Compound Information
Test on : GPCR
Compound Name : GSK200398A
Inchikey : LGOFDYJCRIMGHI-ZHEQYFEDSA-N
ChemSpider : 28485080
Pubchem CID : 57391097
ChEMBL : CHEMBL1909408
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (3.26%) |
TYK2 | inactive (1.01%) |
JAK2 | inactive (-1.59%) |
JAK3 | inactive (1.24%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (0.92%) |
FES | inactive (-1.2%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (2.55%) |
ABL2 | inactive (2.25%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (4.15%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (2.39%) |
BTK | inactive (1.05%) |
TXK | inactive (2.69%) |
TEC | inactive (2.89%) |
ITK | inactive (-0.49%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (2.7%) |
SRM | inactive (2.01%) |
FRK | inactive (-1.26%) |
BLK | inactive (6.27%) |
LCK | inactive (6.67%) |
HCK | inactive (3.3%) |
FGR | inactive (11.25%) |
FYN | inactive (8.19%) |
SRC | inactive (-0.98%) |
YES | inactive (23.08%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (-2.68%) |
EphA4 | inactive (1.79%) |
EphA3 | inactive (0.9%) |
EphB4 | inactive (0.96%) |
EphB3 | inactive (2.72%) |
EphB2 | inactive (1.97%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (-1.26%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (0.67%) |
ZAP70 | inactive (2.2%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (-0.87%) |
ALK | inactive (0.05%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (-0.29%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (1.79%) |
IGF1R | inactive (-0.43%) |
IRR | inactive (-2.28%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (0.22%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (-0.19%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (2.5%) |
TRKB | inactive (-0.38%) |
TRKC | inactive (1.3%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (2.37%) |
MET | inactive (1.77%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (2.46%) |
MER | inactive (9.62%) |
TYRO3 | inactive (1.4%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (4.66%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (-1.28%) |
FGFR2 | inactive (-0.52%) |
FGFR3 | inactive (0.43%) |
FGFR4 | inactive (0.38%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (0.04%) |
KDR | inactive (8.91%) |
FLT4 | inactive (1.5%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (4.04%) |
KIT | inactive (0.9%) |
FLT3 | inactive (-3.41%) |
PDGFRa | inactive (8.81%) |
PDGFRb | inactive (6.66%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (5.18%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (-1.03%) |
TNK1 | inactive (9.52%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | active (83.28%) |
ErbB2 | inactive (48.26%) |
ErbB4 | active (104.45%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (-0.48%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (-2.69%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (2.14%) |
MST1 | inactive (4.54%) |
MST2 | inactive (5.49%) |
MST4 | inactive (2.02%) |
HGK | inactive (2.37%) |
MINK | inactive (1.62%) |
LOK | inactive (7.07%) |
PAK1 | inactive (0.73%) |
PAK3 | inactive (0.69%) |
PAK2 | inactive (-1.35%) |
PAK5 | inactive (-1.71%) |
PAK6 | inactive (0.8%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (-0.55%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (0.76%) |
CK1g2 | inactive (0.77%) |
CK1g1 | inactive (0.82%) |
CK1g3 | inactive (1.79%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (1.79%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (11.13%) |
AurC | inactive (27.65%) |
AurA | inactive (3.44%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (-0.05%) |
NEK2 | inactive (0.04%) |
NEK9 | inactive (-0.45%) |
NEK7 | inactive (1.45%) |
NEK6 | inactive (1.2%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (1.41%) |
IKKe | inactive (2.35%) |
IKKb | inactive (-0.9%) |
IKKa | inactive (-2.78%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (6.25%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (0.44%) |
GPRK6 | inactive (2.38%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (0.33%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (-2.26%) |
MSK2 | inactive (-0.97%) |
RSK1 | inactive (-0.14%) |
RSK2 | inactive (1.52%) |
RSK4 | inactive (-1.11%) |
RSK3 | inactive (-1.02%) |
p70S6K | inactive (-1.65%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (-0.1%) |
AKT1 | inactive (-0.52%) |
AKT3 | inactive (0.11%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (-1.15%) |
SGK3 | inactive (0.07%) |
SGK2 | inactive (4.74%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (-2.51%) |
PKCg | inactive (1.11%) |
PKCa | inactive (-0.04%) |
PKCt | inactive (-1.1%) |
PKCi | inactive (-0.97%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (0.09%) |
PKG1 | inactive (-0.54%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (-0.71%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (-2.07%) |
ROCK2 | inactive (-1.36%) |
MRCKb | inactive (-2.08%) |
MRCKa | inactive (-6.83%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (0.86%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (-1.86%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (-0.25%) |
CaMK1d | inactive (1.04%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (6.5%) |
PHKg2 | inactive (-1.47%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (0.8%) |
CaMK2a | inactive (-1.88%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (-1.44%) |
MAPKAPK2 | inactive (-0.97%) |
MAPKAPK3 | inactive (-0.37%) |
MNK2 | inactive (11.5%) |
MNK1 | inactive (9.35%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (1.45%) |
PKD1 | inactive (1.38%) |
PKD2 | inactive (1.12%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (2.44%) |
MARK3 | inactive (2.28%) |
MARK1 | inactive (3.97%) |
QIK | inactive (1.23%) |
SIK | inactive (-0.04%) |
NuaK1 | inactive (4.34%) |
BRSK1 | inactive (2.54%) |
BRSK2 | inactive (3.58%) |
MELK | inactive (-1.35%) |
CHK1 | inactive (-0.07%) |
PASK | inactive (0.95%) |
AMPKa1 | inactive (3.86%) |
AMPKa2 | inactive (3.11%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (-1.3%) |
TSSK1 | inactive (-0.13%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (-1.55%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (-0.51%) |
PIM3 | inactive (-0.59%) |
PIM1 | inactive (-0.83%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (0.13%) |
p38a | inactive (0.45%) |
p38b | inactive (4.76%) |
p38d | inactive (-2.91%) |
Erk2 | inactive (-0.13%) |
Erk1 | inactive (1.75%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (3.19%) |
GSK3B | inactive (3.77%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-3.6%) |
MSSK1 | inactive (-0.82%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (-0.49%) |
CLK2 | inactive (-0.74%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (-1.24%) |
HIPK4 | inactive (-0.32%) |
DYRK1B | inactive (-0.85%) |
DYRK1A | inactive (-3.74%) |
DYRK2 | inactive (-3.59%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (1.05%) |