Compound Information
Test on : Metz, GPCR
Compound Name
Metz, GPCR : 504433-23-2
Inchikey
Same : NXNQLECPAXXYTR-N
Metz, GPCR : NXNQLECPAXXYTR-UHFFFAOYSA-N
ChemSpider
Metz, GPCR : 17346731
Pubchem CID
Metz, GPCR : 16219401
ChEMBL
Metz, GPCR : CHEMBL1516890
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
AGC
AGC - Akt
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
AKT1 | - | inactive (0.22%) |
AKT2 | inactive (>7943.28nM) | inactive (1.6%) |
AKT3 | inactive (>10000nM) | inactive (0.99%) |
AGC - DMPK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
MRCKa | inactive (>10000nM) | inactive (0.55%) |
ROCK1 | inactive (1258.93nM) | inactive (5.28%) |
ROCK2 | inactive (1584.89nM) | inactive (8.3%) |
MRCKb | - | inactive (0.99%) |
AGC - GRK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
GPRK5 | - | - |
GPRK7 | - | inactive (10.62%) |
GPRK6 | - | inactive (6.18%) |
AGC - PDK1
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
PDK1 | inactive (>3981.07nM) | inactive (2.99%) |
AGC - PKA
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
PKACa | inactive (>7943.28nM) | - |
PRKX | inactive (>1584.89nM) | inactive (0.1%) |
AGC - PKC
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
PKCd | inactive (>7943.28nM) | - |
PKCg | inactive (>7943.28nM) | inactive (-0.93%) |
PKCz | inactive (>7943.28nM) | - |
PKCi | inactive (>5011.87nM) | inactive (1.58%) |
PKCt | - | inactive (0.22%) |
PKCh | - | inactive (-0.57%) |
PKCa | - | inactive (1.29%) |
AGC - PKG
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
PKG1 | inactive (>1995.26nM) | inactive (3.04%) |
PKG2 | inactive (>1584.89nM) | inactive (3.03%) |
AGC - PKN
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
PKN2 | inactive (2511.89nM) | - |
AGC - RSK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
RSK2 | inactive (3162.28nM) | inactive (6.08%) |
p70S6K | inactive (2511.89nM) | inactive (3.78%) |
MSK1 | inactive (>1995.26nM) | inactive (3.29%) |
MSK2 | - | inactive (10.11%) |
RSK1 | - | inactive (5.16%) |
RSK4 | - | inactive (10.19%) |
RSK3 | - | inactive (7.9%) |
AGC - SGK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
SGK1 | inactive (2511.89nM) | inactive (5.51%) |
SGK3 | - | inactive (0.63%) |
SGK2 | - | inactive (1.75%) |
Atypical
Atypical
Test Member No. in Family |
---|
Family | no. Member on 518kinase | Metz | GPCR |
---|
Alpha | 6 | 1 | - |
Atypical - Alpha
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
eEF2K | - | - |
CAMK
CAMK - CAMK1
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
CaMK1a | inactive (>3162.28nM) | - |
CaMK1d | - | inactive (2.41%) |
CaMK4 | - | inactive (-0.07%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
CaMK2b | inactive (>7943.28nM) | - |
CaMK2d | inactive (3981.07nM) | inactive (6.23%) |
CaMK2g | inactive (3981.07nM) | - |
CaMK2a | - | inactive (3.18%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
CHK1 | inactive (>7943.28nM) | inactive (7.2%) |
BRSK1 | inactive (5011.87nM) | inactive (12.26%) |
MARK2 | inactive (1584.89nM) | - |
MARK3 | inactive (1258.93nM) | inactive (7.16%) |
MELK | inactive (>1584.89nM) | inactive (23.5%) |
AMPKa1 | inactive (1584.89nM) | inactive (14.81%) |
PASK | - | inactive (-2.27%) |
MARK4 | - | inactive (6.49%) |
QIK | - | inactive (4.37%) |
MARK1 | - | inactive (9.52%) |
SIK | - | inactive (9.48%) |
NuaK1 | - | inactive (44.53%) |
BRSK2 | - | inactive (12.35%) |
AMPKa2 | - | inactive (8.64%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
DAPK3 | inactive (>1258.93nM) | - |
DRAK1 | active (125.89nM) | - |
DAPK1 | - | inactive (7.28%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
DCLK1 | inactive (>10000nM) | - |
DCLK2 | - | inactive (3.71%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
MAPKAPK2 | inactive (>7943.28nM) | inactive (1.83%) |
MAPKAPK3 | inactive (>10000nM) | inactive (5.11%) |
MNK2 | - | inactive (15.34%) |
MAPKAPK5 | inactive (>1584.89nM) | inactive (1.48%) |
MNK1 | - | inactive (15.49%) |
CAMK - PHK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
PHKg2 | inactive (2511.89nM) | inactive (2.8%) |
PHKg1 | - | inactive (20.78%) |
CAMK - PIM
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
PIM1 | active (630.96nM) | inactive (10.37%) |
PIM2 | inactive (>1584.89nM) | inactive (3.47%) |
PIM3 | inactive (2511.89nM) | inactive (11.49%) |
CAMK - PKD
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
PKD3 | inactive (1584.89nM) | inactive (10.27%) |
PKD2 | inactive (5011.87nM) | inactive (9.92%) |
PKD1 | - | inactive (10.61%) |
CAMK - RAD53
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
CHK2 | active (630.96nM) | inactive (15.55%) |
CAMK - STK33
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
STK33 | - | - |
CAMK - TSSK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
TSSK1 | inactive (>1584.89nM) | inactive (1.12%) |
TSSK2 | inactive (>1584.89nM) | inactive (-0.52%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | Metz | GPCR |
---|
CK1 | 7 | 5 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
CK1a | inactive (1584.89nM) | inactive (14.31%) |
CK1d | active (125.89nM) | - |
CK1g1 | inactive (>6309.57nM) | inactive (4.56%) |
CK1g2 | inactive (>7943.28nM) | inactive (3.63%) |
CK1g3 | inactive (>6309.57nM) | inactive (5.3%) |
CMGC
CMGC - CDK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
CDC2 | inactive (6309.57nM) | - |
CDK2 | inactive (7943.28nM) | - |
CDK5 | inactive (10000nM) | - |
CDK8 | - | - |
CDK7 | - | - |
CDK9 | - | - |
CDK11 | - | - |
CMGC - CK2
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
CK2a1 | inactive (1258.93nM) | inactive (6.39%) |
CMGC - CLK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
CLK2 | active (398.11nM) | inactive (13.71%) |
CLK4 | active (158.49nM) | - |
CLK3 | - | inactive (-1.26%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
DYRK1A | inactive (2511.89nM) | inactive (10.61%) |
DYRK3 | - | - |
DYRK4 | inactive (>7943.28nM) | - |
HIPK2 | inactive (2511.89nM) | - |
HIPK4 | inactive (2511.89nM) | inactive (15.19%) |
DYRK1B | - | inactive (4.49%) |
HIPK1 | - | inactive (13.77%) |
DYRK2 | - | inactive (4.08%) |
CMGC - GSK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
GSK3A | inactive (>7943.28nM) | inactive (12.22%) |
GSK3B | inactive (1995.26nM) | inactive (8.9%) |
CMGC - MAPK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
Erk2 | inactive (>7943.28nM) | inactive (2.73%) |
p38g | inactive (>6309.57nM) | - |
p38d | inactive (>7943.28nM) | inactive (2.23%) |
JNK1 | inactive (>3162.28nM) | - |
JNK2 | inactive (1258.93nM) | inactive (6.24%) |
p38a | - | inactive (7.85%) |
JNK3 | - | - |
NLK | - | - |
p38b | - | inactive (5.58%) |
Erk1 | - | inactive (2.73%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
SRPK1 | inactive (>7943.28nM) | inactive (-4.48%) |
MSSK1 | - | inactive (-0.47%) |
Other
Other - Aur
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
AurB | active (125.89nM) | active (55.15%) |
AurA | active (251.19nM) | active (57%) |
AurC | - | active (62.65%) |
Other - CAMKK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
CaMKK2 | - | - |
Other - CDC7
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
CDC7 | inactive (>1258.93nM) | - |
Other - IKK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
IKKe | - | inactive (-10.6%) |
TBK1 | - | inactive (10.17%) |
IKKa | - | inactive (-0.33%) |
IKKb | - | inactive (1.05%) |
Other - NEK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
NEK2 | inactive (5011.87nM) | inactive (2.9%) |
NEK4 | inactive (6309.57nM) | - |
NEK1 | - | inactive (1.05%) |
NEK9 | - | inactive (4.67%) |
NEK7 | - | inactive (4.49%) |
NEK6 | - | inactive (-1.86%) |
Other - PLK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
PLK1 | inactive (>7943.28nM) | inactive (1.58%) |
PLK3 | inactive (>7943.28nM) | - |
PLK4 | - | - |
Other - TOPK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
PBK | inactive (>10000nM) | - |
Other - WEE
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
Wee1 | - | - |
Other - TTK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
TTK | - | inactive (22.84%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | Metz | GPCR |
---|
STE20 | 31 | 9 | 12 |
STE7 | 7 | 2 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
GCK | active (501.19nM) | inactive (17.88%) |
HGK | active (316.23nM) | inactive (28.96%) |
KHS1 | active (199.53nM) | - |
MINK | active (794.33nM) | inactive (23.62%) |
PAK1 | inactive (>10000nM) | inactive (6%) |
PAK4 | inactive (>5011.87nM) | - |
SLK | active (1000nM) | - |
MST2 | active (316.23nM) | inactive (33.76%) |
TAO1 | inactive (>10000nM) | - |
MST1 | - | inactive (47.89%) |
MST4 | - | inactive (1.1%) |
LOK | - | inactive (11.96%) |
PAK3 | - | inactive (3%) |
PAK2 | - | inactive (0.31%) |
PAK5 | - | inactive (-5.19%) |
PAK6 | - | inactive (0.69%) |
STE - STE7
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
MAP2K1 | - | inactive (7.29%) |
MAP2K2 | - | - |
TK
TK - Abl
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
ABL1 | - | inactive (44.7%) |
ABL2 | - | inactive (20.93%) |
TK - Ack
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
ACK | - | inactive (1.72%) |
TNK1 | - | inactive (9.9%) |
TK - ALK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
ALK | active (794.33nM) | inactive (9.81%) |
LTK | - | inactive (5.51%) |
TK - Axl
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
TYRO3 | inactive (>1995.26nM) | inactive (13.2%) |
AXL | - | inactive (19.15%) |
MER | - | inactive (16.94%) |
TK - Csk
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
CTK | inactive (>1995.26nM) | - |
CSK | - | inactive (-0.79%) |
TK - EGFR
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
EGFR | inactive (>1995.26nM) | inactive (7.13%) |
ErbB2 | inactive (>1584.89nM) | inactive (3.11%) |
ErbB4 | inactive (>3981.07nM) | inactive (9.14%) |
TK - Eph
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
EphA2 | inactive (>3162.28nM) | inactive (0.79%) |
EphA4 | - | inactive (6.23%) |
EphA3 | - | inactive (4.83%) |
EphB4 | - | inactive (5.16%) |
EphB3 | - | inactive (-0.71%) |
EphB2 | - | inactive (12.04%) |
TK - FAK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
FAK | - | - |
PYK2 | - | inactive (25.21%) |
TK - Fer
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
FER | inactive (1258.93nM) | inactive (20.83%) |
FES | inactive (>1995.26nM) | inactive (2.19%) |
TK - FGFR
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
FGFR1 | inactive (5011.87nM) | inactive (17.32%) |
FGFR3 | - | inactive (47.75%) |
FGFR2 | - | inactive (42.19%) |
FGFR4 | - | inactive (14.05%) |
TK - InsR
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
IGF1R | inactive (1258.93nM) | inactive (8.98%) |
INSR | inactive (2511.89nM) | inactive (20.08%) |
IRR | - | inactive (1.8%) |
TK - JakA
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
JAK2 | inactive (>1584.89nM) | inactive (2.77%) |
JAK3 | inactive (>1584.89nM) | inactive (4.53%) |
TYK2 | inactive (>1995.26nM) | inactive (0.73%) |
JAK1 | - | inactive (-6.11%) |
TK - Met
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
MET | - | inactive (5.5%) |
RON | - | inactive (0.13%) |
TK - PDGFR
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
FMS | inactive (>2511.89nM) | inactive (30.86%) |
FLT3 | - | active (66.23%) |
KIT | inactive (>1258.93nM) | active (52.66%) |
PDGFRa | - | active (65.28%) |
PDGFRb | - | inactive (42%) |
TK - Ret
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
RET | active (50.12nM) | active (66.63%) |
TK - Sev
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
ROS | inactive (>1995.26nM) | inactive (10.13%) |
TK - Src
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
BLK | active (398.11nM) | inactive (48.33%) |
LCK | active (398.11nM) | inactive (25.46%) |
LYN | active (15.85nM) | - |
SRC | active (501.19nM) | inactive (42.2%) |
FRK | active (794.33nM) | inactive (3.75%) |
SRM | inactive (>1584.89nM) | inactive (0.18%) |
FYN | inactive (>794.33nM) | inactive (15.37%) |
BRK | - | inactive (2.28%) |
HCK | - | inactive (42.08%) |
FGR | - | inactive (43.99%) |
YES | - | inactive (45.13%) |
TK - Syk
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
SYK | active (501.19nM) | inactive (-2.64%) |
ZAP70 | - | inactive (11.51%) |
TK - Tec
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
BTK | - | inactive (3.46%) |
ITK | active (199.53nM) | inactive (15.72%) |
BMX | - | inactive (4.89%) |
TXK | - | inactive (6.47%) |
TEC | - | inactive (8.75%) |
TK - Trk
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
TRKA | active (316.23nM) | active (66%) |
TRKB | active (794.33nM) | active (75.45%) |
TRKC | active (25.12nM) | active (71.61%) |
TK - VEGFR
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
FLT4 | active (398.11nM) | inactive (30.27%) |
KDR | active (251.19nM) | active (54.79%) |
FLT1 | - | inactive (13.11%) |
TK - DDR
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
DDR2 | - | inactive (4.03%) |
TK - Musk
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
MUSK | - | inactive (12.78%) |
TK - Tie
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
TIE2 | - | inactive (5.24%) |
TKL
TKL - IRAK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
IRAK1 | inactive (1584.89nM) | - |
IRAK4 | active (158.49nM) | inactive (5.04%) |
TKL - LISK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
LIMK1 | - | - |
TKL - LRRK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
LRRK2 | - | - |
TKL - MLK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
ZAK | inactive (6309.57nM) | - |
MLK2 | - | - |
TKL - RAF
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
BRAF | - | inactive (6.52%) |
TKL - STKR
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
ALK2 | - | - |