Compound Information
Test on : GPCR
Compound Name : GW827396X
Inchikey : LKJHBVBZNPEUNP-UHFFFAOYSA-N
ChemSpider : 5021878
Pubchem CID : 6539412
ChEMBL : CHEMBL427159
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (14.56%) |
TYK2 | inactive (-1.25%) |
JAK2 | inactive (1.18%) |
JAK3 | inactive (0.8%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (7.64%) |
FES | inactive (2.57%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (14.71%) |
ABL2 | inactive (11.86%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (8.37%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (6.9%) |
BTK | inactive (0.68%) |
TXK | inactive (5%) |
TEC | inactive (7.67%) |
ITK | inactive (3.13%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (46.2%) |
SRM | inactive (1.37%) |
FRK | inactive (2.26%) |
BLK | inactive (7.65%) |
LCK | inactive (39.14%) |
HCK | inactive (16.47%) |
FGR | active (60.8%) |
FYN | inactive (12.08%) |
SRC | inactive (19.39%) |
YES | active (85.19%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (-0.08%) |
EphA4 | inactive (16.42%) |
EphA3 | inactive (6.3%) |
EphB4 | inactive (7.6%) |
EphB3 | inactive (3.59%) |
EphB2 | inactive (18.59%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (17.91%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-2.02%) |
ZAP70 | inactive (1.2%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (5.06%) |
ALK | inactive (8.04%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (9.74%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (2.06%) |
IGF1R | inactive (3.2%) |
IRR | inactive (3.47%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (34.74%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (3.15%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (3.36%) |
TRKB | inactive (8.32%) |
TRKC | inactive (4.85%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (2.96%) |
MET | inactive (8.73%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-3.4%) |
MER | inactive (7.43%) |
TYRO3 | inactive (6.24%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (18.09%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (0.84%) |
FGFR2 | inactive (7.4%) |
FGFR3 | inactive (7.65%) |
FGFR4 | inactive (0.82%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (6.3%) |
KDR | inactive (20.64%) |
FLT4 | inactive (8.94%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (14.85%) |
KIT | inactive (28.23%) |
FLT3 | inactive (4.16%) |
PDGFRa | inactive (17.66%) |
PDGFRb | inactive (15.34%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (7.31%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (4.87%) |
TNK1 | inactive (9.68%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (9.46%) |
ErbB2 | inactive (5.88%) |
ErbB4 | active (71.35%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (1.76%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (5.29%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (1.49%) |
MST1 | inactive (11.57%) |
MST2 | inactive (10.25%) |
MST4 | inactive (0.76%) |
HGK | inactive (16.35%) |
MINK | inactive (13.81%) |
LOK | inactive (23.51%) |
PAK1 | inactive (5.49%) |
PAK3 | inactive (5.12%) |
PAK2 | inactive (0.93%) |
PAK5 | inactive (0.77%) |
PAK6 | inactive (-1.89%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (3.87%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (6.66%) |
CK1g2 | inactive (3.56%) |
CK1g1 | inactive (4.36%) |
CK1g3 | inactive (3.22%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (2.27%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (14.31%) |
AurC | inactive (6.44%) |
AurA | inactive (28.54%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (2.15%) |
NEK2 | inactive (2.89%) |
NEK9 | inactive (7.17%) |
NEK7 | inactive (4.42%) |
NEK6 | inactive (5.18%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (5.55%) |
IKKe | active (88.22%) |
IKKb | inactive (5.58%) |
IKKa | inactive (8.81%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (-0.7%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (7.95%) |
GPRK6 | inactive (10.11%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (2.46%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (6.45%) |
MSK2 | inactive (4.5%) |
RSK1 | inactive (7.89%) |
RSK2 | inactive (7.14%) |
RSK4 | inactive (1.98%) |
RSK3 | inactive (2.69%) |
p70S6K | inactive (2.58%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (1.42%) |
AKT1 | inactive (2.13%) |
AKT3 | inactive (2.01%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (9.35%) |
SGK3 | inactive (6.1%) |
SGK2 | inactive (7.74%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (7.16%) |
PKCg | inactive (6.44%) |
PKCa | inactive (1.74%) |
PKCt | inactive (7.77%) |
PKCi | inactive (0.63%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (5.3%) |
PKG1 | inactive (3.58%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (8.39%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (1.15%) |
ROCK2 | inactive (6.06%) |
MRCKb | inactive (-0.11%) |
MRCKa | inactive (4.1%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (7.89%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (0.5%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (-4.79%) |
CaMK1d | inactive (1.91%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (10.16%) |
PHKg2 | inactive (9.5%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (7.4%) |
CaMK2a | inactive (4.43%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (4.42%) |
MAPKAPK2 | inactive (2.82%) |
MAPKAPK3 | inactive (32.48%) |
MNK2 | inactive (6.26%) |
MNK1 | inactive (6.32%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (5.09%) |
PKD1 | inactive (5.19%) |
PKD2 | inactive (5.42%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (1.84%) |
MARK3 | inactive (10.46%) |
MARK1 | inactive (8.38%) |
QIK | inactive (7.08%) |
SIK | inactive (8.64%) |
NuaK1 | inactive (5.51%) |
BRSK1 | inactive (7.79%) |
BRSK2 | inactive (7.14%) |
MELK | inactive (4.64%) |
CHK1 | inactive (8.64%) |
PASK | inactive (1.41%) |
AMPKa1 | inactive (9.36%) |
AMPKa2 | inactive (6.49%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (5.03%) |
TSSK1 | inactive (5.79%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (6.8%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (4.2%) |
PIM3 | inactive (6.05%) |
PIM1 | inactive (0.69%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (23.91%) |
p38a | active (80.95%) |
p38b | active (50.85%) |
p38d | inactive (3.31%) |
Erk2 | inactive (5.09%) |
Erk1 | inactive (6.78%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (4.32%) |
GSK3B | inactive (5%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (4.3%) |
MSSK1 | inactive (3.15%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (3.23%) |
CLK2 | inactive (0.41%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (4.38%) |
HIPK4 | inactive (1.58%) |
DYRK1B | inactive (1.01%) |
DYRK1A | inactive (4.84%) |
DYRK2 | inactive (3.6%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (10.46%) |