Compound Information
Test on : GPCR
Compound Name : CHEMBL1096634
Inchikey : NPRGDRYIMFLLIG-HNNXBMFYSA-N
ChemSpider : 10133929
Pubchem CID : 11959683
ChEMBL : CHEMBL1096634
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (-0.29%) |
TYK2 | inactive (-3.88%) |
JAK2 | inactive (1.71%) |
JAK3 | inactive (-0.34%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (7.41%) |
FES | inactive (7.88%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (2.9%) |
ABL2 | inactive (3.84%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (2.13%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (5.18%) |
BTK | inactive (0.56%) |
TXK | inactive (3.73%) |
TEC | inactive (3.05%) |
ITK | inactive (1.49%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (2.72%) |
SRM | inactive (1.99%) |
FRK | inactive (2.68%) |
BLK | inactive (2.85%) |
LCK | inactive (3.65%) |
HCK | inactive (9.34%) |
FGR | inactive (5.54%) |
FYN | inactive (4.61%) |
SRC | inactive (13.71%) |
YES | inactive (7.77%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (-0.31%) |
EphA4 | inactive (4.87%) |
EphA3 | inactive (1.87%) |
EphB4 | inactive (1.24%) |
EphB3 | inactive (1.06%) |
EphB2 | inactive (0.23%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (9.96%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (4.13%) |
ZAP70 | inactive (-2.5%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (17.07%) |
ALK | inactive (9.07%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (9.48%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (1.38%) |
IGF1R | inactive (2.6%) |
IRR | inactive (2.71%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (1.65%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (5.52%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (3.54%) |
TRKB | inactive (2.5%) |
TRKC | inactive (6.42%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (-1.45%) |
MET | inactive (1.76%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-3%) |
MER | inactive (3.59%) |
TYRO3 | inactive (1.88%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (37.99%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (2.91%) |
FGFR2 | inactive (4.18%) |
FGFR3 | inactive (3.32%) |
FGFR4 | inactive (2.04%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (30.44%) |
KDR | active (96.12%) |
FLT4 | active (62.64%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (5.51%) |
KIT | inactive (1.58%) |
FLT3 | inactive (2.43%) |
PDGFRa | inactive (43.79%) |
PDGFRb | active (57.21%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (6.74%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (3.88%) |
TNK1 | inactive (-4.26%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (13.44%) |
ErbB2 | inactive (3.43%) |
ErbB4 | inactive (28.91%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (1.37%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (5.43%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (15.97%) |
MST1 | inactive (42.68%) |
MST2 | inactive (42.41%) |
MST4 | inactive (28.15%) |
HGK | inactive (35.09%) |
MINK | inactive (21.15%) |
LOK | inactive (28.78%) |
PAK1 | inactive (3.91%) |
PAK3 | inactive (4.83%) |
PAK2 | inactive (10.94%) |
PAK5 | active (70.92%) |
PAK6 | active (77.33%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (4.39%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (11.44%) |
CK1g2 | inactive (5.45%) |
CK1g1 | inactive (5.61%) |
CK1g3 | inactive (4.23%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (7.68%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (5.24%) |
AurC | inactive (2.08%) |
AurA | inactive (2.98%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (2.81%) |
NEK2 | inactive (4.1%) |
NEK9 | inactive (3.62%) |
NEK7 | inactive (3.72%) |
NEK6 | inactive (1.56%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (6.85%) |
IKKe | inactive (37.94%) |
IKKb | inactive (4.92%) |
IKKa | inactive (2.58%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (11.21%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (14.98%) |
GPRK6 | inactive (5.48%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (4.43%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (17.73%) |
MSK2 | inactive (20.5%) |
RSK1 | inactive (12.81%) |
RSK2 | inactive (14.53%) |
RSK4 | inactive (7.07%) |
RSK3 | inactive (10.65%) |
p70S6K | inactive (33.14%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | active (91.99%) |
AKT1 | active (90.41%) |
AKT3 | active (91.65%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (3.49%) |
SGK3 | active (57.71%) |
SGK2 | inactive (13.41%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | active (97.12%) |
PKCg | inactive (45.48%) |
PKCa | inactive (32.29%) |
PKCt | active (82.65%) |
PKCi | inactive (3.1%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | active (78.78%) |
PKG1 | active (71.35%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | active (87.07%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (24.74%) |
ROCK2 | active (51.29%) |
MRCKb | inactive (26.58%) |
MRCKa | inactive (36.26%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (11.33%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (1.52%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (4.09%) |
CaMK1d | inactive (4.5%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (-1.37%) |
PHKg2 | inactive (5.27%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (8.64%) |
CaMK2a | inactive (6.26%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (1.6%) |
MAPKAPK2 | inactive (2.99%) |
MAPKAPK3 | inactive (2.95%) |
MNK2 | inactive (2.92%) |
MNK1 | inactive (2.97%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (28.59%) |
PKD1 | inactive (29.93%) |
PKD2 | inactive (25.58%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (18.37%) |
MARK3 | inactive (35.37%) |
MARK1 | inactive (27.34%) |
QIK | inactive (-1.51%) |
SIK | inactive (7.29%) |
NuaK1 | inactive (47.31%) |
BRSK1 | inactive (1.15%) |
BRSK2 | inactive (5.58%) |
MELK | active (82.11%) |
CHK1 | inactive (9.89%) |
PASK | inactive (8.04%) |
AMPKa1 | active (65.67%) |
AMPKa2 | inactive (14.98%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (2.24%) |
TSSK1 | inactive (44.07%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (4.82%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (3.44%) |
PIM3 | inactive (4.27%) |
PIM1 | inactive (3.63%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (9.81%) |
p38a | inactive (7.11%) |
p38b | inactive (4.89%) |
p38d | inactive (1.9%) |
Erk2 | inactive (5.04%) |
Erk1 | inactive (2.26%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | active (73.58%) |
GSK3B | active (71.18%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-1.89%) |
MSSK1 | inactive (-2.11%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (0.92%) |
CLK2 | inactive (12.09%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (12.33%) |
HIPK4 | inactive (6.13%) |
DYRK1B | inactive (2.57%) |
DYRK1A | inactive (2.24%) |
DYRK2 | inactive (4.79%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (4.54%) |