Compound Information
Test on : GPCR
Compound Name : GW809897X
Inchikey : NXPQZPWXVHIWGN-UHFFFAOYSA-N
ChemSpider : 4486982
Pubchem CID : 5329831
ChEMBL : CHEMBL189353
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (19.67%) |
TYK2 | inactive (1.51%) |
JAK2 | inactive (20.68%) |
JAK3 | inactive (2.77%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | active (77.16%) |
FES | inactive (22.52%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | active (53.07%) |
ABL2 | active (55.1%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (19.48%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | active (73.49%) |
BTK | inactive (26.49%) |
TXK | inactive (21.15%) |
TEC | inactive (21.36%) |
ITK | active (71.06%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (43.97%) |
SRM | inactive (3.99%) |
FRK | inactive (14.5%) |
BLK | active (75.01%) |
LCK | active (61.22%) |
HCK | inactive (48.88%) |
FGR | active (51.88%) |
FYN | inactive (12.43%) |
SRC | active (65.38%) |
YES | inactive (28.16%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (7.74%) |
EphA4 | inactive (33.79%) |
EphA3 | inactive (7.13%) |
EphB4 | inactive (8.72%) |
EphB3 | inactive (4.62%) |
EphB2 | inactive (27.33%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (29.68%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-9.25%) |
ZAP70 | inactive (9.82%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (1.45%) |
ALK | inactive (4.6%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (33.46%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (3.45%) |
IGF1R | inactive (4.63%) |
IRR | inactive (4.71%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (26.93%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | active (89.93%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | active (68.74%) |
TRKB | active (55.43%) |
TRKC | active (88.6%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | active (82.1%) |
MET | active (85.01%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (28.56%) |
MER | inactive (29.63%) |
TYRO3 | inactive (17.44%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (48.65%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (-0.4%) |
FGFR2 | inactive (13.36%) |
FGFR3 | inactive (5.59%) |
FGFR4 | inactive (2.06%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | active (51.01%) |
KDR | active (56.31%) |
FLT4 | inactive (41.67%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | active (96.15%) |
KIT | active (95.92%) |
FLT3 | active (84.92%) |
PDGFRa | active (86.57%) |
PDGFRb | active (77.68%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | active (72.13%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (4.21%) |
TNK1 | active (84.08%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (5.8%) |
ErbB2 | inactive (7.2%) |
ErbB4 | inactive (17.07%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (1.26%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (4.11%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (32.85%) |
MST1 | inactive (17.39%) |
MST2 | inactive (11.46%) |
MST4 | inactive (-3.71%) |
HGK | active (73.42%) |
MINK | active (64.51%) |
LOK | active (86.48%) |
PAK1 | inactive (2.17%) |
PAK3 | inactive (1.38%) |
PAK2 | inactive (1.61%) |
PAK5 | inactive (11.93%) |
PAK6 | inactive (0.99%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (5.34%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (1.15%) |
CK1g2 | inactive (0.63%) |
CK1g1 | inactive (1.32%) |
CK1g3 | inactive (-1.25%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (0.37%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | active (84.19%) |
AurC | active (104.02%) |
AurA | active (97.62%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (1.93%) |
NEK2 | inactive (1.07%) |
NEK9 | inactive (-6.03%) |
NEK7 | inactive (1.59%) |
NEK6 | inactive (1.86%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (8.89%) |
IKKe | inactive (8.6%) |
IKKb | inactive (2.65%) |
IKKa | inactive (-10.05%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (19.44%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (1.55%) |
GPRK6 | inactive (3.8%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (22.19%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (4.25%) |
MSK2 | inactive (4.1%) |
RSK1 | inactive (4.66%) |
RSK2 | inactive (3.81%) |
RSK4 | inactive (1.06%) |
RSK3 | inactive (1.78%) |
p70S6K | inactive (2.4%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (2.1%) |
AKT1 | inactive (1.09%) |
AKT3 | inactive (-0.15%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (7.64%) |
SGK3 | inactive (4.02%) |
SGK2 | inactive (22.78%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (3.8%) |
PKCg | inactive (6.65%) |
PKCa | inactive (2.02%) |
PKCt | inactive (3.24%) |
PKCi | inactive (1.5%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (3.22%) |
PKG1 | inactive (3.77%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (3.64%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (2.01%) |
ROCK2 | inactive (9.15%) |
MRCKb | inactive (0.92%) |
MRCKa | inactive (2.97%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (16.8%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (4.12%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (-4.21%) |
CaMK1d | inactive (-0.13%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (8.06%) |
PHKg2 | inactive (6.5%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (-0.38%) |
CaMK2a | inactive (2.73%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (1.46%) |
MAPKAPK2 | inactive (1.08%) |
MAPKAPK3 | inactive (0.31%) |
MNK2 | inactive (45.59%) |
MNK1 | inactive (27.91%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (0.38%) |
PKD1 | inactive (1.18%) |
PKD2 | inactive (2%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (12.76%) |
MARK3 | inactive (13.27%) |
MARK1 | inactive (10.8%) |
QIK | inactive (10.16%) |
SIK | inactive (13.31%) |
NuaK1 | inactive (30.19%) |
BRSK1 | inactive (9.78%) |
BRSK2 | inactive (8.66%) |
MELK | inactive (3.32%) |
CHK1 | inactive (4.63%) |
PASK | inactive (2.77%) |
AMPKa1 | inactive (3.05%) |
AMPKa2 | inactive (3.21%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (1.93%) |
TSSK1 | inactive (3.33%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (4.43%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (0.1%) |
PIM3 | inactive (3.85%) |
PIM1 | inactive (0.34%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (8.85%) |
p38a | inactive (3.34%) |
p38b | inactive (4.6%) |
p38d | inactive (1.46%) |
Erk2 | inactive (2.83%) |
Erk1 | inactive (4.66%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (10.04%) |
GSK3B | inactive (9.63%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (2.16%) |
MSSK1 | inactive (2.4%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (1.23%) |
CLK2 | inactive (5.49%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (5.39%) |
HIPK4 | inactive (18.42%) |
DYRK1B | inactive (1.52%) |
DYRK1A | inactive (0.63%) |
DYRK2 | inactive (1.29%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (6.66%) |