Compound Information
Test on : GPCR
Compound Name : GSK711701A
Inchikey : PGMGCWOOCLJXIF-UHFFFAOYSA-N
ChemSpider : 23285840
Pubchem CID : 25190926
ChEMBL : CHEMBL268885
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (3.15%) |
TYK2 | inactive (-6.53%) |
JAK2 | inactive (3.05%) |
JAK3 | inactive (-0.75%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (5.66%) |
FES | inactive (5.26%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (3.54%) |
ABL2 | inactive (3.9%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (4.45%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (6.04%) |
BTK | inactive (-0.85%) |
TXK | inactive (4.4%) |
TEC | inactive (3.79%) |
ITK | inactive (2.4%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (4.09%) |
SRM | inactive (-2.15%) |
FRK | inactive (3.5%) |
BLK | inactive (3.34%) |
LCK | inactive (2.89%) |
HCK | inactive (7.93%) |
FGR | inactive (2.86%) |
FYN | inactive (2.81%) |
SRC | inactive (14.63%) |
YES | inactive (4.52%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (1.53%) |
EphA4 | inactive (10.13%) |
EphA3 | inactive (4.11%) |
EphB4 | inactive (3.61%) |
EphB3 | inactive (4.65%) |
EphB2 | inactive (8.13%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (12.06%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (4.05%) |
ZAP70 | inactive (4.12%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (6.74%) |
ALK | inactive (7.26%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (14.61%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (5.04%) |
IGF1R | inactive (4.41%) |
IRR | inactive (3.46%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (2.64%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (7.45%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (4.22%) |
TRKB | inactive (3.12%) |
TRKC | inactive (2.2%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (6.97%) |
MET | inactive (5.98%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-6.03%) |
MER | inactive (6.71%) |
TYRO3 | inactive (2.96%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (4.87%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (7.58%) |
FGFR2 | inactive (5.85%) |
FGFR3 | inactive (6.87%) |
FGFR4 | inactive (2.25%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (2.07%) |
KDR | inactive (9.32%) |
FLT4 | inactive (0.39%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (4.74%) |
KIT | inactive (11.17%) |
FLT3 | inactive (3.25%) |
PDGFRa | inactive (9.97%) |
PDGFRb | inactive (1.5%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (7.54%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (3.03%) |
TNK1 | inactive (3.9%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (2.79%) |
ErbB2 | inactive (4.75%) |
ErbB4 | inactive (12.93%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (1.85%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (8.57%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (2.11%) |
MST1 | inactive (4.76%) |
MST2 | inactive (4.15%) |
MST4 | inactive (1.45%) |
HGK | inactive (5.7%) |
MINK | inactive (7.24%) |
LOK | inactive (6.24%) |
PAK1 | inactive (12.11%) |
PAK3 | inactive (7.97%) |
PAK2 | inactive (2.55%) |
PAK5 | inactive (3.56%) |
PAK6 | inactive (-4.53%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (3.65%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (12.56%) |
CK1g2 | inactive (5.53%) |
CK1g1 | inactive (6.12%) |
CK1g3 | inactive (5.9%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (8.71%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (3.28%) |
AurC | inactive (0.52%) |
AurA | inactive (3.86%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (4.16%) |
NEK2 | inactive (5.43%) |
NEK9 | inactive (5.67%) |
NEK7 | inactive (10.43%) |
NEK6 | inactive (1.71%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (3.5%) |
IKKe | inactive (5.47%) |
IKKb | inactive (4.61%) |
IKKa | inactive (1.32%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (12.89%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (2.21%) |
GPRK6 | inactive (7.23%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (3.93%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (3.81%) |
MSK2 | inactive (5.79%) |
RSK1 | inactive (2.12%) |
RSK2 | inactive (2.53%) |
RSK4 | inactive (3.2%) |
RSK3 | inactive (2.98%) |
p70S6K | inactive (4.29%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (1.74%) |
AKT1 | inactive (2.28%) |
AKT3 | inactive (3.15%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (2.71%) |
SGK3 | inactive (3%) |
SGK2 | inactive (5%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (5.18%) |
PKCg | inactive (4.7%) |
PKCa | inactive (1.5%) |
PKCt | inactive (3.92%) |
PKCi | inactive (0.99%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (8.49%) |
PKG1 | inactive (9.49%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (3.72%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (3.19%) |
ROCK2 | inactive (5.06%) |
MRCKb | inactive (2.36%) |
MRCKa | inactive (4.98%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (10.51%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (2.52%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (3.77%) |
CaMK1d | inactive (3.09%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (3.12%) |
PHKg2 | inactive (5.17%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (8.49%) |
CaMK2a | inactive (6.07%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (2.31%) |
MAPKAPK2 | inactive (3.46%) |
MAPKAPK3 | inactive (8.63%) |
MNK2 | inactive (5.44%) |
MNK1 | inactive (11.2%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (4.42%) |
PKD1 | inactive (5.66%) |
PKD2 | inactive (1.99%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (1.37%) |
MARK3 | inactive (2.07%) |
MARK1 | inactive (1.61%) |
QIK | inactive (6.93%) |
SIK | inactive (16.1%) |
NuaK1 | inactive (1.1%) |
BRSK1 | inactive (-0.57%) |
BRSK2 | inactive (1.59%) |
MELK | inactive (14.58%) |
CHK1 | inactive (1.33%) |
PASK | inactive (-1.49%) |
AMPKa1 | inactive (4.47%) |
AMPKa2 | inactive (3.24%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (2.89%) |
TSSK1 | inactive (5.11%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (0.56%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (-0.88%) |
PIM3 | inactive (0.43%) |
PIM1 | inactive (2.23%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (8.22%) |
p38a | inactive (10.28%) |
p38b | inactive (4.22%) |
p38d | inactive (6.61%) |
Erk2 | inactive (5.86%) |
Erk1 | inactive (5.76%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (2.57%) |
GSK3B | inactive (2.65%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-1.89%) |
MSSK1 | inactive (0.68%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (0.31%) |
CLK2 | inactive (5.16%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (-0.59%) |
HIPK4 | inactive (1.94%) |
DYRK1B | inactive (-0.01%) |
DYRK1A | inactive (4.97%) |
DYRK2 | inactive (8.4%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (3.63%) |