%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (-0.46%) |
CLK2 | inactive (0.98%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (-0.07%) |
HIPK4 | inactive (-1.16%) |
DYRK1B | inactive (-3.65%) |
DYRK1A | inactive (-2.81%) |
DYRK2 | inactive (-3.08%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (3.92%) |