Compound in Profiling

Compound Information

Test on : RBC, Metz, Millipore

Compound Name
RBC, Metz, Millipore : alsterpaullone

Inchikey
Same : OLUKILHGKRVDCT-N
RBC, Metz, Millipore : OLUKILHGKRVDCT-UHFFFAOYSA-N

ChemSpider
RBC, Metz, Millipore : 4185120

Pubchem CID
RBC, Metz, Millipore : 5005498

ChEMBL
RBC, Metz, Millipore : CHEMBL50894

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
PDK1	1	1	1	1
Akt	3	3	3	3
DMPK	7	5	3	5
GRK	7	6	1	3
RSK	8	8	4	7
PKA	5	3	2	2
PKC	9	9	5	8
PKG	2	3	2	-
PKN	3	2	1	1
SGK	3	3	1	3
NDR	4	1	-	-

AGC - PDK1

Bioactivity
Kinase	RBC	Metz	Millipore
PDK1	inactive (93.67%)	active (125.89nM)	active (45%)

AGC - Akt

Bioactivity
Kinase	RBC	Metz	Millipore
AKT1	inactive (107.28%)	inactive (>7943.28nM)	inactive (104%)
AKT2	inactive (101.44%)	inactive (>7943.28nM)	inactive (115%)
AKT3	inactive (94.15%)	inactive (>10000nM)	inactive (118%)

AGC - DMPK

Bioactivity
Kinase	RBC	Metz	Millipore
DMPK1	inactive (91.57%)	-	inactive (102%)
MRCKa	inactive (96.21%)	active (199.53nM)	inactive (60%)
MRCKb	inactive (83.31%)	-	active (48%)
ROCK1	inactive (91.22%)	inactive (1584.89nM)	inactive (107%)
ROCK2	inactive (82.03%)	inactive (1995.26nM)	inactive (85%)

AGC - GRK

Bioactivity
Kinase	RBC	Metz	Millipore
BARK1	inactive (91.78%)	-	-
BARK2	inactive (88.91%)	-	-
GPRK4	inactive (99.26%)	-	-
GPRK5	inactive (106.66%)	inactive (>3981.07nM)	inactive (98%)
GPRK6	inactive (93.79%)	-	inactive (93%)
GPRK7	inactive (98.96%)	-	inactive (97%)

AGC - RSK

Bioactivity
Kinase	RBC	Metz	Millipore
MSK1	inactive (106.86%)	inactive (>1584.89nM)	inactive (108%)
MSK2	inactive (90.64%)	-	inactive (96%)
p70S6K	inactive (102.56%)	inactive (3981.07nM)	inactive (106%)
p70S6Kb	inactive (96.5%)	-	-
RSK2	inactive (70.57%)	inactive (>5011.87nM)	inactive (56%)
RSK4	active (38.04%)	-	inactive (64%)
RSK1	inactive (89.72%)	-	active (38%)
RSK3	inactive (62.01%)	-	inactive (106%)

AGC - PKA

Bioactivity
Kinase	RBC	Metz	Millipore
PKACg	-	-	-
PRKX	inactive (74.53%)	inactive (>1995.26nM)	inactive (81%)
PKACa	inactive (87.44%)	inactive (>3981.07nM)	inactive (92%)

AGC - PKC

Bioactivity
Kinase	RBC	Metz	Millipore
PKCa	inactive (59.88%)	-	inactive (100%)
PKCd	inactive (79.83%)	inactive (3162.28nM)	inactive (108%)
PKCe	inactive (110.93%)	-	inactive (91%)
PKCh	inactive (96.89%)	-	inactive (94%)
PKCg	inactive (92.48%)	inactive (>7943.28nM)	inactive (98%)
PKCi	inactive (83.27%)	-	inactive (104%)
PKCt	inactive (98.23%)	inactive (>2511.89nM)	inactive (101%)
PKCz	inactive (108.51%)	inactive (>7943.28nM)	inactive (101%)
PKCb	inactive (105.04%)	-	-

AGC - PKG

Bioactivity
Kinase	RBC	Metz	Millipore
PKG2	inactive (97.58%)	inactive (>1584.89nM)	-
PKG1	inactive (94.27%)	inactive (>1995.26nM)	-

AGC - PKN

Bioactivity
Kinase	RBC	Metz	Millipore
PKN1	inactive (88.22%)	-	-
PKN2	inactive (74.51%)	active (794.33nM)	inactive (98%)

AGC - SGK

Bioactivity
Kinase	RBC	Metz	Millipore
SGK1	inactive (96.04%)	inactive (>10000nM)	inactive (97%)
SGK2	inactive (110.67%)	-	inactive (65%)
SGK3	inactive (102.33%)	-	inactive (96%)

AGC - NDR

Bioactivity
Kinase	RBC	Metz	Millipore
NDR1	active (0%)	-	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
Abl	2	2	1	2
Ack	2	1	1	1
ALK	2	2	2	1
Axl	3	3	2	3
Src	11	11	9	10
Tec	5	5	3	4
PDGFR	5	5	5	5
Csk	2	2	1	1
DDR	2	1	-	1
EGFR	4	3	3	2
Eph	14	12	1	11
FAK	2	2	2	2
Fer	2	2	2	2
FGFR	4	4	2	4
VEGFR	3	3	3	3
InsR	3	3	2	3
JakA	4	4	3	2
Musk	1	1	-	1
Ret	1	1	1	1
Met	2	2	2	2
Sev	1	1	1	1
Syk	2	2	1	2
Tie	2	1	-	1
Trk	3	3	3	2

TK - Abl

Bioactivity
Kinase	RBC	Metz	Millipore
ABL1	inactive (57.65%)	inactive (1584.89nM)	active (47%)
ABL2	inactive (54.6%)	-	inactive (81%)

TK - Ack

Bioactivity
Kinase	RBC	Metz	Millipore
ACK	inactive (74.85%)	inactive (>3981.07nM)	active (44%)

TK - ALK

Bioactivity
Kinase	RBC	Metz	Millipore
ALK	inactive (94.17%)	inactive (>3981.07nM)	inactive (88%)
LTK	inactive (93.89%)	inactive (>2511.89nM)	-

TK - Axl

Bioactivity
Kinase	RBC	Metz	Millipore
AXL	inactive (100.21%)	inactive (>1995.26nM)	inactive (91%)
MER	inactive (83.11%)	-	inactive (100%)
TYRO3	inactive (96.69%)	inactive (>3162.28nM)	inactive (94%)

TK - Src

Bioactivity
Kinase	RBC	Metz	Millipore
BLK	inactive (94.17%)	inactive (1258.93nM)	active (29%)
BRK	inactive (92.7%)	inactive (>2511.89nM)	inactive (111%)
SRC	active (39.66%)	active (398.11nM)	inactive (53%)
FGR	inactive (50.3%)	-	active (40%)
FRK	inactive (97.15%)	-	inactive (67%)
FYN	inactive (53.08%)	inactive (>3162.28nM)	active (20%)
HCK	inactive (71.75%)	-	active (41%)
LCK	inactive (81.18%)	inactive (>3162.28nM)	active (22%)
SRM	inactive (92.88%)	-	-
YES	active (42.35%)	-	inactive (56%)
LYN	active (37.15%)	active (501.19nM)	active (6%)

TK - Tec

Bioactivity
Kinase	RBC	Metz	Millipore
BMX	inactive (109.51%)	-	inactive (74%)
BTK	inactive (98.16%)	inactive (>6309.57nM)	inactive (87%)
ITK	inactive (97.07%)	inactive (>1584.89nM)	inactive (90%)
TEC	inactive (137.38%)	-	-
TXK	inactive (87.27%)	-	active (49%)

TK - PDGFR

Bioactivity
Kinase	RBC	Metz	Millipore
KIT	inactive (83.71%)	inactive (>1258.93nM)	inactive (110%)
FLT3	active (19.65%)	inactive (>2511.89nM)	active (30%)
FMS	inactive (50.97%)	active (1000nM)	active (33%)
PDGFRb	inactive (87.44%)	inactive (>1995.26nM)	inactive (107%)
PDGFRa	inactive (91.75%)	inactive (>2511.89nM)	inactive (109%)

TK - Csk

Bioactivity
Kinase	RBC	Metz	Millipore
CSK	inactive (96.6%)	-	inactive (104%)
CTK	inactive (98.86%)	-	-

TK - DDR

Bioactivity
Kinase	RBC	Metz	Millipore
DDR2	inactive (102.92%)	-	inactive (101%)

TK - EGFR

Bioactivity
Kinase	RBC	Metz	Millipore
EGFR	inactive (86.91%)	inactive (>1000nM)	inactive (96%)
ErbB2	inactive (94.83%)	inactive (>1584.89nM)	-
ErbB4	inactive (87.33%)	inactive (>3981.07nM)	inactive (93%)

TK - Eph

Bioactivity
Kinase	RBC	Metz	Millipore
EphA1	inactive (94.84%)	-	inactive (109%)
EphA2	inactive (92.66%)	inactive (>7943.28nM)	inactive (97%)
EphA3	inactive (97.82%)	-	inactive (90%)
EphA4	inactive (96.49%)	-	inactive (105%)
EphA5	inactive (98.6%)	-	inactive (102%)
EphA6	-	-	-
EphA7	inactive (95.02%)	-	inactive (86%)
EphA8	inactive (103.64%)	-	inactive (94%)
EphB1	inactive (111.51%)	-	inactive (89%)
EphB2	inactive (101.26%)	-	inactive (106%)
EphB3	inactive (102.94%)	-	inactive (124%)
EphB4	inactive (87.23%)	-	inactive (97%)

TK - FAK

Bioactivity
Kinase	RBC	Metz	Millipore
FAK	inactive (88.07%)	inactive (>3162.28nM)	inactive (86%)
PYK2	inactive (82.92%)	inactive (>1584.89nM)	active (45%)

TK - Fer

Bioactivity
Kinase	RBC	Metz	Millipore
FER	inactive (75.14%)	-	inactive (96%)
FES	active (46.28%)	-	active (35%)

TK - FGFR

Bioactivity
Kinase	RBC	Metz	Millipore
FGFR1	inactive (88.62%)	inactive (3981.07nM)	inactive (74%)
FGFR2	inactive (96.73%)	-	inactive (106%)
FGFR3	inactive (90.53%)	inactive (>1995.26nM)	inactive (125%)
FGFR4	inactive (90.62%)	-	inactive (112%)

TK - VEGFR

Bioactivity
Kinase	RBC	Metz	Millipore
FLT1	inactive (98.21%)	inactive (>1995.26nM)	active (49%)
FLT4	inactive (77.82%)	active (158.49nM)	active (29%)
KDR	inactive (87.77%)	inactive (>1584.89nM)	inactive (52%)

TK - InsR

Bioactivity
Kinase	RBC	Metz	Millipore
IGF1R	inactive (93.01%)	inactive (>1995.26nM)	inactive (78%)
IRR	inactive (94.54%)	-	inactive (121%)
INSR	inactive (101.05%)	inactive (>5011.87nM)	inactive (112%)

TK - JakA

Bioactivity
Kinase	RBC	Metz	Millipore
JAK1	inactive (97.84%)	-	-
JAK2	inactive (102.71%)	inactive (>1584.89nM)	inactive (103%)
JAK3	inactive (99.73%)	inactive (>2511.89nM)	inactive (101%)
TYK2	inactive (56.54%)	inactive (>1995.26nM)	-

TK - Musk

Bioactivity
Kinase	RBC	Metz	Millipore
MUSK	inactive (68.5%)	-	inactive (70%)

TK - Ret

Bioactivity
Kinase	RBC	Metz	Millipore
RET	inactive (81.56%)	inactive (>1995.26nM)	inactive (103%)

TK - Met

Bioactivity
Kinase	RBC	Metz	Millipore
RON	inactive (103.1%)	active (1000nM)	inactive (100%)
MET	inactive (116.75%)	inactive (>1995.26nM)	inactive (80%)

TK - Sev

Bioactivity
Kinase	RBC	Metz	Millipore
ROS	inactive (80.19%)	-	inactive (106%)

TK - Syk

Bioactivity
Kinase	RBC	Metz	Millipore
SYK	inactive (53.9%)	-	inactive (93%)
ZAP70	inactive (91.43%)	-	inactive (125%)

TK - Tie

Bioactivity
Kinase	RBC	Metz	Millipore
TIE2	inactive (92.06%)	-	inactive (98%)

TK - Trk

Bioactivity
Kinase	RBC	Metz	Millipore
TRKA	inactive (106.67%)	inactive (>2511.89nM)	inactive (72%)
TRKB	inactive (86.07%)	inactive (>3981.07nM)	inactive (80%)
TRKC	inactive (63.41%)	inactive (>3162.28nM)	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
STKR	12	5	1	2
RAF	5	3	1	1
IRAK	4	2	2	2
LISK	4	1	1	1
LRRK	2	1	1	-
MLK	10	5	2	2
RIPK	5	1	-	1

TKL - STKR

Bioactivity
Kinase	RBC	Metz	Millipore
ALK1	inactive (76.17%)	-	-
ALK2	inactive (79.69%)	active (63.1nM)	-
ALK4	inactive (109.27%)	-	inactive (97%)
TGFbR1	inactive (103.39%)	-	inactive (89%)
TGFbR2	active (19.42%)	-	-

TKL - RAF

Bioactivity
Kinase	RBC	Metz	Millipore
ARAF	inactive (96.19%)	-	-
BRAF	inactive (99.48%)	-	-
RAF1	inactive (114.44%)	-	inactive (93%)

TKL - IRAK

Bioactivity
Kinase	RBC	Metz	Millipore
IRAK1	inactive (93.06%)	active (794.33nM)	inactive (92%)
IRAK4	inactive (166.7%)	inactive (>10000nM)	inactive (78%)

TKL - LISK

Bioactivity
Kinase	RBC	Metz	Millipore
LIMK1	inactive (94.26%)	inactive (>5011.87nM)	inactive (98%)

TKL - LRRK

Bioactivity
Kinase	RBC	Metz	Millipore
LRRK2	inactive (96.48%)	inactive (>2511.89nM)	-

TKL - MLK

Bioactivity
Kinase	RBC	Metz	Millipore
MLK1	active (10.49%)	-	active (7%)
MLK2	active (48.59%)	-	-
MLK3	active (11.81%)	-	-
TAK1	inactive (67.53%)	-	inactive (84%)
ZAK	inactive (91.25%)	inactive (6309.57nM)	-

TKL - RIPK

Bioactivity
Kinase	RBC	Metz	Millipore
RIPK2	active (43.43%)	-	inactive (53%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
CAMKL	20	13	9	12
CAMK1	5	5	2	3
CAMK2	4	4	4	3
RAD53	1	1	1	1
DAPK	5	4	2	4
DCAMKL	3	1	1	1
MAPKAPK	5	5	4	4
MLCK	5	2	-	1
PHK	2	2	1	1
PIM	3	3	3	3
PKD	3	3	2	2
TSSK	5	2	2	2
STK33	1	-	1	-

CAMK - CAMKL

Bioactivity
Kinase	RBC	Metz	Millipore
NuaK1	active (11.97%)	-	active (10%)
BRSK1	active (39.71%)	active (158.49nM)	inactive (83%)
BRSK2	active (34.49%)	-	active (32%)
CHK1	active (37.46%)	inactive (>1584.89nM)	active (39%)
LKB1	inactive (90.23%)	-	inactive (101%)
MARK1	inactive (62.54%)	-	active (34%)
MARK3	inactive (67.66%)	active (630.96nM)	-
MARK4	inactive (55.45%)	-	-
MELK	inactive (71.72%)	inactive (>1584.89nM)	inactive (81%)
PASK	inactive (86.88%)	active (398.11nM)	inactive (96%)
QIK	inactive (56.5%)	-	-
NuaK2	inactive (68.61%)	-	-
MARK2	inactive (52.37%)	active (398.11nM)	inactive (58%)
AMPKa1	-	inactive (>1584.89nM)	active (48%)
AMPKa2	-	-	active (18%)
SIK	-	-	inactive (100%)

CAMK - CAMK1

Bioactivity
Kinase	RBC	Metz	Millipore
CaMK1a	inactive (94.78%)	inactive (>3981.07nM)	inactive (95%)
CaMK1b	inactive (106.95%)	-	-
CaMK1d	-	inactive (>2511.89nM)	inactive (114%)
CaMK1g	inactive (96.01%)	-	-
CaMK4	inactive (89.16%)	-	inactive (114%)

CAMK - CAMK2

Bioactivity
Kinase	RBC	Metz	Millipore
CaMK2a	inactive (88.37%)	inactive (>3981.07nM)	-
CaMK2b	inactive (98.14%)	inactive (>7943.28nM)	inactive (61%)
CaMK2d	inactive (79.28%)	inactive (1995.26nM)	active (32%)
CaMK2g	inactive (94.52%)	inactive (>6309.57nM)	active (24%)

CAMK - RAD53

Bioactivity
Kinase	RBC	Metz	Millipore
CHK2	active (7.9%)	active (19.95nM)	active (3%)

CAMK - DAPK

Bioactivity
Kinase	RBC	Metz	Millipore
DAPK1	inactive (103.52%)	-	inactive (91%)
DAPK2	inactive (97.19%)	-	inactive (85%)
DRAK1	active (46.41%)	-	active (10%)
DAPK3	inactive (102.79%)	inactive (>3162.28nM)	inactive (96%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC	Metz	Millipore
DCLK2	inactive (104.88%)	-	inactive (94%)
DCLK1	-	inactive (>10000nM)	-

CAMK - MAPKAPK

Bioactivity
Kinase	RBC	Metz	Millipore
MAPKAPK2	inactive (77.41%)	inactive (>7943.28nM)	inactive (69%)
MAPKAPK3	inactive (96.99%)	inactive (>10000nM)	inactive (75%)
MAPKAPK5	inactive (92.73%)	inactive (>1258.93nM)	inactive (80%)
MNK1	inactive (76.9%)	-	-
MNK2	inactive (92.88%)	inactive (>10000nM)	inactive (84%)

CAMK - MLCK

Bioactivity
Kinase	RBC	Metz	Millipore
smMLCK	inactive (88.83%)	-	inactive (93%)
skMLCK	inactive (94.85%)	-	-

CAMK - PHK

Bioactivity
Kinase	RBC	Metz	Millipore
PHKg1	active (9.22%)	-	-
PHKg2	inactive (101.41%)	inactive (1258.93nM)	inactive (94%)

CAMK - PIM

Bioactivity
Kinase	RBC	Metz	Millipore
PIM1	inactive (92.02%)	inactive (2511.89nM)	inactive (97%)
PIM2	inactive (112.72%)	inactive (>1584.89nM)	inactive (119%)
PIM3	inactive (62.33%)	-	inactive (102%)

CAMK - PKD

Bioactivity
Kinase	RBC	Metz	Millipore
PKD1	inactive (95.58%)	-	inactive (93%)
PKD3	inactive (88.23%)	inactive (>2511.89nM)	-
PKD2	inactive (100.71%)	inactive (>10000nM)	inactive (97%)

CAMK - TSSK

Bioactivity
Kinase	RBC	Metz	Millipore
TSSK1	inactive (74.69%)	inactive (>1584.89nM)	inactive (76%)
TSSK2	inactive (88.31%)	active (1000nM)	inactive (84%)

CAMK - STK33

Bioactivity
Kinase	RBC	Metz	Millipore
STK33	inactive (79.95%)	-	inactive (89%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
STE11	8	3	-	1
STE-Unique	2	2	-	-
STE20	31	23	9	14
STE7	7	3	2	3

STE - STE11

Bioactivity
Kinase	RBC	Metz	Millipore
MAP3K5	inactive (101.42%)	-	inactive (106%)
MAP3K2	inactive (78.03%)	-	-
MAP3K3	inactive (100.39%)	-	-

STE - STE-Unique

Bioactivity
Kinase	RBC	Metz	Millipore
COT	inactive (99.03%)	-	-
NIK	inactive (131.82%)	-	-

STE - STE20

Bioactivity
Kinase	RBC	Metz	Millipore
GCK	active (8.77%)	active (125.89nM)	active (2%)
HGK	active (4.47%)	active (39.81nM)	-
KHS1	active (15.93%)	active (79.43nM)	-
LOK	inactive (80.37%)	-	inactive (102%)
MINK	active (20.35%)	active (79.43nM)	inactive (60%)
MST1	inactive (52.31%)	-	active (33%)
MST2	inactive (70.3%)	active (199.53nM)	inactive (71%)
MST3	inactive (66.39%)	-	inactive (51%)
MST4	inactive (78.59%)	-	-
OSR1	inactive (97.03%)	-	-
PAK1	active (36.7%)	inactive (>10000nM)	-
PAK2	active (40.98%)	-	active (43%)
PAK3	inactive (80.44%)	-	active (37%)
PAK4	inactive (93.9%)	active (794.33nM)	active (22%)
PAK5	inactive (71.41%)	-	active (24%)
PAK6	inactive (101.18%)	-	inactive (61%)
SLK	inactive (96.17%)	inactive (>6309.57nM)	-
YSK1	inactive (83.64%)	-	-
STLK3	inactive (77.52%)	-	-
TAO1	inactive (66.85%)	inactive (>3162.28nM)	inactive (54%)
TAO2	inactive (88.86%)	-	inactive (78%)
TAO3	inactive (76.69%)	-	inactive (87%)
MYO3B	active (0%)	-	-

STE - STE7

Bioactivity
Kinase	RBC	Metz	Millipore
MAP2K1	inactive (92.59%)	inactive (>3162.28nM)	inactive (103%)
MAP2K2	inactive (92.47%)	inactive (>3981.07nM)	-
MAP2K6	inactive (98.31%)	-	inactive (79%)
MAP2K7	-	-	inactive (73%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
Aur	3	3	2	3
CAMKK	2	2	1	-
Haspin	1	1	-	1
IKK	4	4	4	3
NEK	11	8	2	5
TOPK	1	1	1	-
PLK	4	3	3	3
SgK496	1	1	-	-
NAK	4	1	-	-
TTK	1	1	-	-
ULK	5	3	-	2
WEE	3	1	1	-
WNK	4	2	-	2
TLK	2	1	-	1
CDC7	1	-	1	-

Other - Aur

Bioactivity
Kinase	RBC	Metz	Millipore
AurA	inactive (95.95%)	inactive (>1995.26nM)	inactive (85%)
AurB	inactive (85.91%)	inactive (>1995.26nM)	active (48%)
AurC	inactive (94.99%)	-	inactive (99%)

Other - CAMKK

Bioactivity
Kinase	RBC	Metz	Millipore
CaMKK1	inactive (91.67%)	-	-
CaMKK2	inactive (79.47%)	-	-

Other - Haspin

Bioactivity
Kinase	RBC	Metz	Millipore
Haspin	inactive (106.09%)	-	inactive (70%)

Other - IKK

Bioactivity
Kinase	RBC	Metz	Millipore
IKKa	inactive (102.89%)	inactive (>3981.07nM)	inactive (114%)
IKKb	inactive (101.96%)	inactive (1995.26nM)	inactive (96%)
IKKe	inactive (93.39%)	inactive (>3162.28nM)	-
TBK1	inactive (82.44%)	inactive (>3162.28nM)	inactive (51%)

Other - NEK

Bioactivity
Kinase	RBC	Metz	Millipore
NEK1	inactive (104.94%)	-	-
NEK11	inactive (95.42%)	-	inactive (74%)
NEK2	inactive (92.38%)	inactive (>6309.57nM)	inactive (99%)
NEK4	inactive (108.89%)	inactive (>6309.57nM)	-
NEK6	inactive (97.1%)	-	inactive (115%)
NEK7	inactive (89.67%)	-	inactive (106%)
NEK9	inactive (99.25%)	-	-
NEK3	inactive (108.1%)	-	inactive (78%)

Other - TOPK

Bioactivity
Kinase	RBC	Metz	Millipore
PBK	inactive (85.14%)	inactive (>6309.57nM)	-

Other - PLK

Bioactivity
Kinase	RBC	Metz	Millipore
PLK1	inactive (97.97%)	inactive (>7943.28nM)	inactive (105%)
PLK2	inactive (106.24%)	-	inactive (91%)
PLK3	inactive (98.76%)	inactive (>7943.28nM)	inactive (107%)
PLK4	-	active (158.49nM)	-

Other - SgK496

Bioactivity
Kinase	RBC	Metz	Millipore
SgK496	inactive (90%)	-	-

Other - NAK

Bioactivity
Kinase	RBC	Metz	Millipore
MPSK1	inactive (93.06%)	-	-

Other - TTK

Bioactivity
Kinase	RBC	Metz	Millipore
TTK	inactive (87.43%)	-	-

Other - ULK

Bioactivity
Kinase	RBC	Metz	Millipore
ULK1	inactive (85.1%)	-	-
ULK2	inactive (72.66%)	-	active (49%)
ULK3	active (0%)	-	inactive (75%)

Other - WEE

Bioactivity
Kinase	RBC	Metz	Millipore
Wee1	inactive (98.22%)	-	-

Other - WNK

Bioactivity
Kinase	RBC	Metz	Millipore
Wnk2	inactive (115.96%)	-	inactive (104%)
Wnk3	inactive (99.65%)	-	inactive (95%)

Other - TLK

Bioactivity
Kinase	RBC	Metz	Millipore
TLK2	active (0%)	-	inactive (86%)

Other - CDC7

Bioactivity
Kinase	RBC	Metz	Millipore
CDC7	-	active (398.11nM)	-

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
CK1	7	6	5	4
VRK	3	1	-	1

CK1 - CK1

Bioactivity
Kinase	RBC	Metz	Millipore
CK1d	inactive (101.05%)	inactive (7943.28nM)	inactive (93%)
CK1g1	inactive (100.23%)	inactive (1995.26nM)	inactive (92%)
CK1g2	inactive (91.67%)	inactive (3981.07nM)	inactive (75%)
CK1g3	inactive (90%)	-	inactive (90%)
CK1a	inactive (102.54%)	inactive (>6309.57nM)	-
CK1e	inactive (95.91%)	-	-

CK1 - VRK

Bioactivity
Kinase	RBC	Metz	Millipore
VRK1	inactive (90.8%)	-	-
VRK2	-	-	inactive (103%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
CK2	3	2	1	2
CLK	4	4	2	2
DYRK	10	9	6	4
MAPK	14	10	8	10
GSK	2	2	2	2
SRPK	3	3	1	3
CDK	20	-	7	-

CMGC - CK2

Bioactivity
Kinase	RBC	Metz	Millipore
CK2a1	inactive (86.84%)	active (398.11nM)	inactive (107%)
CK2a2	inactive (64.43%)	-	inactive (94%)

CMGC - CLK

Bioactivity
Kinase	RBC	Metz	Millipore
CLK1	inactive (111.23%)	-	-
CLK2	inactive (97.73%)	inactive (>6309.57nM)	inactive (97%)
CLK3	inactive (105.63%)	-	inactive (99%)
CLK4	inactive (86.38%)	inactive (>1258.93nM)	-

CMGC - DYRK

Bioactivity
Kinase	RBC	Metz	Millipore
DYRK1A	inactive (86.15%)	inactive (>3981.07nM)	-
DYRK1B	inactive (87.53%)	inactive (>2511.89nM)	-
DYRK2	inactive (72.03%)	-	inactive (54%)
DYRK3	inactive (99.34%)	inactive (>6309.57nM)	-
DYRK4	inactive (105.89%)	-	-
HIPK1	inactive (98.49%)	-	inactive (109%)
HIPK2	inactive (109.58%)	inactive (>3162.28nM)	inactive (94%)
HIPK3	inactive (96.58%)	-	inactive (98%)
HIPK4	inactive (102.94%)	inactive (>7943.28nM)	-

CMGC - MAPK

Bioactivity
Kinase	RBC	Metz	Millipore
Erk1	inactive (93.5%)	-	inactive (91%)
Erk2	inactive (106.39%)	inactive (2511.89nM)	inactive (109%)
JNK3	inactive (97.23%)	-	inactive (70%)
NLK	inactive (95.5%)	-	inactive (84%)
p38a	inactive (92.11%)	inactive (>3981.07nM)	inactive (99%)
p38b	inactive (101.63%)	-	inactive (100%)
p38d	inactive (96.33%)	inactive (>7943.28nM)	inactive (90%)
p38g	inactive (112.31%)	inactive (>6309.57nM)	inactive (92%)
JNK1	inactive (99.62%)	inactive (>3981.07nM)	inactive (109%)
JNK2	inactive (97.19%)	inactive (>3981.07nM)	inactive (104%)

CMGC - GSK

Bioactivity
Kinase	RBC	Metz	Millipore
GSK3A	active (0.97%)	-	active (1%)
GSK3B	active (2.68%)	active (15.85nM)	active (-1%)

CMGC - SRPK

Bioactivity
Kinase	RBC	Metz	Millipore
MSSK1	inactive (92.66%)	-	inactive (100%)
SRPK1	inactive (100.37%)	inactive (>6309.57nM)	inactive (105%)
SRPK2	inactive (108.64%)	-	inactive (105%)

CMGC - CDK

Bioactivity
Kinase	RBC	Metz	Millipore
CDC2	-	active (31.62nM)	-
CDK2	-	active (31.62nM)	-
CDK5	-	active (12.59nM)	-
CDK8	-	active (794.33nM)	-
CDK7	-	inactive (>3981.07nM)	-
CDK9	-	active (12.59nM)	-
CDK11	-	inactive (10000nM)	-

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
PDHK	5	1	-	-
Alpha	6	-	1	1
PIKK	6	-	-	1

Atypical - PDHK

Bioactivity
Kinase	RBC	Metz	Millipore
PDHK1	inactive (93.67%)	-	-

Atypical - Alpha

Bioactivity
Kinase	RBC	Metz	Millipore
eEF2K	-	inactive (>3981.07nM)	inactive (96%)

Atypical - PIKK

Bioactivity
Kinase	RBC	Metz	Millipore
FRAP	-	-	inactive (120%)