Compound Information
Test on : GPCR
Compound Name : SB-759335-B
Inchikey : KLJXDQVVVCKVLJ-UHFFFAOYSA-N
ChemSpider : 28484520
Pubchem CID : 57401573
ChEMBL : CHEMBL1909376
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (4.72%) |
TYK2 | inactive (-2.3%) |
JAK2 | inactive (2.86%) |
JAK3 | inactive (-0.7%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (0.82%) |
FES | inactive (4.85%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (3.28%) |
ABL2 | inactive (4.42%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (4.45%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (8.89%) |
BTK | inactive (1.16%) |
TXK | inactive (5.49%) |
TEC | inactive (7.17%) |
ITK | inactive (2.09%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (5.31%) |
SRM | inactive (-2.89%) |
FRK | inactive (4.59%) |
BLK | inactive (4.31%) |
LCK | inactive (5.67%) |
HCK | inactive (9.25%) |
FGR | inactive (2.57%) |
FYN | inactive (2.87%) |
SRC | inactive (16.42%) |
YES | inactive (3.85%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (1.16%) |
EphA4 | inactive (11.31%) |
EphA3 | inactive (2.79%) |
EphB4 | inactive (3.87%) |
EphB3 | inactive (3.77%) |
EphB2 | inactive (7.73%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (9.07%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (3.25%) |
ZAP70 | inactive (4.99%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (5.18%) |
ALK | inactive (5.18%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (7.97%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (9.41%) |
IGF1R | inactive (9.25%) |
IRR | inactive (6.22%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (1.68%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (4.88%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (4.86%) |
TRKB | inactive (4.35%) |
TRKC | inactive (4.33%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (4.33%) |
MET | inactive (2.13%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-9.66%) |
MER | inactive (2.33%) |
TYRO3 | inactive (2.14%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (6.87%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (5.74%) |
FGFR2 | inactive (7.87%) |
FGFR3 | inactive (7.38%) |
FGFR4 | inactive (2.67%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (2.54%) |
KDR | inactive (9.13%) |
FLT4 | inactive (7.52%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (5.74%) |
KIT | inactive (7.52%) |
FLT3 | inactive (4.6%) |
PDGFRa | inactive (9.34%) |
PDGFRb | inactive (4.8%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (5.14%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (1.52%) |
TNK1 | inactive (5.69%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (2.62%) |
ErbB2 | inactive (2.97%) |
ErbB4 | inactive (10.56%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (3.54%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (11.54%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (2.14%) |
MST1 | inactive (5.39%) |
MST2 | inactive (8.25%) |
MST4 | inactive (1.91%) |
HGK | inactive (4.49%) |
MINK | inactive (6.02%) |
LOK | inactive (8.24%) |
PAK1 | inactive (15.35%) |
PAK3 | inactive (9.28%) |
PAK2 | inactive (4.45%) |
PAK5 | inactive (8.13%) |
PAK6 | inactive (0.53%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (4.93%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (9.8%) |
CK1g2 | inactive (4.57%) |
CK1g1 | inactive (6.64%) |
CK1g3 | inactive (3.18%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (14.26%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (4.51%) |
AurC | inactive (1.12%) |
AurA | inactive (2.9%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (3.76%) |
NEK2 | inactive (5.88%) |
NEK9 | inactive (5.61%) |
NEK7 | inactive (10.75%) |
NEK6 | inactive (3.67%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (5.51%) |
IKKe | inactive (7.71%) |
IKKb | inactive (8.59%) |
IKKa | inactive (5.47%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (12.51%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (9.01%) |
GPRK6 | inactive (9.53%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (2.7%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (7.4%) |
MSK2 | inactive (4.71%) |
RSK1 | inactive (3.1%) |
RSK2 | inactive (-0.05%) |
RSK4 | inactive (2.55%) |
RSK3 | inactive (3.01%) |
p70S6K | inactive (4.44%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (2.21%) |
AKT1 | inactive (2.57%) |
AKT3 | inactive (5.1%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (4.77%) |
SGK3 | inactive (6.39%) |
SGK2 | inactive (4.56%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (4.16%) |
PKCg | inactive (0.03%) |
PKCa | inactive (1.73%) |
PKCt | inactive (3.7%) |
PKCi | inactive (0.89%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (7.34%) |
PKG1 | inactive (9.25%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (3.75%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (3.23%) |
ROCK2 | inactive (4.33%) |
MRCKb | inactive (3.02%) |
MRCKa | inactive (7.84%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (5.6%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (1.96%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (1.55%) |
CaMK1d | inactive (2.87%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (4.51%) |
PHKg2 | inactive (7.28%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (6.57%) |
CaMK2a | inactive (4.17%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (2.41%) |
MAPKAPK2 | inactive (5.04%) |
MAPKAPK3 | inactive (10.7%) |
MNK2 | inactive (0.78%) |
MNK1 | inactive (2.99%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (4.94%) |
PKD1 | inactive (6.72%) |
PKD2 | inactive (4.19%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (1.48%) |
MARK3 | inactive (7.99%) |
MARK1 | inactive (3.48%) |
QIK | inactive (6.58%) |
SIK | inactive (14.17%) |
NuaK1 | inactive (2.51%) |
BRSK1 | inactive (-2.27%) |
BRSK2 | inactive (2.15%) |
MELK | inactive (9.51%) |
CHK1 | inactive (13.8%) |
PASK | inactive (-0.89%) |
AMPKa1 | inactive (4.88%) |
AMPKa2 | inactive (3.25%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (3.03%) |
TSSK1 | inactive (5.83%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (8.15%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (-0.88%) |
PIM3 | inactive (2.39%) |
PIM1 | inactive (2.05%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (8.83%) |
p38a | inactive (20.52%) |
p38b | inactive (5.3%) |
p38d | inactive (7.35%) |
Erk2 | inactive (7.48%) |
Erk1 | inactive (7.02%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (2.61%) |
GSK3B | inactive (1.94%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-1.85%) |
MSSK1 | inactive (-1.54%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (1.12%) |
CLK2 | inactive (5.8%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (0.35%) |
HIPK4 | inactive (0.6%) |
DYRK1B | inactive (-0.73%) |
DYRK1A | inactive (4.33%) |
DYRK2 | inactive (7.99%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (2.82%) |