Compound Information
Test on : Metz
Compound Name : Kinome_765
Inchikey : MTCHQDWUHQADSY-UHFFFAOYSA-N
ChemSpider : 24809010
Pubchem CID : 49830423
ChEMBL : CHEMBL1969190
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
AGC
AGC - Akt
Bioactivity |
---|
Kinase | Metz |
---|
AKT1 | inactive (>7943.28nM) |
AKT2 | inactive (>7943.28nM) |
AKT3 | inactive (>10000nM) |
AGC - DMPK
Bioactivity |
---|
Kinase | Metz |
---|
MRCKa | inactive (>10000nM) |
ROCK1 | inactive (1258.93nM) |
ROCK2 | active (316.23nM) |
AGC - GRK
Bioactivity |
---|
Kinase | Metz |
---|
GPRK5 | - |
AGC - PDK1
Bioactivity |
---|
Kinase | Metz |
---|
PDK1 | inactive (>3981.07nM) |
AGC - PKA
Bioactivity |
---|
Kinase | Metz |
---|
PKACa | inactive (>7943.28nM) |
PRKX | inactive (>1584.89nM) |
AGC - PKC
Bioactivity |
---|
Kinase | Metz |
---|
PKCd | inactive (>7943.28nM) |
PKCg | inactive (>7943.28nM) |
PKCz | inactive (>7943.28nM) |
PKCi | inactive (>5011.87nM) |
PKCt | - |
AGC - PKG
Bioactivity |
---|
Kinase | Metz |
---|
PKG1 | inactive (>1995.26nM) |
PKG2 | inactive (>1584.89nM) |
AGC - PKN
Bioactivity |
---|
Kinase | Metz |
---|
PKN2 | inactive (>7943.28nM) |
AGC - RSK
Bioactivity |
---|
Kinase | Metz |
---|
RSK2 | inactive (3162.28nM) |
p70S6K | active (398.11nM) |
MSK1 | active (1000nM) |
MSK2 | - |
AGC - SGK
Bioactivity |
---|
Kinase | Metz |
---|
SGK1 | inactive (>10000nM) |
Atypical
Atypical
Test Member No. in Family |
---|
Family | no. Member on 518kinase | Metz |
---|
Alpha | 6 | 1 |
Atypical - Alpha
Bioactivity |
---|
Kinase | Metz |
---|
eEF2K | inactive (>3981.07nM) |
CAMK
CAMK - CAMK1
Bioactivity |
---|
Kinase | Metz |
---|
CaMK1a | inactive (3162.28nM) |
CaMK1d | - |
CAMK - CAMK2
Bioactivity |
---|
Kinase | Metz |
---|
CaMK2b | inactive (>7943.28nM) |
CaMK2d | inactive (>6309.57nM) |
CaMK2g | inactive (>6309.57nM) |
CaMK2a | - |
CAMK - CAMKL
Bioactivity |
---|
Kinase | Metz |
---|
CHK1 | inactive (>7943.28nM) |
BRSK1 | inactive (7943.28nM) |
MARK2 | active (630.96nM) |
MARK3 | inactive (1995.26nM) |
MELK | inactive (>1584.89nM) |
AMPKa1 | inactive (>1584.89nM) |
PASK | - |
MARK4 | - |
QIK | - |
CAMK - DAPK
Bioactivity |
---|
Kinase | Metz |
---|
DAPK3 | inactive (>1258.93nM) |
DRAK1 | inactive (>3981.07nM) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | Metz |
---|
DCLK1 | inactive (>10000nM) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | Metz |
---|
MAPKAPK2 | inactive (>7943.28nM) |
MAPKAPK3 | inactive (>10000nM) |
MNK2 | inactive (1258.93nM) |
MAPKAPK5 | inactive (>1584.89nM) |
CAMK - PHK
Bioactivity |
---|
Kinase | Metz |
---|
PHKg2 | inactive (>5011.87nM) |
CAMK - PIM
Bioactivity |
---|
Kinase | Metz |
---|
PIM1 | inactive (>10000nM) |
PIM2 | inactive (>1584.89nM) |
PIM3 | inactive (>7943.28nM) |
CAMK - PKD
Bioactivity |
---|
Kinase | Metz |
---|
PKD3 | inactive (6309.57nM) |
PKD2 | inactive (>10000nM) |
CAMK - RAD53
Bioactivity |
---|
Kinase | Metz |
---|
CHK2 | active (316.23nM) |
CAMK - STK33
Bioactivity |
---|
Kinase | Metz |
---|
STK33 | - |
CAMK - TSSK
Bioactivity |
---|
Kinase | Metz |
---|
TSSK1 | inactive (>1584.89nM) |
TSSK2 | inactive (>1584.89nM) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | Metz |
---|
CK1 | 7 | 5 |
CK1 - CK1
Bioactivity |
---|
Kinase | Metz |
---|
CK1a | inactive (>6309.57nM) |
CK1d | inactive (>7943.28nM) |
CK1g1 | inactive (>6309.57nM) |
CK1g2 | inactive (>7943.28nM) |
CK1g3 | inactive (>6309.57nM) |
CMGC
CMGC - CDK
Bioactivity |
---|
Kinase | Metz |
---|
CDC2 | inactive (>7943.28nM) |
CDK2 | inactive (>7943.28nM) |
CDK5 | inactive (>10000nM) |
CDK8 | - |
CDK7 | - |
CDK9 | - |
CDK11 | - |
CMGC - CK2
Bioactivity |
---|
Kinase | Metz |
---|
CK2a1 | inactive (>6309.57nM) |
CMGC - CLK
Bioactivity |
---|
Kinase | Metz |
---|
CLK2 | inactive (5011.87nM) |
CLK4 | inactive (3981.07nM) |
CMGC - DYRK
Bioactivity |
---|
Kinase | Metz |
---|
DYRK1A | inactive (>6309.57nM) |
DYRK3 | inactive (3981.07nM) |
DYRK4 | inactive (>7943.28nM) |
HIPK2 | active (1000nM) |
HIPK4 | active (158.49nM) |
DYRK1B | - |
CMGC - GSK
Bioactivity |
---|
Kinase | Metz |
---|
GSK3A | inactive (>7943.28nM) |
GSK3B | inactive (>6309.57nM) |
CMGC - MAPK
Bioactivity |
---|
Kinase | Metz |
---|
Erk2 | inactive (>7943.28nM) |
p38g | inactive (>6309.57nM) |
p38d | inactive (>7943.28nM) |
JNK1 | inactive (>3162.28nM) |
JNK2 | inactive (>3981.07nM) |
p38a | - |
JNK3 | - |
NLK | active (398.11nM) |
CMGC - SRPK
Bioactivity |
---|
Kinase | Metz |
---|
SRPK1 | inactive (6309.57nM) |
Other
Other - Aur
Bioactivity |
---|
Kinase | Metz |
---|
AurB | active (3.16nM) |
AurA | active (50.12nM) |
Other - CAMKK
Bioactivity |
---|
Kinase | Metz |
---|
CaMKK2 | - |
Other - CDC7
Bioactivity |
---|
Kinase | Metz |
---|
CDC7 | inactive (>1258.93nM) |
Other - IKK
Bioactivity |
---|
Kinase | Metz |
---|
IKKe | - |
TBK1 | - |
IKKa | - |
IKKb | - |
Other - NEK
Bioactivity |
---|
Kinase | Metz |
---|
NEK2 | inactive (1584.89nM) |
NEK4 | inactive (5011.87nM) |
Other - PLK
Bioactivity |
---|
Kinase | Metz |
---|
PLK1 | inactive (>7943.28nM) |
PLK3 | inactive (3981.07nM) |
PLK4 | inactive (>3981.07nM) |
Other - TOPK
Bioactivity |
---|
Kinase | Metz |
---|
PBK | inactive (>10000nM) |
Other - WEE
Bioactivity |
---|
Kinase | Metz |
---|
Wee1 | - |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | Metz |
---|
STE20 | 31 | 9 |
STE7 | 7 | 2 |
STE - STE20
Bioactivity |
---|
Kinase | Metz |
---|
GCK | active (316.23nM) |
HGK | inactive (3162.28nM) |
KHS1 | active (15.85nM) |
MINK | inactive (1995.26nM) |
PAK1 | inactive (>10000nM) |
PAK4 | inactive (>5011.87nM) |
SLK | inactive (1258.93nM) |
MST2 | active (630.96nM) |
TAO1 | inactive (6309.57nM) |
STE - STE7
Bioactivity |
---|
Kinase | Metz |
---|
MAP2K1 | - |
MAP2K2 | - |
TK
TK - Abl
Bioactivity |
---|
Kinase | Metz |
---|
ABL1 | active (501.19nM) |
TK - Ack
Bioactivity |
---|
Kinase | Metz |
---|
ACK | - |
TK - ALK
Bioactivity |
---|
Kinase | Metz |
---|
ALK | - |
LTK | - |
TK - Axl
Bioactivity |
---|
Kinase | Metz |
---|
TYRO3 | inactive (>1995.26nM) |
AXL | active (79.43nM) |
TK - Csk
Bioactivity |
---|
Kinase | Metz |
---|
CTK | inactive (>1995.26nM) |
TK - EGFR
Bioactivity |
---|
Kinase | Metz |
---|
EGFR | inactive (>1995.26nM) |
ErbB2 | inactive (>1584.89nM) |
ErbB4 | inactive (2511.89nM) |
TK - Eph
Bioactivity |
---|
Kinase | Metz |
---|
EphA2 | inactive (>3162.28nM) |
TK - FAK
Bioactivity |
---|
Kinase | Metz |
---|
FAK | active (398.11nM) |
PYK2 | active (794.33nM) |
TK - Fer
Bioactivity |
---|
Kinase | Metz |
---|
FER | active (316.23nM) |
FES | - |
TK - FGFR
Bioactivity |
---|
Kinase | Metz |
---|
FGFR1 | inactive (1584.89nM) |
FGFR3 | inactive (>1995.26nM) |
TK - InsR
Bioactivity |
---|
Kinase | Metz |
---|
IGF1R | inactive (>1995.26nM) |
INSR | inactive (3162.28nM) |
TK - JakA
Bioactivity |
---|
Kinase | Metz |
---|
JAK2 | inactive (>1584.89nM) |
JAK3 | inactive (>1584.89nM) |
TYK2 | inactive (>1995.26nM) |
TK - Met
Bioactivity |
---|
Kinase | Metz |
---|
MET | inactive (1995.26nM) |
RON | - |
TK - PDGFR
Bioactivity |
---|
Kinase | Metz |
---|
FMS | inactive (>2511.89nM) |
FLT3 | active (39.81nM) |
KIT | inactive (>1258.93nM) |
PDGFRa | - |
PDGFRb | - |
TK - Ret
Bioactivity |
---|
Kinase | Metz |
---|
RET | active (79.43nM) |
TK - Sev
Bioactivity |
---|
Kinase | Metz |
---|
ROS | inactive (1995.26nM) |
TK - Src
Bioactivity |
---|
Kinase | Metz |
---|
BLK | active (100nM) |
LCK | active (125.89nM) |
LYN | active (79.43nM) |
SRC | inactive (1995.26nM) |
FRK | active (398.11nM) |
SRM | inactive (>1584.89nM) |
FYN | active (316.23nM) |
BRK | inactive (>2511.89nM) |
HCK | - |
TK - Syk
Bioactivity |
---|
Kinase | Metz |
---|
SYK | inactive (>1584.89nM) |
TK - Tec
Bioactivity |
---|
Kinase | Metz |
---|
BTK | inactive (>1258.93nM) |
ITK | active (794.33nM) |
BMX | - |
TK - Trk
Bioactivity |
---|
Kinase | Metz |
---|
TRKA | inactive (1584.89nM) |
TRKB | inactive (1258.93nM) |
TRKC | - |
TK - VEGFR
Bioactivity |
---|
Kinase | Metz |
---|
FLT4 | active (794.33nM) |
KDR | active (125.89nM) |
FLT1 | active (15.85nM) |
TKL
TKL - IRAK
Bioactivity |
---|
Kinase | Metz |
---|
IRAK1 | inactive (>7943.28nM) |
IRAK4 | inactive (>10000nM) |
TKL - LISK
Bioactivity |
---|
Kinase | Metz |
---|
LIMK1 | inactive (10000nM) |
TKL - LRRK
Bioactivity |
---|
Kinase | Metz |
---|
LRRK2 | - |
TKL - MLK
Bioactivity |
---|
Kinase | Metz |
---|
ZAK | inactive (>7943.28nM) |
MLK2 | - |
TKL - RAF
Bioactivity |
---|
Kinase | Metz |
---|
BRAF | - |
TKL - STKR
Bioactivity |
---|
Kinase | Metz |
---|
ALK2 | - |