Compound Information
Test on : RBC
Compound Name : Tpl2 Kinase Inhibitor
Inchikey : NMEUKWOOQOHUNA-UHFFFAOYSA-N
ChemSpider : 7828216
Pubchem CID : 9549300
ChEMBL : CHEMBL200381
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
AGC
AGC - PDK1
Bioactivity |
---|
Kinase | RBC |
---|
PDK1 | inactive (85.34%) |
AGC - Akt
Bioactivity |
---|
Kinase | RBC |
---|
AKT1 | inactive (98.59%) |
AKT2 | inactive (100.71%) |
AKT3 | inactive (95.14%) |
AGC - DMPK
Bioactivity |
---|
Kinase | RBC |
---|
DMPK1 | inactive (103.84%) |
MRCKa | inactive (80.04%) |
MRCKb | inactive (124.11%) |
ROCK1 | inactive (99.81%) |
ROCK2 | inactive (97.08%) |
AGC - GRK
Bioactivity |
---|
Kinase | RBC |
---|
BARK1 | inactive (95.66%) |
BARK2 | inactive (100.25%) |
GPRK4 | inactive (98.77%) |
GPRK5 | inactive (106.87%) |
GPRK6 | inactive (106.28%) |
GPRK7 | inactive (95.47%) |
AGC - RSK
Bioactivity |
---|
Kinase | RBC |
---|
MSK1 | inactive (102.25%) |
MSK2 | inactive (91.95%) |
p70S6K | inactive (89.43%) |
p70S6Kb | inactive (99.52%) |
RSK2 | inactive (99.13%) |
RSK4 | inactive (103.81%) |
RSK1 | inactive (94.58%) |
RSK3 | inactive (87.28%) |
AGC - PKA
Bioactivity |
---|
Kinase | RBC |
---|
PKACg | inactive (115.01%) |
PRKX | inactive (101.14%) |
PKACa | inactive (92.17%) |
AGC - PKC
Bioactivity |
---|
Kinase | RBC |
---|
PKCa | inactive (89.66%) |
PKCd | inactive (95.21%) |
PKCe | inactive (100.96%) |
PKCh | inactive (116.69%) |
PKCg | inactive (111.33%) |
PKCi | inactive (94.66%) |
PKCt | inactive (113.16%) |
PKCz | inactive (93.85%) |
PKCb | inactive (86.19%) |
AGC - PKG
Bioactivity |
---|
Kinase | RBC |
---|
PKG2 | inactive (90.88%) |
PKG1 | inactive (90.81%) |
AGC - PKN
Bioactivity |
---|
Kinase | RBC |
---|
PKN1 | inactive (100.93%) |
PKN2 | inactive (85.94%) |
AGC - SGK
Bioactivity |
---|
Kinase | RBC |
---|
SGK1 | inactive (93.23%) |
SGK2 | inactive (98.55%) |
SGK3 | inactive (91.53%) |
AGC - NDR
Bioactivity |
---|
Kinase | RBC |
---|
NDR1 | inactive (93.87%) |
TK
TK - Abl
Bioactivity |
---|
Kinase | RBC |
---|
ABL1 | inactive (93.37%) |
ABL2 | inactive (87.35%) |
TK - Ack
Bioactivity |
---|
Kinase | RBC |
---|
ACK | inactive (89.87%) |
TK - ALK
Bioactivity |
---|
Kinase | RBC |
---|
ALK | inactive (107.37%) |
LTK | inactive (95.59%) |
TK - Axl
Bioactivity |
---|
Kinase | RBC |
---|
AXL | inactive (102.56%) |
MER | inactive (67.18%) |
TYRO3 | inactive (97.99%) |
TK - Src
Bioactivity |
---|
Kinase | RBC |
---|
BLK | inactive (99.94%) |
BRK | inactive (84.13%) |
SRC | inactive (92.56%) |
FGR | inactive (84.46%) |
FRK | inactive (100.84%) |
FYN | inactive (103.39%) |
HCK | inactive (92.47%) |
LCK | inactive (97.3%) |
SRM | inactive (104.29%) |
YES | inactive (93.64%) |
LYN | inactive (90.44%) |
TK - Tec
Bioactivity |
---|
Kinase | RBC |
---|
BMX | inactive (84.04%) |
BTK | inactive (98.29%) |
ITK | inactive (99.08%) |
TEC | inactive (117.83%) |
TXK | inactive (88.15%) |
TK - PDGFR
Bioactivity |
---|
Kinase | RBC |
---|
KIT | inactive (92.89%) |
FLT3 | inactive (83.61%) |
FMS | inactive (96.25%) |
PDGFRb | inactive (101.35%) |
PDGFRa | inactive (94.34%) |
TK - Csk
Bioactivity |
---|
Kinase | RBC |
---|
CSK | inactive (95.15%) |
CTK | inactive (95.85%) |
TK - DDR
Bioactivity |
---|
Kinase | RBC |
---|
DDR2 | inactive (91.94%) |
TK - EGFR
Bioactivity |
---|
Kinase | RBC |
---|
EGFR | active (24.29%) |
ErbB2 | inactive (91.71%) |
ErbB4 | inactive (72.63%) |
TK - Eph
Bioactivity |
---|
Kinase | RBC |
---|
EphA1 | inactive (94.54%) |
EphA2 | inactive (101.71%) |
EphA3 | inactive (122.47%) |
EphA4 | inactive (92.76%) |
EphA5 | inactive (90.6%) |
EphA6 | inactive (76.23%) |
EphA7 | inactive (83.72%) |
EphA8 | inactive (91.18%) |
EphB1 | inactive (93.13%) |
EphB2 | inactive (97.41%) |
EphB3 | inactive (98.51%) |
EphB4 | inactive (85.24%) |
TK - FAK
Bioactivity |
---|
Kinase | RBC |
---|
FAK | inactive (99.55%) |
PYK2 | inactive (99.97%) |
TK - Fer
Bioactivity |
---|
Kinase | RBC |
---|
FER | inactive (82.88%) |
FES | inactive (107.99%) |
TK - FGFR
Bioactivity |
---|
Kinase | RBC |
---|
FGFR1 | inactive (83.38%) |
FGFR2 | inactive (103.3%) |
FGFR3 | inactive (91.67%) |
FGFR4 | inactive (92.6%) |
TK - VEGFR
Bioactivity |
---|
Kinase | RBC |
---|
FLT1 | inactive (88%) |
FLT4 | inactive (96.16%) |
KDR | inactive (96.27%) |
TK - InsR
Bioactivity |
---|
Kinase | RBC |
---|
IGF1R | inactive (93.8%) |
IRR | inactive (97.04%) |
INSR | inactive (85.06%) |
TK - JakA
Bioactivity |
---|
Kinase | RBC |
---|
JAK1 | inactive (93.58%) |
JAK2 | inactive (99.05%) |
JAK3 | inactive (86.19%) |
TYK2 | inactive (102.78%) |
TK - Musk
Bioactivity |
---|
Kinase | RBC |
---|
MUSK | inactive (55.62%) |
TK - Ret
Bioactivity |
---|
Kinase | RBC |
---|
RET | inactive (106.84%) |
TK - Met
Bioactivity |
---|
Kinase | RBC |
---|
RON | inactive (89.59%) |
MET | inactive (94.88%) |
TK - Sev
Bioactivity |
---|
Kinase | RBC |
---|
ROS | inactive (98.3%) |
TK - Syk
Bioactivity |
---|
Kinase | RBC |
---|
SYK | inactive (94.37%) |
ZAP70 | inactive (102.53%) |
TK - Tie
Bioactivity |
---|
Kinase | RBC |
---|
TIE2 | inactive (95.49%) |
TK - Trk
Bioactivity |
---|
Kinase | RBC |
---|
TRKA | inactive (96.17%) |
TRKB | inactive (100.61%) |
TRKC | inactive (93.22%) |
TKL
TKL - STKR
Bioactivity |
---|
Kinase | RBC |
---|
ALK1 | inactive (96.92%) |
ALK2 | inactive (95.57%) |
ALK4 | inactive (99.03%) |
TGFbR1 | inactive (99.55%) |
TGFbR2 | inactive (117.82%) |
TKL - RAF
Bioactivity |
---|
Kinase | RBC |
---|
ARAF | inactive (105.66%) |
BRAF | inactive (105.99%) |
RAF1 | inactive (90.94%) |
TKL - IRAK
Bioactivity |
---|
Kinase | RBC |
---|
IRAK1 | inactive (114.17%) |
IRAK4 | inactive (100.5%) |
TKL - LISK
Bioactivity |
---|
Kinase | RBC |
---|
LIMK1 | inactive (101.25%) |
TKL - LRRK
Bioactivity |
---|
Kinase | RBC |
---|
LRRK2 | inactive (86.64%) |
TKL - MLK
Bioactivity |
---|
Kinase | RBC |
---|
MLK1 | inactive (87.47%) |
MLK2 | inactive (101.23%) |
MLK3 | inactive (88.97%) |
TAK1 | inactive (89.49%) |
ZAK | inactive (105.64%) |
TKL - RIPK
Bioactivity |
---|
Kinase | RBC |
---|
RIPK2 | inactive (85.31%) |
CAMK
CAMK - CAMKL
Bioactivity |
---|
Kinase | RBC |
---|
NuaK1 | inactive (103.36%) |
BRSK1 | inactive (94.55%) |
BRSK2 | inactive (100.45%) |
CHK1 | inactive (90.22%) |
LKB1 | inactive (91.14%) |
MARK1 | inactive (91.64%) |
MARK3 | inactive (100.94%) |
MARK4 | inactive (96.38%) |
MELK | inactive (88.04%) |
PASK | inactive (123.63%) |
QIK | inactive (97.59%) |
NuaK2 | inactive (134.85%) |
MARK2 | inactive (93.18%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | RBC |
---|
CaMK1a | inactive (99.11%) |
CaMK1b | inactive (99.77%) |
CaMK1d | inactive (97.83%) |
CaMK1g | inactive (96.13%) |
CaMK4 | inactive (95.23%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | RBC |
---|
CaMK2a | inactive (105.05%) |
CaMK2b | inactive (97.39%) |
CaMK2d | inactive (102.82%) |
CaMK2g | inactive (91.16%) |
CAMK - RAD53
Bioactivity |
---|
Kinase | RBC |
---|
CHK2 | inactive (90.54%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | RBC |
---|
DAPK1 | inactive (102.18%) |
DAPK2 | inactive (107.78%) |
DRAK1 | inactive (79.6%) |
DAPK3 | inactive (101.02%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | RBC |
---|
DCLK2 | inactive (97.2%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | RBC |
---|
MAPKAPK2 | inactive (100.01%) |
MAPKAPK3 | inactive (93.96%) |
MAPKAPK5 | inactive (99.6%) |
MNK1 | inactive (73.19%) |
MNK2 | inactive (79.32%) |
CAMK - MLCK
Bioactivity |
---|
Kinase | RBC |
---|
smMLCK | inactive (105.03%) |
skMLCK | inactive (96.18%) |
CAMK - PHK
Bioactivity |
---|
Kinase | RBC |
---|
PHKg1 | inactive (92.02%) |
PHKg2 | inactive (88.26%) |
CAMK - PIM
Bioactivity |
---|
Kinase | RBC |
---|
PIM1 | inactive (92.73%) |
PIM2 | inactive (101.1%) |
PIM3 | inactive (84.95%) |
CAMK - PKD
Bioactivity |
---|
Kinase | RBC |
---|
PKD1 | inactive (94.55%) |
PKD3 | inactive (90.39%) |
PKD2 | inactive (99.72%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | RBC |
---|
TSSK1 | inactive (84.42%) |
TSSK2 | inactive (100.41%) |
CAMK - STK33
Bioactivity |
---|
Kinase | RBC |
---|
STK33 | inactive (87.38%) |
STE
STE - STE11
Bioactivity |
---|
Kinase | RBC |
---|
MAP3K5 | inactive (106.14%) |
MAP3K2 | inactive (81.18%) |
MAP3K3 | inactive (75.03%) |
STE - STE-Unique
Bioactivity |
---|
Kinase | RBC |
---|
COT | inactive (79.08%) |
NIK | inactive (117.8%) |
STE - STE20
Bioactivity |
---|
Kinase | RBC |
---|
GCK | inactive (72.17%) |
HGK | active (44.43%) |
KHS1 | inactive (61.66%) |
LOK | inactive (52.8%) |
MINK | inactive (77.53%) |
MST1 | inactive (100.19%) |
MST2 | inactive (94.3%) |
MST3 | inactive (95.62%) |
MST4 | inactive (94.98%) |
OSR1 | inactive (87.66%) |
PAK1 | inactive (95.73%) |
PAK2 | inactive (66.58%) |
PAK3 | inactive (99.17%) |
PAK4 | inactive (85.41%) |
PAK5 | inactive (98.26%) |
PAK6 | inactive (104.18%) |
SLK | inactive (86.55%) |
YSK1 | inactive (95.59%) |
STLK3 | inactive (78.59%) |
TAO1 | inactive (89.9%) |
TAO2 | inactive (86.08%) |
TAO3 | inactive (99.16%) |
MYO3B | inactive (87.91%) |
STE - STE7
Bioactivity |
---|
Kinase | RBC |
---|
MAP2K1 | inactive (86.23%) |
MAP2K2 | inactive (104.55%) |
MAP2K6 | inactive (114.93%) |
Other
Other - Aur
Bioactivity |
---|
Kinase | RBC |
---|
AurA | inactive (98.1%) |
AurB | inactive (90.11%) |
AurC | inactive (91.81%) |
Other - CAMKK
Bioactivity |
---|
Kinase | RBC |
---|
CaMKK1 | inactive (105.3%) |
CaMKK2 | inactive (90.15%) |
Other - Haspin
Bioactivity |
---|
Kinase | RBC |
---|
Haspin | inactive (82.49%) |
Other - IKK
Bioactivity |
---|
Kinase | RBC |
---|
IKKa | inactive (96.32%) |
IKKb | inactive (102.94%) |
IKKe | inactive (90.59%) |
TBK1 | inactive (83.45%) |
Other - NEK
Bioactivity |
---|
Kinase | RBC |
---|
NEK1 | active (20.5%) |
NEK11 | inactive (87.1%) |
NEK2 | inactive (75.19%) |
NEK4 | inactive (71.65%) |
NEK6 | inactive (104.45%) |
NEK7 | inactive (102.41%) |
NEK9 | inactive (96.35%) |
NEK3 | inactive (55.97%) |
Other - TOPK
Bioactivity |
---|
Kinase | RBC |
---|
PBK | inactive (84.76%) |
Other - PLK
Bioactivity |
---|
Kinase | RBC |
---|
PLK1 | inactive (92.64%) |
PLK2 | inactive (110.45%) |
PLK3 | inactive (91.13%) |
Other - SgK496
Bioactivity |
---|
Kinase | RBC |
---|
SgK496 | inactive (87.25%) |
Other - NAK
Bioactivity |
---|
Kinase | RBC |
---|
MPSK1 | inactive (93.83%) |
Other - TTK
Bioactivity |
---|
Kinase | RBC |
---|
TTK | inactive (99.1%) |
Other - ULK
Bioactivity |
---|
Kinase | RBC |
---|
ULK1 | inactive (76.13%) |
ULK2 | inactive (102.39%) |
ULK3 | inactive (72.02%) |
Other - WEE
Bioactivity |
---|
Kinase | RBC |
---|
Wee1 | inactive (74.31%) |
Other - WNK
Bioactivity |
---|
Kinase | RBC |
---|
Wnk2 | inactive (91.09%) |
Wnk3 | inactive (92.4%) |
Other - TLK
Bioactivity |
---|
Kinase | RBC |
---|
TLK2 | inactive (106.06%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC |
---|
CK1 | 7 | 6 |
VRK | 3 | 1 |
CK1 - CK1
Bioactivity |
---|
Kinase | RBC |
---|
CK1d | inactive (88.4%) |
CK1g1 | inactive (86.95%) |
CK1g2 | inactive (102.2%) |
CK1g3 | inactive (102.81%) |
CK1a | inactive (100.93%) |
CK1e | inactive (81.84%) |
CK1 - VRK
Bioactivity |
---|
Kinase | RBC |
---|
VRK1 | inactive (99.22%) |
CMGC
CMGC - CK2
Bioactivity |
---|
Kinase | RBC |
---|
CK2a1 | inactive (95.85%) |
CK2a2 | inactive (75.23%) |
CMGC - CLK
Bioactivity |
---|
Kinase | RBC |
---|
CLK1 | inactive (91.04%) |
CLK2 | inactive (79.89%) |
CLK3 | inactive (96.74%) |
CLK4 | inactive (63.32%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | RBC |
---|
DYRK1A | inactive (52.7%) |
DYRK1B | inactive (65.17%) |
DYRK2 | inactive (95.46%) |
DYRK3 | inactive (96.26%) |
DYRK4 | inactive (84.37%) |
HIPK1 | inactive (98.6%) |
HIPK2 | inactive (93.16%) |
HIPK3 | inactive (96.52%) |
HIPK4 | inactive (93.08%) |
CMGC - MAPK
Bioactivity |
---|
Kinase | RBC |
---|
Erk1 | inactive (99.95%) |
Erk2 | inactive (104.6%) |
JNK3 | inactive (95.01%) |
NLK | inactive (87.97%) |
p38a | inactive (114.54%) |
p38b | inactive (101.98%) |
p38d | inactive (100.98%) |
p38g | inactive (96.96%) |
JNK1 | inactive (110.05%) |
JNK2 | inactive (100.13%) |
CMGC - GSK
Bioactivity |
---|
Kinase | RBC |
---|
GSK3A | inactive (88.53%) |
GSK3B | inactive (99.75%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | RBC |
---|
MSSK1 | inactive (96.41%) |
SRPK1 | inactive (101.67%) |
SRPK2 | inactive (100.84%) |
Atypical
Atypical
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC |
---|
PDHK | 5 | 1 |
Atypical - PDHK
Bioactivity |
---|
Kinase | RBC |
---|
PDHK1 | inactive (85.34%) |