Compound Information
Test on : GPCR
Compound Name : GSK248233A
Inchikey : KODFUVBIVXFWPF-UHFFFAOYSA-N
ChemSpider : 17257760
Pubchem CID : 16099859
ChEMBL : CHEMBL220465
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (2.7%) |
TYK2 | inactive (-0.04%) |
JAK2 | inactive (0.27%) |
JAK3 | inactive (-1.1%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (2.5%) |
FES | inactive (1.31%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (3.99%) |
ABL2 | inactive (2.42%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (-0.54%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (1.66%) |
BTK | inactive (-0.69%) |
TXK | inactive (3.29%) |
TEC | inactive (2.35%) |
ITK | inactive (0.86%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (-0.57%) |
SRM | inactive (6.2%) |
FRK | inactive (0.64%) |
BLK | inactive (2.27%) |
LCK | inactive (1.33%) |
HCK | inactive (4.03%) |
FGR | inactive (-22.97%) |
FYN | inactive (1.97%) |
SRC | inactive (1.89%) |
YES | inactive (2.45%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (-3.39%) |
EphA4 | inactive (-0.31%) |
EphA3 | inactive (4.01%) |
EphB4 | inactive (0.71%) |
EphB3 | inactive (3.26%) |
EphB2 | inactive (7.72%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (3.58%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (0.64%) |
ZAP70 | inactive (2.72%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (0.1%) |
ALK | inactive (1.96%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (3.39%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (3.14%) |
IGF1R | inactive (0.33%) |
IRR | inactive (0.53%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (1.45%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (2.13%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (-1.16%) |
TRKB | inactive (0.73%) |
TRKC | inactive (1.6%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (1.27%) |
MET | inactive (-4.37%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-3.3%) |
MER | inactive (0.04%) |
TYRO3 | inactive (0.87%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (4.26%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (0.12%) |
FGFR2 | inactive (3.9%) |
FGFR3 | inactive (3.54%) |
FGFR4 | inactive (-0.05%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (4.41%) |
KDR | inactive (8.86%) |
FLT4 | inactive (2.01%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (0.23%) |
KIT | inactive (1.33%) |
FLT3 | inactive (1.09%) |
PDGFRa | inactive (6.4%) |
PDGFRb | inactive (6.43%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (4.62%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (0.38%) |
TNK1 | inactive (6.93%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (1.68%) |
ErbB2 | inactive (-0.18%) |
ErbB4 | inactive (9.63%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (0.95%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (5.71%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (3.56%) |
MST1 | inactive (1.47%) |
MST2 | inactive (2.32%) |
MST4 | inactive (0.84%) |
HGK | inactive (29.38%) |
MINK | inactive (28.21%) |
LOK | inactive (5.59%) |
PAK1 | inactive (6.82%) |
PAK3 | inactive (2.25%) |
PAK2 | inactive (0.22%) |
PAK5 | inactive (-2.93%) |
PAK6 | inactive (-2.65%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (2.61%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (7.22%) |
CK1g2 | inactive (1.09%) |
CK1g1 | inactive (1.65%) |
CK1g3 | inactive (0.52%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (1.97%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (18.12%) |
AurC | inactive (43.68%) |
AurA | active (79.18%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (4.28%) |
NEK2 | inactive (1.24%) |
NEK9 | inactive (5.29%) |
NEK7 | inactive (1.46%) |
NEK6 | inactive (2.25%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (6.31%) |
IKKe | inactive (14.05%) |
IKKb | inactive (1.85%) |
IKKa | inactive (2.52%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (2.67%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (4.11%) |
GPRK6 | inactive (2.85%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (3.39%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | active (80.55%) |
MSK2 | active (79.01%) |
RSK1 | active (68.3%) |
RSK2 | active (52.83%) |
RSK4 | inactive (15.2%) |
RSK3 | active (63.59%) |
p70S6K | active (90.41%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (8.4%) |
AKT1 | inactive (7.63%) |
AKT3 | inactive (10.24%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (49.66%) |
SGK3 | active (83.53%) |
SGK2 | active (61.94%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | active (87.96%) |
PKCg | inactive (28.33%) |
PKCa | inactive (7.8%) |
PKCt | inactive (32.33%) |
PKCi | inactive (44.97%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | active (60.82%) |
PKG1 | active (73%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | active (55.76%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | active (87.14%) |
ROCK2 | active (86.02%) |
MRCKb | active (62.92%) |
MRCKa | active (53.42%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (8.31%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (0.72%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (1.14%) |
CaMK1d | inactive (2.17%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (2.21%) |
PHKg2 | inactive (-0.74%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (17.34%) |
CaMK2a | inactive (5.87%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (-1.26%) |
MAPKAPK2 | inactive (0.16%) |
MAPKAPK3 | inactive (2.85%) |
MNK2 | inactive (27.81%) |
MNK1 | inactive (11.54%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (2.97%) |
PKD1 | inactive (4.29%) |
PKD2 | inactive (5.77%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (3.87%) |
MARK3 | inactive (12.21%) |
MARK1 | inactive (10.83%) |
QIK | inactive (4.74%) |
SIK | inactive (2.47%) |
NuaK1 | inactive (18.7%) |
BRSK1 | inactive (3.54%) |
BRSK2 | inactive (2.76%) |
MELK | inactive (44.25%) |
CHK1 | inactive (5.78%) |
PASK | inactive (1.54%) |
AMPKa1 | inactive (2.17%) |
AMPKa2 | inactive (10.09%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (-0.76%) |
TSSK1 | active (52.21%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (0.59%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (1.39%) |
PIM3 | inactive (1.67%) |
PIM1 | inactive (8.74%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (3.41%) |
p38a | inactive (8.29%) |
p38b | inactive (1.94%) |
p38d | inactive (2.57%) |
Erk2 | inactive (3.77%) |
Erk1 | inactive (1.36%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (46.57%) |
GSK3B | inactive (40.98%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-1.86%) |
MSSK1 | inactive (-3.41%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (0.75%) |
CLK2 | inactive (1.15%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (1.69%) |
HIPK4 | inactive (3.8%) |
DYRK1B | inactive (4.48%) |
DYRK1A | inactive (5.38%) |
DYRK2 | inactive (2.79%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (0.04%) |