Compound Information
Test on : GPCR
Compound Name : IKK-3 Inhibitor
Inchikey : LDTAHRLHGHFHKP-UHFFFAOYSA-N
ChemSpider : 9801674
Pubchem CID : 11626927
ChEMBL : CHEMBL373751
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (5.39%) |
TYK2 | inactive (1.09%) |
JAK2 | inactive (29.39%) |
JAK3 | active (55%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (10.32%) |
FES | inactive (3.13%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (48.95%) |
ABL2 | inactive (17.96%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (4.26%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (33.09%) |
BTK | inactive (11.84%) |
TXK | inactive (42.49%) |
TEC | inactive (35.47%) |
ITK | inactive (11.49%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (9.89%) |
SRM | inactive (26.86%) |
FRK | inactive (4.36%) |
BLK | active (72.3%) |
LCK | active (69.25%) |
HCK | active (61.81%) |
FGR | active (59.64%) |
FYN | active (76.77%) |
SRC | active (50.12%) |
YES | inactive (39.21%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (34.38%) |
EphA4 | active (57.27%) |
EphA3 | inactive (13.64%) |
EphB4 | inactive (17.11%) |
EphB3 | inactive (4.4%) |
EphB2 | inactive (35.96%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (25.65%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-2.95%) |
ZAP70 | inactive (4%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (7.89%) |
ALK | inactive (9.85%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | active (68.74%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (5.1%) |
IGF1R | inactive (5.83%) |
IRR | inactive (3.13%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (8.19%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | active (50.61%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (18.76%) |
TRKB | active (57.18%) |
TRKC | active (56.07%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (8.3%) |
MET | inactive (15.56%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (43.51%) |
MER | active (77.14%) |
TYRO3 | inactive (20.11%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | active (63.73%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (19.33%) |
FGFR2 | inactive (31.65%) |
FGFR3 | inactive (24.07%) |
FGFR4 | inactive (1.47%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (15.74%) |
KDR | active (67.35%) |
FLT4 | active (73.37%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (33.25%) |
KIT | inactive (7.97%) |
FLT3 | inactive (11.56%) |
PDGFRa | active (81.62%) |
PDGFRb | active (78.06%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (14.61%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (38.02%) |
TNK1 | active (77.87%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (11.83%) |
ErbB2 | inactive (-1.42%) |
ErbB4 | inactive (8.72%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (10.85%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (8.14%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (41.33%) |
MST1 | active (66.36%) |
MST2 | active (51.53%) |
MST4 | inactive (0.22%) |
HGK | active (90.54%) |
MINK | active (83.5%) |
LOK | active (71.65%) |
PAK1 | inactive (5.61%) |
PAK3 | inactive (5.52%) |
PAK2 | inactive (2.17%) |
PAK5 | inactive (4.97%) |
PAK6 | inactive (9.78%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (7.23%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (3.58%) |
CK1g2 | inactive (3.78%) |
CK1g1 | inactive (4.23%) |
CK1g3 | inactive (2.61%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (47.48%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | active (73.62%) |
AurC | active (93.8%) |
AurA | active (77.24%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (3%) |
NEK2 | inactive (14.4%) |
NEK9 | inactive (1.96%) |
NEK7 | inactive (3.13%) |
NEK6 | inactive (-0.15%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | active (82.95%) |
IKKe | active (114.68%) |
IKKb | inactive (1.17%) |
IKKa | inactive (5.75%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (11.1%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (40.41%) |
GPRK6 | inactive (3.6%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (24.26%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (11.02%) |
MSK2 | inactive (10.01%) |
RSK1 | inactive (14.01%) |
RSK2 | inactive (13.72%) |
RSK4 | inactive (16.41%) |
RSK3 | inactive (10.16%) |
p70S6K | inactive (5.33%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (1.33%) |
AKT1 | inactive (1.02%) |
AKT3 | inactive (1.68%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (4.47%) |
SGK3 | inactive (4.05%) |
SGK2 | inactive (4.38%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (-1.63%) |
PKCg | inactive (6.46%) |
PKCa | inactive (2.72%) |
PKCt | inactive (3.61%) |
PKCi | inactive (3.79%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (5.2%) |
PKG1 | inactive (5.27%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (2.89%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (6.5%) |
ROCK2 | inactive (6.61%) |
MRCKb | inactive (4.7%) |
MRCKa | inactive (5.41%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (43.05%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (0.47%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (1.69%) |
CaMK1d | inactive (6.21%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | active (76.46%) |
PHKg2 | inactive (10.92%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | active (62.77%) |
CaMK2a | inactive (29.95%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (-0.19%) |
MAPKAPK2 | inactive (1.54%) |
MAPKAPK3 | inactive (4.59%) |
MNK2 | active (76.83%) |
MNK1 | inactive (47.73%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (5.43%) |
PKD1 | inactive (5.45%) |
PKD2 | inactive (4.79%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | active (76.59%) |
MARK3 | active (88.26%) |
MARK1 | active (80%) |
QIK | active (69.43%) |
SIK | active (61.05%) |
NuaK1 | active (54.33%) |
BRSK1 | active (76.3%) |
BRSK2 | active (82.21%) |
MELK | inactive (8.3%) |
CHK1 | inactive (23.31%) |
PASK | inactive (0.31%) |
AMPKa1 | active (74.56%) |
AMPKa2 | inactive (31.17%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (4.54%) |
TSSK1 | active (69.22%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (6.48%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (1.39%) |
PIM3 | inactive (-0.82%) |
PIM1 | inactive (0.97%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (6.08%) |
p38a | inactive (8.47%) |
p38b | inactive (6.97%) |
p38d | inactive (3.85%) |
Erk2 | inactive (5.43%) |
Erk1 | inactive (4.78%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (11.32%) |
GSK3B | inactive (8.83%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-1.66%) |
MSSK1 | inactive (1.49%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (3.74%) |
CLK2 | inactive (10.85%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (28%) |
HIPK4 | active (78.95%) |
DYRK1B | inactive (13.9%) |
DYRK1A | inactive (19.32%) |
DYRK2 | inactive (4.87%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (5%) |