Compound in Profiling

Compound Information

Test on : DRx, Metz

Compound Name
DRx, Metz : Tamatinib

Inchikey
Same : NHHQJBCNYHBUSI-N
DRx, Metz : NHHQJBCNYHBUSI-UHFFFAOYSA-N

ChemSpider
DRx, Metz : 9388620

Pubchem CID
DRx, Metz : 11213558

ChEMBL
DRx, Metz : CHEMBL475251

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

Other

Test Member No. in Family
Family	no. Member on 518kinase	DRx	Metz
NAK	4	4	-
Aur	3	3	2
CAMKK	2	2	1
PEK	4	2	-
IRE	2	1	-
IKK	4	4	4
NEK	11	9	2
WEE	3	3	1
PLK	4	4	3
SgK496	1	1	-
NKF1	3	2	-
NKF4	2	1	-
ULK	5	4	-
TLK	2	2	-
TTK	1	1	-
CDC7	1	-	1
TOPK	1	-	1

Other - NAK

Bioactivity
Kinase	DRx	Metz
AAK1	active (410nM)	-
BIKE	active (1900nM)	-
GAK	active (250nM)	-
MPSK1	active (1.7nM)	-

Other - Aur

Bioactivity
Kinase	DRx	Metz
AurA	active (160nM)	active (501.19nM)
AurB	active (110nM)	-
AurC	active (41nM)	-

Other - CAMKK

Bioactivity
Kinase	DRx	Metz
CaMKK1	inactive (10001nM)	-
CaMKK2	inactive (10001nM)	inactive (>2511.89nM)

Other - PEK

Bioactivity
Kinase	DRx	Metz
HRI	inactive (10001nM)	-
PKR	active (180nM)	-

Other - IRE

Bioactivity
Kinase	DRx	Metz
IRE1	active (1600nM)	-

Other - IKK

Bioactivity
Kinase	DRx	Metz
IKKa	active (120nM)	-
IKKb	active (71nM)	-
IKKe	active (13nM)	active (100nM)
TBK1	active (23nM)	active (100nM)

Other - NEK

Bioactivity
Kinase	DRx	Metz
NEK1	active (170nM)	-
NEK11	active (170nM)	-
NEK2	active (260nM)	active (199.53nM)
NEK3	active (170nM)	-
NEK4	active (1800nM)	active (199.53nM)
NEK5	active (13nM)	-
NEK6	active (6.3nM)	-
NEK7	active (11nM)	-
NEK9	active (16nM)	-

Other - WEE

Bioactivity
Kinase	DRx	Metz
MYT1	inactive (10001nM)	-
Wee1	active (890nM)	-
Wee1B	inactive (9400nM)	-

Other - PLK

Bioactivity
Kinase	DRx	Metz
PLK1	active (830nM)	inactive (>7943.28nM)
PLK2	active (34nM)	-
PLK3	active (5.1nM)	active (50.12nM)
PLK4	active (4.2nM)	active (10nM)

Other - SgK496

Bioactivity
Kinase	DRx	Metz
SgK496	inactive (10001nM)	-

Other - NKF1

Bioactivity
Kinase	DRx	Metz
SBK	active (93nM)	-
SgK110	active (190nM)	-

Other - NKF4

Bioactivity
Kinase	DRx	Metz
CLIK1	active (1400nM)	-

Other - ULK

Bioactivity
Kinase	DRx	Metz
Fused	active (230nM)	-
ULK1	active (14nM)	-
ULK2	active (19nM)	-
ULK3	active (7.1nM)	-

Other - TLK

Bioactivity
Kinase	DRx	Metz
TLK1	active (490nM)	-
TLK2	active (380nM)	-

Other - TTK

Bioactivity
Kinase	DRx	Metz
TTK	active (1100nM)	-

Other - CDC7

Bioactivity
Kinase	DRx	Metz
CDC7	-	active (7.94nM)

Other - TOPK

Bioactivity
Kinase	DRx	Metz
PBK	-	inactive (>10000nM)

TK

Test Member No. in Family
Family	no. Member on 518kinase	DRx	Metz
Abl	2	2	1
ALK	2	2	2
Axl	3	3	2
Src	11	11	9
Tec	5	5	3
PDGFR	5	5	5
Csk	2	2	1
DDR	2	2	-
EGFR	4	4	3
Eph	14	13	1
FAK	2	2	2
Fer	2	2	2
FGFR	4	4	2
VEGFR	3	3	3
InsR	3	3	2
JakA	4	4	3
Met	2	2	2
Musk	1	1	-
Ret	1	1	1
Sev	1	1	1
Syk	2	2	1
Tie	2	2	-
Ack	2	2	1
Trk	3	3	3

TK - Abl

Bioactivity
Kinase	DRx	Metz
ABL1	active (530nM)	inactive (>1995.26nM)
ABL2	active (720nM)	-

TK - ALK

Bioactivity
Kinase	DRx	Metz
ALK	active (240nM)	inactive (1258.93nM)
LTK	active (800nM)	inactive (>1000nM)

TK - Axl

Bioactivity
Kinase	DRx	Metz
AXL	active (82nM)	-
MER	active (170nM)	-
TYRO3	active (1900nM)	inactive (>2511.89nM)

TK - Src

Bioactivity
Kinase	DRx	Metz
BLK	active (25nM)	active (6.31nM)
BRK	active (360nM)	active (630.96nM)
FGR	active (33nM)	-
FRK	active (68nM)	active (12.59nM)
FYN	active (28nM)	active (794.33nM)
HCK	active (150nM)	active (199.53nM)
LCK	active (30nM)	active (158.49nM)
LYN	active (26nM)	active (12.59nM)
SRC	active (8.4nM)	active (6.31nM)
SRM	active (610nM)	inactive (>1258.93nM)
YES	active (35nM)	-

TK - Tec

Bioactivity
Kinase	DRx	Metz
BMX	active (180nM)	-
BTK	active (190nM)	active (630.96nM)
ITK	active (400nM)	active (79.43nM)
TEC	active (1600nM)	-
TXK	active (140nM)	-

TK - PDGFR

Bioactivity
Kinase	DRx	Metz
FMS	active (31nM)	inactive (>1258.93nM)
FLT3	active (0.71nM)	active (63.1nM)
KIT	active (6.8nM)	inactive (>2511.89nM)
PDGFRa	active (60nM)	active (199.53nM)
PDGFRb	active (3.3nM)	active (50.12nM)

TK - Csk

Bioactivity
Kinase	DRx	Metz
CSK	active (160nM)	-
CTK	inactive (10001nM)	inactive (>1995.26nM)

TK - DDR

Bioactivity
Kinase	DRx	Metz
DDR1	active (9.3nM)	-
DDR2	active (43nM)	-

TK - EGFR

Bioactivity
Kinase	DRx	Metz
EGFR	active (300nM)	active (63.1nM)
ErbB2	inactive (10001nM)	active (31.62nM)
ErbB3	inactive (10001nM)	-
ErbB4	active (600nM)	active (316.23nM)

TK - Eph

Bioactivity
Kinase	DRx	Metz
EphA1	active (67nM)	-
EphA2	active (140nM)	active (100nM)
EphA3	active (360nM)	-
EphA4	active (150nM)	-
EphA5	active (860nM)	-
EphA6	active (120nM)	-
EphA7	active (39nM)	-
EphA8	active (1300nM)	-
EphB1	active (390nM)	-
EphB2	active (880nM)	-
EphB3	inactive (10001nM)	-
EphB4	active (600nM)	-
EphB6	active (310nM)	-

TK - FAK

Bioactivity
Kinase	DRx	Metz
FAK	active (250nM)	active (630.96nM)
PYK2	active (29nM)	-

TK - Fer

Bioactivity
Kinase	DRx	Metz
FER	active (130nM)	active (12.59nM)
FES	active (200nM)	-

TK - FGFR

Bioactivity
Kinase	DRx	Metz
FGFR1	active (44nM)	active (158.49nM)
FGFR2	active (73nM)	-
FGFR3	active (56nM)	active (15.85nM)
FGFR4	active (350nM)	-

TK - VEGFR

Bioactivity
Kinase	DRx	Metz
FLT1	active (16nM)	active (25.12nM)
FLT4	active (9.1nM)	-
KDR	active (40nM)	active (19.95nM)

TK - InsR

Bioactivity
Kinase	DRx	Metz
IGF1R	active (1300nM)	inactive (1258.93nM)
INSR	active (1100nM)	active (794.33nM)
IRR	inactive (4600nM)	-

TK - JakA

Bioactivity
Kinase	DRx	Metz
JAK1	active (21nM)	-
JAK2	active (3.5nM)	-
JAK3	active (36nM)	active (794.33nM)
TYK2	active (190nM)	active (15.85nM)

TK - Met

Bioactivity
Kinase	DRx	Metz
MET	active (280nM)	active (1000nM)
RON	active (470nM)	inactive (>3981.07nM)

TK - Musk

Bioactivity
Kinase	DRx	Metz
MUSK	active (100nM)	-

TK - Ret

Bioactivity
Kinase	DRx	Metz
RET	active (4.1nM)	active (12.59nM)

TK - Sev

Bioactivity
Kinase	DRx	Metz
ROS	active (29nM)	active (6.31nM)

TK - Syk

Bioactivity
Kinase	DRx	Metz
SYK	active (19nM)	active (6.31nM)
ZAP70	active (21nM)	-

TK - Tie

Bioactivity
Kinase	DRx	Metz
TIE1	active (76nM)	-
TIE2	active (310nM)	-

TK - Ack

Bioactivity
Kinase	DRx	Metz
TNK1	active (25nM)	-
ACK	active (70nM)	active (125.89nM)

TK - Trk

Bioactivity
Kinase	DRx	Metz
TRKA	active (170nM)	inactive (>1584.89nM)
TRKB	active (900nM)	active (1000nM)
TRKC	active (570nM)	active (1000nM)

TKL

Test Member No. in Family
Family	no. Member on 518kinase	DRx	Metz
STKR	12	10	1
RIPK	5	4	-
RAF	5	2	1
MLK	10	8	2
IRAK	4	3	2
LISK	4	3	1
LRRK	2	1	1

TKL - STKR

Bioactivity
Kinase	DRx	Metz
ALK2	inactive (4800nM)	inactive (>3981.07nM)
ALK4	active (1100nM)	-
ACTR2	inactive (10001nM)	-
ACTR2B	inactive (10001nM)	-
ALK1	inactive (10001nM)	-
BMPR1A	inactive (10001nM)	-
BMPR1B	active (720nM)	-
BMPR2	inactive (10001nM)	-
TGFbR1	active (2600nM)	-
TGFbR2	active (330nM)	-

TKL - RIPK

Bioactivity
Kinase	DRx	Metz
SgK288	active (330nM)	-
RIPK1	inactive (10001nM)	-
RIPK2	active (970nM)	-
ANKRD3	active (220nM)	-

TKL - RAF

Bioactivity
Kinase	DRx	Metz
BRAF	active (240nM)	-
RAF1	active (840nM)	-

TKL - MLK

Bioactivity
Kinase	DRx	Metz
DLK	inactive (10001nM)	-
LZK	inactive (10001nM)	-
MLK1	active (4.3nM)	-
MLK2	active (3.8nM)	active (3.98nM)
MLK3	active (11nM)	-
TAK1	active (49nM)	-
HH498	active (310nM)	-
ZAK	inactive (10001nM)	inactive (>7943.28nM)

TKL - IRAK

Bioactivity
Kinase	DRx	Metz
IRAK1	active (9.7nM)	active (10nM)
IRAK3	active (11nM)	-
IRAK4	active (140nM)	active (63.1nM)

TKL - LISK

Bioactivity
Kinase	DRx	Metz
LIMK1	active (620nM)	-
LIMK2	active (1400nM)	-
TESK1	active (360nM)	-

TKL - LRRK

Bioactivity
Kinase	DRx	Metz
LRRK2	active (36nM)	active (31.62nM)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	DRx	Metz
ABC1	5	2	-
PIKK	6	1	-
RIO	3	3	-
Alpha	6	1	1

Atypical - ABC1

Bioactivity
Kinase	DRx	Metz
ADCK3	active (1100nM)	-
ADCK4	active (64nM)	-

Atypical - PIKK

Bioactivity
Kinase	DRx	Metz
FRAP	inactive (10001nM)	-

Atypical - RIO

Bioactivity
Kinase	DRx	Metz
RIOK1	active (340nM)	-
RIOK2	inactive (3400nM)	-
RIOK3	active (210nM)	-

Atypical - Alpha

Bioactivity
Kinase	DRx	Metz
ChaK2	inactive (10001nM)	-
eEF2K	-	-

AGC

Test Member No. in Family
Family	no. Member on 518kinase	DRx	Metz
Akt	3	3	3
DMPK	7	7	3
GRK	7	3	1
NDR	4	4	-
MAST	5	1	-
PDK1	1	1	1
PKA	5	3	2
PKN	3	2	1
PKC	9	5	5
PKG	2	2	2
RSK	8	1	4
SGK	3	1	1
YANK	3	3	-

AGC - Akt

Bioactivity
Kinase	DRx	Metz
AKT1	inactive (10001nM)	inactive (>7943.28nM)
AKT2	inactive (10001nM)	inactive (>7943.28nM)
AKT3	inactive (10001nM)	inactive (>10000nM)

AGC - DMPK

Bioactivity
Kinase	DRx	Metz
CRIK	active (440nM)	-
DMPK1	inactive (10001nM)	-
DMPK2	inactive (10001nM)	-
MRCKa	inactive (10001nM)	inactive (>10000nM)
MRCKb	inactive (10001nM)	-
ROCK1	active (590nM)	inactive (>2511.89nM)
ROCK2	active (560nM)	inactive (>2511.89nM)

AGC - GRK

Bioactivity
Kinase	DRx	Metz
RHOK	active (870nM)	-
GPRK4	active (450nM)	-
GPRK7	active (2000nM)	-
GPRK5	-	inactive (>3981.07nM)

AGC - NDR

Bioactivity
Kinase	DRx	Metz
LATS1	inactive (10001nM)	-
LATS2	inactive (4000nM)	-
NDR1	inactive (9400nM)	-
NDR2	inactive (10001nM)	-

AGC - MAST

Bioactivity
Kinase	DRx	Metz
MAST1	inactive (10001nM)	-

AGC - PDK1

Bioactivity
Kinase	DRx	Metz
PDK1	active (120nM)	active (7.94nM)

AGC - PKA

Bioactivity
Kinase	DRx	Metz
PKACa	active (600nM)	active (251.19nM)
PKACb	active (510nM)	-
PRKX	inactive (10001nM)	inactive (>2511.89nM)

AGC - PKN

Bioactivity
Kinase	DRx	Metz
PKN1	active (660nM)	-
PKN2	active (2600nM)	inactive (>2511.89nM)

AGC - PKC

Bioactivity
Kinase	DRx	Metz
PKCd	inactive (4100nM)	inactive (>7943.28nM)
PKCe	inactive (10001nM)	-
PKCh	inactive (10001nM)	-
PKCi	inactive (10001nM)	inactive (>5011.87nM)
PKCt	inactive (10001nM)	inactive (>2511.89nM)
PKCg	-	active (251.19nM)
PKCz	-	inactive (>7943.28nM)

AGC - PKG

Bioactivity
Kinase	DRx	Metz
PKG1	inactive (10001nM)	inactive (>1995.26nM)
PKG2	inactive (3600nM)	inactive (>1584.89nM)

AGC - RSK

Bioactivity
Kinase	DRx	Metz
p70S6K	inactive (10001nM)	active (199.53nM)
RSK2	-	inactive (>2511.89nM)
MSK1	-	inactive (>1995.26nM)
MSK2	-	-

AGC - SGK

Bioactivity
Kinase	DRx	Metz
SGK3	inactive (10001nM)	-
SGK1	-	inactive (>7943.28nM)

AGC - YANK

Bioactivity
Kinase	DRx	Metz
YANK1	active (2300nM)	-
YANK2	inactive (10001nM)	-
YANK3	inactive (10001nM)	-

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	DRx	Metz
CAMKL	20	19	9
CAMK1	5	4	2
CAMK2	4	4	4
CASK	1	1	-
RAD53	1	1	1
DAPK	5	5	2
DCAMKL	3	3	1
MAPKAPK	5	4	4
MLCK	5	4	-
PHK	2	2	1
PIM	3	3	3
PKD	3	3	2
STK33	1	1	1
TSSK	5	1	2

CAMK - CAMKL

Bioactivity
Kinase	DRx	Metz
AMPKa1	active (300nM)	inactive (>1000nM)
AMPKa2	active (750nM)	-
NuaK1	active (75nM)	-
BRSK1	inactive (10001nM)	inactive (>10000nM)
BRSK2	inactive (10001nM)	-
CHK1	active (2500nM)	inactive (1995.26nM)
HUNK	inactive (10001nM)	-
LKB1	inactive (3400nM)	-
MARK1	active (270nM)	-
MARK2	active (280nM)	-
MARK3	active (1900nM)	active (1000nM)
MARK4	active (89nM)	active (100nM)
MELK	inactive (10001nM)	inactive (>1000nM)
NIM1	active (660nM)	-
QSK	inactive (10001nM)	-
SIK	active (53nM)	-
QIK	active (78nM)	active (25.12nM)
NuaK2	active (65nM)	-
SNRK	inactive (10001nM)	-
PASK	-	-

CAMK - CAMK1

Bioactivity
Kinase	DRx	Metz
CaMK1a	active (230nM)	inactive (>2511.89nM)
CaMK1d	active (200nM)	inactive (>1995.26nM)
CaMK1g	active (460nM)	-
CaMK4	inactive (10001nM)	-

CAMK - CAMK2

Bioactivity
Kinase	DRx	Metz
CaMK2a	active (1100nM)	inactive (>6309.57nM)
CaMK2b	inactive (10001nM)	inactive (>7943.28nM)
CaMK2d	active (3000nM)	inactive (>6309.57nM)
CaMK2g	active (920nM)	active (398.11nM)

CAMK - CASK

Bioactivity
Kinase	DRx	Metz
CASK	inactive (10001nM)	-

CAMK - RAD53

Bioactivity
Kinase	DRx	Metz
CHK2	inactive (10001nM)	inactive (>1584.89nM)

CAMK - DAPK

Bioactivity
Kinase	DRx	Metz
DAPK1	active (55nM)	-
DAPK2	active (62nM)	-
DAPK3	active (13nM)	active (79.43nM)
DRAK1	active (32nM)	active (39.81nM)
DRAK2	active (9.2nM)	-

CAMK - DCAMKL

Bioactivity
Kinase	DRx	Metz
DCLK1	inactive (10001nM)	inactive (>10000nM)
DCLK2	inactive (10001nM)	-
DCLK3	active (600nM)	-

CAMK - MAPKAPK

Bioactivity
Kinase	DRx	Metz
MAPKAPK2	inactive (10001nM)	inactive (>7943.28nM)
MAPKAPK5	inactive (10001nM)	inactive (>1584.89nM)
MNK1	active (230nM)	-
MNK2	active (130nM)	active (63.1nM)
MAPKAPK3	-	inactive (>10000nM)

CAMK - MLCK

Bioactivity
Kinase	DRx	Metz
caMLCK	inactive (10001nM)	-
smMLCK	inactive (6500nM)	-
skMLCK	inactive (10001nM)	-
SgK085	active (810nM)	-

CAMK - PHK

Bioactivity
Kinase	DRx	Metz
PHKg1	inactive (10001nM)	-
PHKg2	active (940nM)	inactive (>5011.87nM)

CAMK - PIM

Bioactivity
Kinase	DRx	Metz
PIM1	inactive (10001nM)	inactive (>6309.57nM)
PIM2	inactive (10001nM)	inactive (>1584.89nM)
PIM3	inactive (10001nM)	active (630.96nM)

CAMK - PKD

Bioactivity
Kinase	DRx	Metz
PKD1	inactive (10001nM)	-
PKD2	inactive (10001nM)	active (630.96nM)
PKD3	inactive (3900nM)	inactive (1258.93nM)

CAMK - STK33

Bioactivity
Kinase	DRx	Metz
STK33	active (970nM)	-

CAMK - TSSK

Bioactivity
Kinase	DRx	Metz
TSSK1	active (1000nM)	active (100nM)
TSSK2	-	inactive (>1584.89nM)

STE

Test Member No. in Family
Family	no. Member on 518kinase	DRx	Metz
STE11	8	8	-
STE20	31	27	9
STE7	7	7	2

STE - STE11

Bioactivity
Kinase	DRx	Metz
MAP3K5	inactive (10001nM)	-
MAP3K6	inactive (10001nM)	-
MAP3K1	inactive (10001nM)	-
MAP3K7	inactive (10001nM)	-
MAP3K2	active (94nM)	-
MAP3K3	active (150nM)	-
MAP3K4	active (840nM)	-
MAP3K8	active (67nM)	-

STE - STE20

Bioactivity
Kinase	DRx	Metz
HPK1	active (1400nM)	-
LOK	active (70nM)	-
GCK	active (670nM)	inactive (>1995.26nM)
KHS2	active (2400nM)	-
HGK	inactive (10001nM)	inactive (>5011.87nM)
KHS1	inactive (10001nM)	inactive (>6309.57nM)
MINK	inactive (10001nM)	-
MST1	inactive (10001nM)	-
MST2	active (3000nM)	inactive (>6309.57nM)
MST3	inactive (10001nM)	-
MST4	inactive (10001nM)	-
MYO3A	inactive (10001nM)	-
MYO3B	inactive (10001nM)	-
OSR1	inactive (3100nM)	-
PAK1	active (260nM)	active (630.96nM)
PAK2	active (340nM)	-
PAK3	active (690nM)	-
PAK4	active (96nM)	active (125.89nM)
PAK6	active (310nM)	-
PAK5	active (69nM)	-
SLK	active (33nM)	active (25.12nM)
STLK3	inactive (10001nM)	-
TAO1	active (490nM)	active (630.96nM)
TAO2	active (640nM)	-
TAO3	inactive (4600nM)	-
TNIK	active (1300nM)	-
YSK1	inactive (9200nM)	-

STE - STE7

Bioactivity
Kinase	DRx	Metz
MAP2K1	active (320nM)	inactive (>2511.89nM)
MAP2K2	active (730nM)	inactive (>3981.07nM)
MAP2K3	active (100nM)	-
MAP2K4	active (200nM)	-
MAP2K5	active (41nM)	-
MAP2K6	active (480nM)	-
MAP2K7	inactive (10001nM)	-

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	DRx	Metz
CDK	20	8	7
CDKL	5	4	-
CLK	4	4	2
CK2	3	2	1
DYRK	10	8	6
MAPK	14	14	8
GSK	2	2	2
RCK	3	2	-
SRPK	3	3	1

CMGC - CDK

Bioactivity
Kinase	DRx	Metz
PITSLRE	inactive (10001nM)	-
CHED	inactive (10001nM)	-
CDK11	inactive (10001nM)	-
PCTAIRE1	inactive (10001nM)	-
PCTAIRE2	active (330nM)	-
PCTAIRE3	inactive (10001nM)	-
PFTAIRE2	inactive (10001nM)	-
PFTAIRE1	inactive (10001nM)	-
CDC2	-	active (398.11nM)
CDK2	-	active (125.89nM)
CDK5	-	inactive (1584.89nM)
CDK8	-	inactive (>3981.07nM)
CDK7	-	inactive (>3981.07nM)
CDK9	-	inactive (>1584.89nM)

CMGC - CDKL

Bioactivity
Kinase	DRx	Metz
CDKL1	active (2100nM)	-
CDKL2	inactive (5900nM)	-
CDKL3	inactive (10001nM)	-
CDKL5	inactive (10001nM)	-

CMGC - CLK

Bioactivity
Kinase	DRx	Metz
CLK1	active (1200nM)	-
CLK2	active (1600nM)	inactive (>2511.89nM)
CLK3	active (1900nM)	-
CLK4	active (360nM)	active (125.89nM)

CMGC - CK2

Bioactivity
Kinase	DRx	Metz
CK2a1	active (64nM)	active (39.81nM)
CK2a2	active (14nM)	-

CMGC - DYRK

Bioactivity
Kinase	DRx	Metz
DYRK1A	active (260nM)	inactive (>1584.89nM)
DYRK1B	inactive (10001nM)	inactive (>2511.89nM)
DYRK2	active (470nM)	-
HIPK1	active (820nM)	-
HIPK2	inactive (4800nM)	active (199.53nM)
HIPK3	inactive (3200nM)	-
HIPK4	active (2800nM)	inactive (>7943.28nM)
PRP4	inactive (10001nM)	-
DYRK3	-	-
DYRK4	-	inactive (1584.89nM)

CMGC - MAPK

Bioactivity
Kinase	DRx	Metz
Erk1	inactive (10001nM)	-
Erk2	inactive (10001nM)	inactive (>7943.28nM)
Erk3	inactive (10001nM)	-
Erk4	inactive (10001nM)	-
Erk5	inactive (10001nM)	-
Erk7	active (640nM)	-
JNK1	active (38nM)	active (79.43nM)
JNK2	active (47nM)	active (79.43nM)
JNK3	active (37nM)	active (10nM)
NLK	inactive (10001nM)	-
p38a	inactive (10001nM)	inactive (>3981.07nM)
p38b	inactive (10001nM)	-
p38d	active (690nM)	inactive (3981.07nM)
p38g	active (390nM)	active (125.89nM)

CMGC - GSK

Bioactivity
Kinase	DRx	Metz
GSK3A	active (2500nM)	inactive (1584.89nM)
GSK3B	active (120nM)	inactive (>1995.26nM)

CMGC - RCK

Bioactivity
Kinase	DRx	Metz
ICK	inactive (10001nM)	-
MAK	inactive (10001nM)	-

CMGC - SRPK

Bioactivity
Kinase	DRx	Metz
SRPK1	active (590nM)	inactive (>7943.28nM)
SRPK2	inactive (10001nM)	-
MSSK1	active (400nM)	-

CK1

Test Member No. in Family
Family	no. Member on 518kinase	DRx	Metz
CK1	7	7	5
VRK	3	1	-

CK1 - CK1

Bioactivity
Kinase	DRx	Metz
CK1a	inactive (10001nM)	inactive (>5011.87nM)
CK1a2	inactive (10001nM)	-
CK1d	inactive (10001nM)	inactive (>7943.28nM)
CK1e	inactive (10001nM)	-
CK1g1	inactive (10001nM)	inactive (>6309.57nM)
CK1g2	inactive (10001nM)	inactive (>7943.28nM)
CK1g3	inactive (10001nM)	inactive (>6309.57nM)

CK1 - VRK

Bioactivity
Kinase	DRx	Metz
VRK2	inactive (10001nM)	-