Compound Information
Test on : Millipore
Compound Name : Rho Kinase Inhibitor IV
Inchikey : NFDQHCCABRRTFB-XJCLVHIMSA-N
ChemSpider : 21395818
Pubchem CID : 16760635
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - Abl
Bioactivity |
---|
Kinase | Millipore |
---|
ABL1 | inactive (88%) |
ABL2 | inactive (106%) |
TK - Ack
Bioactivity |
---|
Kinase | Millipore |
---|
ACK | inactive (69%) |
TK - ALK
Bioactivity |
---|
Kinase | Millipore |
---|
ALK | inactive (76%) |
TK - Axl
Bioactivity |
---|
Kinase | Millipore |
---|
AXL | inactive (88%) |
MER | inactive (79%) |
TYRO3 | inactive (83%) |
TK - Src
Bioactivity |
---|
Kinase | Millipore |
---|
BLK | inactive (122%) |
BRK | inactive (101%) |
SRC | inactive (86%) |
FGR | inactive (99%) |
FYN | inactive (93%) |
HCK | inactive (69%) |
LCK | inactive (97%) |
LYN | inactive (82%) |
FRK | inactive (87%) |
YES | inactive (105%) |
TK - Tec
Bioactivity |
---|
Kinase | Millipore |
---|
BMX | inactive (77%) |
BTK | inactive (104%) |
ITK | inactive (101%) |
TXK | inactive (100%) |
TK - PDGFR
Bioactivity |
---|
Kinase | Millipore |
---|
KIT | inactive (112%) |
FLT3 | inactive (100%) |
FMS | inactive (73%) |
PDGFRa | inactive (115%) |
PDGFRb | inactive (100%) |
TK - Csk
Bioactivity |
---|
Kinase | Millipore |
---|
CSK | inactive (112%) |
TK - DDR
Bioactivity |
---|
Kinase | Millipore |
---|
DDR2 | inactive (126%) |
TK - EGFR
Bioactivity |
---|
Kinase | Millipore |
---|
EGFR | inactive (120%) |
ErbB4 | inactive (89%) |
TK - Eph
Bioactivity |
---|
Kinase | Millipore |
---|
EphA1 | inactive (54%) |
EphA2 | inactive (92%) |
EphA3 | inactive (96%) |
EphA4 | inactive (109%) |
EphA5 | inactive (104%) |
EphA7 | inactive (105%) |
EphA8 | inactive (98%) |
EphB1 | inactive (75%) |
EphB2 | inactive (110%) |
EphB3 | inactive (118%) |
EphB4 | inactive (109%) |
TK - FAK
Bioactivity |
---|
Kinase | Millipore |
---|
FAK | inactive (102%) |
PYK2 | inactive (122%) |
TK - Fer
Bioactivity |
---|
Kinase | Millipore |
---|
FER | inactive (109%) |
FES | inactive (114%) |
TK - FGFR
Bioactivity |
---|
Kinase | Millipore |
---|
FGFR1 | inactive (76%) |
FGFR2 | inactive (101%) |
FGFR3 | inactive (106%) |
FGFR4 | inactive (109%) |
TK - VEGFR
Bioactivity |
---|
Kinase | Millipore |
---|
FLT1 | inactive (82%) |
FLT4 | inactive (78%) |
KDR | inactive (99%) |
TK - InsR
Bioactivity |
---|
Kinase | Millipore |
---|
IGF1R | inactive (134%) |
INSR | inactive (107%) |
IRR | inactive (116%) |
TK - JakA
Bioactivity |
---|
Kinase | Millipore |
---|
JAK2 | inactive (108%) |
JAK3 | inactive (92%) |
TK - Met
Bioactivity |
---|
Kinase | Millipore |
---|
MET | inactive (84%) |
RON | inactive (89%) |
TK - Musk
Bioactivity |
---|
Kinase | Millipore |
---|
MUSK | inactive (90%) |
TK - Ret
Bioactivity |
---|
Kinase | Millipore |
---|
RET | inactive (91%) |
TK - Sev
Bioactivity |
---|
Kinase | Millipore |
---|
ROS | inactive (90%) |
TK - Syk
Bioactivity |
---|
Kinase | Millipore |
---|
SYK | inactive (119%) |
ZAP70 | inactive (104%) |
TK - Tie
Bioactivity |
---|
Kinase | Millipore |
---|
TIE2 | inactive (78%) |
TK - Trk
Bioactivity |
---|
Kinase | Millipore |
---|
TRKA | inactive (64%) |
TRKB | inactive (113%) |
TKL
TKL - STKR
Bioactivity |
---|
Kinase | Millipore |
---|
ALK4 | inactive (137%) |
TGFbR1 | inactive (78%) |
TKL - RAF
Bioactivity |
---|
Kinase | Millipore |
---|
RAF1 | inactive (79%) |
TKL - IRAK
Bioactivity |
---|
Kinase | Millipore |
---|
IRAK1 | inactive (82%) |
IRAK4 | inactive (107%) |
TKL - LISK
Bioactivity |
---|
Kinase | Millipore |
---|
LIMK1 | inactive (92%) |
TKL - MLK
Bioactivity |
---|
Kinase | Millipore |
---|
MLK1 | inactive (86%) |
TAK1 | inactive (88%) |
TKL - RIPK
Bioactivity |
---|
Kinase | Millipore |
---|
RIPK2 | inactive (95%) |
CAMK
CAMK - CAMKL
Bioactivity |
---|
Kinase | Millipore |
---|
AMPKa1 | inactive (98%) |
AMPKa2 | inactive (97%) |
NuaK1 | inactive (95%) |
BRSK1 | inactive (57%) |
BRSK2 | inactive (89%) |
CHK1 | inactive (88%) |
LKB1 | inactive (91%) |
MARK1 | inactive (73%) |
MELK | inactive (74%) |
MARK2 | inactive (96%) |
PASK | inactive (104%) |
SIK | inactive (84%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | Millipore |
---|
CaMK1a | inactive (97%) |
CaMK4 | inactive (91%) |
CaMK1d | inactive (94%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | Millipore |
---|
CaMK2b | inactive (76%) |
CaMK2g | inactive (95%) |
CaMK2d | inactive (98%) |
CAMK - RAD53
Bioactivity |
---|
Kinase | Millipore |
---|
CHK2 | inactive (80%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | Millipore |
---|
DAPK1 | inactive (88%) |
DAPK2 | inactive (90%) |
DRAK1 | inactive (116%) |
DAPK3 | inactive (83%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | Millipore |
---|
DCLK2 | inactive (66%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | Millipore |
---|
MAPKAPK2 | inactive (88%) |
MAPKAPK3 | inactive (98%) |
MNK2 | inactive (107%) |
MAPKAPK5 | inactive (82%) |
CAMK - MLCK
Bioactivity |
---|
Kinase | Millipore |
---|
smMLCK | inactive (94%) |
CAMK - PHK
Bioactivity |
---|
Kinase | Millipore |
---|
PHKg2 | inactive (82%) |
CAMK - PIM
Bioactivity |
---|
Kinase | Millipore |
---|
PIM1 | inactive (100%) |
PIM2 | inactive (106%) |
PIM3 | inactive (92%) |
CAMK - PKD
Bioactivity |
---|
Kinase | Millipore |
---|
PKD1 | inactive (83%) |
PKD2 | inactive (100%) |
CAMK - STK33
Bioactivity |
---|
Kinase | Millipore |
---|
STK33 | inactive (102%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | Millipore |
---|
TSSK1 | inactive (95%) |
TSSK2 | inactive (80%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | Millipore |
---|
STE11 | 8 | 1 |
STE20 | 31 | 14 |
STE7 | 7 | 3 |
STE - STE11
Bioactivity |
---|
Kinase | Millipore |
---|
MAP3K5 | inactive (98%) |
STE - STE20
Bioactivity |
---|
Kinase | Millipore |
---|
GCK | inactive (82%) |
LOK | inactive (54%) |
MINK | inactive (91%) |
MST1 | inactive (87%) |
MST2 | inactive (102%) |
MST3 | inactive (61%) |
PAK2 | inactive (107%) |
PAK3 | inactive (67%) |
PAK4 | inactive (90%) |
PAK5 | inactive (86%) |
PAK6 | inactive (88%) |
TAO1 | inactive (81%) |
TAO2 | inactive (102%) |
TAO3 | inactive (93%) |
STE - STE7
Bioactivity |
---|
Kinase | Millipore |
---|
MAP2K1 | inactive (102%) |
MAP2K6 | inactive (70%) |
MAP2K7 | inactive (82%) |
Other
Other - Aur
Bioactivity |
---|
Kinase | Millipore |
---|
AurA | inactive (64%) |
AurB | active (6%) |
AurC | active (5%) |
Other - Haspin
Bioactivity |
---|
Kinase | Millipore |
---|
Haspin | inactive (91%) |
Other - IKK
Bioactivity |
---|
Kinase | Millipore |
---|
IKKa | inactive (93%) |
IKKb | inactive (116%) |
TBK1 | inactive (68%) |
Other - NEK
Bioactivity |
---|
Kinase | Millipore |
---|
NEK11 | inactive (88%) |
NEK2 | inactive (78%) |
NEK3 | inactive (113%) |
NEK6 | inactive (88%) |
NEK7 | inactive (88%) |
Other - PLK
Bioactivity |
---|
Kinase | Millipore |
---|
PLK1 | inactive (90%) |
PLK3 | inactive (98%) |
PLK2 | inactive (104%) |
Other - TLK
Bioactivity |
---|
Kinase | Millipore |
---|
TLK2 | inactive (104%) |
Other - ULK
Bioactivity |
---|
Kinase | Millipore |
---|
ULK2 | inactive (93%) |
ULK3 | inactive (97%) |
Other - WNK
Bioactivity |
---|
Kinase | Millipore |
---|
Wnk2 | inactive (108%) |
Wnk3 | inactive (103%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | Millipore |
---|
CK1 | 7 | 4 |
VRK | 3 | 1 |
CK1 - CK1
Bioactivity |
---|
Kinase | Millipore |
---|
CK1g1 | inactive (92%) |
CK1g2 | inactive (91%) |
CK1g3 | inactive (93%) |
CK1d | inactive (83%) |
CK1 - VRK
Bioactivity |
---|
Kinase | Millipore |
---|
VRK2 | inactive (94%) |
CMGC
CMGC - CK2
Bioactivity |
---|
Kinase | Millipore |
---|
CK2a1 | inactive (95%) |
CK2a2 | inactive (128%) |
CMGC - CLK
Bioactivity |
---|
Kinase | Millipore |
---|
CLK2 | inactive (113%) |
CLK3 | inactive (76%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | Millipore |
---|
DYRK2 | inactive (91%) |
HIPK1 | inactive (94%) |
HIPK2 | inactive (97%) |
HIPK3 | inactive (92%) |
CMGC - GSK
Bioactivity |
---|
Kinase | Millipore |
---|
GSK3A | inactive (115%) |
GSK3B | inactive (98%) |
CMGC - MAPK
Bioactivity |
---|
Kinase | Millipore |
---|
JNK1 | inactive (95%) |
JNK2 | inactive (105%) |
JNK3 | inactive (72%) |
Erk1 | inactive (79%) |
Erk2 | inactive (101%) |
NLK | inactive (90%) |
p38a | inactive (74%) |
p38b | inactive (100%) |
p38g | inactive (102%) |
p38d | inactive (97%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | Millipore |
---|
MSSK1 | inactive (107%) |
SRPK1 | inactive (114%) |
SRPK2 | inactive (94%) |
AGC
AGC - DMPK
Bioactivity |
---|
Kinase | Millipore |
---|
DMPK1 | inactive (102%) |
MRCKa | inactive (98%) |
MRCKb | inactive (89%) |
ROCK1 | active (34%) |
ROCK2 | active (1%) |
AGC - GRK
Bioactivity |
---|
Kinase | Millipore |
---|
GPRK5 | inactive (98%) |
GPRK6 | inactive (84%) |
GPRK7 | inactive (79%) |
AGC - RSK
Bioactivity |
---|
Kinase | Millipore |
---|
MSK1 | inactive (126%) |
MSK2 | inactive (66%) |
p70S6K | inactive (113%) |
RSK3 | inactive (116%) |
RSK2 | inactive (60%) |
RSK1 | inactive (101%) |
RSK4 | inactive (90%) |
AGC - PDK1
Bioactivity |
---|
Kinase | Millipore |
---|
PDK1 | inactive (102%) |
AGC - PKA
Bioactivity |
---|
Kinase | Millipore |
---|
PKACa | inactive (69%) |
PRKX | inactive (57%) |
AGC - Akt
Bioactivity |
---|
Kinase | Millipore |
---|
AKT1 | inactive (102%) |
AKT2 | inactive (149%) |
AKT3 | inactive (100%) |
AGC - PKC
Bioactivity |
---|
Kinase | Millipore |
---|
PKCa | inactive (99%) |
PKCg | inactive (113%) |
PKCd | active (7%) |
PKCe | inactive (58%) |
PKCz | inactive (88%) |
PKCh | active (27%) |
PKCt | active (21%) |
PKCi | inactive (82%) |
AGC - PKN
Bioactivity |
---|
Kinase | Millipore |
---|
PKN2 | active (22%) |
AGC - SGK
Bioactivity |
---|
Kinase | Millipore |
---|
SGK1 | inactive (88%) |
SGK2 | inactive (111%) |
SGK3 | inactive (93%) |
Atypical
Atypical
Test Member No. in Family |
---|
Family | no. Member on 518kinase | Millipore |
---|
Alpha | 6 | 1 |
PIKK | 6 | 1 |
Atypical - Alpha
Bioactivity |
---|
Kinase | Millipore |
---|
eEF2K | inactive (72%) |
Atypical - PIKK
Bioactivity |
---|
Kinase | Millipore |
---|
FRAP | inactive (114%) |