Compound Information
Test on : GPCR
Compound Name : GW828525X
Inchikey : MQWZYEDJGHLFFI-UHFFFAOYSA-N
ChemSpider : 5021884
Pubchem CID : 6539418
ChEMBL : CHEMBL185939
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (24.27%) |
TYK2 | inactive (5.73%) |
JAK2 | inactive (-0.89%) |
JAK3 | inactive (4.36%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (12.12%) |
FES | inactive (1.22%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (13.74%) |
ABL2 | inactive (9.47%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (6.46%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (0.4%) |
BTK | inactive (7.22%) |
TXK | inactive (4.7%) |
TEC | inactive (5.21%) |
ITK | inactive (4.7%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (12.03%) |
SRM | inactive (8.73%) |
FRK | inactive (2.35%) |
BLK | inactive (15.73%) |
LCK | inactive (42.51%) |
HCK | inactive (15.09%) |
FGR | active (61.1%) |
FYN | inactive (21.16%) |
SRC | inactive (15.78%) |
YES | active (83.27%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (3.45%) |
EphA4 | inactive (21.18%) |
EphA3 | inactive (2.49%) |
EphB4 | inactive (10.25%) |
EphB3 | inactive (-4.69%) |
EphB2 | inactive (36.72%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (1.96%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (0.25%) |
ZAP70 | inactive (5.21%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (3.42%) |
ALK | inactive (1.59%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (9.43%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (0.63%) |
IGF1R | inactive (-2.92%) |
IRR | inactive (0.97%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (24.95%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (14.97%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (0.14%) |
TRKB | inactive (3.15%) |
TRKC | inactive (4.32%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (0.63%) |
MET | inactive (12.08%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (7.56%) |
MER | inactive (8.55%) |
TYRO3 | inactive (5.58%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (29.18%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (6.28%) |
FGFR2 | inactive (11.05%) |
FGFR3 | inactive (6.94%) |
FGFR4 | inactive (11.7%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (4.89%) |
KDR | inactive (9.68%) |
FLT4 | inactive (4.74%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (10.3%) |
KIT | inactive (41.44%) |
FLT3 | inactive (0.28%) |
PDGFRa | inactive (19.54%) |
PDGFRb | inactive (17.43%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (33.81%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (8.14%) |
TNK1 | inactive (22.23%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (19.25%) |
ErbB2 | inactive (12.49%) |
ErbB4 | inactive (43.5%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (1.44%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (-1.17%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (6.88%) |
MST1 | inactive (7.46%) |
MST2 | inactive (8.12%) |
MST4 | inactive (7.92%) |
HGK | inactive (12.01%) |
MINK | inactive (11.52%) |
LOK | inactive (30.12%) |
PAK1 | inactive (0.84%) |
PAK3 | inactive (4.75%) |
PAK2 | inactive (1.42%) |
PAK5 | inactive (11.32%) |
PAK6 | inactive (15.5%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (-1.13%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (4.54%) |
CK1g2 | inactive (0.81%) |
CK1g1 | inactive (0.59%) |
CK1g3 | inactive (1.72%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (-1.77%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (11.16%) |
AurC | inactive (12.12%) |
AurA | inactive (29.24%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (2.05%) |
NEK2 | inactive (1.32%) |
NEK9 | inactive (-0.89%) |
NEK7 | inactive (-5.62%) |
NEK6 | inactive (1.37%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (4.67%) |
IKKe | inactive (-1.52%) |
IKKb | inactive (2.22%) |
IKKa | inactive (0.75%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (2.98%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (11.6%) |
GPRK6 | inactive (12.56%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (1.37%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (4.3%) |
MSK2 | inactive (6.41%) |
RSK1 | inactive (3.18%) |
RSK2 | inactive (5.4%) |
RSK4 | inactive (0.72%) |
RSK3 | inactive (0.6%) |
p70S6K | inactive (2.06%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (0.25%) |
AKT1 | inactive (0.98%) |
AKT3 | inactive (-0.79%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (10.2%) |
SGK3 | inactive (12.89%) |
SGK2 | inactive (10.75%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (6.69%) |
PKCg | inactive (5.47%) |
PKCa | inactive (1.28%) |
PKCt | inactive (5.32%) |
PKCi | inactive (3.53%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (4.83%) |
PKG1 | inactive (5.3%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (8.53%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (2.51%) |
ROCK2 | inactive (8.18%) |
MRCKb | inactive (4.64%) |
MRCKa | inactive (5.17%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (5.26%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (2.77%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (-4.43%) |
CaMK1d | inactive (-0.58%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (8.64%) |
PHKg2 | inactive (6.97%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (-2.99%) |
CaMK2a | inactive (-2.19%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (5.39%) |
MAPKAPK2 | inactive (3.56%) |
MAPKAPK3 | inactive (30.58%) |
MNK2 | inactive (9.7%) |
MNK1 | inactive (10.95%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (-0.07%) |
PKD1 | inactive (-1.71%) |
PKD2 | inactive (3.07%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (6.4%) |
MARK3 | inactive (11.21%) |
MARK1 | inactive (6.64%) |
QIK | inactive (0.08%) |
SIK | inactive (0.84%) |
NuaK1 | inactive (5.73%) |
BRSK1 | inactive (8.29%) |
BRSK2 | inactive (11.65%) |
MELK | inactive (-0.13%) |
CHK1 | inactive (1.68%) |
PASK | inactive (10.89%) |
AMPKa1 | inactive (4.07%) |
AMPKa2 | inactive (4.55%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (5.84%) |
TSSK1 | inactive (4.75%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (1.79%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (5.12%) |
PIM3 | inactive (10.25%) |
PIM1 | inactive (1.86%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (32.65%) |
p38a | active (67.47%) |
p38b | inactive (36.75%) |
p38d | inactive (0.38%) |
Erk2 | inactive (-1.13%) |
Erk1 | inactive (3.1%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (6.68%) |
GSK3B | inactive (9.99%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (13.04%) |
MSSK1 | inactive (1.12%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (5.27%) |
CLK2 | inactive (2.93%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (7.72%) |
HIPK4 | inactive (11.18%) |
DYRK1B | inactive (5.88%) |
DYRK1A | inactive (6.32%) |
DYRK2 | inactive (0.53%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (19.81%) |