Compound in Profiling

Compound Information

Test on : RBC, Millipore

Compound Name
RBC : -
Millipore : herbimycin a

Inchikey
Same : MCAHMSDENAOJFZ-N
RBC : MCAHMSDENAOJFZ-SCUXEZOQSA-N
Millipore : MCAHMSDENAOJFZ-NDSMKMDISA-N

ChemSpider
RBC : -
Millipore : 21395930

Pubchem CID
RBC : -
Millipore : 16760502

ChEMBL
RBC : -
Millipore : -

RBC	Millipore
	CANNOT FIND

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDK1	1	1	1
Akt	3	3	3
DMPK	7	5	5
GRK	7	6	3
RSK	8	8	7
PKA	5	3	2
PKC	9	9	8
PKG	2	3	-
PKN	3	2	1
SGK	3	3	3
NDR	4	1	-

AGC - PDK1

Bioactivity
Kinase	RBC	Millipore
PDK1	inactive (102.3%)	inactive (112%)

AGC - Akt

Bioactivity
Kinase	RBC	Millipore
AKT1	inactive (93.29%)	inactive (112%)
AKT2	inactive (94.37%)	inactive (96%)
AKT3	inactive (94.15%)	inactive (94%)

AGC - DMPK

Bioactivity
Kinase	RBC	Millipore
DMPK1	inactive (99.52%)	inactive (147%)
MRCKa	inactive (91.58%)	inactive (114%)
MRCKb	inactive (100.55%)	inactive (97%)
ROCK1	inactive (105.03%)	inactive (121%)
ROCK2	inactive (95.36%)	inactive (106%)

AGC - GRK

Bioactivity
Kinase	RBC	Millipore
BARK1	inactive (95.71%)	-
BARK2	inactive (101.27%)	-
GPRK4	inactive (103.35%)	-
GPRK5	inactive (104.94%)	inactive (70%)
GPRK6	inactive (105.58%)	inactive (97%)
GPRK7	inactive (102.88%)	inactive (100%)

AGC - RSK

Bioactivity
Kinase	RBC	Millipore
MSK1	inactive (98.16%)	inactive (115%)
MSK2	inactive (96.65%)	inactive (92%)
p70S6K	inactive (95.62%)	inactive (75%)
p70S6Kb	inactive (104.5%)	-
RSK2	inactive (98.98%)	active (50%)
RSK4	inactive (104.31%)	inactive (113%)
RSK1	inactive (76.76%)	inactive (93%)
RSK3	inactive (94.19%)	inactive (115%)

AGC - PKA

Bioactivity
Kinase	RBC	Millipore
PKACg	-	-
PRKX	inactive (97.17%)	inactive (80%)
PKACa	inactive (94.16%)	inactive (79%)

AGC - PKC

Bioactivity
Kinase	RBC	Millipore
PKCa	inactive (123.07%)	inactive (110%)
PKCd	inactive (96.81%)	inactive (107%)
PKCe	inactive (98.25%)	inactive (100%)
PKCh	inactive (95.32%)	inactive (118%)
PKCg	inactive (90.4%)	inactive (111%)
PKCi	inactive (95.43%)	inactive (92%)
PKCt	inactive (93.02%)	inactive (100%)
PKCz	inactive (86.81%)	inactive (104%)
PKCb	inactive (96.91%)	-

AGC - PKG

Bioactivity
Kinase	RBC	Millipore
PKG2	inactive (98.18%)	-
PKG1	inactive (95.71%)	-

AGC - PKN

Bioactivity
Kinase	RBC	Millipore
PKN1	inactive (103.75%)	-
PKN2	inactive (100.07%)	inactive (111%)

AGC - SGK

Bioactivity
Kinase	RBC	Millipore
SGK1	inactive (91.58%)	inactive (98%)
SGK2	inactive (96.06%)	inactive (97%)
SGK3	inactive (101.7%)	inactive (95%)

AGC - NDR

Bioactivity
Kinase	RBC	Millipore
NDR1	active (0%)	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Abl	2	2	2
Ack	2	1	1
ALK	2	2	1
Axl	3	3	3
Src	11	11	10
Tec	5	5	4
PDGFR	5	5	5
Csk	2	2	1
DDR	2	1	1
EGFR	4	3	2
Eph	14	12	11
FAK	2	2	2
Fer	2	2	2
FGFR	4	4	4
VEGFR	3	3	3
InsR	3	3	3
JakA	4	4	2
Musk	1	1	1
Ret	1	1	1
Met	2	2	2
Sev	1	1	1
Syk	2	2	2
Tie	2	1	1
Trk	3	3	2

TK - Abl

Bioactivity
Kinase	RBC	Millipore
ABL1	inactive (103.7%)	inactive (94%)
ABL2	inactive (94.75%)	inactive (111%)

TK - Ack

Bioactivity
Kinase	RBC	Millipore
ACK	inactive (96.97%)	inactive (92%)

TK - ALK

Bioactivity
Kinase	RBC	Millipore
ALK	inactive (89.72%)	inactive (71%)
LTK	inactive (98.49%)	-

TK - Axl

Bioactivity
Kinase	RBC	Millipore
AXL	inactive (95.32%)	inactive (104%)
MER	inactive (95.33%)	inactive (105%)
TYRO3	inactive (96.93%)	inactive (86%)

TK - Src

Bioactivity
Kinase	RBC	Millipore
BLK	inactive (100.97%)	inactive (90%)
BRK	inactive (103.61%)	inactive (109%)
SRC	inactive (102.58%)	inactive (101%)
FGR	inactive (90.3%)	inactive (99%)
FRK	inactive (96.7%)	inactive (114%)
FYN	inactive (99.34%)	inactive (88%)
HCK	inactive (106.94%)	inactive (78%)
LCK	inactive (91.81%)	inactive (142%)
SRM	inactive (95.77%)	-
YES	inactive (90.51%)	inactive (101%)
LYN	inactive (109.45%)	inactive (85%)

TK - Tec

Bioactivity
Kinase	RBC	Millipore
BMX	inactive (101.08%)	inactive (94%)
BTK	inactive (102.73%)	inactive (83%)
ITK	inactive (101.83%)	inactive (106%)
TEC	inactive (147.26%)	-
TXK	inactive (98.13%)	inactive (89%)

TK - PDGFR

Bioactivity
Kinase	RBC	Millipore
KIT	inactive (106.5%)	inactive (104%)
FLT3	inactive (96.82%)	inactive (85%)
FMS	inactive (104.06%)	inactive (131%)
PDGFRb	inactive (104.14%)	inactive (108%)
PDGFRa	inactive (92.11%)	inactive (114%)

TK - Csk

Bioactivity
Kinase	RBC	Millipore
CSK	inactive (97.96%)	inactive (108%)
CTK	inactive (95.13%)	-

TK - DDR

Bioactivity
Kinase	RBC	Millipore
DDR2	inactive (97.89%)	inactive (98%)

TK - EGFR

Bioactivity
Kinase	RBC	Millipore
EGFR	inactive (95.13%)	inactive (108%)
ErbB2	inactive (101.82%)	-
ErbB4	inactive (99.91%)	inactive (92%)

TK - Eph

Bioactivity
Kinase	RBC	Millipore
EphA1	inactive (103.2%)	inactive (94%)
EphA2	inactive (107.13%)	inactive (105%)
EphA3	inactive (98.02%)	inactive (101%)
EphA4	inactive (105.84%)	inactive (110%)
EphA5	inactive (112.2%)	inactive (107%)
EphA6	-	-
EphA7	inactive (102.37%)	inactive (95%)
EphA8	inactive (94.38%)	inactive (96%)
EphB1	inactive (103.55%)	inactive (109%)
EphB2	inactive (86.91%)	inactive (115%)
EphB3	inactive (91.27%)	inactive (111%)
EphB4	inactive (96.94%)	inactive (94%)

TK - FAK

Bioactivity
Kinase	RBC	Millipore
FAK	inactive (102.62%)	inactive (110%)
PYK2	inactive (104.12%)	inactive (124%)

TK - Fer

Bioactivity
Kinase	RBC	Millipore
FER	inactive (88.2%)	inactive (110%)
FES	inactive (95.97%)	inactive (111%)

TK - FGFR

Bioactivity
Kinase	RBC	Millipore
FGFR1	inactive (93.13%)	inactive (82%)
FGFR2	inactive (109.57%)	inactive (104%)
FGFR3	inactive (93.87%)	inactive (112%)
FGFR4	inactive (104.83%)	inactive (109%)

TK - VEGFR

Bioactivity
Kinase	RBC	Millipore
FLT1	inactive (102.4%)	inactive (86%)
FLT4	inactive (99.74%)	inactive (92%)
KDR	inactive (90.25%)	inactive (97%)

TK - InsR

Bioactivity
Kinase	RBC	Millipore
IGF1R	inactive (103.56%)	inactive (137%)
IRR	inactive (95.2%)	inactive (133%)
INSR	inactive (95.63%)	inactive (109%)

TK - JakA

Bioactivity
Kinase	RBC	Millipore
JAK1	inactive (98.99%)	-
JAK2	inactive (94.15%)	inactive (114%)
JAK3	inactive (95.45%)	inactive (94%)
TYK2	inactive (102.09%)	-

TK - Musk

Bioactivity
Kinase	RBC	Millipore
MUSK	inactive (95.25%)	inactive (104%)

TK - Ret

Bioactivity
Kinase	RBC	Millipore
RET	inactive (95.74%)	inactive (108%)

TK - Met

Bioactivity
Kinase	RBC	Millipore
RON	inactive (102.81%)	inactive (85%)
MET	inactive (134.84%)	inactive (114%)

TK - Sev

Bioactivity
Kinase	RBC	Millipore
ROS	inactive (91.89%)	inactive (92%)

TK - Syk

Bioactivity
Kinase	RBC	Millipore
SYK	inactive (89.53%)	inactive (110%)
ZAP70	inactive (101.99%)	inactive (98%)

TK - Tie

Bioactivity
Kinase	RBC	Millipore
TIE2	inactive (96.34%)	inactive (84%)

TK - Trk

Bioactivity
Kinase	RBC	Millipore
TRKA	inactive (92.3%)	inactive (120%)
TRKB	inactive (94.01%)	inactive (113%)
TRKC	inactive (116.68%)	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STKR	12	5	2
RAF	5	3	1
IRAK	4	2	2
LISK	4	1	1
LRRK	2	1	-
MLK	10	5	2
RIPK	5	1	1

TKL - STKR

Bioactivity
Kinase	RBC	Millipore
ALK1	inactive (100.76%)	-
ALK2	inactive (102.04%)	-
ALK4	inactive (99.51%)	inactive (112%)
TGFbR1	inactive (103.04%)	inactive (99%)
TGFbR2	inactive (127.9%)	-

TKL - RAF

Bioactivity
Kinase	RBC	Millipore
ARAF	inactive (92.38%)	-
BRAF	inactive (95.69%)	-
RAF1	inactive (92.67%)	inactive (93%)

TKL - IRAK

Bioactivity
Kinase	RBC	Millipore
IRAK1	inactive (71.83%)	inactive (106%)
IRAK4	inactive (104.6%)	inactive (107%)

TKL - LISK

Bioactivity
Kinase	RBC	Millipore
LIMK1	inactive (89.07%)	inactive (109%)

TKL - LRRK

Bioactivity
Kinase	RBC	Millipore
LRRK2	inactive (92.03%)	-

TKL - MLK

Bioactivity
Kinase	RBC	Millipore
MLK1	inactive (105.48%)	inactive (92%)
MLK2	inactive (101.42%)	-
MLK3	inactive (89.96%)	-
TAK1	inactive (98.31%)	inactive (96%)
ZAK	inactive (92.18%)	-

TKL - RIPK

Bioactivity
Kinase	RBC	Millipore
RIPK2	inactive (115.11%)	inactive (93%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CAMKL	20	13	12
CAMK1	5	5	3
CAMK2	4	4	3
RAD53	1	1	1
DAPK	5	4	4
DCAMKL	3	1	1
MAPKAPK	5	5	4
MLCK	5	2	1
PHK	2	2	1
PIM	3	3	3
PKD	3	3	2
TSSK	5	2	2
STK33	1	-	-

CAMK - CAMKL

Bioactivity
Kinase	RBC	Millipore
NuaK1	inactive (90.06%)	inactive (93%)
BRSK1	inactive (97.93%)	inactive (76%)
BRSK2	inactive (95.24%)	inactive (92%)
CHK1	inactive (95.44%)	inactive (96%)
LKB1	inactive (102.29%)	inactive (97%)
MARK1	inactive (90.46%)	inactive (92%)
MARK3	inactive (112.18%)	-
MARK4	inactive (93.28%)	-
MELK	inactive (97.94%)	inactive (60%)
PASK	inactive (95.11%)	inactive (125%)
QIK	inactive (103.01%)	-
NuaK2	inactive (106.01%)	-
MARK2	inactive (103.9%)	inactive (114%)
AMPKa1	-	inactive (94%)
AMPKa2	-	inactive (92%)
SIK	-	inactive (82%)

CAMK - CAMK1

Bioactivity
Kinase	RBC	Millipore
CaMK1a	inactive (91.34%)	inactive (115%)
CaMK1b	inactive (98.47%)	-
CaMK1d	inactive (92.82%)	inactive (112%)
CaMK1g	inactive (104.87%)	-
CaMK4	inactive (97.71%)	inactive (89%)

CAMK - CAMK2

Bioactivity
Kinase	RBC	Millipore
CaMK2a	inactive (98.3%)	-
CaMK2b	inactive (100.4%)	inactive (97%)
CaMK2d	inactive (100.63%)	inactive (102%)
CaMK2g	inactive (89.58%)	inactive (107%)

CAMK - RAD53

Bioactivity
Kinase	RBC	Millipore
CHK2	inactive (100.55%)	inactive (91%)

CAMK - DAPK

Bioactivity
Kinase	RBC	Millipore
DAPK1	inactive (101.03%)	inactive (96%)
DAPK2	inactive (95.79%)	inactive (104%)
DRAK1	inactive (92.93%)	inactive (86%)
DAPK3	inactive (98.94%)	inactive (108%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC	Millipore
DCLK2	inactive (96.93%)	inactive (89%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC	Millipore
MAPKAPK2	inactive (95.9%)	inactive (101%)
MAPKAPK3	inactive (105.45%)	inactive (110%)
MAPKAPK5	inactive (95.89%)	inactive (107%)
MNK1	inactive (109.84%)	-
MNK2	inactive (91.48%)	inactive (104%)

CAMK - MLCK

Bioactivity
Kinase	RBC	Millipore
smMLCK	inactive (97.64%)	inactive (98%)
skMLCK	inactive (93.65%)	-

CAMK - PHK

Bioactivity
Kinase	RBC	Millipore
PHKg1	inactive (100.27%)	-
PHKg2	inactive (100.31%)	inactive (97%)

CAMK - PIM

Bioactivity
Kinase	RBC	Millipore
PIM1	inactive (98.85%)	inactive (85%)
PIM2	inactive (86.98%)	inactive (99%)
PIM3	inactive (98.21%)	inactive (98%)

CAMK - PKD

Bioactivity
Kinase	RBC	Millipore
PKD1	inactive (97.34%)	inactive (119%)
PKD3	inactive (100.42%)	-
PKD2	inactive (93.71%)	inactive (102%)

CAMK - TSSK

Bioactivity
Kinase	RBC	Millipore
TSSK1	inactive (93.04%)	inactive (100%)
TSSK2	inactive (98.34%)	inactive (97%)

CAMK - STK33

Bioactivity
Kinase	RBC	Millipore
STK33	inactive (97.03%)	inactive (98%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STE11	8	3	1
STE-Unique	2	2	-
STE20	31	23	14
STE7	7	3	3

STE - STE11

Bioactivity
Kinase	RBC	Millipore
MAP3K5	inactive (99.38%)	inactive (88%)
MAP3K2	inactive (101.63%)	-
MAP3K3	inactive (102.54%)	-

STE - STE-Unique

Bioactivity
Kinase	RBC	Millipore
COT	inactive (97.98%)	-
NIK	inactive (67.94%)	-

STE - STE20

Bioactivity
Kinase	RBC	Millipore
GCK	inactive (120.17%)	inactive (92%)
HGK	inactive (92.05%)	-
KHS1	inactive (109.21%)	-
LOK	inactive (95.58%)	inactive (100%)
MINK	inactive (90.83%)	inactive (95%)
MST1	inactive (95.65%)	inactive (101%)
MST2	inactive (95.05%)	inactive (110%)
MST3	inactive (79.61%)	inactive (68%)
MST4	inactive (85.28%)	-
OSR1	inactive (107.07%)	-
PAK1	inactive (94.12%)	-
PAK2	inactive (96.1%)	inactive (108%)
PAK3	inactive (98.33%)	inactive (68%)
PAK4	inactive (108.75%)	inactive (106%)
PAK5	inactive (93.79%)	inactive (92%)
PAK6	inactive (96.32%)	inactive (99%)
SLK	inactive (97.14%)	-
YSK1	inactive (98.96%)	-
STLK3	inactive (86.47%)	-
TAO1	inactive (99.27%)	inactive (98%)
TAO2	inactive (89.4%)	inactive (99%)
TAO3	inactive (101.86%)	inactive (107%)
MYO3B	active (0%)	-

STE - STE7

Bioactivity
Kinase	RBC	Millipore
MAP2K1	inactive (99.02%)	inactive (102%)
MAP2K2	inactive (101.09%)	-
MAP2K6	inactive (89.23%)	inactive (72%)
MAP2K7	-	inactive (92%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Aur	3	3	3
CAMKK	2	2	-
Haspin	1	1	1
IKK	4	4	3
NEK	11	8	5
TOPK	1	1	-
PLK	4	3	3
SgK496	1	1	-
NAK	4	1	-
TTK	1	1	-
ULK	5	3	2
WEE	3	1	-
WNK	4	2	2
TLK	2	1	1

Other - Aur

Bioactivity
Kinase	RBC	Millipore
AurA	inactive (91%)	inactive (77%)
AurB	inactive (93.62%)	inactive (72%)
AurC	inactive (99.49%)	inactive (76%)

Other - CAMKK

Bioactivity
Kinase	RBC	Millipore
CaMKK1	inactive (119.42%)	-
CaMKK2	inactive (97.3%)	-

Other - Haspin

Bioactivity
Kinase	RBC	Millipore
Haspin	inactive (91.9%)	inactive (88%)

Other - IKK

Bioactivity
Kinase	RBC	Millipore
IKKa	inactive (99.91%)	inactive (85%)
IKKb	inactive (94.16%)	inactive (111%)
IKKe	inactive (102.98%)	-
TBK1	inactive (100.96%)	inactive (77%)

Other - NEK

Bioactivity
Kinase	RBC	Millipore
NEK1	inactive (100.08%)	-
NEK11	inactive (103.9%)	inactive (97%)
NEK2	inactive (102.41%)	inactive (95%)
NEK4	inactive (95.39%)	-
NEK6	inactive (101.41%)	inactive (103%)
NEK7	inactive (100.18%)	inactive (89%)
NEK9	inactive (103.19%)	-
NEK3	inactive (110.88%)	inactive (101%)

Other - TOPK

Bioactivity
Kinase	RBC	Millipore
PBK	inactive (100.51%)	-

Other - PLK

Bioactivity
Kinase	RBC	Millipore
PLK1	inactive (99.52%)	inactive (86%)
PLK2	inactive (101.72%)	inactive (100%)
PLK3	inactive (100.24%)	inactive (99%)

Other - SgK496

Bioactivity
Kinase	RBC	Millipore
SgK496	inactive (109.66%)	-

Other - NAK

Bioactivity
Kinase	RBC	Millipore
MPSK1	inactive (100.7%)	-

Other - TTK

Bioactivity
Kinase	RBC	Millipore
TTK	inactive (117.97%)	-

Other - ULK

Bioactivity
Kinase	RBC	Millipore
ULK1	inactive (92.73%)	-
ULK2	inactive (106.63%)	inactive (100%)
ULK3	active (0%)	inactive (88%)

Other - WEE

Bioactivity
Kinase	RBC	Millipore
Wee1	inactive (101.65%)	-

Other - WNK

Bioactivity
Kinase	RBC	Millipore
Wnk2	inactive (98.31%)	inactive (100%)
Wnk3	inactive (99.4%)	inactive (112%)

Other - TLK

Bioactivity
Kinase	RBC	Millipore
TLK2	active (0%)	inactive (90%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK1	7	6	4
VRK	3	1	1

CK1 - CK1

Bioactivity
Kinase	RBC	Millipore
CK1d	inactive (97.17%)	inactive (90%)
CK1g1	inactive (101.42%)	inactive (91%)
CK1g2	inactive (97.46%)	inactive (73%)
CK1g3	inactive (95.2%)	inactive (87%)
CK1a	inactive (107.35%)	-
CK1e	inactive (85.86%)	-

CK1 - VRK

Bioactivity
Kinase	RBC	Millipore
VRK1	inactive (91.94%)	-
VRK2	-	inactive (108%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK2	3	2	2
CLK	4	4	2
DYRK	10	9	4
MAPK	14	10	10
GSK	2	2	2
SRPK	3	3	3

CMGC - CK2

Bioactivity
Kinase	RBC	Millipore
CK2a1	inactive (101.52%)	inactive (88%)
CK2a2	inactive (90.79%)	inactive (99%)

CMGC - CLK

Bioactivity
Kinase	RBC	Millipore
CLK1	inactive (100.94%)	-
CLK2	inactive (89.33%)	inactive (100%)
CLK3	inactive (93.09%)	inactive (88%)
CLK4	inactive (86.87%)	-

CMGC - DYRK

Bioactivity
Kinase	RBC	Millipore
DYRK1A	inactive (104.16%)	-
DYRK1B	inactive (103.75%)	-
DYRK2	inactive (93.38%)	inactive (95%)
DYRK3	inactive (100.53%)	-
DYRK4	inactive (94.02%)	-
HIPK1	inactive (106.03%)	inactive (102%)
HIPK2	inactive (102.39%)	inactive (108%)
HIPK3	inactive (102.22%)	inactive (100%)
HIPK4	inactive (108.29%)	-

CMGC - MAPK

Bioactivity
Kinase	RBC	Millipore
Erk1	inactive (90.64%)	inactive (88%)
Erk2	inactive (94.38%)	inactive (105%)
JNK3	inactive (88.67%)	inactive (113%)
NLK	inactive (101.68%)	inactive (110%)
p38a	inactive (93.9%)	inactive (95%)
p38b	inactive (95.89%)	inactive (98%)
p38d	inactive (103.68%)	inactive (89%)
p38g	inactive (95.38%)	inactive (110%)
JNK1	inactive (103.46%)	inactive (120%)
JNK2	inactive (97.08%)	inactive (114%)

CMGC - GSK

Bioactivity
Kinase	RBC	Millipore
GSK3A	inactive (113.32%)	inactive (100%)
GSK3B	inactive (98.75%)	inactive (92%)

CMGC - SRPK

Bioactivity
Kinase	RBC	Millipore
MSSK1	inactive (99.55%)	inactive (116%)
SRPK1	inactive (88.75%)	inactive (104%)
SRPK2	inactive (95.8%)	inactive (104%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDHK	5	1	-
Alpha	6	-	1
PIKK	6	-	1

Atypical - PDHK

Bioactivity
Kinase	RBC	Millipore
PDHK1	inactive (102.3%)	-

Atypical - Alpha

Bioactivity
Kinase	RBC	Millipore
eEF2K	-	inactive (120%)

Atypical - PIKK

Bioactivity
Kinase	RBC	Millipore
FRAP	-	inactive (95%)