Compound Information
Test on : GPCR
Compound Name : GW830365A
Inchikey : NOIDWOQNGSHXOA-UHFFFAOYSA-N
ChemSpider : 28483784
Pubchem CID : 57391091
ChEMBL : CHEMBL1909361
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (14.96%) |
TYK2 | inactive (-0.59%) |
JAK2 | inactive (9.94%) |
JAK3 | inactive (7.15%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (20.63%) |
FES | inactive (7.78%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (21.75%) |
ABL2 | inactive (36.03%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (13.06%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (22.59%) |
BTK | inactive (2.3%) |
TXK | active (57.67%) |
TEC | inactive (24.75%) |
ITK | inactive (9.06%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (8.9%) |
SRM | inactive (1.22%) |
FRK | inactive (0.89%) |
BLK | inactive (8.61%) |
LCK | inactive (11.04%) |
HCK | inactive (13.63%) |
FGR | inactive (11.35%) |
FYN | inactive (1.63%) |
SRC | inactive (18.43%) |
YES | inactive (8.5%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (2.79%) |
EphA4 | inactive (19.61%) |
EphA3 | inactive (5.54%) |
EphB4 | inactive (3.53%) |
EphB3 | inactive (4.14%) |
EphB2 | inactive (17.06%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | active (57.84%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-6.78%) |
ZAP70 | inactive (2.72%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (5.29%) |
ALK | inactive (5.11%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (43.49%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (4%) |
IGF1R | inactive (4.94%) |
IRR | inactive (2.84%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | active (76.02%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (8.61%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (5.98%) |
TRKB | inactive (8%) |
TRKC | inactive (11.27%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (15.64%) |
MET | inactive (41.4%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-4.88%) |
MER | inactive (6.28%) |
TYRO3 | inactive (6.95%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | active (58.48%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (0.91%) |
FGFR2 | inactive (14.83%) |
FGFR3 | inactive (10.27%) |
FGFR4 | inactive (1.61%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (30.68%) |
KDR | inactive (34.81%) |
FLT4 | inactive (20.65%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | active (96.98%) |
KIT | active (94.22%) |
FLT3 | active (83.65%) |
PDGFRa | active (84.41%) |
PDGFRb | active (77.1%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (29.34%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (8.46%) |
TNK1 | active (63.48%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (1.28%) |
ErbB2 | inactive (4.12%) |
ErbB4 | inactive (4.94%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (1.07%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (7.4%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (3.53%) |
MST1 | inactive (18.77%) |
MST2 | inactive (13.61%) |
MST4 | inactive (0.96%) |
HGK | inactive (14.74%) |
MINK | inactive (7.42%) |
LOK | inactive (34.17%) |
PAK1 | inactive (4.43%) |
PAK3 | inactive (3.94%) |
PAK2 | inactive (1.58%) |
PAK5 | inactive (13.54%) |
PAK6 | inactive (9.1%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (7.12%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (2.52%) |
CK1g2 | inactive (1.47%) |
CK1g1 | inactive (3.24%) |
CK1g3 | inactive (2.32%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (1.42%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | active (76.92%) |
AurC | active (104.4%) |
AurA | active (93.86%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (4.64%) |
NEK2 | inactive (1.94%) |
NEK9 | inactive (4.91%) |
NEK7 | inactive (3.17%) |
NEK6 | inactive (3.91%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (4.49%) |
IKKe | active (95.17%) |
IKKb | inactive (3.83%) |
IKKa | inactive (8%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (7.72%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (5.28%) |
GPRK6 | inactive (7.67%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (5.15%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (3.65%) |
MSK2 | inactive (3.19%) |
RSK1 | inactive (3.56%) |
RSK2 | inactive (2.69%) |
RSK4 | inactive (2.33%) |
RSK3 | inactive (2.28%) |
p70S6K | inactive (1.23%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (0.37%) |
AKT1 | inactive (-0.42%) |
AKT3 | inactive (0.19%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (5%) |
SGK3 | inactive (2.63%) |
SGK2 | inactive (3.1%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (5.63%) |
PKCg | inactive (4.99%) |
PKCa | inactive (-0.33%) |
PKCt | inactive (3.43%) |
PKCi | inactive (2.1%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (0.57%) |
PKG1 | inactive (2.49%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (4.38%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (8.01%) |
ROCK2 | inactive (18.13%) |
MRCKb | inactive (0.6%) |
MRCKa | inactive (2.59%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (6.85%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (0.61%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (-5.39%) |
CaMK1d | inactive (0.15%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (5.5%) |
PHKg2 | inactive (6.71%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (3.97%) |
CaMK2a | inactive (1.11%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (3.14%) |
MAPKAPK2 | inactive (2.7%) |
MAPKAPK3 | inactive (3.83%) |
MNK2 | inactive (9.63%) |
MNK1 | inactive (8.84%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (0.94%) |
PKD1 | inactive (1.78%) |
PKD2 | inactive (1.04%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (5.47%) |
MARK3 | inactive (9.85%) |
MARK1 | inactive (7.21%) |
QIK | inactive (11.15%) |
SIK | inactive (17.45%) |
NuaK1 | inactive (41.61%) |
BRSK1 | inactive (4.74%) |
BRSK2 | inactive (5.48%) |
MELK | inactive (7.07%) |
CHK1 | inactive (3.14%) |
PASK | inactive (2.08%) |
AMPKa1 | inactive (4.22%) |
AMPKa2 | inactive (4.4%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (3.15%) |
TSSK1 | inactive (5.87%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (4.97%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (0.65%) |
PIM3 | inactive (2%) |
PIM1 | inactive (-0.22%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (3.59%) |
p38a | inactive (5.83%) |
p38b | inactive (6.58%) |
p38d | inactive (3.21%) |
Erk2 | inactive (8.36%) |
Erk1 | inactive (3.72%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (8.02%) |
GSK3B | inactive (5.02%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (2.58%) |
MSSK1 | inactive (2.7%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (1.43%) |
CLK2 | inactive (2.52%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (5.06%) |
HIPK4 | inactive (31.89%) |
DYRK1B | inactive (2.44%) |
DYRK1A | inactive (3.45%) |
DYRK2 | inactive (3.05%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (11.88%) |