Compound Information
Test on : GPCR
Compound Name : GW607049C
Inchikey : LCFRJLLZJJURNJ-UHFFFAOYSA-N
ChemSpider : 28484041
Pubchem CID : 56604030
ChEMBL : CHEMBL1909365
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (-4.92%) |
TYK2 | inactive (0.01%) |
JAK2 | inactive (2.1%) |
JAK3 | inactive (2.49%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (1.11%) |
FES | inactive (-0.58%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (32.96%) |
ABL2 | active (58.91%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (7.52%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (-0.17%) |
BTK | inactive (2.1%) |
TXK | inactive (4.98%) |
TEC | inactive (5.46%) |
ITK | inactive (0.87%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (1.4%) |
SRM | inactive (-0.15%) |
FRK | inactive (0.7%) |
BLK | inactive (2.36%) |
LCK | inactive (34.7%) |
HCK | inactive (14.4%) |
FGR | inactive (3.71%) |
FYN | inactive (3.27%) |
SRC | inactive (12.5%) |
YES | inactive (5.58%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | active (89.59%) |
EphA4 | active (81.62%) |
EphA3 | inactive (34.54%) |
EphB4 | active (57.18%) |
EphB3 | inactive (11.32%) |
EphB2 | active (79.89%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (0.15%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-0.54%) |
ZAP70 | inactive (-0.65%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (-2.11%) |
ALK | inactive (2.57%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (0.19%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (-0.75%) |
IGF1R | inactive (6.91%) |
IRR | inactive (-0.55%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | active (83.47%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | active (78.7%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | active (82.99%) |
TRKB | active (71.76%) |
TRKC | active (69.52%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (-0.55%) |
MET | inactive (36.19%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (10.86%) |
MER | inactive (2.34%) |
TYRO3 | inactive (21.88%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | active (74.14%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (-3.15%) |
FGFR2 | inactive (4%) |
FGFR3 | inactive (2.77%) |
FGFR4 | inactive (-0.24%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (37.67%) |
KDR | inactive (46.7%) |
FLT4 | inactive (21.66%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (3.42%) |
KIT | inactive (43.93%) |
FLT3 | inactive (32.63%) |
PDGFRa | active (57.59%) |
PDGFRb | inactive (16.52%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | active (70.71%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (1.64%) |
TNK1 | inactive (25.33%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (2.67%) |
ErbB2 | inactive (1.41%) |
ErbB4 | - |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (0.72%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (14.84%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (27.46%) |
MST1 | inactive (3.26%) |
MST2 | inactive (1.83%) |
MST4 | inactive (-1.61%) |
HGK | inactive (7.12%) |
MINK | inactive (0.67%) |
LOK | active (72.7%) |
PAK1 | inactive (-1.32%) |
PAK3 | inactive (0.83%) |
PAK2 | inactive (0.18%) |
PAK5 | inactive (-2.02%) |
PAK6 | inactive (1.21%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (0.12%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (1.98%) |
CK1g2 | inactive (1.01%) |
CK1g1 | inactive (0.47%) |
CK1g3 | inactive (0.39%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (0.84%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (8.08%) |
AurC | inactive (6.4%) |
AurA | inactive (7.64%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (1.18%) |
NEK2 | inactive (-0.82%) |
NEK9 | inactive (-0.45%) |
NEK7 | inactive (-3.05%) |
NEK6 | inactive (-0.98%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (2.38%) |
IKKe | inactive (-1.36%) |
IKKb | inactive (-1.08%) |
IKKa | inactive (-2%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (8.33%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (-6.83%) |
GPRK6 | inactive (-0.1%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (1.97%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (2.08%) |
MSK2 | inactive (0.37%) |
RSK1 | inactive (0.24%) |
RSK2 | inactive (-1.87%) |
RSK4 | inactive (0.24%) |
RSK3 | inactive (2.97%) |
p70S6K | inactive (7.6%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (-0.51%) |
AKT1 | inactive (0.76%) |
AKT3 | inactive (0.99%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (4.52%) |
SGK3 | inactive (0.03%) |
SGK2 | inactive (0.74%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (0.54%) |
PKCg | inactive (4.57%) |
PKCa | inactive (0.15%) |
PKCt | inactive (0.22%) |
PKCi | inactive (0.22%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (0.57%) |
PKG1 | inactive (1.52%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (-1.11%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (-0.72%) |
ROCK2 | inactive (-0.19%) |
MRCKb | inactive (-1%) |
MRCKa | inactive (0.4%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (0.37%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (0.05%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (1.75%) |
CaMK1d | inactive (0.37%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (-0.17%) |
PHKg2 | inactive (0.05%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (2.79%) |
CaMK2a | inactive (4.35%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (-0.97%) |
MAPKAPK2 | inactive (0.6%) |
MAPKAPK3 | inactive (12.56%) |
MNK2 | inactive (1.48%) |
MNK1 | inactive (4.58%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (0.51%) |
PKD1 | inactive (0.37%) |
PKD2 | inactive (0.52%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (-0.2%) |
MARK3 | inactive (1.81%) |
MARK1 | inactive (2.38%) |
QIK | inactive (0.47%) |
SIK | inactive (0.98%) |
NuaK1 | inactive (-4.85%) |
BRSK1 | inactive (0.16%) |
BRSK2 | inactive (1.01%) |
MELK | inactive (-2.88%) |
CHK1 | inactive (1.17%) |
PASK | inactive (2%) |
AMPKa1 | inactive (0.23%) |
AMPKa2 | inactive (1.29%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (-1.84%) |
TSSK1 | inactive (-2.84%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (4.23%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (-0.09%) |
PIM3 | inactive (2.48%) |
PIM1 | inactive (-0.09%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (6.37%) |
p38a | inactive (39.29%) |
p38b | inactive (34.27%) |
p38d | inactive (2.44%) |
Erk2 | inactive (-0.71%) |
Erk1 | inactive (1.55%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (0.68%) |
GSK3B | inactive (1.89%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-0.09%) |
MSSK1 | inactive (8.97%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (2.87%) |
CLK2 | inactive (-0.84%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (3.89%) |
HIPK4 | inactive (25.48%) |
DYRK1B | inactive (3.2%) |
DYRK1A | inactive (1.72%) |
DYRK2 | inactive (0.89%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (6.92%) |